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8993526 Method for counteracting the perception of sweat malodour by decreasing the function of carboxylic acid-binding olfactory receptors  
The invention relates to the identification of carboxylic acids, present in human sweat, as natural ligands of a specific subgroup of seven olfactory receptor (OR) belonging to class 1 within the...
8980820 Fatty acid binding proteins as drug targets for endocannabinoids  
The invention provides a method of modulating the level of an endocannabinoid in a subject in need thereof comprising administering an effective amount of an agent that inhibits the interaction of...
8940683 Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors  
The present invention is drawn to methods and compositions for treating inflammatory disorders of the lower airways, comprising administering an effective amount of an agent, which modulates the...
8936806 Periostin induces proliferation of cardiomyocytes and promotes cardiac regeneration  
The present invention provides compositions and methods for increasing proliferation, increasing cell cycle activity, and/or proliferation of postmitotic mammalian differentiated cardiomyocytes....
8900591 Vaccines comprising mutant GPCRs with increased conformational stability relative to parent receptors  
There is provided a G protein coupled receptor (GPCR) or a polynucleotide encoding said GPCR for use as a vaccine. There is also provided methods of antagonizing or agonizing A GPCR in vivo...
8871192 IL-1F8 polypeptides  
The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins.
8846601 Melanocortin receptor-specific peptides  
Melanocortin receptor-specific cyclic peptides of the formula where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and z are as defined in the specification, compositions and formulations including the...
8815795 Methods for preventing or treating eye diseases using adiponectin  
A composition for preventing or treating an eye disease includes adiponectin as an active ingredient. Adiponectin as an active ingredient is eventually revealed to show prevention or therapeutic...
8815817 Long term disease modification using immunostimulatory oligonucleotides  
The invention provides methods for treating asthma by using multiple rounds of administration of ISS over a period of time to confer long term disease modification.
8802628 Stable solid formulation of a GC-C receptor agonist polypeptide suitable for oral administration  
Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a...
8728526 Coacervate microparticles useful for the sustained release administration of therapeutic agents  
The present invention relates to novel microparticles formed using a coacervation process, methods of forming the microparticles, and methods of using the microparticles for the sustained release...
8715701 Microstructural protein preparations containing adsorbed biologically active substances and their application in medicine and cosmetics  
Protein preparations containing biologically active compounds and the application of the protein preparations obtained, particularly as a component of medicinal and cosmetic preparations as...
8709734 Method for identifying modulators of GPCR GPR1 function  
The invention relates to the identification of Humanin and derivatives thereof as ligands of the GPR1 GPCR (G-protein coupled receptor). The invention encompasses the use of the interaction of...
8658602 Multimeric constructs  
Multimeric fusion proteins of an Ig-like domain of Flt-1 are rendered functional by inclusion of a linker moiety. Vectors encoding the fusion proteins and host cells expressing the fusion proteins...
8633163 Template-fixed peptidomimetics  
Template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 4 α-amino acid residues which, depending on their positions in the chain (counted...
8569229 Compositions and methods which modulate G-protein signaling for the treatment of inflammatory disorders such as asthma and allergic conjunctivitis  
Compositions and methods for the treatment of asthma and inflammatory ocular disorders are disclosed.
8568720 High concentration antibody-containing liquid formulation  
The problem to be solved is to provide an antibody-containing formulation which is stable and suited for subcutaneous administration, wherein dimerization and deamidation is prevented during...
8563519 Methods of activating or inhibiting G protein coupled receptors (GPCRs)  
The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
8501717 Methods to treat and/or prevent mucositis  
The present invention relates to methods useful for treating and/or preventing mucositis using an active vitamin D compound.
8486908 Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response  
The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated...
8470333 Chimeric peptides comprising HER-2 B-cell epitopes and T-helper epitopes  
Compositions, methods, and vaccines that may stimulate the immune system and that may be used for treating malignancies associated with overexpression of the HER-2 protein are provided. Such...
8440627 G protein coupled receptor agonists and antagonists and methods of use  
The invention relates generally to G protein coupled receptors (GPCRs) and in particular to GPCR agonists and antagonists, use of these compounds and their pharmaceutical compositions, e.g., in...
8435961 Methods and compositions for increasing the activity of inhibitory RNA  
The invention provides methods for increasing the activity of an inhibitory RNA (RNAi) in a subject requiring administering one or more poly-ADP-ribose polymerase (PARP) inhibitors and/or one or...
8389478 Methods and compositions for treating neurodegenerative disorders and Alzheimer's disease and improving normal memory  
The disclosure relates generally to neurodegenerative disorders and more specifically to a group of presenilin/G-protein/c-src binding polypeptides and methods of use for modulating signaling and...
8389484 Methods for targeting RNA molecules  
Described are methods for identifying targets in RNA molecules based on differences in RNA secondary structure related to sequence variances between different allelic forms. Also described are...
8389480 G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same  
The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
8354378 G protein coupled receptor antagonists and methods of activating and inhibiting G protein coupled receptors using the same  
The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
8349801 Peptide ligands for G-protein coupled receptors  
Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating myocardial and ischemic disorders associated with G-protein coupled receptor activation.
8324172 G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same  
The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
8299028 Chimeric peptide antagonist for GPCR135 or GPCR142  
The chimeric polypeptide R3(BΔ23-27)R/I5 is described, which is a high-affinity antagonist for GPCR1 35 and GPCR1 42 over LGR7.
8268789 PAR-2 antagonists  
Compounds represented by the general formula (1) or salts thereof or solvates of both; PAR-2 antagonists containing the compounds; and preventive or therapeutic agents for PAR-2 related diseases...
8236763 Use of antagonists of the CB1 receptor for the manufacture of a composition useful for the treatment of hepatic diseases  
The invention relates to the use of antagonists to the CB1 receptor for the preparation of a composition for the treatment of hepatic diseases and preferably to the use of...
8173605 Kokumi-imparting agent  
The present invention encompasses a method for screening for a kokumi-imparting substance by using the calcium receptor activity as an index, a composition containing a kokumi-imparting substance...
8163692 Protection against and treatment of ionizing radiation  
Methods of preparing a proteoliposome comprise the step of contacting a liposome with an effective portion of RalBP1 to create a proteoliposome. RalBP1 is effective for the protection and...
8133864 PAR-2 agonist  
The present invention relates to a pharmaceutical composition for preventing/treating conditions associated with PAR-2. The present invention also relates to a method for preventing/treating the...
8088388 Stabilized synthetic immunogen delivery system  
The present invention provides an immunostimulatory complex specifically adapted to act as adjuvant and as a peptide immunogen stabilizer. The immunostimulatory complex comprises a CpG...
7998931 Vascular endothelial cell growth factor antagonists and uses thereof  
The present invention provides vascular endothelial cell growth factor (VEGF) antagonists and methods of using VEGF antagonists. VEGF antagonists contemplated by the invention include VEGF...
7960340 Cystine knot molecules  
The present invention relates generally to a molecular framework having a cyclic structure. More particularly, the present invention provides cyclic proteins and derivatives thereof in which...
7939052 Method of measuring the biological activity of an urotensin II receptor  
Administration of U-II to rats caused an increase in the redness or the skin temperature of the ear of the rats. The increase was inhibited by compounds that decease the biological activity of the...
7932227 Lacritin-syndecan fusion proteins  
The present invention relates to methods and compositions useful for the regulation of lacritin, syndecan, and lacritin-syndecan interactions and the signaling pathway downstream of...
7932226 NFκB transcriptional activity inhibitory agent and anti-inflammatory agent and a steroid action enhancing agent  
It is intended to surely and effectively inhibit the transcriptional activity of NFκB and to obtain a more effective anti-inflammatory effect. Further, it is intended to obtain an equivalent...
7928072 Multimeric constructs  
Multimeric fusion proteins of an Ig-like domain of Flt-1 are rendered functional by inclusion of a linker moiety. Vectors encoding the fusion proteins and host cells expressing the fusion proteins...
7923432 Implant depots to deliver growth factors to treat avascular necrosis  
The present invention relates to the design and composition of a depot implant for optimal delivery of growth factors to treat bone avascular necrosis, in that such depot implant is constructed to...
7915221 Methods for construction and screening of libraries of chemokine variants  
The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells...
7906483 Method for treating transplant rejection  
Compositions and methods for treating transplant rejection in a mammalian transplant recipient are provided. The method involves administering a therapeutically effective amount of Serp-1, its...
7902151 Methods and compositions for modulating immunity  
Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of a CD200 protein or a nucleic acid encoding a CD200 protein. The...
7897163 Bone graft and scaffolding materials immobilized with osteogenesis enhancing peptides on the surface  
The present invention relates to a bone graft material and a scaffold for tissue engineering applications, which have an osteogenesis-promoting peptide immobilized on the surface. More...
7897569 Use of HMGB fragments as anti-inflammatory agents  
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The...
7888323 Potent compstatin analogs  
Compounds comprising peptides and peptidomimetics capable of binding C3 protein and inhibiting complement activation are disclosed. These compounds display greatly improved complement...
7879802 Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders  
The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a...

Matches 1 - 50 out of 241 1 2 3 4 5 >