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7618941 |
Treating degenerative joint disorders with tribonectins
The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.
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7618939 |
Compositions and methods to prevent cancer with cupredoxins
The present invention relates to compositions comprising peptides that may be variants, derivatives and structural equivalents of cupredoxins that inhibit the development of premalignant lesions in...
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7618938 |
Treating cerebrovascular diseases with erythropoietin and granulocyte-colony stimulating factor jointly
A method for treating a cerebrovascular disease with erythropoietin (EPO) and granulocyte-colony stimulating factor (G-CSF) jointly by first identifying a subject in need of the treatment and then...
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7618937 |
Peptidomimetic polymers for antifouling surfaces
Peptidomimetic polymers comprising one or more DOPA moieties and related coatings and composites.
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7618936 |
Methods for treating and diagnosing cancer with WNT inhibitory Factor-1 (WIF-1)
This invention provides compositions, methods and kits for the diagnosis and treatment of cancers wherein Wnt Inhibitory Factor-1 (WIF-1) is underexpressed.
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7618935 |
Chaperonin 10 immunosuppression
The invention is directed to the use of cpnl0 in transplantation and particularly to treatment and/or prevention of graft versus host disease. The invention provides a method of administration of...
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7618653 |
Biological artificial nerve guide and method of making
A biological nerve guide for implantation into a human body is made by providing a natural animal tissue membrane, crosslinking and fixing the membrane, minimizing the antigens from the membrane,...
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7618636 |
Antigenic meningococcal peptides
WO99/36544 discloses a large number of proteins from Neisseria Meningitidis . The present invention relates to fragments of those proteins which comprise at least one antigenic determinant....
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7615533 |
TPO peptide compounds for treatment of anemia
Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.
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7615531 |
Methods of reducing the likelihood of spontaneous abortion
Compositions, kits and methods for the prevention of, for example, spontaneous abortion, preeclampsia, preterm labor or implantation failure during assisted reproduction are provided. The...
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7615530 |
Immunogenic compositions and methods of use
Disclosed herein are immunogenic compositions comprising a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A...
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7615529 |
Methods and compositions for modulating hyperstabilized c-met
The invention provides methods and compositions for modulating the HGF/c-met signaling pathway, in particular by inhibiting a hyperstabilized c-met protein.
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7615528 |
Methods for alleviating deleterious effects of 3-deoxyglucosone
Disclosed is a class of compounds which inhibit the enzymatic conversion of fructose-lysine into fructose-lysine-3-phosphate in an ATP dependent reaction in a recently discovered metabolic pathway....
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7615527 |
Peptides which modulate blood coagulation and methods of use thereof
Peptide fragments that modulate thrombosis and methods of use thereof are provided. Also provided are synthetic bioactive anti-coagulation peptides, compositions comprising such peptides and...
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7615212 |
Compositions and methods for the systemic treatment of arthritis
The present invention includes compositions and methods for treating arthritic joints found in patients with autoinflammation, e.g., systemic onset juvenile idiopathic arthritis, by administering...
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7612176 |
Polymer-based sustained release device
This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically...
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7612171 |
DB, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In...
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7612169 |
Osteoprotegerin variant proteins
The present invention relates to novel osteoprotegerin variant proteins (OVPs) that demonstrate reduced binding affinity for their ligand TRAIL when compared to wild-type osteoprotegerin. Nucleic...
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7612164 |
Cardiac muscle function and manipulation
This invention relates to polypeptides which affect myocardial cell differentiation and organisation of cardiac muscle contractile units, assay for identifying such polypeptides, and methods for...
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7612163 |
Prokineticin 2β peptide and its use
A PK2β peptide is described, which, as an agonist of prokineticin receptor 1, is useful for treating lung and gastrointestinal diseases or disorders mediated by PKR1 activity.
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7612162 |
Peptide analogs capable of enhancing stimulation of a glioma-specific CTL response
The invention provides a peptide derived from the interleukin-13 receptor α2, which serves as a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope. The invention can be used as a vaccine for...
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7612050 |
Drug for the treatment of osteonecrosis and for the management of patients at risk of developing osteonecrosis
A bisphosphonate for the treatment of osteonecrosis and/or osteonecrosis dissecans. The drug may further he used to prevent the onset of osteonecrosis and/or osetonecrosis dissecans and any...
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7612043 |
Method of reducing or inhibiting ObR signaling using a leptin antagonist consisting of SEQ id No: 2
Disclosed herein are peptides comprising a leptin sequence and methods for their use in preventing ObR signaling in a leptin-responsive cell. A leptin peptide of the present invention binds to but...
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7612040 |
Lefty polypeptides and derivatives thereof
The disclosure relates to Lefty derivatives and the uses of Lefty polypeptides as antagonists of the function of certain ligands such as Nodal, GDF-8 (Myostatin), and GDF-11. These derivatives may...
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7612038 |
Biglycan and related therapeutics and methods of use
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with...
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7612037 |
Cross-linked glycopeptide-cephalosporin antibiotics
This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical...
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7612036 |
Peptoid compounds
The invention relates to new peptoid compounds of formula (I), as well as their use in the treatment of bacterial infections, such as those caused by vancomycin resistant microorganisms, and to...
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7612035 |
Inhibition of mitogen-activated protein kinase (MAPK) pathway: a selective therapeutic strategy against melanoma
Inhibitors of the MAPK pathway, including MEK-directed proteases and small molecule inhibitors, are cytotoxic to human melanoma cells in vitro and in vivo via apoptotic mechanisms. These compounds...
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7612034 |
Treatment of subnormal bone mineral density
A method of treating an individual to increase the individual's bone mineral density (BMD) is disclosed. The method includes co-administering a calcitonin-like agent and a DHEA-like agent. Also...
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7612033 |
Methods for delivering compounds into a cell
The present invention is directed, inter alia, to a method for delivering a compound into a cell comprising administering to the cell the compound to be delivered, an organic halide, and/or a...
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7612032 |
Method for treating oncological diseases
A method to treat solid tumors and other oncological diseases consists of parenterally injecting an agent which destroy's blood's extracellular DNA into the systemic blood circulation of a cancer...
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7611867 |
CC-chemokine binding tick proteins
A novel CC-chemokine binding protein is isolated from the saliva of Rhipicephalus sanguineus . Compounds prepared in accordance with the present invention can be used as anti-inflammatory and...
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7608682 |
Substrates of N-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrates
The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel...
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7608590 |
HCV NS-3 serine protease inhibitors
Compounds of the formula
where the variables are as defined in the specification inhibit the NS3 protease of flavivirus such as hepatitis C virus (HCV). The compounds comprise a novel linkage...
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7608582 |
Delivery vehicle comprising a modified MscL protein channel
The invention relates to the field of drug delivery, in particular, to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles...
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7608581 |
Biofunctional, antimicrobial coatings for medical devices
The present invention provides compositions and methods for an improved coating for medical devices. Provided is an interfacial biomaterial or biofunctional coating composition comprising at least...
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7608580 |
Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins
An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising...
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7608579 |
Lung volume reduction using glue compositions
The present invention relates to methods and compositions for sealing localized regions of damaged lung tissue to reduce overall lung volume. The glue compositions provide a glue featuring an...
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7608578 |
Obesity controlling method
A method of controlling obesity by injecting bio-compatible bulking material into the pyloric sphincter area of the stomach. The injection of this material bulks the pyloric sphincter, retarding...
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7608577 |
Peptidyl ketones as inhibitors of DPIV
The present invention relates to compounds of the general formula 1
and pharmaceutically acceptable salts thereof, to the use of the compounds for the treatment of impaired glucose tolerance,...
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7608284 |
Enamel matrix protein composition for treatment of systemic inflammatory response syndrome
The present invention relates to the use of a preparation of an active enamel matrix substance, such as an amelogenin, for the manufacture of a pharmaceutical composition for modulating an immune...
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7608269 |
Compositions and methods for treating cancer by modulating HER-2 and EGF receptors
An alternative HER-2/neu product, herstatin, consists of subdomains I and II from the ectodomain of p185HER-2 and a unique 79 amino acid C-terminus encoded by intron 8. Recombinant herstatin added...
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7608268 |
Ferritin fusion proteins for use in vaccines and other applications
An isolated ferritin fusion protein is provided in which ferritin is fused with a protein or peptide capable of being fused to ferritin without interfering with the polymeric self-assembly of the...
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7608261 |
VEGF antagonist formulations suitable for intravitreal administration
Ophthalmic formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided suitable for intravitreal administration to the eye. The ophthalmic...
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7605232 |
Hydrogels for protein concentration
A method of concentrating proteins from whole blood comprising exposing whole blood to covalently crosslinked hydrogel to remove water from the blood into the hydrogel to thereby concentrate the...
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7605231 |
Gelatin derivatives and high-molecular micelle comprising the derivatives
The present invention relates to a gelatin derivative having an organic compound as a graft chain and a high-molecular weight micelle containing the gelatin derivative. As the organic compound, a...
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7605227 |
Melanoma antigen peptide analogues
Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at...
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7605150 |
Drug therapy for Celiac Sprue
Administering an effective dose of a tTGase inhibitor to a Celiac or dermatitis herpetiformis patient reduces the toxic effects of toxic gluten oligopeptides, thereby attenuating or eliminating the...
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7605130 |
Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction
A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
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7605129 |
Splice variant of human placental growth hormone
This invention relates to a protein, termed INSP105, herein identified as a splice variant of human placental growth hormone and to the use of this protein and nucleic acid sequences from the...
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