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6838440 |
Kolla2-desiccated avian sternal cartilage powder
Kolla2 powder compositions, method of preparing the compositions and use of the compositions in treating arthritic joint cartilage diseases. The compositions are orally administered to human in...
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6838441 |
Albumin for treating meconium aspiration syndrome
The present invention provides a method of treating meconium aspiration syndrome, said method comprising administering to a subject in need of treatment a therapeutically effective amount of...
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6835715 |
Mammalian dihydroouabain-like factor and therapeutic compositions
A novel mammalian dihydroouabain-like factor is disclosed which substantially fails to cross-react with mammalian ouabain-like factor (OLF) for binding to anti-OLF antibody, but cross-reacts with...
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6833132 |
Method of stimulating epithelial cells using keratinocyte growth factor (KGF) and method of inhibiting KGF activity
Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used sucessfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other...
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6833358 |
Lacrimal secretion promoters or eye drops for treating keratoconjunctival failure containing as the active ingredient natriuretic peptides
The object of the present invention is to find new effects of natriuretic peptides in an ophthalmological field. The present invention provides eyedrops for promoting lacrimal secretion or for...
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6828305 |
Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
Mixtures of conjugates in which each conjugate in the mixture comprises a growth hormone drug coupled to an oligomer that includes a polyalkylene glycol moiety wherein the mixtures have a molecular...
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6828306 |
Charged lipid compositions and methods for their use
The invention provides a pharmaceutical composition comprising a synthetic or naturally occurring charged phospholipid, which is formulated into a dosage form for administration to a subject or...
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6818407 |
Anti-endotoxic antimicrobial cationic peptides and methods of use therfor
A novel class of cationic peptides having antimicrobial activity is provided. Exemplary peptides of the invention include KWKSFIKKLTSAAKKVVTTAKPLALIS (SEQ ID NO:3) and KGWGSFFKKAAHVGKHVGKAALTHYL...
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6815427 |
Sericin-containing material, process for producing the same method of using the same
The object of the present invention is to elucidate a biologically active function of a component constituting undegraded sericin and to provide a novel medical material, cosmetic material, etc....
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6809084 |
Compositions containing polysaccharides from phellinus linteus and methods for treating diabetes mellitus using same
The present invention relates to a novel use of polysaccharides (PL) from Phellinus linteus for treating diabetes mellitus, which provides medicine or food comprising polysaccharide as active...
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6790825 |
Method of using secretin and compositions made therefrom for the treatment of autism and other neurological, behavioral and immunological disorders
Secretin and secretin compositions are used for the treatment of autism and other neurological, behavioral and immunological disorders. The method includes administering an effective amount of...
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6790438 |
Cross-linked collagenic peptide for preventing post-surgical adhesions
The aim of the invention is to provide a modified collagen peptide for preventing post-operative adhesions that is non-toxic, economic, in addition to being easy to obtain, sterilize, manipulate...
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6780841 |
Hyaluronic acid and chondroitin sulfate based hydrolyzed collagen type II and method of making same
Hydrolyzed collagen type II powder compositions for inducing cartilage formation in an individual, method of preparing the compositions and use of the compositions in treating connective tissue...
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6776983 |
Protein free formulations
A stable granulocyte colony-stimulating factor-containing formulation comprising a granulocyte colony-stimulating factor and at least one pharmaceutically acceptable surfactant in an amount of 1...
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6777052 |
Plastic container containing albumin solution
The present invention provides a plastic container containing albumin solution and a packaged plastic container containing an albumin solution. The plastic container containing an albumin solution...
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6777390 |
Stable blood coagulation inhibitor-free factor vii preparation and method for preparing same
Stable pharmaceutical preparations containing blood coagulation Factor VII is disclosed. The pharmaceutical preparations containing blood coagulation Factor VII are free of coagulation inhibitors...
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6770625 |
Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
Pharmaceutical compositions that include a drug-oligomer conjugate, a fatty acid component, and a bile salt component are described. The drug is covalently coupled to an oligomeric moiety. The...
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6767544 |
Methods for treating cardiovascular diseases with botulinum toxin
The present invention provides for methods of treating cardiovascular diseases in a mammal. The methods include a step of administering an effective amount of a botulinum toxin directly to a blood...
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6756362 |
Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the...
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6753311 |
Collagen or collagen-like peptide containing polymeric matrices
Tissue engineering scaffolds comprising collagen or a collagen-like peptides incorporated within or between polymeric fibers and methods for their production are provided.
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6750198 |
Preparation for the treatment of pigmentation disorders
The invention relates to a preparation for the treatment of pigmentation disorders. The preparation contains a physiologically active quantity of the DCoH protein, the DNA and/or RNA coding for the...
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6750203 |
Product derived from milk substantially free of beta casein from non-human mammals and relative use
The present invention is related to a product derived from milk, substantially free of beta casein from non-human mammals. The invention is also related to the use of such a product especially in...
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6743773 |
Method of using lectins for contraception, prophylaxis against diseases transmittable by sexual contact, and therapy of such diseases, and apparatus for administering lectins
In order to prevent conception and/or the spread of sexually transmitted diseases (STD's) one or more lectins capable of binding sperm and/or the pathogenic microorganisms responsible for STD's are...
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6740638 |
Methods for treatment of multiple sclerosis using peptide analogues at position 91 of human myelin basic protein
Peptide analogues of human myelin basic protein containing residues 87-99 are provided. Residue 91 of the peptide analogues is altered from the L-lysine residue found in the native protein to any...
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6737398 |
Modulation of &ggr &dgr T cells to regulate airway hyperresponsiveness
Disclosed is a method for regulation of airway hyperresponsiveness by modulating the action of γδ T cells in a patient. Also disclosed are methods for identifying compounds hyperresponsiveness by...
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6733793 |
Oral composition with insulin-like activities and methods of use
An orally administered, novel dietary supplement or therapeutic composition capable of insulin-like activity in animals, preferably humans, is provided. Contained in the composition are...
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6730323 |
Microclysmic gel for treatment of tissue trauma and burns
A therapeutic wound gel is provided which will enhance healing of the wound and reduce swelling and increase elasticity of the skin. Humatrix is bacteriostatic protectant with no bacteriocidal...
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6723699 |
Treating disorders by application of insulin-like growth factors and analogs
A method of enhancing the survival of neuronal cells in a mammal, the cells being at risk of dying, the method comprising administering to the mammal an effective amount of one of the following...
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6719984 |
Composition and method for immunomodulation in mammals
This invention relates to compositions and processes utilized to modulate the immune system of mammals. More particularly, the present invention relates to the use of low molecular weight...
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6716434 |
Composition and method for immunostimulation in non- mammalian vertebrates
This invention relates to compositions utilized to modulate the immune system of non-mammalian vertebrates. More particularly, the present invention relates to the use of low molecular weight...
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6716809 |
Mage-A3 peptides presented by HLA class molecules
The invention describes HLA class II binding peptides encoded by the MAGE-A3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides...
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6713453 |
Fibrin/fibrinogen-binding conjugate
A fibrin/fibrinogen binding conjugate for forming a depot for the sustained release of a pharmaceutically active substance from a fibrin clot. The conjugate comprises a fibrin/fibrinogen binding...
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6713449 |
E2F activity inhibitory compounds
E2F-inhibiting compounds are represented by the formula: R 1 —A—R 2 wherein A represents a peptide sequence comprising a partial amino acid sequence having at least 12 continuous residues in...
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6713444 |
Buforin I as a specific inhibitor and therapeutic agent for botulinum toxin B and tetanus neurotoxins
The compounds of the invention are generally described by the formula: X 1 X 2 B 3 X 4 B 5 X* 6 X 7 X 8 B 9 X 10 B 11 X 12 B 13 X 14 B 15 X 16 B 17 X* 18 X* 19 B 20 X 21 X 22 X 23 Q 24 F 25 Z* 26...
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6703362 |
Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related methods
This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g.,...
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6702998 |
Methods and devices for treating lung dysfunction
Methods and devices useful for treatment of lung conditions resulting from dysfunction of normal pulmonary physiology.
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6699490 |
Aqueous prolonged release formulation
Prolonged parenteral release into the circulatory system of a cow of a bioactive bovine somatotropin at desirably effective levels can be achieved using novel compositions in which the bovine...
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6699484 |
Fibrin sealants or adhesives comprising a hyaluronic acid derivative material
An especially useful fibrin glue composition comprises a biocompatible, bioabsorbable hyaluronic acid derivative material, upon which are applied or chemically bonded fibrinogen and thrombin, along...
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6696056 |
Pharmaceutical compositions of erythropoietin
The present invention provides aqueous pharmaceutical formulations of erythropoietin that are free of human serum blood products, stabilized with a quantity of an amino acid and a sorbitan...
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6696422 |
Combination therapy for HIV infections
The present invention discloses a method of treating patients having AIDS or HIV infections by parenterally administering Product R, a peptide-nucleic acid preparation, in a combination with one or...
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6693073 |
Pulmonary delivery of active agents
The present invention provides methods for administering an active agent to an animal in need of the agent by the pulmonary route. This method comprises administering via the pulmonary route, a...
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6689748 |
Method of treating mast cell activation-induced diseases with a proteoglycan
The invention provides a method for preventing and treating the harmful biological effects of biochemicals secreted from activated mast cells in the organism of warm blooded animals and more...
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6686332 |
Method of treating depressed reticuloendothelial system function
The present invention provides methods of treating adverse physiological effects associated with depressed reticuloendothelial system function comprising administering to a subject suffering from...
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6683050 |
Compounds with anti-KS and anti-HIV activity
The present invention relates to a compound having anti-KS and anti-HIV pharmaceutical activity which comprises an HCG-like inhibitory protein and fragments or derivatives thereof, said protein and...
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6682760 |
Cross-linked collagen matrices and methods for their preparation
A method for preparing cross-linked collagen and cross-linked collagen products. The method includes incubating collagen in a solution including water, at least one polar solvent and at least one...
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6679918 |
Implantable putty material
The present invention provides compositions for an implantable putty material for delivery of active compounds to a patient. More specifically, the present invention provides a material having a pH...
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6676985 |
Bovine lactation associated immunotropic protein (CD14), encoding gene and application in B cell activation
A protein purified from bovine colostral whey and isolated nucleotide sequences encoding the protein is identified. The isolated bovine protein is termed Bovine Lactation Associated Immunotropic...
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6673770 |
Peptides for the treatment, prophylaxis, diagnosis and monitoring of autoimmune diseases
The invention provides a peptide suitable for the prophylaxis, treatment, diagnosis or monitoring of arthritis. The peptide contains a contiguous sequence element of 9 amino acid residues...
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6673609 |
Recombinant human erythropoietin with advantageous glycosylation profile
A method for the production of a polypeptide, the method comprising culturing, under conditions which allow for the expression of DNA encoding SEQ ID NO:2 in an eukaryotic host cell, wherein the...
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6667292 |
Nitric monoxide metabolite-polyoxyalkylene-hemoglobin complex
Disclosed is a nitric monoxide metabolite-polyoxyalkylene-hemoglobin complex having a molecular weight of from 100,000 to 2,000,000 daltons, in which a polyoxyalkylene derivative is bound to from...
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