|
Match
|
Document |
Document Title |
|
|
7488724 |
7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors
The invention provides compounds of formula (I):
wherein: R 1 -R 4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for...
|
|
|
6916801 |
7-Alkylidene-3-substituted-3-cephem-4-carboxylates as β-lactamase inhibitors
The invention provides compounds of formula (I):
wherein: R 1 -R 4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for...
|
|
|
6846492 |
Use of phenylethylamine derivatives for the antimicrobial treatment of surfaces
The use of compounds of formula (1) is described, in which compounds R 1 , R 2 and R 3 are each independently of the others hydrogen; C 1 -C 20 alkyl; C 3 -C 7 cycloalkyl; C 2 -C 20 alkenyl; C 4...
|
|
|
6723716 |
7-acylamino-3-heteroarylthio-3-cephem carboxylic acid antibiotics and prodrugs thereof
The present invention relates to a cephem prodrug having formula III or formula IV: or a pharmaceutically acceptable salt thereof, wherein R′ 1 is selected from the group consisting of...
|
|
|
6599892 |
7-alkylidene cephalosporanic acid derivatives and methods of using the same
Derivatives of 7-alkylidene cephalosporanic acid sulfone and the pharmaceutically active salts thereof are found to be potent inhibitors of β-lactamase enzymes.
|
|
|
6599893 |
Cephalosporin antibiotics and prodrugs thereof
The present invention relates to chemical compounds having the formula: or a pharmaceutically acceptable salt thereof. R 1 is selected from the group consisting of: R 2 is selected from the...
|
|
|
6583133 |
Propenyl cephalosporin derivatives and process for the manufacture thereof
Disclosed are cephalosporin derivatives of the general formula wherein R is an organic residue with a molecular weight not exceeding 400 bonded to the adjacent sulphur atom via carbon and...
|
|
|
6407091 |
β-lactamase inhibiting compounds
The invention provides compounds of formula I and IV: wherein R 1 -R 11 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for...
|
|
|
6329363 |
Cephalosporin antibiotics
The invention provides new fluorinated cephalosporin antibiotics and methods of preventing or treating infection, particularly mastitis in ruminants, using these antibiotics, and veterinary and...
|
|
|
6319904 |
Formulation comprising antibacterial substance and antiulcer substance
The present invention includes a formulation which comprises an antibacterial substance and an antiulcer substance, wherein at least either of them is formulated into a gastrointestinal...
|
|
|
6159706 |
Application of enzyme prodrugs as anti-infective agents
The present invention provides a method for targeting toxic antimetabolites to gram negative infections. It provides a means of taking advantage of a key disease resistance mechanism to activate...
|
|
|
6150351 |
Cephem compounds and pharmaceutical use thereof
This invention relates to new cephem compound represented by the following general formula (I): ##STR1## wherein each symbol is as defined in the specification or a salt thereof, which has...
|
|
|
6090801 |
Pharmaceutical compositions containing ceftriaxone and penems
|
|
|
6087355 |
Cephalosporin antibiotics
The present invention includes novel compounds of formula ##STR1## where A, B, D, and E are selected from the group consisting of carbon, nitrogen and sulfur, R 99 is selected from the group...
|
|
|
5994340 |
Azetidinone derivatives as β-lactamase inhibitors
New 2-oxo-1-azetidine sulfonic acid derivatives with an aminoalkyl substituted "anti" (E-isomer) oxyimino group in the acylamino substituent at the 3 position of the monobactam ring. These...
|
|
|
5945414 |
Process for the preparation of new intermediates useful in the synthesis of cephalosporins
Cefazolin, cefazedone, cefoperazone, cefamandole, cefatrizine or ceftriaxone is prepared by reacting glutaryl 7-ACA of the formula: ##STR1## with a compound of formula (II): R--SH ...
|
|
|
5728691 |
Quinolonylcarboxamidocephalosporin derivatives and pharmaceutical compositions containing them
Derivatives of 7-aminoceph-3-em-4-carboxylic acid with 6-fluoroquinolone derivatives in which the cephem and 6-fluoroquinolone moieties are bound to each other through a carboxamido bond as well as...
|
|
|
5710146 |
Cephem derivatives and processes for their manufacture
Cephem derivatives of the general formula ##STR1## in which the R 2 O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against...
|
|
|
5705496 |
Crystalline benzathine salt of cefonicid and its preparation
The present invention relates to benzathine salts of cefonicid, a member of the cephalosporin family of antibiotics, which are crystalline. ##STR1##
|
|
|
5698544 |
Cephem compound, process for producing the compound, and antimicrobial composition containing the same
The present invention provides a cephem compound having a high antimicrobial activity against various pathogenic bacteria. The cephem compound of the invention is represented by the formula...
|
|
|
5698547 |
Cephalosporin antibiotics
The present invention includes novel (7R)-7-(acylamino)-3-(arylthio)-3-cephem-4-carboxylic acids or their pharmacologically acceptable salts which exhibit antibiotic activity against a wide...
|
|
|
5635501 |
Alphalosporins and 1-carba-1-dethia cephalosporins
Compound of formula (I) or salts thereof wherein R 1 is hydrogen, methoxy or formamido; R 2 is an acyl group; CO 2 R 3 is a carboxy group or a carboxylate anion, or R 3 is a readily removable...
|
|
|
5587373 |
2-acyloxycephem derivatives
The present invention provides cephalosporin sulphones of formula (I) and the pharmaceutically and veterinarily acceptable salts thereof: ##STR1## wherein n is one or two: A and B are both or each...
|
|
|
5580865 |
2,2-disubstituted cephem sulphones
The present invention provides cephalosporin sulphones or formula (I), and pharmaceutically or veterinarily acceptable salts thereof; ##STR1## wherein n is zero, one or two; R 1 is hydrogen,...
|
|
|
5571804 |
Cephalosporin antibiotics
Cephalosporin compounds of formula (I): ##STR1## wherein: R 1 is a hydrogen or an amino protecting group; R 2 and R 3 are, independently, a hydrogen or a hydroxy protecting group, or form...
|
|
|
5446037 |
2-[(substituted) methylene]cephalosporin sulfones as antiinflammatory, antidegenerative and antithrombin agents
This invention relates to 2-[(substituted)methylene]cephalosporin sulfones and in particular 2-[(heteroaryl substituted)methylene]cephalosporin sulfones which are effective elastase inhibitors as...
|
|
|
5439904 |
2-spiro(2'-spirocycloalkyl)cyclopropyl cephalosporin sulfones as antiinflammatory and antigenerative agents
2-spiro (2'-spirocycloalkyl) cyclopropyl cephalosporin sulfone compounds, methods of treating patients for elastase inhibition, and processes for preparing such compounds.
|
|
|
5373000 |
7Beta-(thiadiazolyl)-2-iminoacetamido-3cephem compounds
A cephalosporin derivative represented by the formula: ##STR1## wherein R 1 represents a lower alkyl group, and A is selected from: a group of the following formula: ##STR2## where R 2 and R 3 ...
|
|
|
5364848 |
Substituted cephalosporin sulfones as anti-inflammatory and antidegenerative agents
New substituted cephalosporin sulfones are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
|
|
|
5356888 |
1,1-dioxo-cephem-4-carbothiolic acid derivatives
There are provided compounds I ##STR1## wherein A is a hydrogen atom or an organic group, R 1 is hydrogen or halogen atom or an organic group, R 2 is hydrogen or halogen atom, C 1 -C 4 ...
|
|
|
5348952 |
β-lactam derivatives of the cephem sulphone type
Cephalosporins of the formula (I): ##STR1## wherein m is one or two; n is zero, one or two; A and B are organic residues; and R 1 and R 2 are halogen or hydrogen atoms or organic groups are...
|
|
|
5312813 |
Biofilm reduction method
A method of killing microorganisms which form a biofilm on a tissue or implant surfaces in a patient, and which are refractory to a biocide at a dose which is effective to kill the microorganism in...
|
|
|
5077286 |
Beta-lactam derivatives of the 4-acylcephem sulphone and 3-acylpenam sulphone-type
Compounds of formulae Ia and Ib ##STR1## wherein A is hydrogen atom or an organic residue, R 1 is halogen atom, or an organic group, R 2 is hydrogen or halogen atom, C 1 -C 4 alkyl or alkoxy...
|
|
|
4943567 |
Cephalosporin compound and pharmaceutical composition thereof
Cephalosporin compounds represented by the general formula (I): ##STR1## wherein R 1 and R 5 independently represent a hydrogen atom or a protective group for an amino group; R 2 represents an...
|
|
|
4891370 |
Cephalosporin derivatives as anti-inflammatory agents
Derivatives of cephalosporin esters are found to be potent elastase inhibitors and therefore are useful antiinflammatory agents.
|
|
|
4845088 |
Tetrazolyl derivatives of beta-lactams useful as elastase inhibitors
Tetrazolyl derivatives of β-lactams are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
|
|
|
4803196 |
Pharmaceutical compositions containing β-lactam antibiotics
A solid pharmaceutical composition comprising one or more β-lactam antibiotics in acid or amphoteric form in association with at least one physiologically acceptable base in the presence of a...
|
|
|
4786633 |
Cephalosporin compounds
A cephalosporin compound of the formula: ##STR1## wherein: R 2 is a group of the formula: ##STR2## R 4 is a lower alkenyl group, a lower alkyl group or a lower alkyl group substituted with a...
|
|
|
4760060 |
3-heteroaralkylthio carbacephem compounds and antibacterial pharmaceutical composition
Carbacephem and cephem compounds represented by the formula: ##STR1## [Wherein X is S or CH 2 ; n is an integer of 1 to 5; R 1 is an unsubstituted or substituted heterocyclic group (where the...
|
|
|
4758558 |
N-(substituted)-[7-(2-cyanoacetamido)cephalosporanic]amide derivatives having antibiotic utility
Disclosed herein are the derivatives of substituted cephalosporanic acid represented by the formula (I): ##STR1## wherein R 1 represents a 4-pyridylthiomethyl group, an alpha-aminobenzyl group, a...
|
|
|
4749694 |
Novel lysine esters used as absorption
Novel lysine esters used as absorption enhancing agents for gastrointestinally and rectally administered drugs. Also provided are processes for preparation of said lysine ester compounds as well as...
|
|
|
4737492 |
Sparingly soluble salts of cefamandole, and ophthalmic compositions containing same
The hydrabamine and benzathine salts of cefamandole are useful in aqueous ophthalmic compositions which have good stability and shelf life.
|
|
|
4734407 |
Alpha-aminoacyl-penicillins and cephalosporins
Antibacterially active and animal growth-regulating novel β-lactam compounds of the formula ##STR1## in which R 1 represents an optionally substituted radical of the formula ##STR2## Z represents...
|
|
|
4731363 |
Thromboxane synthase inhibitors as insulin lowering agents and antiobesity agents
The present disclosure relates to the use of thromboxane synthase inhibitors as antiobesity agents and insulin lowering agents. Such compounds fall into a variety of classes among which are...
|
|
|
4692441 |
Chorine esters as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal cavities
Choline esters are used as drug absorption enhancing agents for drugs which are poorly absorbed from the nasal, oral, and vaginal cavities.
|
|
|
4684643 |
Pharmaceutical compositions for storage in plastic containers and process therefor
The instant invention is a pharmaceutical composition suitable for storage in plastic containers which comprises a pharmaceutical compound in powder form coated with a surfactant. A second aspect...
|
|
|
4656166 |
Antibiotic compounds derived from cephalosporins, process for their production and pharmaceutical compositions
The compounds according to the invention correspond to the formula: ##STR1## in which: The COOA group at the 4 position is an acid radical, or an alkaline or alkaline-earth salt, or an amino acid...
|
|
|
4654331 |
Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group
The (5-R-2-oxo-1,3-dioxolen-4-yl)methyl moiety: ##STR1## wherein R is loweralkyl of 1-6 carbon atoms, especially methyl or t-butyl; when utilized as an ester on a pharmaceutical having a carboxylic...
|
|
|
4637999 |
Substituted cephalosporins as anti-inflammatory and antidegenerative agents
Substituted cephalosporins are found to be potent elastase inhibitors and thereby useful antiinflammatory/antidegenerative agents.
|
|
|
4623645 |
Substituted cephalosporin sulfoxides as anti-inflammatory and antidegenerative agents
Substituted cephalosporin sulfoxides are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
|