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9029318 Peptides and compositions for prevention of cell adhesion and methods of using same  
Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of YDYNWY (SEQ ID NO: 1), YDYNLY (SEQ ID NO: 2), YDYSFY (SEQ ID...
9029319 Water buffalo derived peptide antibiotic therapies  
The present disclosure relates to antimicrobial agents and methods of using such agents. The disclosure includes antimicrobial agents having broad spectrum antimicrobial activity, nucleic acids...
9017692 Antimicrobial agent, bacterial strain, biosynthesis, and methods of use  
Provided herein is a biologically pure culture of Paenibacillus thiaminolyticus, identified as OSY-SE, as well as an antimicrobial agent isolated and/or purified from the culture having any one of...
9018158 Alginate oligomers for use in overcoming multidrug resistance in bacteria  
The invention provides a method of overcoming resistance to at least one antibiotic in a multidrug resistant bacterium, said method comprising contacting said bacterium with an alginate oligomer...
9012396 Use of lipid conjugates in the treatment of conjunctivitis  
In one embodiment, the invention provides a method of suppressing, inhibiting, preventing, or treating conjunctivitis in a subject, comprising the step of administering an effective amount of a...
9012521 Pyrroloquinoline quinone gel  
An object of the present invention is to provide a gel containing pyrroloquinoline quinone that is capable of easily forming a gel near room temperature and is useful even in the food sector, and...
9006173 Microcystins as agents for treatment of cancer  
This invention relates to the use of microcystins as agents for treatment of cancer. Also provided are methods of screening for microcystins with improved cytotoxicity.
9006174 Antimicrobial peptides based on CMAP27  
The invention concerns derivatives of CMAP27, which have a good antimicrobial activity and a low haemolytic activity as compared to the wild-type CMAP27 peptide. These derivatives can be used for...
8999922 Linear peptide antibiotics  
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the...
8999923 Heat-stable, aqueous lactoferrin composition and its preparation and use  
The invention pertains to an aqueous composition containing lactoferrin, 35-70 wt % carbohydrate and/or polyol stabilizers, based on the total weight of the aqueous composition, said composition...
8999924 Pea protein peptides with anti Helicobacter pylori activity  
The invention relates to a composition comprising pea protein hydrolysate for the treatment and/or prevention of infection by gastrointestinal pathogens, in particular Helicobacter pylori and/or a...
8993514 Prion protein based hemin binders and methods of use  
Methods of using portions of the N-terminal domain of prion protein for binding hemin are disclosed. In a particular embodiment, a method comprises administering at least one isolated amino acid...
8992940 Agent for treating allergic or hypersensitivity condition  
The use of an agent in the manufacture of a medicament to affect an allergic condition and/or a hypersensitivity condition is described. The agent is capable of modulating a ganglioside associated...
8987194 Mutant Nisin ser 29 derivatives and the use thereof  
A Nisin derivative or variant, comprising an amino acid substitution at amino acid position 29 in the amino acid sequence. The Nisin derivative exhibits enhanced antimicrobial activity when...
8987193 Nisin derivatives and the use thereof  
The present invention relates to a nisin derivative comprising amino acid substitutions in the peptide sequence encoding the hinge region of the protein, wherein the derivative exhibits an...
8980279 Personalized site-specific immunomodulation  
The invention provides methods of treating inflammation in a specific organ or tissue of an individual. The method involves determining whether the individual has previously been infected with at...
8980844 Peptide having antibacterial or anti-inflammatory activity and pharmaceutical composition containing the same as an active ingredient  
A peptide having antibacterial or anti-inflammatory activity and a pharmaceutical composition containing the same as an active ingredient are described. Also, a peptide having antibacterial or...
8968726 Lactoferrin and angiogenin compositions and uses thereof  
Compositions are described which contain lactoferrin and angiogenin. The described compositions are useful in treatment of a variety of conditions, particularly in promoting bone health and relief...
8968781 Therapeutic compositions  
The present invention provides oral formulations of poorly bioavailable and/or poorly absorbable, and/or poorly water soluble therapeutic agents. The invention features pharmaceutical composition...
8969290 Matrix scaffold with antimicrobial activity  
The invention provides a scaffold of extracellular matrix polymers with recombinant chimeric peptides tethered thereto. The invention also provides recombinant chimeric peptides of antimicrobial...
8961873 Antinfection protecting healthcare workers to prevent spreading of communicable and nosocomial infections  
The present invention describes a new system and method, named “Antinfection”, to protect primarily healthcare workers (HCWs) and patients against communicable and nosocomial infections. It's...
8962550 Identification of inhibitors of a bacterial stress response  
A system, a composition, a method and a kit for identifying anti-bacterial agents are provided. The invention described herein is useful in identifying inhibitors of any bacterial stress response....
8951958 Purification of caspofungin intermediates  
The present invention relates to a method for the purification of cyclopeptides of general formula (3) by means of a silicate.
8951961 Structural and mechanistic basis for novel compound biosynthesis using 4-electron hexose oxidase  
A novel pharmaceutical composition comprising a compound of formula (I) is disclosed. The novel compound can include a pharmaceutically acceptable carrier. The invention further comprises methods...
8951960 Synergistic combination of DBNPA and polycyclic antibacterial peptide as biocide in bioethanol production  
Methods for controlling the growth of bacteria in ethanol fermentation systems with antibiotic alternatives, which can be nonoxidizing biocides, stabilized oxidizers, or any combinations thereof,...
8945540 Compositions for enhancing the antibacterial activity of myeloperoxidase and methods of use thereof  
Methods and compositions are provided for inhibiting the growth of susceptible microorganisms by contacting the microorganisms, in the presence of a peroxide and chloride or bromide, with...
8946145 Modified compstatin with peptide backbone and C-terminal modifications  
Compounds comprising peptides capable of binding C3 protein and inhibiting complement activation are disclosed. These compounds display greatly improved complement activation-inhibitory activity...
8946144 Phosphonated glycopeptide and lipoglycopeptide antibiotics and uses thereof for the prevention and treatment of bone and joint infections  
The present invention is directed to antimicrobial compounds which have an affinity for binding bones. More particularly, the invention is directed to phosphonated derivatives of glycopeptide or...
8940687 Antimicrobial angiogenin complexes (ANGex) and uses thereof  
Antimicrobial compositions based upon stabilized angiogenin compositions also contain osteopontin and antimicrobial proteins such as lactoperoxidase (LPO), myeloperoxidase (MPO), salivary...
8936782 Interferon beta as antibacterial agents  
The present invention describes method of treating bacterial infections, including MRSA. In various embodiments, the methods can use interferon beta, which is found to have antimicrobial activity....
8937040 Antibiotic compositions for the treatment of gram negative infections  
Provided herein is an antibacterial compound of the following formula: or a pharmaceutically acceptable salt thereof. The antibacterial compound has antibacterial properties against a diverse...
8933018 Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof  
Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some...
8933017 CD44V6 peptides as inhibitors of bacterial infections  
A method for treatment of infection with Listeria spp., Plasmodium spp., or Shigella spp. includes administering a peptide or a pharmaceutically acceptable salt of the peptide to an individual in...
8933029 Antimicrobial and anti-inflammatory peptides  
Antimicrobial and/or anti-inflammatory peptide compositions and therapeutic uses thereof are provided. The peptides and analogs or derivatives thereof may be used as an antimicrobial agent and/or...
8933016 Metallodrugs having improved pharmacological properties and methods of manufacture and use thereof  
It is an object of the present invention to provide antimicrobial metallodrugs comprising an antimicrobial peptide (“AMP”) and/or an antibiotic covalently bound to a metal binding moiety. These...
8927487 Antimicrobial cationic peptides and formulations thereof  
Compositions and methods for making and using therapeutic formulations of antimicrobial cationic peptides are provided. The antimicrobial cationic peptide formulations may be used, for example, in...
8921071 Targeting poly-gamma-glutamic acid to treat Staphylococcus epidermidis and related infections  
Immunogenic compositions and methods for eliciting an immune response against S. epidermidis and other related staphylococci are provided. The immunogenic compositions can include immunogenic...
8921309 Lipopeptide compounds and their use  
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain lipopeptide compounds comprising a cyclic peptide bearing a lipid side chain (for...
8921308 Antimicrobial peptide, branched forms thereof and their use in the treatment of bacteria infections  
The instant invention refers to an antibacterial peptide with all amino acids in D-configuration, possessing strong antimicrobial activity against Gram-negative and Gram-positive bacteria and...
8916516 Treatment of fungal and/or protist infections  
The present invention relates to the use of a polypeptides, comprising repeats of a peptide derived from a Heparan Sulphate Proteoglycan (HSPG) receptor binding region of an apolipoprotein, for...
8912140 PEGylated mutated clostridium botulinum toxin  
The invention relates to a modified botulinum toxin comprising a natural heavy chain and a modified light chain, characterized in that the modification of the light chain resides in that it...
8912192 Extended release preparation  
Disclosed is a sustained release preparation which releases a poorly soluble medicinal agent in a pH-independent manner. Also disclosed is a sustained release preparation which is capable of...
8906364 Antimicrobial compositions and uses thereof  
The present invention provides compositions for preventing growth and proliferation of biofilm embedded microorganisms on devices comprising: (a) a cationic polypeptide and (b) a bis-guanide or a...
8906866 Antibiotic compositions for the treatment of gram negative infections  
Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a...
8906897 Antimicrobial agents based on hemin derivatives  
The invention relates to novel antimicrobial, including antibacterial and antifungal, agents and compositions based on hemin derivatives of general formula (I), and also to the production of novel...
8906365 Antimicrobial agents  
The application relates to antimicrobial agents against Gram-negative bacteria, in particular to fusion proteins composed of an enzyme having the activity of degrading the cell wall of...
8901070 Pharmaceutical compositions comprising pore-forming proaerolysin protein (PRX302)  
The present disclosure includes methods and compositions for treating any condition involving prostatitis and similar diseases and/or conditions. These methods and compositions involve the use of...
8901071 Compounds and their use  
The present invention relates to peptides and their use in the treatment of microbial infections, in particular bacterial infections. In particular, the invention relates to peptides wherein at...
8895501 Eye-drop vaccine containing copolymer 1 for therapeutic immunization  
The invention provides an eye-drop vaccine for therapeutic immunization of a mammal comprising Copolymer 1, a Copolymer 1-related peptide, or a Copolymer 1-related polypeptide, for treating...
8889121 Bacterium comprising a regulated rfaH nucleic acid  
The present invention encompasses a recombinant bacterium comprising a regulated rfaH nucleic acid, as well as a vaccine comprising said recombinant bacterium. Other embodiments of the present...