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6984628 |
Ophthalmic compositions comprising trefoil factor family peptides
This invention relates to compositions comprising trefoil family factor peptides which are useful in preventing or treating dry eye by topical administration of the composition to eye of the...
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6982249 |
Bradykinin analogs as selective inhibitors of cell activation
The present invention provides bradykinin peptide analogs, compositions, and methods of inhibiting thrombin-induced platelet and other cell activation. The bradykinin analogs comprise single or...
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6982256 |
Tolerance of 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine in intravenous administration
The invention relates to new formulations for improving the local tolerance of intravenously administered 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-b
enzoylguanidine or one of the...
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6982248 |
Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue
Individuals in need of treatment of ischemia-related reperfusion are treated, preferably intravenously, with a composition which includes a compound which binds to a receptor for the glucagon-like...
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6979445 |
Method for treating von willebrand's disease
Use of factor XIII for treating von Willebrand's disease. A patient having von Willebrand's disease is treated by administering factor XIII generally in conjunction with factor VIII concentrate,...
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6979670 |
Matrix protein compositions for grafting
Enamel matrix, enamel matrix derivatives and/or enamel matrix proteins are used in the preparation of a pharmaceutical composition for promoting the take of a graft, e.g. in soft tissue such as...
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6974798 |
Treatment of balance impairments
Compositions and methods are provided for prophylactic or therapeutic treatment of balance impairments involving neuronal damage, loss, or degeneration, preferably of vestibular ganglion neurons,...
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6969525 |
Surgically implanted time release medication for post-surgical treatment of a patient
A method of administering a medication to a post operative patient with the medication being administered at the site of a surgery performed on the patient. The medication is formed into a time...
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6958322 |
Factor X analog with an improved ability to be activated
This invention describes a factor Xa analog which has a substitution of a minimum of one of the amino acid between Glu226 and Arg234 and possibly Ile235, relative to the amino acid numbering...
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6956027 |
N-terminally chemically modified protein compositions and methods
Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and...
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RE38827 |
Adhesive sealant composition
This invention is related to an adhesive composition which may be used to bond or seal tissue in vivo. The adhesive composition is readily formed from a two component mixture which includes a first...
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6949512 |
Therapeutic agent for the treatment of septicaemia its preparation and use
A therapeutic agent for the treatment of septicemia, its preparation and use, with application in the pharmaceutical industry and medicine. This therapeutic agent contains essential element, the...
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6943151 |
Method of inhibiting bone resorption and/or promoting bone formation using GLP-2 and related compounds
Disclosed are methods of inhibiting bone resorption and/or promoting bone formation using GLP-2 and related Compounds. The invention has a wide spectrum of important uses including...
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6942663 |
Laser treatment of cutaneous vascular lesions
Methods for treating maladies such as cutaneous vascular lesions. A patient in need of vascular lesion treatment is identified. A hyperosmotic agent is administered to a region adjacent the lesion....
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6943150 |
Survivin, a protein that inhibits cellular apoptosis and its modulation
The present invention provides the amino acid of a protein that inhibits cellular apoptosis, herein termed the Survivin protein and nucleic acid molecules that encode Survivin. Based on this...
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6939852 |
Methods and compositions for the treatment of cerebral palsy
The invention provides for the use of a botulinum toxin to treat cerebral palsy in juvenile patients by transdermal administration of the botulinum toxin. The juvenile patients are preferably...
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6936423 |
Anti-LTNF for in vitro assay of biological toxins
Lethal Toxin Neutralizing Factor has been isolated in purity from opossum serum by high pressure liquid chromatography (HPLC) fractionation. The amino acid sequence from the N-terminal for the...
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6933272 |
Use of non-peptidyl compounds for the treatment of insulin related ailments
The present invention relates to the use of at least a non-peptidyl compound as a biological modulator of insulin activity or insulin-related activity, which compound possesses ionic and...
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6932985 |
Azide method and composition for controlling deleterious organisms
Disclosed is both a method and composition for controlling deleterious organisms, such as insects, nematodes and weeds by applying a compound comprised of a liquid medium comprising azide and...
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6929806 |
Agents for improving lipid metabolism and reducing high blood pressure
A milk-derived basic protein fraction and a basic peptide fraction are provided for use as an effective component for agents for improving lipid metabolism and reducing high blood pressure which...
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6930093 |
Use of ribofuranose derivatives against inflammatory bowel diseases
A method for the prophylaxis or treatment of an inflammatory bowel disease is provided, comprising administering to a patient having or at risk of developing an inflammatory bowel disease a...
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6930090 |
Methods of activating a receptor using amphiphilic drug-oligomer conjugates
The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier (“BBB”) and to methods of making and using such conjugates. An amphiphilic...
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6926884 |
GPIb-lipid bond construct and use thereof
The present invention provides a conjugate wherein GP (glycoprotein) Ib and a lipid are bonded via polyalkylene oxide. The present invention also provides a complex (GPIb lipid complex) containing...
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6924270 |
Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
Ribavirin derivatives represented by the formula II, pharmaceutical compositions containing them as well as methods of using the ribavirin derivatives represented by the formula II for the...
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6921527 |
Composition for pulmonary administration comprising a drug and a hydrophobic amino acid
According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible...
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6919309 |
Methods and compositions for inhibiting angiogenesis
The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits...
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6916790 |
Treatment of osteoporosis
A substantially pure complex including IGFIIE polypeptide and IGFBP2 polypeptide is described. Methods for treating an osteoporosis patient and targeting a compound to the skeletal extracellular...
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6913903 |
Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
Methods for synthesizing proinsulin polypeptides are described that include a contacting a proinsulin polypeptide including an insulin polypeptide coupled to one or more peptides by peptide bond(s)...
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6911334 |
Protease for activating clotting factor VII
A protease for activating the blood clotting factor VII is described, wherein the protease is inhibited by the presence of aprotinin and is increased in its activity by calcium ions and/or heparin...
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6911216 |
Targeted delivery via biodegradable polymers
Delivery of bioactive molecules such as nucleic acid molecules encoding a protein can be significantly enhanced by immobilization of the bioactive molecule in a polymeric material adjacent to the...
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6908898 |
Angiogenesis related molecules
The present invention provides the sequence of a protein capable of acting as an angiostatin receptor as well as the nucleic acid sequence thereof. The invention also relates to the use thereof in...
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6906034 |
Acid-labile subunit (ALS) of insulin-like growth factor binding protein complex
The acid-labile sub-unit (ALS) of insulin like growth factor binding protein complex in biologically pure form is described. ALS has a molecular weight between 80-115 kd as determined by SDS...
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6905704 |
Peptide SY
Peptide SY is produced by applying a mixture of peptides obtained by processing fish meat with a protease to a peptide-adsorbing resin (ODS resin or the like), eluting this with water, then with a...
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6903071 |
Cartilage/bone inducing materials for reparation
A cartrilage and bone morphogenetic repairing composition comprising a collagen-free aqueous solution of a polyoxyethylene-polyoxypropylene and an effective amount of a bone morphogenetic protein,...
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6900180 |
Pharmaceutical compositions for alleviating discomfort
The invention relates to products for complete nutrition of infants or diseased or elderly persons. The products are characterized by increased levels of folic acid, vitamin B6 and vitamin B12 or...
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6896899 |
Pharmaceutical preparations of glutathione and methods of administration thereof
A method of increasing glutathione levels in mammalian cells comprising administering an oral bolus of encapsulated pharmaceutically stabilized glutathione in a rapidly dissolving formulation to a...
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6893653 |
Chemical cleaning of biological material
The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as...
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6894029 |
Use of jellyfish collagen (type II) in the treatment of rheumatoid arthritis
Compositions of substantially homogeneous type II-like collagen from invertebrates belonging to the class Scyphozoa, phylum Coelenterata, i.e., jellyfish, particularly Stomolophus meleagris , and...
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6890902 |
Cytotoxic modified lactoferrin peptides
The present invention provides a modified lactoferrin peptide which is cytotoxic, 7 to 25 amino acids in length, with three or more cationic residues and which has one or more extra bulky and...
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6887850 |
Method to provide nutritional composition
A method is described to provide composition for a nutritional supplement for convalescing patients recovering from illness or surgery, those with limited appetite such as the elderly, children or...
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6872704 |
Acidic mammalian proteins and polynucleotides encoding the same
Genes are disclosed that are differentially-regulated during feeding and fasting cycles. These genes, and their encoded polypeptides are useful to combat obesity and other metabolic disorders.
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6872724 |
Polymorphs with tyrosine kinase activity
The present invention relates to active polymorphs of 4-[2-(5-cyano-thiazol-2-ylamino)-pyridin-4-ylmethyl]-piperaz
ine-1-carboxylic acid methylamide which inhibit, regulate and/or modulate tyrosine...
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6872404 |
Ophthalmologic uses of protein C
The present invention provides a method of reducing intraocular fibrin comprising the administration of a pharmacologically effective dose of Protein C to an individual having elevated levels of...
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6867193 |
Amino acid-containing albumin preparation
An albumin preparation that prevents onset of hepatic encephalopathy caused by conventional amino acid preparations and enhances an effect of improving the symptoms is provided. The albumin...
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6867178 |
Calorically dense nutritional composition
An enteral composition and method for providing nutrition to metabolically stressed patients. The enteral composition has an energy density of about 1.4 to 1.8 kcal/ml. The enteral composition...
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6864232 |
Agent for treating visual cell function disorder
The present invention provides an agent for treating retinopathy containing a tricyclo compound of formula (I)
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6858576 |
Methods for regulating gastrointestinal motility
Methods for reducing gastric motility and delaying gastric emptying for therapeutic and diagnostic purposes are disclosed which comprise administration of an effective amount of an exendin or an...
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6858580 |
Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
A non-polydispersed mixture of conjugates in which each conjugate in the mixture comprises a drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may...
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6852700 |
Colostrinin, and uses thereof
The use of Colostrinin as a medicament, particularly in the treatment of chronic disorders of the central nervous system and the immune system.
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6846299 |
Method for continuous recirculating peritoneal dialysis
Method for a continuous recirculating peritoneal dialysis wherein the peritoneal dialysis fluid is infused into a peritoneal cavity of a patient and then, typically on a continuous process basis a...
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