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7341993 |
Cross-linked glycopeptide—cephalosporin antibiotics
This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical...
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7262183 |
Substituted 5-membered n-heterocyclic compounds and their uses for treating or preventing neurodegenerative diseases
This invention relates to substituted 5-membered N-Herterocyclic neurotrophic compounds of formula (I) or pharmaceutically acceptable salts or hydrates thereof, wherein R 1 , R 2 , R 3 , R 4 , V,...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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6906054 |
Compositions for inhibiting beta-lactamase
The invention provides pharmaceutical compositions comprising compounds of formula I and IV:
wherein R 1 -R 11 and A have any of the values defined in the specification, and their...
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6613807 |
Therapeutic polyanhydride compounds for drug delivery
Polyanhydrides which link low molecular weight drugs containing a carboxylic acid group and an amine, thiol, alcohol or phenol group within their structure into polymeric drug delivery systems are...
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6599892 |
7-alkylidene cephalosporanic acid derivatives and methods of using the same
Derivatives of 7-alkylidene cephalosporanic acid sulfone and the pharmaceutically active salts thereof are found to be potent inhibitors of β-lactamase enzymes.
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6489319 |
Neurotherapeutic use of carboxypeptidase inhibitors
Administration of inhibitors of carboxypeptidase E provides significant neurotropic effects in warm-blooded vertebrates evidenced inter alia by anxiolytic and anti-aggressive behavior and enhanced...
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6486214 |
Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
Polyanhydrides which link low molecular weight drugs containing a carboxylic acid group and an amine, thiol, alcohol or phenol group within their structure into polymeric drug delivery systems are...
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6013647 |
Benzoxazinedione derivatives, method of producing them and uses thereof
This invention relates to new benzoxazinedione derivatives corresponding to the formula I: ##STR1## wherein R 1 =H or carboxyalkyl, R 2 =H, alkyl or phenyl, and R 3 represents different acid...
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5994340 |
Azetidinone derivatives as β-lactamase inhibitors
New 2-oxo-1-azetidine sulfonic acid derivatives with an aminoalkyl substituted "anti" (E-isomer) oxyimino group in the acylamino substituent at the 3 position of the monobactam ring. These...
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5994086 |
Method for assessing infertility by binding of mannose to sperm cells
Methods for labeling mannose lectins on the surface of mammalian sperm cells are described, and methods of categorizing and quantifying the numbers of cells exhibiting particular labeling patterns...
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5681563 |
7-vinylidene cephalosporins and methods of using the same
Cephalosporins with an exocyclic allene in the 7-position and their pharmaceutically active salts are potent inhibitors of β-lactamases and are therefore useful in the treatment of penicillin...
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5663162 |
Cephem derivatives
Compounds represented by the following formula (I), that is, cephem derivatives having substituted or unsubstituted imidazo[5,1-b]thiazolium-6-yl as a substituent at the 3-position of the cephem...
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5602117 |
Cephalosporin compounds
β-lactam antibiotics of formula (I) or a salt thereof, wherein R 1 is hydrogen, methoxy of formamido; R 2 is an acyl group, in particular that of an antibacterially active cephalosporin; CO 2 R...
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5446037 |
2-[(substituted) methylene]cephalosporin sulfones as antiinflammatory, antidegenerative and antithrombin agents
This invention relates to 2-[(substituted)methylene]cephalosporin sulfones and in particular 2-[(heteroaryl substituted)methylene]cephalosporin sulfones which are effective elastase inhibitors as...
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5436250 |
Isatineoxime derivatives, their preparation and use
A compound having the formula ##STR1## wherein R 4 and R 5 independently are hydrogen, halogen, CF 3 , CN, NO 2 or SO 2 NR 1 R 2 wherein R 1 is hydrogen or C 1 -6 -alkyl which may be...
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5409917 |
Topical treatment of acne with cephalosporins
A method and composition for topically treating acne and acneiform dermal disorders includes applying an amount of a cephalosporin antibiotic effective to treat the acne and acneiform dermal...
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5364848 |
Substituted cephalosporin sulfones as anti-inflammatory and antidegenerative agents
New substituted cephalosporin sulfones are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
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5348951 |
Cephalosporins
Cephalosporin compounds having a 3-position substituent of the formula (I) are described, --CH 2 --Y--Q (I) wherein Y is a bond or a linking group --NR 4...
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5312813 |
Biofilm reduction method
A method of killing microorganisms which form a biofilm on a tissue or implant surfaces in a patient, and which are refractory to a biocide at a dose which is effective to kill the microorganism in...
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5275816 |
Cephalosporin derivatives
7 α-formamido cephalosporin derivatives having a 3[N-(optionally substituted)aminothiopyridinium thiomethyl] substituent have anti-bacterial activity and are of use in anti-bacterial therapy....
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5258377 |
2-spirocyclopropyl 4-acylcephems
Derivatives of 2-spirocyclopropyl 4-acylcephem sulfones of the formula (I) ##STR1## are provided which are useful as potent elastase inhibitors and hence are useful in the prevention, control and...
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5246926 |
Cephalosporin derivatives
β-Lactam compounds of the formula (Ia) including pharmaceutically acceptable salts and in vivo hydrolysable esters, processes for their preparation and their use as antibiotics: ##STR1## wherein R...
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5232918 |
Cephalosporin derivatives
Cephalosporin derivatives having a 3-position substituent of formula I are described: ##STR1## wherein R 1 is hydrogen, alkenyl or optionally substituted alkyl, Het is a 5- or 6-membered...
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5219848 |
Cephem compounds
Cephalosporin antibiotics having a 3-position substituent of the formula: ##STR1## are described, wherein X is --CO--, --SO 2 -- or --COCH 2 --; Y is --CO--, --SO 2 -- or --CH 2 --; Q is a...
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5190748 |
Absorption enhancement of antibiotics
The absorption of antibiotics given through oral and rectal routes of administration is significantly enhanced by use of the antibiotic in conjunction with a two-component absorption enhancing...
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5158946 |
Cephalosporin derivatives and pharmaceutical compositions
β-Lactam compounds of the formula (I) including pharmaceutically acceptable salts and in vivo hydrolysable esters, processes for their preparation and their use as antibiotics: ##STR1## wherein R...
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5147871 |
Anti-bacterial cephalosporin compounds
There are presented anti-bacterial cephalosporins having broad antimicrobial activity of the formula ##STR1## wherein R 1 is an antibiotically active quinolonyl; R 2 is selected from the group...
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5143910 |
Piperaziniocephalosporins
Antibacterial hydroxyarylpiperazinocephalosporins of the formula: ##STR1## wherein R 1 is amino or acylamino; R 2 is H or methoxy; R 3 is alkyl; R 4 is --(P--C--Q) n --, where P and Q each are...
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5134138 |
Phenacylpyridiniothiocephalosporins
An antibacterial 3-vic-dihydroxyaroylmethylpyridiniothiomethyl cephalosporin (I) and its salts represented by the following formula: ##STR1## (wherein, R 1 is amino group or acylamino; R 2 is...
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RE33948 |
β-lactam antibiotics
Antibacterially active and animal growth-promoting novel β-lactam compounds of the formula ##STR1## in which R 1 represents the radical ##STR2## Y representing N or CR 9 , or Y--R 7 representing...
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5114933 |
Cephalosporin compounds
Cephalosporin compounds having a 3-position substituent of the formula (I) are described: --CH 2 --Y--Q (I) wherein Y is a bond or a linking group --NR 4...
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5077286 |
Beta-lactam derivatives of the 4-acylcephem sulphone and 3-acylpenam sulphone-type
Compounds of formulae Ia and Ib ##STR1## wherein A is hydrogen atom or an organic residue, R 1 is halogen atom, or an organic group, R 2 is hydrogen or halogen atom, C 1 -C 4 alkyl or alkoxy...
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5069899 |
Anti-thrombogenic, anti-microbial compositions containing heparin
Anti-thrombobenic, anti-microbial compositions containing heparin reacted with quaternary ammonium components and bound with water-insoluble polymers are disclosed. Such compositions may also...
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5064824 |
Cephalosporin compounds
Cephalosporin antibiotics having a 3-position substituent of the formula: ##STR1## are described; wherein R 1 is hydrogen or certain substituted alkyl groups, Z is CH or N, R 2 and R 3 are...
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5055462 |
Cephalosporin compounds
Cephalosporin antibiotics having a 3-position substituent of the formula: --CH 2 NR 1 --Y--A--Z--Q are described, wherein R 1 is hydrogen or certain optionally substituted alkyl groups; Y is...
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5049558 |
Cephalosporin derivatives
A cephalosporin derivative of the formula I: ##STR1## in which X is ##STR2## represents one of C-7 acyl groups known in the cephalosporin art, R3 is hydrogen or methoxy, R4 is hydrogen, optionally...
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5028427 |
"Cephalosporin" compounds
β-Lactam antibiotics have the formula (Ia) or are pharmaceutically acceptable salts or pharmaceutically acceptable in vivo hydrolysable esters thereof: ##STR1## in which the group CO 2 R 1 is...
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5019570 |
Cephalosporin compounds
Cephalosporin derivatives having a 3-position substituent of the formula I are described: ##STR1## wherein R 1 is hydrogen, alkenyl or optionally substituted alkyl, Het us a 5- or 6-membered...
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5017569 |
Cephalosporin derivatives
Cephalosporin compounds having a 3-position substituent of the formula (I) are described: --CH 2 --Y--Q (I) wherein Y is a linking group --NR 4 ...
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5013730 |
Cephem derivatives
Cephalosporins having a 3-position substituent of the formula: ##STR1## are described, wherein R 5 is hydrogen, alkenyl, alkyl or substituted alkyl, Q is a mono- or bicyclic heterocyclic ring,...
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5008258 |
Cephalosporin derivatives
Cephalosporin compounds having as a 3-substituent the group: ##STR1## wherein Y represents a bond, optionally substituted alkylene or --CH 2 CH 2 NHCO--, P is a benzene ring substituted by groups...
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4956358 |
Tricyclic cepham compounds and use
The compounds having a 4,11-dioxo-3-oxa-8(or 7)-thia-1-azatricyclo[7,2,0,0 2 ,6 ]undecane-2-carboxylic acid skeleton as the base structures, their esters and their salts are useful antibacterial...
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4950660 |
Beta-lactam compound and process for production thereof
The present invention relates to a cephem compound of formula (III) shown in the description. The compound is useful as an intermediate for the synthesis of β-lactam antibiotics of new class and...
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4940702 |
Cephem compounds
β-Lactam antibiotics are disclosed which have the formulae (Ia) or pharmaceutically acceptable salts or pharmaceutically acceptable in vivo hydrolysable esters thereof: ##STR1## wherein R 1 is...
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4908443 |
7-Beta-substituted 3-lower alkanoylacetoxy-methyl-7-alpha-methoxy-3-cephem-4-carboxylic acid
Novel cephem compounds are provided which are useful for synthesizing cephamycin compounds useful as antibacterial agents. The novel compounds have the formula (I): ##STR1## wherein R 1 represents...
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4894371 |
3-substituted-aminomethyl cephalosporin derivatives
An antibacterial cephalosporin derivative of the formula I: ##STR1## in which X is S,O,CH 2 or S0; R2 is hydrogen, methoxy or formylamino; R3 is carboxy or a biodegradable ester thereof; R1...
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4891370 |
Cephalosporin derivatives as anti-inflammatory agents
Derivatives of cephalosporin esters are found to be potent elastase inhibitors and therefore are useful antiinflammatory agents.
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4877783 |
β-lactam antibacterial agents
β-Lactam antibiotics having an α-formamido substituent on the carbon atom adjacent to the carbonyl group of the β-lactam ring and in particular bicyclic compounds having the partial structure:...
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4835150 |
Cephem compounds
β-Lactam antibiotics are disclosed which have the formula (IA) or pharmaceutically acceptable salts or pharmaceutically acceptable in vivo hydrolyzable esters thereof: ##STR1## wherein R 1 is...
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