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7488724 |
7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors
The invention provides compounds of formula (I):
wherein: R 1 -R 4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for...
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7485632 |
Cephalosporins
A compound of formula
wherein the substituents have various meanings, useful as a pharmaceutical.
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7384928 |
Broad spectrum cephem compounds
A compound of the formula:
(wherein,
T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower...
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7341993 |
Cross-linked glycopeptide—cephalosporin antibiotics
This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical...
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6916801 |
7-Alkylidene-3-substituted-3-cephem-4-carboxylates as β-lactamase inhibitors
The invention provides compounds of formula (I):
wherein: R 1 -R 4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for...
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6599893 |
Cephalosporin antibiotics and prodrugs thereof
The present invention relates to chemical compounds having the formula: or a pharmaceutically acceptable salt thereof. R 1 is selected from the group consisting of: R 2 is selected from the...
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6599892 |
7-alkylidene cephalosporanic acid derivatives and methods of using the same
Derivatives of 7-alkylidene cephalosporanic acid sulfone and the pharmaceutically active salts thereof are found to be potent inhibitors of β-lactamase enzymes.
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6486149 |
Composition comprising a crystallographically stable, amorphous cephalosporin and processes for the preparation thereof
Processes are provided for the preparation of orally administrable, yellow and powdery compositions essentially consisting of particles composed of a homogeneous mixture of an amorphous Cefditoren...
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6440957 |
Cephalosporines having cyclic aminoguanidine substituents as antibiotics
A compound useful as an anti-bacterial agent, having the formula wherein R 2 together with the nitrogen atom to which it is attached forms a cyclic aminoguanidine group or derivative thereof as...
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6407091 |
β-lactamase inhibiting compounds
The invention provides compounds of formula I and IV: wherein R 1 -R 11 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for...
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6159706 |
Application of enzyme prodrugs as anti-infective agents
The present invention provides a method for targeting toxic antimetabolites to gram negative infections. It provides a means of taking advantage of a key disease resistance mechanism to activate...
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6150350 |
Antimicrobial compositions
The invention relates to antimicrobial compositions comprising a combination of (1) a therapeutically effective amount of a compound of formula I ##STR1## with (2) a second ingredient selected from...
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6133254 |
Use of aspirochlorine or derivatives thereof as immunosuppressive agents
Use of a compound of formula (I) wherein R represents hydrogen or chlorine, for preparing an immunosuppressive medicament.
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6090801 |
Pharmaceutical compositions containing ceftriaxone and penems
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6087355 |
Cephalosporin antibiotics
The present invention includes novel compounds of formula ##STR1## where A, B, D, and E are selected from the group consisting of carbon, nitrogen and sulfur, R 99 is selected from the group...
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6063778 |
Cephalosporin derivatives and processes for the preparation thereof
The invention provides novel cephalosporin derivatives of the formula (I) ##STR1## and salts thereof for use in pharmaceutical compositions. Also novel precursors for synthesis of the...
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5994340 |
Azetidinone derivatives as β-lactamase inhibitors
New 2-oxo-1-azetidine sulfonic acid derivatives with an aminoalkyl substituted "anti" (E-isomer) oxyimino group in the acylamino substituent at the 3 position of the monobactam ring. These...
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5958915 |
Antibacterial composition for oral administration
A new, antibacterial composition for use in oral administration is now provided, which composition comprises a mixture of Cefditoren pivoxyl with a water soluble casein salt. This composition has a...
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5830884 |
Pharmaceutical products containing thermally-inhibited starches
Thermally-inhibited starches and flours are used in pharmaceutical products as a diluent, filler, carrier, binder, disintegrant, coating, thickener, moisture sink, and the like. The starches and...
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5827845 |
Cephalosporin derivative
A cephalosporin derivative which has a substituted or unsubstituted 2-(5-thiazolyl)vinyl group at the 3-position and is represented by the following formula (I) ##STR1## wherein X is CH or N, R 1 ...
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5804577 |
Cephalosporin derivatives
The present invention relates to compounds of formula I ##STR1## wherein R 1 is a group selected from 2-, 3-, and 4-hydroxyphenyl, 3-nitrophenyl, and 3-fluoro-4-hydroxyphenyl; as well as readily...
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5736151 |
Antibiotic oil suspensions
The present invention provides for the inclusion of small amounts of water in oil suspensions of active drugs, such as ceftiofur hydrochloride of formula I. The resulting suspensions have improved...
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RE35754 |
Cephem derivatives
Cephem derivatives of the general formula ##STR1## is which the R 2 O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against...
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5728691 |
Quinolonylcarboxamidocephalosporin derivatives and pharmaceutical compositions containing them
Derivatives of 7-aminoceph-3-em-4-carboxylic acid with 6-fluoroquinolone derivatives in which the cephem and 6-fluoroquinolone moieties are bound to each other through a carboxamido bond as well as...
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5721229 |
Soluble forms of cephalosporins and treatment of animals
A dry solid mixture of a hydroxypolycarboxylic acid and a cephalosporin where the hydroxypolycarboxylic acid of the formula ##STR1## where x and y are 0 or 1 and z is 0 to 3, in the weight ration...
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5712268 |
Compositions of tricyclic β-lactams and uses thereof
There are described pharmaceutical compositions comprising (a) compounds of the formula ##STR1## in which R signifies lower alkoxycarbonyl, lower alkoxy-carbonylamino, the acyl residue of an α-...
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5698577 |
Compositions of bicyclic β-lactams and uses thereof
There are described pharmaceutical compositions comprising (a) compounds of the formula ##STR1## in which R signifies lower alkoxycarbonyl, lower alkoxy-carbonylamino, the acyl residue of an α-...
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5698547 |
Cephalosporin antibiotics
The present invention includes novel (7R)-7-(acylamino)-3-(arylthio)-3-cephem-4-carboxylic acids or their pharmacologically acceptable salts which exhibit antibiotic activity against a wide...
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5656623 |
Antimicrobial lactam-quinolones
Antimicrobial lactam-quinolone compounds comprising a lactam-containing moiety linked to a quinolone moiety, of the formula: ##STR1## wherein (1) A 1 , A 2 , A 3 , R 1 , R 4 and R 6 generally...
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5635501 |
Alphalosporins and 1-carba-1-dethia cephalosporins
Compound of formula (I) or salts thereof wherein R 1 is hydrogen, methoxy or formamido; R 2 is an acyl group; CO 2 R 3 is a carboxy group or a carboxylate anion, or R 3 is a readily removable...
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5620968 |
7-substituted-amino-3-substituted-3-cephem-4-carboxylic acids
The invention provides compounds of the formula: ##STR1## wherein the variables are hereinbelow described; and salts thereof. Also, pharmaceutical formulations and methods for treating bacterial...
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5607927 |
Cephalosporin derivative
An aminothiazolyl- or aminothiadiazolyl-cephalosporin derivative represented by the following general formula (I) which has a condensed-ring thio group as a 3-positioned substituent group that...
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5605895 |
Cephalosporin antibiotics and processes for preparation thereof
The present invention relates to a cephalosporin compound represented by the following general formula (I), its pharmaceutically acceptable non-toxic salt, physiologically hydrolyzable ester,...
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5595986 |
Stably storable and readily water soluble composition of cephalosporin for injections
A stably storable and readily water soluble composition for use in preparing injections and containing Cefditoren, namely a cephalosporin of the formula ##STR1## is now provided, which composition...
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5571804 |
Cephalosporin antibiotics
Cephalosporin compounds of formula (I): ##STR1## wherein: R 1 is a hydrogen or an amino protecting group; R 2 and R 3 are, independently, a hydrogen or a hydroxy protecting group, or form...
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5541177 |
3-aryl or heteroaryl-7-heteroaralkylamido cephalosporin compounds, compositions and methods of use
A compound of the formula I is disclosed. ##STR1## R 13 represents hydrogen, NH 2 , C1-4 alkyl, C1-4 alkylamino or di(C1-4)alkylamino-; Y represents CH or N; Y" represents (a) CR y ' R z '...
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5534508 |
Cephem compounds and antimicrobial agents
Herein disclosed are novel cephem compounds represented by the following general formula (I), and novel antimicrobial, and especially anti-MRSA, agents which contain as an active ingredient at...
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5523400 |
Cephalosporin antibiotics
The present invention relates to compounds of the formula ##STR1## wherein R 1 is an acyl group derived from a carboxylic acid, hydrogen, or an amino protecting group; R 2 is hydrogen,...
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5504076 |
Cephalosporin compounds
7β- 2-(aminothiazolyl and thiadiazolyl)-2-oxyiminoacetamido!cephalosporin derivatives having a 3- N-(optionally substituted) aminopyridiniumthiomethyl! substituent have antibacterial activity and...
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5480879 |
Quinolonecarboxylic acids
The invention relates to novel derivatives of quinolonecarboxylic acid and naphthyridonecarboxylic acid which are linked to a β-lactam antibiotic, to their salts, to processes for their...
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5464829 |
Cephalosporin derivatives
A cephalosporin derivative having a quaternary salt type substituent group at the 3-position, represented by formula (I): ##STR1## wherein X is a carbon atom or a nitrogen atom; Y is a sulfur atom,...
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5438053 |
Cephem compounds compositions and method
Novel cephem compounds having, at the 3-position of the cephem nucleus, a group of the formula: --CH 2 --S--A--Y--B wherein A stands for a further optionally substituted divalent nonionic...
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5438052 |
Cephalosporin derivatives
Cephalosporin derivatives have the formula ##STR1## wherein Z 1 , Z 2 , X, Y, P, Q, m, n and p are as defined in the following text. Also described are the readily hydrolyzable esters and...
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5432182 |
Compounds substituted quinoline derivatives
Substituted 4-aminoquinazoline derivatives which are inhibitors of gastric acid secretion. A compound of the invention are the salts of strong acids of...
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5416081 |
Cephalosporin compounds
The present invention relates to novel cephalosporin compounds, pharmaceutically acceptable non-toxic salts, physiologically hydrolyzable esters, hydrates and solvates and isomers thereof which...
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5409917 |
Topical treatment of acne with cephalosporins
A method and composition for topically treating acne and acneiform dermal disorders includes applying an amount of a cephalosporin antibiotic effective to treat the acne and acneiform dermal...
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5407930 |
Cephalosporin derivatives
The present invention relates to a compound represented by the structural formula I: ##STR1## its pharmaceutically acceptable salt or ester, or its crystalline, which is a novel optically active...
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5407929 |
Triazolylthiomethylthio cephalosporin hydrochhloride, its crystalline hydrate and the production of the same
7β-[(Z)-2-(2-Amino-4-thiazolyl)-2-hydroxyiminoacetamido]-3-
(1,2,3-tria zol-4-yl)thiomethylthio-3-cephem-4-carboxylic acid hydrochloride and its crystalline hydrate, have a potent antibiotic...
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5389627 |
Cephem compounds
The present invention relates to novel cephem compounds having the formula: ##STR1## wherein, Q is a carbon or nitrogen atom; X is an oxygen atom, or a nitroalkyl or cyanoimine group, with the...
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5362722 |
Cephalosporin antibacterial agents
The present invention provides compounds of the formula ##STR1## wherein R is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, or C 1 -C 6 haloalkyl; ...
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