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7476650 |
Enzyme inhibition
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of...
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7185647 |
Determination of smoothness of canisters containing inhalable medicaments
Disclosed are methods for determining the smoothness index of the interior of a metered dose container.
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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6906054 |
Compositions for inhibiting beta-lactamase
The invention provides pharmaceutical compositions comprising compounds of formula I and IV:
wherein R 1 -R 11 and A have any of the values defined in the specification, and their...
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6815426 |
Angiogenesis-inhibitory tripeptides, compositions and their methods of use
This invention pertains to methods and compositions for inhibiting endothelial cell tube formation, the initial step of tumor angiogenesis. More specifically, the present invention relates to...
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6599892 |
7-alkylidene cephalosporanic acid derivatives and methods of using the same
Derivatives of 7-alkylidene cephalosporanic acid sulfone and the pharmaceutically active salts thereof are found to be potent inhibitors of β-lactamase enzymes.
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6489319 |
Neurotherapeutic use of carboxypeptidase inhibitors
Administration of inhibitors of carboxypeptidase E provides significant neurotropic effects in warm-blooded vertebrates evidenced inter alia by anxiolytic and anti-aggressive behavior and enhanced...
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6475522 |
Synthetic polymer compositions containing antibiotics as antidegradants
Synthetic polymer compositions contain antibiotics as antidegradants. Antibiotics from classes of glycopeptides and β-lactams have been found to prevent or inhibit synthetic polymer degradation.
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6458779 |
Hydroxamic acid derivatives as inhibitors of the production of human CD23 and of the TNF release
Compounds of Formula (1) wherein: R is methyl substituted by one to three groups from alkyl, aryl, alkenyl, and alkynyl; n is ) or 1; R 1 is arylmethyl or heterocyclylmethyl; R 2 is alkyl,...
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6407091 |
β-lactamase inhibiting compounds
The invention provides compounds of formula I and IV: wherein R 1 -R 11 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for...
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6180621 |
Method and treatment using 1-methylcarbapenem derivatives as an anti-helicobacter pylori agent
A method for the prophylaxis or treatment of infectious diseases caused by helicobacter pyloir, by administering a pharmacologically effective amount of a 1-methoylcarbapenem coumpund of formula...
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6121255 |
Phloroglucide derivatives and their pharmceutical use
A phloroglucide derivative having the following formula: ##STR1## wherein Q is halogen; X is CH 2 or CO; Y is cephalosporin having a formula of ##STR2## wherein Ph is phenyl, Ac is acetoxy, or...
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5994340 |
Azetidinone derivatives as β-lactamase inhibitors
New 2-oxo-1-azetidine sulfonic acid derivatives with an aminoalkyl substituted "anti" (E-isomer) oxyimino group in the acylamino substituent at the 3 position of the monobactam ring. These...
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5760027 |
Use of 7-alkylidene cephalosporins to inhibit elastase activity
The present invention relates to the use of 7-alkylidene derivatives of cephalosporin esters, such as sulfides, sulfoxides, and sulfones, as inhibitors of human leukocyte elastase. These materials...
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5721229 |
Soluble forms of cephalosporins and treatment of animals
A dry solid mixture of a hydroxypolycarboxylic acid and a cephalosporin where the hydroxypolycarboxylic acid of the formula ##STR1## where x and y are 0 or 1 and z is 0 to 3, in the weight ration...
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5681563 |
7-vinylidene cephalosporins and methods of using the same
Cephalosporins with an exocyclic allene in the 7-position and their pharmaceutically active salts are potent inhibitors of β-lactamases and are therefore useful in the treatment of penicillin...
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5650394 |
Use of urinastatin-like compounds to prevent premature delivery
The present invention provides a method of diagnosing and treating a pregnant female at risk for impending preterm delivery. The method comprises the step of diagnosing imminent preterm delivery by...
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5637291 |
Surfactant-free oil-in-water emulsion stabilized by hollow thermoplastic particles
An emulsion of an oily phase in a surfactant-free gelled aqueous phase containing expanded hollow thermoplastic particles of acrylonitrile polymer or copolymer. The particles ensure the dispersion...
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5580865 |
2,2-disubstituted cephem sulphones
The present invention provides cephalosporin sulphones or formula (I), and pharmaceutically or veterinarily acceptable salts thereof; ##STR1## wherein n is zero, one or two; R 1 is hydrogen,...
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5409917 |
Topical treatment of acne with cephalosporins
A method and composition for topically treating acne and acneiform dermal disorders includes applying an amount of a cephalosporin antibiotic effective to treat the acne and acneiform dermal...
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5312813 |
Biofilm reduction method
A method of killing microorganisms which form a biofilm on a tissue or implant surfaces in a patient, and which are refractory to a biocide at a dose which is effective to kill the microorganism in...
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5278157 |
Stable cephradine hydrate
The invention relates to a novel stable form of cephradine, processes for its production and intermediates used therein.
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5069899 |
Anti-thrombogenic, anti-microbial compositions containing heparin
Anti-thrombobenic, anti-microbial compositions containing heparin reacted with quaternary ammonium components and bound with water-insoluble polymers are disclosed. Such compositions may also...
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5028601 |
Cephalosporin compounds and antibacterial agents
Cephalosporin compounds of the formula (I): ##STR1## wherein R 1 and R 2 may be the same or different and are a hydrogen atom or a lower alkyl group of 1-5 carbon atoms and A is a hydrogen atom...
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4971961 |
Cephalosporin compounds and antibacterial agents
This invention provides cephalosporin compounds represented by the following general formula: ##STR1## wherein R 1 and R 2 are same or different hydrogen atom or a lower alkyl group of 1 to 5...
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4943568 |
Cephalosporins
Antibacterially active novel cephalosporins of the formula ##STR1## in which R 1 represents alkyl, alkenyl, alkoxy, alkylthio, halogen, trifluoromethyl or trifluoromethoxy, R 2 represents...
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4692441 |
Chorine esters as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal cavities
Choline esters are used as drug absorption enhancing agents for drugs which are poorly absorbed from the nasal, oral, and vaginal cavities.
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4623644 |
Acylation of tirandamycic, streptolic and sorbic acids to cephalosporin and penicillin nuclei
This invention relates to the hybridization of streptolydigin, tirandamycin and sorbic acid to penicillin and cephalosporin nuclei.
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4605651 |
Antibiotic amino acid derivatives of cephalosporins
1. A cephalosporin derivatives of the general formula ##STR1## wherein R 1 is an α-, β- or γ-amino acid residue (bonded by the ester linkage), which may optionally be substituted by one or two...
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4560553 |
Use of eucalyptol for enhancing skin permeation of bio-affecting agents
Eucalyptol is used to enhance skin permeation of bio-affecting agents.
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4496561 |
Cephalosporin derivative
A cephalosporin derivative having an antibacterial activity similar to a cephalosporin antibiotic in living bodies without affecting the intestinal bacterial colonies, a method for preparing the...
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4490370 |
Naphthylglycyl cephalosporin derivatives
Naphthylglycyl and tetrahydronaphthylglycyl cephalosporins are potent antibacterial agents and are particularly useful as oral treatments for upper respiratory infections.
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4474780 |
Crystalline cephalosporin
7-(D-2-Naphthylglycylamido)-3-methyl-3-cephem-4-carboxylic acid tetrahydrate is a stable crystal form of a potent orally active gram positive antibiotic.
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4455306 |
Method for concentrating β-lactam antibiotic solution
The present invention relates to a method for concentrating a dilute aqueous solution of a β-lactam antibiotic which is readily susceptible to heat, by subjecting a dilute aqueous solution of a...
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4444755 |
Treatment for skin disorders
Use of γ-linolenic acid and related materials alone or with zinc or β-lactam antibiotics to treat skin disorders.
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4425337 |
Adjuvants for rectal delivery of drug
A method and drug form enhancing the rate of absorption of a rectally administered drug from the rectal compartment into the blood stream of a warm blooded animal. The method includes the steps of...
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4415554 |
Treatment for menstrual disorders
Use of γ-linolenic acid and related materials alone or with zinc or β-lactam antibiotics to treat menstrual disorders.
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4406896 |
Adjuvants for rectal delivery of drug substances
A method and drug form for enhancing the rate of absorption of a rectally administered drug from the rectal compartment into the blood stream of a warm blooded animal. The method includes the steps...
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4393049 |
Treatment for obesity
Use of γ-linolenic acid and related materials alone or with zinc or β-lactam antibiotics to treat obesity.
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4386070 |
Pharmaceutical compositions endowed with an antibacterial activity and their use in the treatment of infections due to gram-positive and gram-negative pathogens
Pharmaceutical compositions consisting of an antibiotic (cephalosporins, tetracyclines, kanamycin) associated with a heterocyclicic β-ketoacid (nalidixic acid, oxolinic acid, cinoxacine, piromidic...
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4376767 |
Pyridylmethyl esters of selected bio-affecting carboxylic acids
Novel pharmaceutically useful derivatives of selected known bio-affecting carboxylic acids are disclosed, said derivatives having the structural formula ##STR1## wherein R 1 and R 2 , which can be...
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4374134 |
Cephalosporin compounds with terminal aminocarboxylic acid groupings and anti-bacterial use thereof
Acylamido-3-cephem-4-carboxylic acid compounds of the formula ##STR1## in which the index n represents an integer of from 1 to 4, the index m represents 0 or 1, X represents oxygen, sulphur...
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4363807 |
Cepham compounds
This invention relates to novel cepham compounds of antimicrobial activity, useful as intermediates in the preparation of antibiotics, said novel cepham compounds being of the formula: ##STR1##...
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4296111 |
7-Substituted methyl cephalosporins derivatives and analogues thereof
Disclosed are antibiotic 7-(substituted methyl) cephalosporins, derivatives and nuclear analogues thereof; wherein the methyl substituent is, inter alia, hydroxyl, ketonic oxygen, imino nitrogen,...
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4250166 |
Long acting preparation of cefalexin for effective treatments of bacterial infection sensitive to cefalexin
A cefalexin preparation coated with a coating layer the solubility of which layer is pH-dependent and dissolves in the upper intestine is preferably administered concurrently with a normal (plain,...
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4235900 |
Cephradine compositions
Dry solid cephradine compositions are provided comprising cephradine and arginine, for reconstruction as injectables upon addition of water. A method is also provided for fomulating injectable...
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4166115 |
Syn 7-oxoimino substituted derivatives of cephalosporanic acid
The present invention relates to new syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and pharmaceutically acceptable salts thereof. More particularly, it relates to new...
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4162314 |
7[2(Substituted phenyl)2-(amino)acetamido]cephalosporin derivatives
Novel β-lactam antibiotics are compounds of the formula: ##STR1## wherein R is alkyl of up to 6 carbon atoms or, when A is oxygen, R is hydrogen; A is oxygen or --OCO--; Z is ##STR2## R 1 is...
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4143129 |
Cephalexin tablets
A small tablet containing over 90% by weight of an orally active cephalosporin such as cephalexin and which utilizes as a binder polyvinyl pyrrolidone having a number average molecular weight of...
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4086341 |
Cephalosporin derivatives
Penicillin and cephalosporin derivatives characterized by the presence of a nitroalkyl, nitrocycloalkyl, nitrophenylalkyl or nitroanilinoalkyl group in the side chain are antibacterial agents. The...
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