Patents in Class 514/202

Matches 1 - 50 out of 278

1 2 3 4 5 6 >

Match	Document	Document Title
1	7488724	7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors The invention provides compounds of formula (I): wherein: R 1 -R 4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for...
2	7485632	Cephalosporins A compound of formula wherein the substituents have various meanings, useful as a pharmaceutical.
3	7384928	Broad spectrum cephem compounds A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower...
4	7378408	Methods of treatment and formulations of cephalosporin Formulations containing an antibacterial alkali metal salt of a cephalosporin compound and methods of treating bacterial infections in dogs and cats.
5	7351419	Oral pharmaceutical suspension of Cefdinir crystal The present invention relates to a novel oral pharmaceutical suspension of Cefdinir crystal. More specifically, the present invention relates to a novel kit for preparation of an oral...
6	7341993	Cross-linked glycopeptide—cephalosporin antibiotics This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical...
7	7192943	Cephem compounds The present invention relates to a compound of the formula [I]: wherein R 1 is lower alkyl or hydroxy(lower)alkyl, and R 2 is hydrogen or amino protecting group, or R 1 and R 2 are bonded...
8	7179801	Cephem compounds The present invention relates to a compound of the formula [I]: wherein A is lower alkylene or lower alkenylene; R 1 is lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl,...
9	7129232	Cephem compounds The present invention relates to a compound of the formula [I]: wherein R 1 is lower alkyl, hydroxy(lower)alkyl or halo(lower)alkyl, and R 2 is hydrogen or amino protecting group, or R...
10	7115624	Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 The present invention provides a method of inhibiting a member of a family of Protein Tyrosine Phosphatases (PTPases, PTPs) such as PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTPα, PTPε, PTPμ, PTPδ,...
11	7094431	Method of healing skin wounds in mammals and a composition therefor This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
12	6916801	7-Alkylidene-3-substituted-3-cephem-4-carboxylates as β-lactamase inhibitors The invention provides compounds of formula (I): wherein: R 1 -R 4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for...
13	6911441	Prolonged release pharmaceutical composition Novel pharmaceutical compositions of a cephalosporin in a prolonged release vehicle, comprising an oil and aluminium distearate, provide a prolonged duration of effective blood-plasma concentration...
14	6906054	Compositions for inhibiting beta-lactamase The invention provides pharmaceutical compositions comprising compounds of formula I and IV: wherein R 1 -R 11 and A have any of the values defined in the specification, and their...
15	6727243	Compositions comprising cefuroxime axetil Cefuroxime axetil in a non-gelatinous form on contact with an aqueous liquid, e.g., in the form of a solid dispersion on a carrier, e.g., useful for the production of pharmaceutical compositions...
16	6693095	Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates A compound of formula wherein W, V, R 1 , R 5 , R 2 , R 3 and R 4 have various meanings, a process for their production and their use as a pharmaceutical.
17	6583133	Propenyl cephalosporin derivatives and process for the manufacture thereof Disclosed are cephalosporin derivatives of the general formula wherein R is an organic residue with a molecular weight not exceeding 400 bonded to the adjacent sulphur atom via carbon and...
18	6534494	Process for the preparation of cefuroxime axetil in an amorphous form A process for preparing cefuroxime axetil in substantially amorphous form comprises forming a mixture of crystalline cefuroxime axetil and at least one pharmaceutically acceptable excipient, and...
19	6486149	Composition comprising a crystallographically stable, amorphous cephalosporin and processes for the preparation thereof Processes are provided for the preparation of orally administrable, yellow and powdery compositions essentially consisting of particles composed of a homogeneous mixture of an amorphous Cefditoren...
20	6465428	Pharmaceutical combinations based on dalfopristine and quinupristine, and on cefepime The present invention relates to pharmaceutical combinations of group A and group B streptogramins, in particular to combinations of dalfopristine and quinupristine, with cefepime, which...
21	6407091	β-lactamase inhibiting compounds The invention provides compounds of formula I and IV: wherein R 1 -R 11 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for...
22	6342493	Crystallographically stable amorphous cephalosporin compositions and process for producing the same Processes are provided for the preparation of orally administrable, yellow and powdery compositions essentially consisting of particles composed of a homogeneous mixture of an amorphous Cefditoren...
23	6323193	Bioavailable oral dosage form of cefuroxime axetil This invention relates to a bioavailable oral dosage form comprising of amorphous cefuroxime axetil containing from 7 to 25% crystalline cefuroxime axetil.
24	6300347	2-substituted 4,5-diaryl imidazoles Novel 2-substituted 4,5-diaryl imidazoles are provided, in particular compounds of Formula I ##STR1## wherein R1, R2, R3 and R4 are as defined, in free or pharmaceutically-acceptable acid addition...
25	6262044	Modulators of protein tyrosine phosphatases (PTPASES) The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein...
26	6232306	Derivatives of 3-(2-oxo-[1,3']bipyrrolidinyl-3-ylidenemethyl)-cephams The present invention provides compounds of formula I ##STR1## wherein R 1 is hydrogen, C 1 -6 -alkyl, C 1 -6 -alkyl substituted by fluoro, or C 3 -6 -cycloalkyl; R 2 is hydrogen or a...
27	6180621	Method and treatment using 1-methylcarbapenem derivatives as an anti-helicobacter pylori agent A method for the prophylaxis or treatment of infectious diseases caused by helicobacter pyloir, by administering a pharmacologically effective amount of a 1-methoylcarbapenem coumpund of formula...
28	6150350	Antimicrobial compositions The invention relates to antimicrobial compositions comprising a combination of (1) a therapeutically effective amount of a compound of formula I ##STR1## with (2) a second ingredient selected from...
29	6063778	Cephalosporin derivatives and processes for the preparation thereof The invention provides novel cephalosporin derivatives of the formula (I) ##STR1## and salts thereof for use in pharmaceutical compositions. Also novel precursors for synthesis of the...
30	6020329	Cephaloporins and homologues, preparations and pharmaceutical compositions β-Lactam antibiotics of formula (I) or a salt thereof, wherein R 1 is hydrogen, methoxy or formamido; R 2 is an acy group; CO 2 R 3 is a carboxy group or a carboxylate anion, or R 3 is a...
31	6013647	Benzoxazinedione derivatives, method of producing them and uses thereof This invention relates to new benzoxazinedione derivatives corresponding to the formula I: ##STR1## wherein R 1 =H or carboxyalkyl, R 2 =H, alkyl or phenyl, and R 3 represents different acid...
32	5994340	Azetidinone derivatives as β-lactamase inhibitors New 2-oxo-1-azetidine sulfonic acid derivatives with an aminoalkyl substituted "anti" (E-isomer) oxyimino group in the acylamino substituent at the 3 position of the monobactam ring. These...
33	5981519	Vinyl-pyrrolidinone cephalosporins The present invention relates to compounds having the formula ##STR1## wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are as defined herein as well as readily hydrolyzable esters thereof,...
34	5925632	Derivatives of 3-pyrrolidylidene-2-one-cephalsporines Compounds of formula (I) ##STR1## wherein R 1 is hydrogen, lower alkyl, aralkyl, cycloalkyl, R 3 CO-- or --C(R 4 R 5 )CO 2 R 6 ; where R 4 and R 5 are each independently hydrogen or lower...
35	5856320	Cephem compounds, their preparation and their use as antimicrobial agents Novel cephalosporin derivatives of formula (II): ##STR1## wherein R 2 is hydrogen, methyl, or fluoromethyl; R 3 is hydrogen, methyl or carboxyl; R 4 is hydrogen or methyl; A is methylene or...
36	5843937	DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents The present invention relates to novel DNA alkylating agents and the prodrugs of these agents which are useful as antitumor agents and DNA labelling agents. The compounds are hydroxy...
37	5804577	Cephalosporin derivatives The present invention relates to compounds of formula I ##STR1## wherein R 1 is a group selected from 2-, 3-, and 4-hydroxyphenyl, 3-nitrophenyl, and 3-fluoro-4-hydroxyphenyl; as well as readily...
38	5760027	Use of 7-alkylidene cephalosporins to inhibit elastase activity The present invention relates to the use of 7-alkylidene derivatives of cephalosporin esters, such as sulfides, sulfoxides, and sulfones, as inhibitors of human leukocyte elastase. These materials...
39	5753667	1-oxo-2- (phenylsulphonylamino) pentylpiperidine derivatives, their preparation and their therapeutic application The present invention provides a compound of formula (I) ##STR1## in which R 1 represents a hydrogen atom or a (C 1 -C 4 )alkyl group, R 2 represents a hydrogen atom or a straight or branched (C...
40	5747484	Crystalline cepham acid addition salts and processes for their preparation Novel crystalline cephem acid addition salts and processes for their preparation Compounds of the formula I ##STR1## in which n is equal to 1 or 2 and m is 0.4-2.6, and where X is the anion...
41	5728691	Quinolonylcarboxamidocephalosporin derivatives and pharmaceutical compositions containing them Derivatives of 7-aminoceph-3-em-4-carboxylic acid with 6-fluoroquinolone derivatives in which the cephem and 6-fluoroquinolone moieties are bound to each other through a carboxamido bond as well as...
42	5721229	Soluble forms of cephalosporins and treatment of animals A dry solid mixture of a hydroxypolycarboxylic acid and a cephalosporin where the hydroxypolycarboxylic acid of the formula ##STR1## where x and y are 0 or 1 and z is 0 to 3, in the weight ration...
43	5710147	7-benzyloxyimino-cephalosporins The syn isomer of (R) or (S) or (R,S) mixture, in the form of internal salts or salts with acids or bases of a compound of the formula ##STR1## wherein the substituents are defined as in the...
44	5710146	Cephem derivatives and processes for their manufacture Cephem derivatives of the general formula ##STR1## in which the R 2 O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against...
45	5663163	Cephem compounds and processes for preparation thereof The present invention relates to new cephem compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same and anti-bacterial methods of using the same. The...
46	5663162	Cephem derivatives Compounds represented by the following formula (I), that is, cephem derivatives having substituted or unsubstituted imidazo[5,1-b]thiazolium-6-yl as a substituent at the 3-position of the cephem...
47	5661144	Cephem derivatives with 3-substituted bis heterocycles Compounds represented by the following formula (I), that is, cephem derivatives having substituted or unsubstituted 3-(imidazo[5,1-b]thiazolium-6-yl)-1-propenyl as a substituent at the 3-position...
48	5656623	Antimicrobial lactam-quinolones Antimicrobial lactam-quinolone compounds comprising a lactam-containing moiety linked to a quinolone moiety, of the formula: ##STR1## wherein (1) A 1 , A 2 , A 3 , R 1 , R 4 and R 6 generally...
49	5620968	7-substituted-amino-3-substituted-3-cephem-4-carboxylic acids The invention provides compounds of the formula: ##STR1## wherein the variables are hereinbelow described; and salts thereof. Also, pharmaceutical formulations and methods for treating bacterial...
50	5602117	Cephalosporin compounds β-lactam antibiotics of formula (I) or a salt thereof, wherein R 1 is hydrogen, methoxy of formamido; R 2 is an acyl group, in particular that of an antibacterially active cephalosporin; CO 2 R...

Matches 1 - 50 out of 278

1 2 3 4 5 6 >