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7135457 |
Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related methods
This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g.,...
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7128922 |
Compositions of leukaemia inhibitory factor
The present invention relates generally to compositions and more particularly to compositions comprising leukaemia inhibitory factor (hereinafter referred to as “LIF”) or derivative or...
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7125851 |
Endoprosthesis with long-term stability
The invention relates to the use of an active substance complex for creating biological parts, in particular organs for living organisms, with the following components which differ from one another...
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7125862 |
Porphyrin-metal complexes and oxygen infusions containing the same
A porphyrin metal complex that can form a stable oxygen complex and acts effectively as an oxygen infusion, which comprises:
a transition metal ion M of period 4 or 5 coordinating to a porphyrin...
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7118737 |
Polymer-modified synthetic proteins
The present invention relates to methods and compositions for modifying peptides, polypeptides and proteins with polymers, especially glyco-mimetic polymers, so as to improve their biological...
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7119062 |
Methods and compositions for improved articular surgery using collagen
The invention provides methods for treating post-surgical articular or incisional pain and/or discomfort in a patient. The invention further provides improved surgical methods and controlled...
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7115578 |
Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
Ribavirin derivatives represented by the formula V, pharmaceutical compositions containing them as well as the use of the ribavirin derivatives represented by the formula V for the preparation of a...
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7112571 |
Peptide Y-2
Peptide which is obtained by treating fish meat such as sardine with an alkaline protease is adsorbed with a peptide-adsorbing resin (such as ODS resin) and eluted with 10 aqueous ethanol to obtain...
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7109159 |
Leptin as an inhibitor of tumor cell proliferation
The use of leptin and leptin-related molecules in oncology is disclosed.
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7109173 |
Transport of nucleotides, oligonucleotides and polynucleotides into the cytoplasm and nucleus of cells by peptides
The invention discloses the discovery of naturally occurring peptides that contain fatty acyl and prenyl moieties which permit the transfer of nucleotides, oligonucleotides, and polynucleotides...
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7105490 |
Methods and compositions for treating polycystic ovary syndrome
The present invention relates to methods of treating polycystic ovary syndrome (PCOS) comprising administering glucagon-like peptide-1 (GLP-1), exendin, and analogs and agonists thereof, to...
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7105489 |
Methods and compositions for treating polycystic ovary syndrome
The present invention relates to methods of treating polycystic ovary syndrome (PCOS) comprising administering glucagon-like peptide-1 (GLP-1) to subjects suffering therefrom.
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7101842 |
Targeted delivery of drugs for the treatment of parasitic infections
Targeting agents such as transferrin and transcobalamin can be conjugated with anti-protozoan drugs for the treatment of protozoan infections. Any suitable anti-protozoan drug can be used,...
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7101846 |
Methods and compositions for optimization of oxygen transport by cell-free systems
Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof....
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7091180 |
Hyaluronic acid and chondroitin sulfate based hydrolyzed collagen type II and method of making same
Hydrolyzed collagen type II powder compositions for inducing cartilage formation in an individual, method of preparing the compositions and use of the compositions in treating connective tissue...
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7087578 |
Formulations and methods for treating hypercoagulable states
A method of treating a human patient with a hypercoagulable state or protein C deficiency, which comprises administering activated Protein C and protein C Zymogen.
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7087248 |
Pharmaceutical component based on human parathyroid hormone and a pharmaceutical composition for intranasal administration comprising the component
A medical component comprising a human parathyroid hormone peptide or its derivative, and acetic acid contained at a concentration less than its chemical equivalent with respect to the human...
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7087577 |
Method of promoting natural bypass
An angiogenic factor comprising a mixture of proteins derived from bone. The angiogenic protein mixture is produced by a series of steps that allow the proteins to be kept in solution. The...
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7084121 |
Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
A mixture of conjugates in which each conjugate in the mixture comprises a calcitonin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may lower...
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7078378 |
Method of tissue repair II
A substantially solid biomolecular solder for joining tissue comprising a partially denatured biomolecule. The solder can be formed into shapes to suit the needs of a user. The invention also...
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7070942 |
Method of inducing or enhancing chondrogenesis with extracellular matrix containing GDF-5
A method and composition are provided for inducing or enhancing chondrogenesis in vivo or in vitro. The method is performed by exposing the cells in vitro or in vivo to an extracellular matrix...
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7067139 |
Method for treating autoimmune diseases
A method of treating patients having rheumatoid arthritis by administering Product R, a peptide-nucleic acid preparation, is disclosed.
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7067492 |
Method of promoting healing of a tympanic membrane perforation
The present invention relates to the use of plasminogen and plasmin as agents for enhancing healing of tympanic membrane perforations or other wounds, and for reducing scars or necrotic tissue...
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7067488 |
Modified GLP-1 peptides with increased biological potency
The present invention relates to a GLP-1 peptide having the following formula, or a pharmaceutically acceptable salt thereof:
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7060684 |
Device for treating diabetes and methods thereof
A composite supported vascular graft comprising Vascular Endothelial Growth Factor (VEGF) and/or Platelet Derived Growth Factor (PDGF) for enhanced site-specific angiogenesis and methods thereof...
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7052721 |
Recovery of compounds using a natural adsorbent
The invention provides a method for recovery of compounds by adsorption fish scales. The method can be used for natural and synthetic compounds such as various natural pigments including...
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7049081 |
Diagnostic methods based on human BTG-2 and BTG-3 polypeptides
The present invention relates to novel antiproliferative genes. More specifically, isolated nucleic acid molecules are provided encoding the human B-cell translocation genes 2 and 3 (BTG-2 and...
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7049282 |
Inhibition of complement action
The present invention relates to a method of blocking biochemical function of the classical complement pathway and thereby preventing immunologic damage in a variety of diseases and conditions...
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7045141 |
Allograft bone composition having a gelatin binder
The invention is directed toward an osteoimplant for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing composition of demineralized...
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7045501 |
Method of treating chronic cardiac disease
New therapeutic uses for BPI protein products that involve treatment of chronic cardiac disease.
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7037892 |
Hematopoietic stem cell proliferating agents
This invention relates to a hematopoietic stem cell proliferating agent comprising IGF-I, a hematopoietic stem cell proliferating agent comprising IGF-I and at least one protein selected from among...
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7034003 |
Somatostatin and somatostatin agonists for decreasing body weight
The present invention relates to a method of decreasing body weight in a patient. The method includes the step of administering a therapeutically effective amount of a somatostatin or a...
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7033999 |
Nitrosated and nitrosylated heme proteins
Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet...
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7030091 |
Non-aqueous injectable formulation preparation with pH adjusted for extended release of somatotropin
The present invention provides compositions of matter which allow for the extended release and enhanced bioavailability of biologically-active polypeptides following parenteral delivery to an...
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7030082 |
Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
Pharmaceutical compositions that include a drug and/or drug-oligomer conjugate, a fatty acid component and a bile salt component, or a bile salt component without a fatty acid component are...
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7030084 |
Drug-oligomer conjugates with polyethylene glycol components
The present invention relates generally to hydrolyzable drug-oligomer conjugates, pharmaceutical compositions comprising such conjugates, and to methods for making and using such conjugates and...
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7026284 |
Formative agent of protein complex
The present invention proposes formative agent of protein complex, in which a polyphenol is useful component, and the agent is useful as gene complex, cell adhesion inhibitor or immune tolerogen....
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7026295 |
Lactoferrin in the reduction of circulating cholesterol, vascular inflammation, atherosclerosis and cardiovascular disease
The present invention relates to methods of using lactoferrin (LF) to reduce circulating levels of cholesterol and vascular inflammation, in order to treat, prevent or reduce the incidence of...
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7022666 |
Method of inducing formation of kidney epithelia from mesenchymal precursors
This invention provides methods of using a gp130 receptor ligand, e.g. leukemia inhibitory factor, to induce the formation of kidney epithelia, to treat subjects suffering from kidney failure, and...
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7015199 |
Treatment of psoriasis through down-regulation of the EGF-receptor with topically-applied EGF
Topical agent formulations for the treatment of psoriasis containing epidermal growth factor (EGF) as the active agent. EGF precursors or biological equivalents can be used. The formulation can...
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7015198 |
Materials for soft tissue augmentation and methods of making and using same
Materials for soft tissue augmentation in mammals are prepared by cross-linking blood plasma proteins, preferably with a zero-length cross-linking agent. The cross-linked blood plasma proteins can...
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7011825 |
Erythropoietin solution preparation
This invention provides an erythropoietin solution preparation containing an amino acid as a stabilizer, and having excellent long-term storage stability.
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7011833 |
Enhancing immune responses with B7-1 or B7-2 in the absence of a crosslinking agent
Methods of enhancing immune responses in which soluble forms of costimulatory molecules, e.g., B7 molecules, are administered to augment immune responses to antigens, e.g., to tumor cells and...
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7008634 |
Cell growth substrates with tethered cell growth effector molecules
Described are compositions with tethered growth effector molecules, and methods of using these compositions for growing cells and tissues. Growth effector molecules, including growth factors and...
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6998389 |
Pharmaceutical composition comprised of spider venoms, the production thereof, and its use for treating tumor diseases
The present invention describes pharmaceutically effective substances from the poison of spiders of the family of Sicariidae as well as their preparation and their use in medicine.
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6998388 |
High density lipoprotein against organ dysfunction following haemorrhagic shock
Use of high density lipoprotein and/or derivatives in the manufacture of a medicament for the prevention or treatment of organ dysfunction following ischaemia and reperfusion injury. In particular,...
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6992065 |
Sustained release formulations
A composition for sustained release comprises a carrier material containing a non-polymeric, non-water soluble liquid material having a viscosity of at least 5,000 cP at 37° C. that does not...
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6989373 |
Method for restoring a fat-pad
The present invention relates to a method for treating damaged or degenerated fat pads in a foot of a host in need thereof. The method comprises the step of injecting into the fat pad of the host a...
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6989368 |
Use of calmodulin to promote bone regeneration
The present invention provides methods and compositions for promoting bone regeneration, comprising administration of calmodulin. The method of bone regeneration is applied to subjects having bone...
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6984628 |
Ophthalmic compositions comprising trefoil factor family peptides
This invention relates to compositions comprising trefoil family factor peptides which are useful in preventing or treating dry eye by topical administration of the composition to eye of the...
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