Patents in Class 514/20

Matches 1 - 50 out of 76

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Match	Document	Document Title
1	7553876	Polycationic compounds and uses thereof Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a...
2	7449446	Combination product comprising melagatran and dexamethasone There is provided a combination product comprising; (A) melagatran or a pharmaceutically acceptable derivative thereof; and (B) dexamethasone or a pharmaceutically acceptable derivative there of,...
3	7322369	Methods of detaching microorganisms from, or of inhibiting microbial attachment to, animal or poultry carcasses or seafood or parts thereof Methods of detaching microorganisms (e.g., bacteria) from, or of inhibiting microbial (e.g., bacterial) attachment to, animal or poultry carcasses or seafood or parts thereof, wherein the method...
4	7297689	Method for preparing peritoneal dialysate Carbonyl compounds generated and accumulated in the peritoneal dialysate can be inactivated or eliminated by a carbonyl compound-trapping agent such as aminoguanidine. Carbonyl compounds generated...
5	7256176	Methods of modulating β cell function Methods of modulating pancreatic function by modulating MCH signaling in a β cell.
6	7232803	Antimicrobial compounds and formulations The invention relates to the use of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto at least two bulky and lipophilic groups and having...
7	7169814	Guanidinium transport reagents and conjugates Transport reagents and conjugates of therapeutic agents linked to transport reagents are described. In particular, the transport reagents have a plurality of guanidinium moieties that are either...
8	7163921	Peptide derivatives and medicinal compositions The present invention to novel nociceptin receptor agonists which are peptide derivatives represented by the following general formula (1): (in which A is alkylene, —CH 2 ) n CO— or a...
9	7060708	Active agent delivery systems and methods for protecting and administering active agents The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active...
10	7034002	Angiotensin converting enzyme inhibitor The present invention provides an angiotensin converting enzyme inhibitor having strong activity of inhibiting angiotensin converting enzyme, good hue and easily to take in which is a composition...
11	7026297	Neuroprotective agents Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN—, (where X and Y are hydrogen or various groups); R a represents alkylene; R b and R c ...
12	6962905	Pharmaceutical formulation comprising a low molecular weight thrombin inhibitor and its prodrug A kit of parts containing (a) a pharmaceutical formulation including a low molecular weight thrombin inhibitor, or a pharmaceutically acceptable derivative thereof, in admixture with a...
13	6919326	Carbonyl-stress improving agent and peritoneal dialysate Carbonyl compounds generated and accumulated in the peritoneal dialysate can be inactivated or eliminated by a carbonyl compound-trapping agent such as aminoguanidine. Carbonyl compounds generated...
14	6869934	Method of purifying calcium ion-binding protein The present invention relates to a method for purifying a calcium ion-binding protein by cation exchange chromatography. The present invention provide a method for isolating and purifying a calcium...
15	6833136	Vaccine for preventing pythiosis in humans and animals The present invention provides antigen vaccines and methods of use thereof for the treatment of Pythium insidiosum infections, as well as prophylaxis against these infections, in humans and...
16	6753316	Acryloyl derivatives analogous to distamycin, process for preparing them, and their use as antitumor agents Compounds which are acryloyl substituted distamycin derivatives of formula (I) wherein: n is 2, 3 or 4; m is 1 or 2; X and Y are the same or different and are selected, independently for each...
17	6689754	Heterocyclic glycyl β-alanine derivatives The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salts thereof, pharmaceutical compositions containing such compounds and...
18	6492350	Chitin oligosaccharides and/or chitosan oligosaccharides for preventing or treating common cold or treating pain A new method is presented which is useful in the prevention of the common cold (also called non-allergic rhinitis, viral upper respiratory tract infection, viral URI, etc and for this presentation...
19	6440937	Dipeptide benzamidine as a kininogenase inhibitor Compounds of the formula I where R, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 , and l, m and n have the meanings stated in the description, and their preparation are described. The novel compounds...
20	6433017	Amphiphilic polyamine compounds In accordance with the present invention, there are provided amphiphilic polyamine compounds and derivatives thereof having the property of promoting transfection of polynucleotides and...
21	6417161	Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors The present invention is directed to aminoguanidine and alkoxyguanidine compounds, including compounds of Formula I: wherein X is O or NR 19 and A 1 , A 2 , R 7 -R 10 , R 18 , R a , R b , R c ,...
22	6410598	Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis The present invention relates generally to the non-enzymatic glycosylation of amyloidogenic proteins and the consequent formation of advanced glycosylation endproducts (AGEs). It has been found...
23	6362165	Hydroxyphenyl derivatives with HIV integrase inhibitory properties An hydroxyphenyl derivative selected from the group consisting of a compound of formula and when a compound of formula I comprises a carboxylic acid group pharmaceutically acceptable salts...
24	6358928	Peptidyl sulfonyl imidazolides as selective inhibitors of serine proteases Novel α-amino and peptidyl sulfonyl imidazolides, a method for their synthesis, and a method for inhibiting serine proteases therewith are disclosed. Pharmaceutical compositions containing...
25	6352976	Selective inhibitors of MMP-12 The present invention provides novel mercaptoacetylamido dipeptide carboxylic acids of the formula which are MMP inhibitors useful for the treatment of smoking-induced emphysema.
26	6348499	Amphiphilic polyamide compounds Amphiphilic polyamide compounds and derivatives thereof having the property of promoting transfection of polynucleotides and polypeptides into cells, and formulations comprising said compounds.
27	6287573	Method and vaccine for treatment of Pythiosis insidiosi in humans and lower animals A method and vaccine for treatment of pythiosis in humans and animals is described. In particular a vaccine comprising a mixture of extracellular and intracellular proteins is described. The...
28	6274557	Inhibition of nitric oxide synthase by amino acids and dipeptides Methods and compositions for inhibiting at least one isoform of nitric oxide synthase are provided. Pharmaceutical compositions include derivatives of arginine as well as dipeptides and dipeptide...
29	6255285	Phenethylamine derivatives The present invention has as its object providing phenethylamine derivatives that typically function as a motilin receptor antagonist and which are useful as medicines. The invention provides...
30	6251869	Enhancement of oxazolidinone antibacterial agents activity by using arginine derivatives The present invention provides methods and compositions for enhancing the effectiveness of oxazolidinone antibacterial agents against gram-negative organisms infection by using an arginine derivative.
31	6211156	Peptides for treatment of erectile dysfunction The present invention relates to small peptides that cause penile erections in male animals when injected into the paraventricular nucleus of the hypothalamus or when given systemically...
32	6160021	Method for treating epidermal or dermal conditions A method of treating a subject for an unwanted epidermal or dermal condition comprising administering to the subject, a treatment which modulates the level of nitric oxide (NO) in the skin.
33	6159941	Use of somatostatin agonists and antagonists for treating diseases related to the eye The invention relates to the use of a somatostatin receptor ligand of nonpeptide origin, e.g. of the general formula Ia or Ib ##STR1## or a pharmaceutically acceptable salt thereof, which has high...
34	6159938	Serine protease inhibitors comprising α-keto heterocycles Provided are methods of inhibiting the activity of a serine protease using protease inhibitors that include an alpha-keto heterocycle in their structure. The methods are useful in the treatment of...
35	6127343	Somatostatin agonists and antagonists The present invention relates to compounds, compositions containing them, and their use for treating medical disorders related to binding to human somatostatin receptor subtypes.
36	6127340	Serine protease inhibitors This invention is directed to peptide inhibitors of serine proteases, espcecially thrombin, in which the P1-P2 natural amide linkage is replaced by another bond. Exemplary thrombin inhibitors have...
37	6117842	Fibrinogen receptor antagonists Compounds of this invention have the formula: X--(CH 2 ) n --C(O)NH--A--C(COOR 5 )R 3 R 4 or a pharmaceutically acceptable salt thereof, e.g. ##STR1## which are useful for inhibiting fibrinogen...
38	6090786	Serine proteases, their activity and their synthetic inhibitors
39	6034067	Serine protease inhibitors The invention relates to a compound having formula (I), wherein A, B, X, N, Z and Q are defined as described in the description. The compounds of the invention have anticoagulant activity and can...
40	5994406	Geminal cationic surfactants of the type Nα Nω bis (Nα-acyl-arginin) α,ω diamino alkyl dichlorohydrates as antimicrobial agents Surfactants having general formula (II) ##STR1## wherein X=8-14; n=2-8. The process for obtaining such surfactants comprises the following steps; a) producing nitroarginin; b) producing N α...
41	5981492	Substituted 5-membered ring heterocycles, their preparation and their use The present invention pertains to 5-ring heterocycles of general formula (I), wherein W, Y, Z, B, D, E and R as well as b, c, d, e, f, g, and h are as indicated in the description; to methods for...
42	5872122	Pyrimidinylamidino β-amino acid derivatives useful as inhibitors of platelet aggregation This invention provides a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutical compositions of such compounds and a method of...
43	5814342	Prolonged release microcapsules This invention provides a microcapsule designed for zero order release of a physiologically active polypeptide over a period of at least two months, which is produced by preparing a water-in-oil...
44	5811099	Method and composition for preserving antigens and process for utilizing cytological material produced by same A method and composition for fixing and stabilizing tissues, cells, and cell components such that the antigenic sites are preserved for a useful period of time is provided. The fixative employs a...
45	5741661	Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are...
46	5731290	Method of improving the immune response The invention provides diet supplements for pre-operative treatment of patients due for surgery.
47	5691356	Disubstituted heterocyclic thrombin inhibitors Disubstituted heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein G is ##STR2## wherein n is 0, 1 or 2 or 3; m is 0, 1, 2 or 3; Y is NH or S; p is 0, 1 or 2, Q...
48	5691307	O.sup.6 -substituted guanine compositions and methods for depleting O.sup.6 Novel O 6 -substituted guanine compounds and pharmaceutical compositions thereof are useful for effectively reducing O 6 -alkylguanine-DNA alkyltransferase (AGT). The novel compounds are useful...
49	5681820	Guanidinoalkyl glycine β-amino acids useful for inhibiting tumor metastasis This invention herein relates to a method of treating a condition mediated by inhibition of α v β 3 integrins and a method of inhibiting tumor metastasis by administering a therapeutically...
50	5672583	Carboxy-peptidyl derivatives as antidegenerative active agents Novel Carboxy-peptidyl compounds of Formula I are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis, septic arthritis,...

Matches 1 - 50 out of 76

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