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8129348 |
Conjugates of biologically active proteins having a modified in vivo half-life
Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating...
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8124073 |
Targeting of glycoprotein therapeutics
Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described. Improved targeting of glycoproteins to specific tissues is achieved by masking the natural...
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8101575 |
Glycopeptide phosphonate derivatives
Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide...
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8101196 |
Polysaccharide biomaterials and methods of use thereof
The invention includes a medical hydrogel made from polymerized polysaccharide macromers. The macromers are preferably polysaccharides decorated with polymerizable groups, for example,...
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8092780 |
Polyvalent conjugate vaccine for cancer
This invention provides a polyvalent vaccine comprising at least two conjugated antigens selected from a group containing glycolipid antigen, polysaccharide antigen, mucin antigen, glycosylated...
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8076299 |
Method for producing peptide thioester
It is an object of the present invention to provide a novel method for producing a peptide thioester. In the present invention, general peptide synthesis is performed on a solid-phase resin,...
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7985731 |
Sugar chain added GLP-1 peptide
The present invention relates to an oligosaccharide chain added GLP-1 peptide that has higher stability in blood than that of GLP-1 and, preferably, exhibits higher activity of controlling...
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7923432 |
Implant depots to deliver growth factors to treat avascular necrosis
The present invention relates to the design and composition of a depot implant for optimal delivery of growth factors to treat bone avascular necrosis, in that such depot implant is constructed to...
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7906140 |
Compositions for mucosal delivery of agents
Compositions and methods for mucosal delivery of agents are provided. The compositions are intended for administration to mucosal surface, such as oral and nasal mucosa. The compositions provided...
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7897164 |
Compositions and methods for nucleus pulposus regeneration
Compositions for nucleus pulposus regeneration is provided. Such composition may comprise a scaffolding material and a pore creating agent dispersed within the scaffolding material. The pore...
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7893029 |
Recombinant lubricin molecules and uses thereof
Recombinant lubricin molecules and uses thereof. Novel recombinant lubricin molecules and their uses as lubricants, anti-adhesive agents and/or intra-articular supplements for, e.g., synovial...
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7879799 |
Methods for characterizing glycoproteins and generating antibodies for same
The invention provides methods for generating an antibody specific for the deglycosylated form of a glycopolypeptide using a peptide corresponding to an N-linked glycosylation site of a...
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7875591 |
Delivery system for heparin-binding growth factors
A device comprising a scaffold coated with a protein having at least 83% identity to the amino acid sequence of the core protein of domain I of a mammalian perlecan, wherein at least one...
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7767643 |
Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
Methods and compositions are provided for protecting or enhancing an erythropoietin-responsive cell, tissue, organ or body part function or viability in vivo, in situ or ex vivo in mammals,...
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7759307 |
Compositions for protection against superficial vasodilator flush syndrome, and methods of use
Compositions for protection against SVFS syndromes are composed of a flavonoid compound of the basic structures 2-phenyl-4H-1-benzopyran or 2-phenyl-4-keto-1-benzopyran or glycosides thereof, an...
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7759314 |
Treatment of muscular dystrophies and related disorders
The invention provides, among other aspects, compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan;...
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7723296 |
Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof
Methods to introduce highly phosphorylated mannopyranosyl oligosaccharide derivatives containing mannose-6-phosphate (M6P), or other oligosaccharides bearing other terminal hexoses, to carbonyl...
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7709439 |
Biomaterials for enhanced healing
The present invention relates to novel biomaterials and methods of using these new biomaterials to facilitate wound healing. The novel biomaterial may be a biocompatible polymer to which at least...
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7700551 |
Hydrolysable polymeric FMOC-linker
The invention relates to Fmoc (9-fluorenyl-methoxycarbonyl)-based polymeric conjugates. These conjugates are useful for extending the in-vivo circulation of protein and peptide drugs.
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7700317 |
Truncated baff receptors
The disclosure provides a non-naturally occurring BAFF-R glycoprotein having a deletion in the extracellular domain which results in an altered 0-linked glycosylation pattern. The disclosure also...
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7696154 |
Methods for treating interleukin-18 mediated disorders with interleukin-18 binding proteins
Interleukin-18 binding proteins which are capable of binding IL-18 and of modulating and/or blocking IL-18 activity are provided. Methods for the isolation and recombinant production, DNAs encoding...
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7696163 |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying...
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7691817 |
System and method for inhibiting cellular proliferation with tachykinins
Systems and methods are described providing therapeutic preparations of tachykinins, and more specifically sialokinins, for treating various types of abnormal cellular proliferation conditions in...
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7691396 |
Chimeric peptides comprising HER-2 B-cell epitopes and measles virus fusion protein T-cell epitopes
Compositions, methods, and vaccines that may stimulate the immune system and that may be used for treating malignancies associated with overexpression of the HER-2 protein are provided. Such...
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7671018 |
Delivery system for heparin-binding growth factors
New uses of proteoglycans to bind and present growth factors, methods of accelerating wound, tissue or bone repair using such proteoglycans, pharmaceutical compositions of such proteoglycans, and...
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7666838 |
Analogs of gastric inhibitory polypeptide and their use for treatment of diabetes
The present invention provides peptides which stimulate the release of insulin. The peptides, based on GIP 1-42 include substitutions and/or modifications which enhance and influence secretion...
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7618941 |
Treating degenerative joint disorders with tribonectins
The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.
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7612038 |
Biglycan and related therapeutics and methods of use
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with...
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7608269 |
Compositions and methods for treating cancer by modulating HER-2 and EGF receptors
An alternative HER-2/neu product, herstatin, consists of subdomains I and II from the ectodomain of p185HER-2 and a unique 79 amino acid C-terminus encoded by intron 8. Recombinant herstatin added...
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7605125 |
DNA-binding polyamide drug conjugates
A conjugate of formula: V—(Y)a—Z-T: (I), T-X—B—(Y)a—Z-T′: (II), V—(Y)a Z—(Y′)a V′: (III), T-X—B—(Y)a—Z—(Y′)a—X′—B′-T′: (IV), V—(Y)a—Z—(Y′)a—X—B-T: (V), V—(Y)a—Z—X—B...
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7563446 |
Methods and compositions for inducing autoimmunity in the treatment of cancers
Disclosed are methods and compositions for the prevention and treatment of cancers using lipid-carrier protein conjugate compositions for generating lipid-specific immune responses in an animal....
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7550429 |
Glycoproteins having lipid mobilising properties and therapeutic applications thereof
A biologically active lipid mobilising agent for use in therapy is disclosed which has the properties and characteristics of a Zn-α2-glycoprotein, or of a fragment thereof having an apparent ...
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7550154 |
Methods of treatment with drug loaded polymeric materials
Polymeric microparticles have been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and can have targeting ligands directly bound to...
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7541335 |
Nogo-receptors and methods of use
Disclosed are compositions relating to the Nogo receptor (NgR) family as well as fragments, chimeras, and variants thereof. The invention provides polypeptides, nucleic acids, vectors, expression...
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7541328 |
Coupling proteins to a modified polysaccharide
The invention relates to a method for coupling proteins to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the protein is based on a...
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7528108 |
Compositions and methods for treating or preventing overweight or obesity with zinc-charged protein fragments
Compositions and methods for treating or preventing, for example, overweight or obesity are provided. Compositions provided comprise zinc-charged, protease digested serum or milk proteins....
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7524821 |
Scaffolded maleimide clusters for multivalent peptide assembly
Disclosed are scaffolded maleimide clusters, methods of making said clusters and use of said clusters as templates for multivalent peptide assembly. Multiple maleimide functionalities were...
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7504115 |
Shark cartilage extracts and use thereof for immunomodulation
Disclosed is a composition from shark cartilage comprising immunoactive proteoglycans and other immunoactive components having a molecular weight greater than about 100 KD, wherein the composition...
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7494975 |
Anti-HIV composition, production method thereof and medicament
The present invention relates to an anti-HIV composition and to the method for producing it. The composition of the present invention comprises a polyanion and a molecule capable of inducing the...
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7455840 |
Compositions and methods to reduce mutagenesis
The present invention provides methods and compositions for said inhibition of drug resistance. In one embodiment, said invention provides methods and compositions for said inhibition of antibiotic...
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7438890 |
Binding peptides for carcinoembryonic antigen (CEA)
The present invention provides binding moieties for CEA, which have a variety of uses wherever detecting, isolating or localizing CEA, and particularly CEA as opposed to cross-reactive antigens...
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7432236 |
Vasostatin as marrow protectant
Specific fragments of vasostatin are disclosed. Also disclosed is a method of stimulating the proliferation or survival of a hematopoietic cell exposed to a chemotherapeutic agent or irradiation...
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7405193 |
Use of Acrp30 globular head to promote increases in muscle mass and muscle differentiation
The present invention relates to the field of muscle research, in particular to the discovery of a compound effective for increasing muscle mass, muscle cell differentiation, and oxidation of free...
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7405199 |
Cross-linked glycopeptide-cephalosporin antibiotics
This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical...
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7387777 |
Methods of treating hemophilia or von willebrand disease with p-selectin
The present invention identifies P-selectin as a modulator of hemostasis. Accordingly, the present invention relates to methods for the identification and use of modulators of P-selectin activity...
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7368422 |
Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the...
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7365053 |
Selective N-acylation of A82846 glygopeptides analogs
The present invention provides a process for selectively acylating an A82846A, A82846B, A82846C or PA-42867-A glycopeptide at the N1, N2 or N3 positions and the monoacylated compounds prepared...
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7358226 |
Ultrasonic concentration of drug delivery capsules
Methods, compositions and apparatus for localized delivery of compounds are provided. In certain embodiments, radiation force is used to direct carriers to a target site, and additional radiation...
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7357936 |
Adjuvant systems and vaccines
The present invention provides vaccine and adjuvant formulation comprising an immunostimulant and a metal salt. The immunostimulant is adsorbed onto a particle of metal salt and the resulting...
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7351694 |
Human NK-3 related prostate specific gene-1
The present invention relates to a novel member of the NK family of homeobox genes. In particular, isolated nucleic acid molecules are provided encoding the human NK-3 prostate specific gene 1...
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