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8183202 |
Use of type-B lantibiotic-based compounds having antimicrobial activity
A method for the treatment or prophylaxis of a microbial infection of the lower intestine or colon in a subject is described, wherein the method comprises administration to the subject of a type-B...
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8183341 |
Antibacterial compounds and processes for its production
This invention relates to a novel antibiotic compounds, pharmaceutically acceptable salts and derivatives thereof, and to methods for obtaining such compounds.
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8071541 |
Methods for preparing internally constrained peptides and peptidomimetics
The present invention relates to a method for preparing a peptide having a stable, internally constrained alpha-helical, beta-sheet/beta-turn, 310-helical, or pi-helical region and a method of...
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8034768 |
Composition and method for the treatment of diseases affected by histone deacetylase inhibitors
The present invention includes methods of treatment and compositions for treating diseases related to the activity of a histone deacetylase in a subject by administering to the subject an effective...
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8008250 |
Macrocyclic compounds and compositions useful as BACE inhibitors
Macrocyclic compounds of the formula in which R1, R3, V1, V2, X1, X2, Y, Z, Ar, AA and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15,...
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7994118 |
Template fixed beta-hairpin loop mimetics and their use in phage display
Template-fixed β-hairpin mimetics and libraries including a plurality of these mimetics are provided. The template-fixed β-hairpin mimetics are of the following general formula: R1-Cys-Z-Cys-R2 (...
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7943128 |
Anti-microbial compositions comprising a cationic peptide and a glycylglycine endopeptidase
There is provided an anti-microbial composition comprising a cationic peptide and a glycineglycine endopeptidase. The composition has been found to be synergistic against bacteria, especially Gram...
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7902148 |
Use of an echinocandin antifungal agent in combination with a glycopeptide antibacterial agent
This invention is directed to methods of administering an echinocandin antifungal agent in combination with a glycopeptide antibacterial agent having a substituent comprising at least about 8...
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7851439 |
EFTU inhibitors or aminothiazoles and their uses
Organic compounds that are useful for the treatment, prevention and/or amelioration of diseases are described.
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7795207 |
Lipopeptide compositions
The invention relates to a pharmaceutical composition comprising as an active agent a lipopeptide in a physiologically effective dose and a cyclodextrin or a cyclodextrin derivative.
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7786079 |
Substituted nonadepsipeptides
The invention relates to nonadepsipeptides and methods for their preparation and their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular...
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7740867 |
Method for identification of virulence determinants
Disclosed are methods for the determination of virulence determinants in bacteria and in particular bacteria of the genus Mycobacterium. Also disclosed are compositions and methods for stimulating...
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7727956 |
Deoxonadepsipeptides
Nonadepsipeptides and methods for their preparation and their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases are...
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7718611 |
Cyclic nonapeptide amides
The invention relates to cyclic nonapeptide amides and to methods for their preparation and to their use for the production of medicaments for the treatment and/or prophylaxis of diseases,...
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7687454 |
Effectors of innate immunity determination
A method of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described. A method of...
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7683028 |
Kahalalide compositions
The present invention is directed to new kahalalide antitumoral compounds, in particular to analogs of kahalalide F, useful as antitumoral, antiviral, and antifungal agents.
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7655623 |
Dab9 derivatives of lipopeptide antibiotics and methods of making and using the same
The present invention provides Dab9 derivatives of amphomycin-type lipopepetide antibiotics that display antimicrobial activity against Gram-positive bacteria, methods and intermediates for...
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7553872 |
Compounds and compositions for delivering active agents
Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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7517852 |
Compositions and methods for treating bacteria
The present invention relates to the field of bacteriology. In particular, the present invention provides compositions (e.g., comprising a lantibiotic and mupirocin or gentamicin) and methods of...
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7507718 |
Polymyxin B analogs for LPS detoxification
The invention relates to SAEP II peptide dimers that mimic polymyxin B i.a. in its ability to bind non-covalently the lipopolysaccharide (LPS) of Gram-negative bacteria with high affinity, and...
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7435716 |
Compounds pharmaceutical compositions and methods for treatment of bacteremia and/or septicemia
Novel conjugates of bacterial outer membrane binding peptides, preferably having bacterial sensitization activity, and immune cells chemotactic peptides, and pharmaceutical compositions containing...
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7427408 |
Quorum sensing and biofilm formation
The present invention is based on the discovery that interspecies quorum sensing is related to biofilm formation. The present invention provides methods useful for treating or preventing biofilm...
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7419954 |
Staphylococcus peptides for bacterial interference
The present invention provides a cyclic peptide comprising the structure: wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide...
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7405199 |
Cross-linked glycopeptide-cephalosporin antibiotics
This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical...
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7390787 |
Compositions and methods for treating infections using analogues of indolicidin
Compositions and methods for treating infections, especially bacterial infections, are provided. Indolicidin peptide analogues containing at least two basic amino acids are prepared. The analogues...
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7368422 |
Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the...
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7365047 |
Use of pentagastrin to inhibit gastric acid secretion or as a diuretic
This invention pertains to the discovery that pentagastrin, when administered in conjunction with a proton pump inhibitor (PPI) is synergistic with the PPI and significantly increases the efficacy...
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7364747 |
Process and product for inhibiting or preventing bacterial infections
The combination of a polymyxin composition and a hop composition produces unexpected and synergistic activity against gram positive bacteria.
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7351741 |
Compounds and compositions for delivering active agents
Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provide as well.
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7351687 |
Antibiotic 107891, its factors A1 and A2, pharmaceutically acceptable salts and compositions, and use thereof
The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated antibiotic 107891 which is produced by fermentation of Microbispora sp. ATCC PTA-5024, the...
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7348309 |
Glycorandomization and production of novel vancomycin analogs
The present invention provides combinatorial methods for rapidly generating a diverse library of glycorandomized structures, comprising incubating one or more aglycons and a pool of NDP-sugars in...
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7345018 |
Method of treating side effects induced by therapeutic agents
The invention relates to agents for the prevention of organ damage, in particular of the kidneys and the inner ear, induced by the administration of aminoglycosides. Agents according to the...
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7341993 |
Cross-linked glycopeptide—cephalosporin antibiotics
This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical...
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7326684 |
Peptides for enhancing resistance to microbial infections
The present invention is related to novel bioactive pentapeptides, pentarphins, the main indication of which is enhancing phagocytic activity of macrophages against microbes. In particular, the...
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7326683 |
Treatment of membrane-associated diseases and disorders using lantibiotic containing compositions
Compositions useful for treating membrane-associated diseases, conditions, and disorders, including inflammatory diseases, dry mouth, primary ciliary dyskinesia and platelet aggregating disorders,...
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7317001 |
Use of ramoplanin to treat diseases associated with the use of antibiotics
The invention features a method of treating or preventing a disease associated with the use of antibiotics in a patient in need thereof by administering to the patient ramoplanin in an amount and...
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7307062 |
Method for treating a mental disorder
A method of treating an individual exhibiting at least one symptom of a mental disorder is provided which comprises administering to the individual an antimicrobial composition in an amount...
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7294616 |
Capreomycin derivatives and their use as antibacterials
The present subject matter relates to phenylurea capreomycin derivatives, and to metabolites and pharmaceutically acceptable salts and solvates thereof. The compounds of the present subject matter...
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7273845 |
Polymeric prodrugs of vancomycin
Methods of preparing vancomycin-polymer conjugates are disclosed. In preferred aspects, polymer residues which are preferably releasable, are selectively attached to the sugar amino and/or N-methyl...
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7271147 |
Antibiotics, tripropeptins and process for producing the same
By culturing Lysobacter sp. BMK333-48F3 (deposit number of FERM BP-7477), an antibiotic, tripropeptin Z, tripropeptin A, tripropeptin B, tripropeptin C or tripropeptin D represented by the general...
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7259141 |
Vancomycin analogs and methods thereof
The present invention provides vancomycin analogs and methods related to synthesis of these analogs via chemoenzymatic techniques. In a preferred embodiment, the vancomycin analogs have a...
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7232799 |
Streptogramin derivatives and compositions thereof
The present invention discloses and claims pharmaceutical compositions comprising Group A streptogramin derivatives of formula (I) and salts thereof in combination with at least one natural group B...
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7186414 |
Compounds and compositions for delivering active agents
Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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7169756 |
Streptogramin antibiotics
Disclosed is a cyclic peptide antibiotic in which an enzyme-sensitive bond is replaced by an enzyme-resistant bond.
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7166594 |
Streptogramin derivatives, their preparation and compositions containing them
Group A streptogramin derivatives of general formula (I) in which: R1 represents a halogen atom or an azido or thiocyanato radical,R2 represents a hydrogen atom or a methyl or ethyl radical,R3...
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7144858 |
Antibacterial compounds and methods for treating Gram positive bacterial infections
The present inventive subject matter relates to novel antibacterial compounds that are capable of inhibiting bacterial multiplication and killing living bacteria. The present inventive subject...
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7125844 |
Dab9 derivatives of lipopeptide antibiotics and methods of making and using the same
The present invention provides Dab9 derivatives of amphomycin-type lipopeptide antibiotics that display antimicrobial activity against Gram-positive bacteria, methods and intermediates for...
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7119061 |
Dalbavancin compositions for treatment of bacterial infections
The invention provides methods and compositions for treatment of bacterial infections. Methods of the invention include administration of dalbavancin formulations for treatment of a bacterial...
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7115564 |
Stable pharmaceutical compositions of dalbavancin and methods of administration
The invention provides methods and compositions for treatment of bacterial infections. Methods of the invention include administration of dalbavancin for treatment of a bacterial infection, in...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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