Matches 151 - 200 out of 278 < 1 2 3 4 5 6 >
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4758558 N-(substituted)-[7-(2-cyanoacetamido)cephalosporanic]amide derivatives having antibiotic utility  
Disclosed herein are the derivatives of substituted cephalosporanic acid represented by the formula (I): ##STR1## wherein R 1 represents a 4-pyridylthiomethyl group, an alpha-aminobenzyl group, a...
4749694 Novel lysine esters used as absorption  
Novel lysine esters used as absorption enhancing agents for gastrointestinally and rectally administered drugs. Also provided are processes for preparation of said lysine ester compounds as well as...
4748172 3-bicyclicpyridinium-methyl cephalosporins  
Cephalosporin compounds substituted in the 7-position by a 2-(5- or 6-membered heterocyclic)-2-oximinoacetylamino group and in the 3-position with an imidazolo, oxazolo or thiazolopyridinium-methyl...
4748171 Cephem compounds having at the 3-position a (1,4-methylene-1-piperidinio)methyl group or a (1-quinuclidinio)methyl group  
Described herein is a cephem derivative represented by the general formula: ##STR1## wherein n stands for 1 or 2, Y stands for CH or nitrogen atoms, R 1 represents a lower hydrocarbon group or a...
4742053 3-Isoquinoliniomethyl cephalosporin derivatives  
The invention relates to an antibiotic comprising a compound having the formula: ##STR1## wherein R 1 is a straight chain, branched chain, or cyclic lower alkyl group which may be substituted by a...
4734407 Alpha-aminoacyl-penicillins and cephalosporins  
Antibacterially active and animal growth-regulating novel β-lactam compounds of the formula ##STR1## in which R 1 represents an optionally substituted radical of the formula ##STR2## Z represents...
4731361 Alkeneamidocephalosporin esters  
An oral antibacterial, 7beta-[(Z)-2-(2-aminothiazol-4-yl)-2-alkenoylamino]-3-cephem -4-carboxylic acid pharmaceutically acceptable ester represented by the following formula: ##STR1## (wherein R is...
4731362 Alkylcarbamoyloxymethylcephem compounds  
An antibacterial 3-(alkylcarbamoyloxymethyl)-3-cephem-4-carboxylic acid or its derivatives represented by the following formula ##STR1## (wherein R is hydrogen or an amino-protecting group, R 1 ...
4729991 Cephem compounds  
The invention relates to novel cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R 1 is amino or protected amino, R 2 is halogen, R 3 is hydrogen or lower...
4727070 3-Propenzl cephalosporin isomer separation process and derivative  
The antibiotic 7-[D-2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-1-propenyl ]ceph-3-em-4-c arboxylic acid (BMY-28100) forms imidazolidinone derivatives on reaction with ketones. These derivatives...
4716158 7-(2-amin othiazol-4-yl)-2-(syn)-methoxyiminoacetamido)-3-methoxymethyl-3-cepham-4- carboxylates  
Compounds of formula (I): ##STR1## wherein: R 1 represents a lower alkyl group selected from methyl groups and ethyl groups; R 2 represents a hydrogen atom or a methyl group; and R 3 ...
4708955 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof  
This invention provides novel cephalosporanic acids and esters thereof having the general formula ##STR1## wherein R 2 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, cyclo(lower)alkyl or...
4705784 Cephem compounds  
A cephem compound represent by the general formula ##STR1## wherein, R 1 represents hydrogen or lower alkyl, R 2 and R 3 are the same or different and each represents hydrogen or lower alkyl, R...
4703046 Cephem compounds and processes for preparation thereof  
This invention concerns antibiotic cephalosporins of the formula ##STR1## wherein R 1 is amino or protected amino; R 2 is halogen; R 3 is alkyl; and R 6 is carboxy or protected carboxy.
4699777 Compositions and method for enhancement of the transdermal flux of albuterol with a combination of 1-dodecyl-azacyclopheptan-2-one and urea  
A topical albuterol composition having superior transdermal flux containing various amounts of albuterol, 1-dodecyl-azacycloheptan-2-one and urea in a non-aqueous environment. The enhancement...
4699904 Tetrazolyl derivatives of β-lactams useful as elastase inhibitors  
Tetrazolyl derivatives of β-lactams are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
4698336 3-(pyrrolidinio)methyl-3-cephem derivatives  
Described herein is 3-(pyrrolidinio)methyl-3-cephem derivative represented by the general formula: ##STR1## wherein Y stands for CH or nitrogen atom, R 1 and R 2 are the same or different, and...
4692441 Chorine esters as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal cavities  
Choline esters are used as drug absorption enhancing agents for drugs which are poorly absorbed from the nasal, oral, and vaginal cavities.
4687769 3-(3,3,3-trifluoropropenyl) cephalosporins  
A class of new cephem compounds is now provided, which is useful as antibacterial agent and is represented by the general formula (I) ##STR1## wherein R 1 is methyl group or carboxymethyl group...
4686216 7-[2-(2- aminothiazol-4-yl)-2-oximino-acetamido-3-quaternary-ammonium-methyl-3-cep hem-4-carboxylates  
Novel cephalosporins of the formula ##STR1## in which R 1 is an aliphatic or cycloaliphatic hydrocarbyl radical of up to 6 carbon atoms which is optionally substituted by a carboxyl group,...
4684642 7-Hydroxyaminocephalosporin antibiotics  
7α-Hydroxyamino-7β-[2-substituted-2-(acylamino)acetamido]c ephalo sporin antibiotics, pharmaceutically-acceptable salts and in vivo hydrolyzable esters thereof, a method of treating susceptible...
4683227 Antibiotic derivatives of 7β-[2-(thiazol-4-yl)acetamide]-3-chloro-3-cephem-4-carboxylic acids and compositions and method of use thereof  
7β-Heterocyclicacetylamino-(and 7β-heterocyclicthioacetamido)-3-chloro-3-cephem-4-carboxyli c acids and pharmaceutically acceptable salts thereof, e.g.,...
4668504 Use of substituted propenoates to prevent nephrotoxicity of certain antibiotics  
Antibiotics to prevent nephrotoxicity.
4666899 3-(Optionally substituted-but-1-en-3-ynyl) cephalosporins  
Compounds of general formula I ##STR1## (wherein R represents NH 2 -- or an acylated or silylated amino group; R 2 represents a hydrogen, halogen, alkyl, aryl, carboxyl or lower alkoxycarbonyl...
4665065 3-pyrazolo(1,5-aαpyridinium cephem compounds  
A compound of the formula; ##STR1## wherein R 0 stands for hydrogen atom, nitrogen-containing heterocyclic group, acyl group or amino-protecting group, Z stands for S, S➝O, O or CH 2 , R 4 ...
4656166 Antibiotic compounds derived from cephalosporins, process for their production and pharmaceutical compositions  
The compounds according to the invention correspond to the formula: ##STR1## in which: The COOA group at the 4 position is an acid radical, or an alkaline or alkaline-earth salt, or an amino acid...
4654331 Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group  
The (5-R-2-oxo-1,3-dioxolen-4-yl)methyl moiety: ##STR1## wherein R is loweralkyl of 1-6 carbon atoms, especially methyl or t-butyl; when utilized as an ester on a pharmaceutical having a carboxylic...
4639448 7-amino-3-[substituted vinyl]-3-cephem-4-carboxylates having antimicrobial activity  
The invention relates to cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R 1 is amino or acylamino, R 2 is lower alkyl, and Y is CH or N.
4632918 Novel β-lactam antibiotics  
Novel β-lactam antibiotics of the formula ##STR1## in which R 1 , R 2 and R 3 , which may be identical or different, denote a substituted or unsubstituted alkyl radical or a monocyclic or...
4631274 Halovinyl cephem compounds  
The invention relates to novel halovinyl cephem derivatives of high antimicrobial activity of the formula: ##STR1## wherein R 1 is a group of the formula: R 4 --A--CONH-- in which R 4 is...
4626533 7-(2-thienylacetamido)-3-acylaminomethyl-cephalosporins  
The invention relates to novel compounds of the formula: ##STR1## where R=4-chlorophenylmethyl or 2,6-dichlorophenylmethyl or an alkalimetal salt thereof. The compounds have utility as antibiotics.
4623644 Acylation of tirandamycic, streptolic and sorbic acids to cephalosporin and penicillin nuclei  
This invention relates to the hybridization of streptolydigin, tirandamycin and sorbic acid to penicillin and cephalosporin nuclei.
4618606 Antibiotic 7-(thiazolyl)-3-(pyrazinylmethyl) or (pyridazinylmethyl) cephalosporins  
The invention relates to antibiotic compounds of the formula: ##STR1## wherein R 1 represents a hydrogen atom or a carboxyl-protecting group; R 2 represents a group of the formula: ##STR2## R 3 ...
4609653 Crystalline cephem-acid addition salts and processes for their preparation  
Crystalline cephem-acid addition salts of the formula ##STR1## and their hydrates, processes for the preparation of the acid addition salts, pharmaceutical products containing these compounds and...
4609730 7-[substituted imino-2-(2-aminothiazol-4-yl)-acetamido]-3(2,2-dihalovinyl or ethynyl)-3-cephem-4-carboxylic acid (syn isomers), having antimicrobial activities  
The invention relates to novel cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R 1 is amino, lower alkanoylamino, ar(lower)alkanoylamino, amino- or...
4608373 Cephem compounds  
Novel cephem compounds are provided having the formula: ##STR1## wherein R represents lower alkyl, which may be substituted with lower acyloxy, lower alkylthio or certain 5 or 6-membered...
4604386 3-(alkynylalkyloxy) cephalosporins  
3-(alkynylalkyloxy)cephalosporin antibiotics and the intermediates therefor are disclosed. Pharmaceutical compositions for the antibiotics are also disclosed.
4602012 Cephalosporin antibiotics  
There are described compounds of formula (I) ##STR1## wherein R, R 1 and R 2 which may be the same or different, each represents a hydrogen atom or a C 1 -4 alkyl group and R 3 represents a C 1...
4596829 7-acylaminocephalosporanic acid derivatives and processes for the preparation thereof  
This invention relates to novel 7-acylaminocephalosporanic acid derivatives and pharmaceutically acceptable salts thereof, of high antimicrobial activity, said novel derivatives having the formula...
4590186 Cephem compounds having 3-bicyclic heterocyclic cation groups  
The invention relates to cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R 1 is amino or protected amino, R 2 is lower aliphatic hydrocarbon group, R 3 is...
4585860 7-acylamino-3-vinylcephalosporanic acid derivatives useful for treatment of infectious diseases in human beings and animals  
The invention relates to novel compounds of high antimicrobial activity of the formula: ##STR1## in which R 1 is amino-substituted-heterocyclic group which may have halogen, protected...
4581352 Thienothienylglycyl cephalosporin derivatives  
7-(Thienothienyl)glycylamido cephalosporins have good gram positive activity and favorable pharmacokinetics and are orally effective.
4562181 Amorphous form of cefuroxime ester  
There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the...
4560683 Cephalosporin antibiotics  
Cephalosporin antibiotics of general formula ##STR1## (wherein R 1 represents a hydrogen atom or a methyl or 2-chloroethyl group) and non-toxic salts and non-toxic metabolically labile esters...
4559334 7-Substituted-3-vinyl-3-cephem compounds and processes for production of the same  
The invention relates to novel compounds of high antimicrobial activity of the formula: ##STR1## in which R 1 is amino or a protected amino group, and R 2 is carboxy or a protected carboxy...
4546101 New cephem compounds useful for treating infectious diseases in human being and animals and processes for preparation thereof  
The invention relates to cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R 1 is amino or acylamino, R 2 is lower alkyl, and Y is CH or N.
4537886 β-lactam antibacterial agents and compositions containing them  
A compound of formula (1) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof: ##STR1## wherein R 1 is phenyl, substituted phenyl or a 5- or 6-membered heterocyclic ring...
4526962 Cephalosporin derivatives  
New cephalosporin derivatives of the formula: ##STR1## in which R' represents a protected carboxyl radical, Hal represents a halogen atom, X 1 represents a sulphur or oxygen atom or a sulphinyl...
4525473 Cephalosporins  
Compounds of the formula ##STR1## wherein R 1 is hydrogen or a conventional amino-protecting group, R 2 is a straight or branched chain alkyl, alkenyl or alkynyl containing from 1 to 4 carbon...
4515789 β-Lactam antibiotics  
A 3-β-(vic-dihydroxyphenylmethyleneamino-2-oxo-imidazolidine) - or 3-β-(vic-dihydroxyphenyl-methyleneamino-2,3-dioxo-piperazin e)-1-carbo nylamino-acetamidoazetidin-2-one having an acidic...
Matches 151 - 200 out of 278 < 1 2 3 4 5 6 >