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7612037 Cross-linked glycopeptide-cephalosporin antibiotics  
This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical...
7601690 Cross-linked glycopeptide-cephalosporin antibiotics  
This invention provides cross-linked glycopeptides—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides...
7488724 7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors  
The invention provides compounds of formula (I): wherein: R 1 -R 4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for...
7358237 Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2  
Cyclooxygenase (COX2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Inducible NOS specifically binds to COX2 and S-nitrosylates it, enhancing COX2 catalytic...
7307062 Method for treating a mental disorder  
A method of treating an individual exhibiting at least one symptom of a mental disorder is provided which comprises administering to the individual an antimicrobial composition in an amount...
7189708 Topical composition for skin  
A topical skin composition containing a dipeptide compound represented by formula (1) or a salt of the dipeptide: wherein R 1 represents a hydrogen atom, an alkyl group, an alkanoyl group, or...
7101572 Taste masked aqueous liquid pharmaceutical composition  
A substantially taste masked liquid pharmaceutical composition containing a pharmaceutically effective amount of an unpleasant tasting drug dissolved or dispersed in an aqueous excipient base, said...
7094431 Method of healing skin wounds in mammals and a composition therefor  
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
7087588 Nitric oxide donors capable of reducing toxicity from drugs  
Use of organic compounds containing the —ONO 2 function, or inorganic compound containing the —NO group or compositions comprising said compounds to reduce the toxicity caused by drugs to the...
7011826 Control of acidosis  
The present invention relates to a vaccine for the prevention of lactic acidosis in a vertebrate, said vaccine comprising at least one isolated microorganism, or fragment or fragments thereof,...
6998397 Method for decreasing cholesterol level in blood  
A method for improving blood cholesterol and its conjugates levels in a mammal, which is based on the administration of steroidal plant hormone 24-epibrassinolide.
6949521 Therapeutic azide compounds  
Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and...
6916801 7-Alkylidene-3-substituted-3-cephem-4-carboxylates as β-lactamase inhibitors  
The invention provides compounds of formula (I): wherein: R 1 -R 4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for...
6906054 Compositions for inhibiting beta-lactamase  
The invention provides pharmaceutical compositions comprising compounds of formula I and IV: wherein R 1 -R 11 and A have any of the values defined in the specification, and their...
6869976 Inorganic-polymer complexes for the controlled release of compounds including medicinals  
This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used is calcium...
6709678 Easy to swallow oral medicament composition  
An oral composition which is adapted to be dispersed in an aqueous carrier substantially immediately prior to administration comprises a multiplicity of particles comprising an active substance,...
6645959 Method for treating postoperative ileus  
This invention is a method for preventing or treating postoperative ileus comprising administering a vasopressin antagonist such as a compound of Formula (1), where R 1 , R 2 , and R 3 include...
6627625 Treatment of behavioral disorders with β-lactam compounds  
Administration of β-lactam compounds including β-lactam antibiotics and β-lactamase inhibitors provides significant neurotropic effects in warm-blooded vertebrates evidenced inter alia by...
6599892 7-alkylidene cephalosporanic acid derivatives and methods of using the same  
Derivatives of 7-alkylidene cephalosporanic acid sulfone and the pharmaceutically active salts thereof are found to be potent inhibitors of β-lactamase enzymes.
6583133 Propenyl cephalosporin derivatives and process for the manufacture thereof  
Disclosed are cephalosporin derivatives of the general formula wherein R is an organic residue with a molecular weight not exceeding 400 bonded to the adjacent sulphur atom via carbon and...
6565882 Antibiotic composition with inhibitor  
Antibiotic composition having four dosage forms with different release profiles providing for initial release of a beta lactam antibiotic followed by release of a beta-lactamase inhibitor, followed...
6537985 Antibiotic formulation and a method of making this formulation  
An antibiotic formulation in a true solution is provided. This formulation includes an antibiotic and N-methyl-2-pyrrolidone. It also may include a preservative, an antioxidant, and/or an additive....
6489319 Neurotherapeutic use of carboxypeptidase inhibitors  
Administration of inhibitors of carboxypeptidase E provides significant neurotropic effects in warm-blooded vertebrates evidenced inter alia by anxiolytic and anti-aggressive behavior and enhanced...
6486149 Composition comprising a crystallographically stable, amorphous cephalosporin and processes for the preparation thereof  
Processes are provided for the preparation of orally administrable, yellow and powdery compositions essentially consisting of particles composed of a homogeneous mixture of an amorphous Cefditoren...
6468964 Control of acidic gut syndrome  
According to the present invention there is provided a method for the treatment or prophylaxis of acidic gut syndrome resulting from the accumulation of acid and production of endotoxin in the...
6461607 Probiotic, lactic acid-producing bacteria and uses thereof  
The present invention discloses compositions and methodologies for the utilization of probiotic organisms in therapeutic compositions. More specifically, the present invention relates to the...
6420355 Pharmaceutical compositions containing cyclosporins  
A pharmaceutical composition in the form of an emulsion preconcentrate for oral administration and containing a cyclosporin. The pharmaceutical composition has a carrier medium for the cyclosporin...
6407091 β-lactamase inhibiting compounds  
The invention provides compounds of formula I and IV: wherein R 1 -R 11 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for...
6380181 Synthetic catechol derivatives, method for production and use thereof  
Catechol derivatives of general formula (I) in which R 1 denotes O-acyl and R 2 represents amino acid residues in the 3- and/or 4-position function as siderophores and/or as biological...
6369049 Treatment of mastitis  
The invention provides new fluorinated cephalosporin antibiotics of Formula I wherein R a , R b , R c , R d and R e , independently, are H, F or a C 1 -C 6 alkyl-(Z) n — group having at...
6342493 Crystallographically stable amorphous cephalosporin compositions and process for producing the same  
Processes are provided for the preparation of orally administrable, yellow and powdery compositions essentially consisting of particles composed of a homogeneous mixture of an amorphous Cefditoren...
6333305 Antibiotic TKR2999, process for the preparation thereof and microbe  
The antibiotic TKR2999 having the physicochemical properties described below and its pharmacologically acceptable salt: (1) FAB-MS m/z 971 [M+H)] + , (2) the molecular formula: C 44 H 78 N 10 ...
6323193 Bioavailable oral dosage form of cefuroxime axetil  
This invention relates to a bioavailable oral dosage form comprising of amorphous cefuroxime axetil containing from 7 to 25% crystalline cefuroxime axetil.
6319904 Formulation comprising antibacterial substance and antiulcer substance  
The present invention includes a formulation which comprises an antibacterial substance and an antiulcer substance, wherein at least either of them is formulated into a gastrointestinal...
6316015 Hyperbactericidal surfaces  
A surface is provided with antibiotic or antiseptic properties. A solid substrate is modified by covalently fixing one or more spacers having reactive extremities via a proximate reactive...
6303644 Proton pump inhibitor in therapeutic combination with antibacterial substances  
The invention relates to the use of proton pump inhibitors as combination therapeutics in the treatment of bacterial diseases which do not affect the gastrointestinal track using antibacterially...
6271212 Prodrug azide compositions and compounds  
Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and...
6248718 Lesion-directed dry dosage forms of antibacterial agents for the treatment of acute mucosal infections of the oral cavity  
The invention provides a medicament for topically treating acute bacterial infections in the oral mucosa, and methods of use. The medicament comprises a dry dosage (such as a troche or powder) of...
6187768 Kit for flushing medical devices and method of preparation  
A kit and for flushing a medical device a method of preparing the kit is disclosed. The kit includes a container containing a mixed solution a unit dose of a pharmacologically effective amount of...
6143742 Treatment for necrotizing infections  
The treatment of for arresting the destructive effects of proteolytic enzymes produced by a host infecting organism, such as "flesh eating bacteria", is carried out using therapy with includes the...
6121255 Phloroglucide derivatives and their pharmceutical use  
A phloroglucide derivative having the following formula: ##STR1## wherein Q is halogen; X is CH 2 or CO; Y is cephalosporin having a formula of ##STR2## wherein Ph is phenyl, Ac is acetoxy, or...
6107290 Non-crystalline cefuroxime axetil solid dispersant, process for preparing same and composition for oral administration thereof  
A non-crystalline cefuroxime axetil solid dispersant showing no absorption peak on a Differential Scanning Calorimetry scan is prepared by (a) dissolving cefuroxime axetil and a surfactant in an...
6090801 Pharmaceutical compositions containing ceftriaxone and penems  
6066676 Pharmaceutical composition and methods for using it  
Disclosed is a method of treating problems or disorders of the human nervous system or a method of imparting an anaesthetic effect, by applying to a patient in need of such treatment a...
6048852 β-thiopropionyl-aminoacid derivatives and their use as β-lactamase inhibitors  
6015808 Synthesis of pharmaceutical compositions with lactams and β-lactams/oxo thia azabicyclo compounds  
Pharmaceutical compositions with heretofore unknown and enhanced physical, chemical, and biological properties are prepared by combining known biologically active parent compounds with oxo thia...
5994340 Azetidinone derivatives as β-lactamase inhibitors  
New 2-oxo-1-azetidine sulfonic acid derivatives with an aminoalkyl substituted "anti" (E-isomer) oxyimino group in the acylamino substituent at the 3 position of the monobactam ring. These...
5981499 Lesion-directed antibiotics in dry dosage forms for the treatment of shallow ulcers of the oral mucosa  
The invention provides a medicament for topically treating aphthous ulcers in the oral mucosa, and methods of use. The medicament comprises a troche or powder comprising a dry dosage of one or more...
5972964 Aminomethylindans, -benzofurans and -benzothiophenes  
Compounds of formula I ##STR1## wherein R1(cyclo)alk(en)yl, aralkyl, alkyl(oxy)carbonyl, CONH2, etc.; R2H, (cyclo)alk(en)yl, aralkyl, etc.; R3-R5H, halo, alkyl, alkoxy, etc.; R6,R7H,...
5972309 Identification of an exogenous intra-erythrocytic bacterium in patients having systemic lupus erythematosus, and treatment  
Intra-erythrocytic exogenous bacterial structures or parasites seen by giemsa and phase contrast microscopy in several patients with systemic lupus erythematosus (SLE) and not in controls were...
Matches 1 - 50 out of 152 1 2 3 4 >