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5866546 |
Treatment for diabetes
A composition for the treatment of diabetes and a method of use thereof. composition includes an immunoregulator, preferably Linomide, and a β cell proliferative agent, preferably reg protein. The...
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5863892 |
Use of platelet derived growth factor in ophthalmic wound healing
A method of accelerating corneal wound healing in the corneal anterior stroma and/or improving the quality of wound healing in a mammal comprises: (1) providing an ophthalmically compatible...
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5861315 |
Use of stem cell factor and soluble interleukin-6 receptor for the ex vivo expansion of hematopoietic multipotential cells
Stem cell factor in combination with soluble interleukin-6 receptor, interleukin-6, for gp130 signaling, supports the proliferation, differentiation and terminal maturation of blood cells from...
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5861377 |
Antistasin type serine protease inhibitors
The present invention relates to novel inhibitors belonging to the family of antistasin-type serine proteinase inhibitors, to their isolation from the medical leech Hirudo medicinalis, to DNA...
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5858966 |
Fetal growth
A method of enhancing fetal growth and/or development and/or neonatal survival by the administration over a period of insulin-like growth factor (IGF-1), to either the amniotic fluid or direct to...
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5858364 |
Pharmaceutical dosage form for treatment of multiple sclerosis
The invention is directed to a method of treating a T cell-mediated autoimmune disease in animals, including humans, by the oral administration of autoantigens, fragments of autoantigens, or...
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5858975 |
Oxyntomodulin peptide having cardiotonic activity and insulin release-bromating activity
An oxyntomodulin peptide has cardiotonic activity and insulin release-promoting activity. The peptide or pharmaceutical salts thereof can be used for prevention or treatment of cardiopathy or...
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5855920 |
Total hormone replacement therapy
A hormone replenishment method particularly useful in maintaining the body's neuroendocrine clock at optimal levels and combating conditions associated with advancing age is disclosed. The method...
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5854214 |
Therapeutic uses of bactericidal/permeability increasing protein products
The present invention provides therapeutic methods for treatment of conditions including the neutralization of the anti-coagulant activity of heparin, inhibition of angiogenesis, tumor and...
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5851985 |
Treatment of tumors by arginine deprivation
Method, compositions and apparatus for the treatment of tumors by systemic deprivation of an essential amino acid, preferably of arginine, by extracorporeal treatment of the patient's blood...
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5851993 |
Suppression of tumor cell growth by syndecan-1 ectodomain
Methods of reducing tumor growth, including the suppression of tumor growth in a patient, are provided by the administration of efficacious levels of syndecan ectodomain to the extracellular...
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5851986 |
Promoting bone formation and inhibiting bone resorption with high mobility group protein-1 (HMG-1)
A method for promoting osteoblast proliferation or inhibiting bone resorption comprising administering to a subject in need thereof, a composition comprising High Mobility Group Protein (HMG-1) is...
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5851997 |
Use of human chorionic gonadotropin as an immune-potentiating antiviral agent
Prophylaxis against viral infections, as well as treatment for individuals infected with a virus, can be achieved through the administration of human chorionic gonadotropin (HCG). Exemplary of the...
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5851554 |
Purified cardiac troponin I
A method is provided for isolating substantially intact cardiac troponin I from cardiac tissue comprising extracting the, troponin I and purifying it in the presence of an effective amount of a...
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5851992 |
Treatment of growth hormone deficiency
A pharmaceutical formulation comprising a growth hormone and asparagine as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds....
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5851996 |
Materials and methods for treatment of plaquing diseases
Methods and compositions are provided for alleviation of disease states involving plaque formation, such as are manifested in Alzheimer's Disease and other amyloid disorders, and arteriosclerotic...
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5851989 |
Method of extending the plasma half-life of vascular endothelial cell growth factor
The invention provides a method for extending the plasma half-life of heparin-binding proteins by coadministering such proteins with a therapeutically acceptable compound capable of inhibiting...
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5849336 |
Method using sturgeon notochord for alleviating the symptoms of arthritis
This invention provides a composition comprising notochord and extracts thereof in therapeutic amounts. The invention more specifically relates to a method of treating arthritis in mammals, more...
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5849713 |
Chemotactic factors for human spermatozoa and their use in human assisted fertilization
The invention relates to chemotactic factors for human spermatozoa that are purifiable from human follicular fluid. The factors are of peptidic and hydrophilic nature and have, one, a molecular...
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5849703 |
Pre-formed anticoagulant heparin/TFPI complexes
A pre-formed anticoagulant heparin/TFPI complex which consists of a weight ratio of at least 1.25 parts of heparin to one part of TFPI and its use in inhibiting blood cogulation.
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5849722 |
Oligosaccharide having affinity for fibroblast growth factor and process for producing same
An oligosaccharide having an affinity for fibroblast growth factor, which is composed of 8 to 18 monosaccharide residues, wherein a principal disaccharide unit comprising L-iduronic acid 2-sulfate...
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5846548 |
Combined administration of mitogenic immumo stimulator and a thymomimetic
A method of tumor therapy involves controlling the immune system by co-administration of a mitogenic immuno-stimulating substance and a thymomimetic substance.
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5846929 |
Purification of type G botulinum neurotoxin and pharmaceutical compositions thereof
The isolation and purification of type G botulinum neurotoxin and complexes thereof is disclosed. Compositions containing the type G neurotoxin and the preparation of a type G toxoid are also...
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5843449 |
Proteins and novel peptides derived from autoantigen for use in immunotherapy of autoimmune diseases
The present invention relates to novel peptides derived from the autoantigen HC gp-39, said peptides comprising at least one of the amino acid sequences FGRSFTILAS (SEQ ID No. 1), FTLASSETG (SEQ ID...
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5843899 |
Use of insulin-like growth factors I and II for inhibition of inflammatory response
The present invention relates to methods for using IGF as inhibitors of inflammatory response, ischemic injury, and organ rejection.
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5843887 |
Compositions for delivery of polypeptides, and methods
Compositions comprising intrinsic factor (IF), and in particular, compositions comprising substantially pure intrinsic factor (IF) and a polypeptide wherein said composition is substantially free...
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5843445 |
Method of treating rheumatoid arthritis with type II collagen
The present invention is directed to a method and pharmaceutical formulations for the treatment of autoimmune arthritis and animal models therefore in mammals, including humans, by the oral,...
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5840514 |
Methods of testing cancer and anticancer drugs
The testing of tumor cells, including human tumors capable of metastases, in assays employing fibronectin-depleted substrates is described. Ex vivo induction of cells, including biopsied human...
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5840700 |
Methods of producing transfer factor
The invention relates to substantially pure transfer factor with a specific activity of at least 5000 units per absorbance unit at 214 nm. The present invention also relates to a process for...
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5837688 |
Use of thrombolytic reagents for prevention of vascular disease
The present invention relates to the administration of thrombolytic reagents such as tissue plasminogen activator (t-PA), streptokinase and/or urokinase, over prolonged periods of time for...
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5834418 |
Process for the preparation of platelet growth factors extract
The present invention relates to a process for the preparation of porcine platelet-extract containing matured growth factors, which comprises the steps of: a) centrifuging whole porcine blood at...
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5834424 |
Use of lactoferrin for therapy of acute of chronic infectious diseases by the intracellular gram-positive pathogens streptococcus pyogenes and staphylococcus aureus
Compositions of lactoferrin, ovotransferrin or serotransferrin in apo or iron-saturated form are provided which have bacterial anti-invasive properties against Streptococcus pyogenes and...
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5830453 |
Use of IL-13 to induce 15-lipoxygenase
Methods are disclosed for inducing the production of 15-lipoxygenase (15-LO) in animal or human cells comprising monocytes via the administration of Interleukin 13 (IL-13). These methods are...
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5830859 |
Complex for inducing bone growth in the maxillary sinus
A protein complex for inducing growth of bone in the maxillary sinus of an animal is disclosed. The complex is generally made from animal bone, defated, demineralized, ground, slurried, and...
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5830863 |
Neurokinin A antagonists
Antagonists of neurokinin A which are derivatives of naturally occurring neurokinin A in which the amide bond connecting the two amino acids on the carboxy terminal end is modified are described....
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5830700 |
Hybrid proteins having cross-linking and tissue-binding activities
Hybrid proteins having cross-linking and tissue-binding activities, DNA molecules encoding such proteins and methods for producing the hybrid proteins from recombinant host cells are disclosed. The...
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5830860 |
Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
The invention provides biologically active peptides derived from or corresponding to regions of a bactericidal permeability increasing factor (B/PI). The peptides are preferably about 10 to 100...
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5827818 |
Agent for subcutaneous administration of protein C
The invention relates to a pharmaceutical agent which is suitable for subcutaneous injection of protein C, wherein it comprises protein C and a pharmaceutically acceptable carrier.
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5827823 |
Method of producing analgesia using neurotrophins
Infusions of brain-derived neurotrophic factor, neurotrophin-3 or neurotrophin-4 are used to produce analgesia in mammals. In addition, these neurotrophins are used to treat other diseases or...
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5824637 |
Activin antagonists as novel contraceptives
A method for contraception which features administering to a patient a contraceptive agent having activin-antagonist activity. The contraceptive agent results in inhibition of the...
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5824330 |
Highly purified interleukin-2 and method
This invention provides a composition comprising a therapeutically effective amount of purified human interleukin-2 and a pharmaceutically acceptable carrier.
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5824644 |
Method of attenuating arterial stenosis
A method is disclosed for attenuating stenosis after balloon angioplasty. The method comprises administering to a host parenterally or locally to the luminal surface of the blood vessel subjected...
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5817631 |
Therapeutic uses of melanin
The invention is directed to the treatment of degenerative diseases of tissues which have lost melanin and which share a common embryological basis as tissues of the nervous system by the...
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5817625 |
Methods of prevention of oral mucositis with transforming growth factor beta
The present invention provides methods of preventing oral mucositis in a subject susceptible to mucositis which comprises administering to the subject a prophylactically effective amount of...
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5814307 |
Method for regulating cell growth, leukocyte differentiation and tumor cell growth using Oncostatin M to stimulate synthesis of IL-6
The present invention relates to methods of using oncostatin M (OM). In particular, it relates to the use of OM to stimulate interleukin 6 (IL-6) synthesis in target cells, especially human...
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5814612 |
Retinol derivatives and uses thereof
The present invention provides a purified retinoid compound characterized by a molecular mass of about 320 daltons and an atomic composition of C 20 H 32 O 3 . The present invention also provides...
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5814308 |
Methods for the treatment of gastrointestinal tract disorders
Methods for treating gastrointestinal tract disorders by protection, regeneration and repair of intestinal epithelium are described. Macrophage stimulating protein is found to promote colony...
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5814328 |
Preparation of collagen using papain and a reducing agent
Purified collagen is produced by contacting a collagen sample with a first proteolytic enzyme, a reducing agent and a second proteolytic enzyme. Preferably, the first and second proteolytic enzymes...
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5814600 |
Method and composition for treatment of insulin requiring mammals
Method and compositions for treating a mammal by administering to that mammal an insulin (having the in vitro activity of stimulating glucose incorporation into glycogen in rat soleus muscle) and...
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5814602 |
Heparin-binding proteins
A heparin-binding protein (HBP) which has, in glycosylated state, an apparent molecular weight of about 28 kDa, determined by SDS-PAGE under reducing conditions, and exhibits angiogenic properties...
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