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7517960 |
Rat KCNQ5 voltage-gated potassium channel
Disclosed herein are nucleic acid and polypeptide sequences of a novel rat voltage-gated potassium channel, KCNQ5. Also disclosed herein are methods related to the use of the aforementioned...
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7517667 |
Methods for promoting, inhibiting and detecting toxin entry into cells
In vitro delivery of the diphtheria toxin (DT) catalytic (C) domain from the lumen of purified early endosomes to the external milieu requires the addition of both ATP and a cytosolic translocation...
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7517533 |
Pseudomonas aeruginosa antigens
Proteins derived from Pseudomonas aeruginosa are antigenic and are of use in the treatment, prophylaxis and diagnosis of P. aeruginosa infection.
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7517950 |
Tumor antigen based on products of the tumor suppressor gene WT1
A tumor antigen that comprises, as an active ingredient, a product of the Wilms' tumor suppressor gene WT1 or a peptide composed of 7-30 contiguous amino acids containing an anchor amino acid for...
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7517528 |
Method and composition for treating skin wounds with epidermal growth factor
Epidermal growth factor (EGF) produced by an excretory recombinant approach was tested for its efficacy in treating various skin wounds. In a randomized double blind controlled study, local cream...
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7517530 |
Methods for treatment of insulin-like growth factor-1 (IGF-1) deficiency comprising administration of IGF-1 and growth hormone
The present invention provides methods and compositions for increasing the growth rates, alleviating the symptoms, or improving the metabolism of human patients having insulin-like growth factor-1...
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7517856 |
Bioconjugates comprising sulfated polysaccharides and their uses
The present invention provides bioconjugates comprising a sulfated polysaccharide such as alginate sulfate and hyaluronan sulfate and at least one bioactive polypeptide capable of binding a sulfate...
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7517849 |
Inhibition of ABC transporters by transmembrane domain analogs
ATP-binding cassette (ABC) transporters generally contain a number of transmembrane helices. The present invention provides synthetic peptides derived from these transmembrane helices. The peptides...
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7517870 |
Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization
The present invention concerns the use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular...
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7517955 |
Streptococcus uberis adhesion molecule
A polypeptide, designated as “ Streptococcus uberis Adhesion Molecule” (SUAM), and fragments of SUAM, prevent internalization and adherence of Streptococcus uberis and other streptococcal...
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7517958 |
Interleukin-17 receptor homologue
Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor14.”
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7517948 |
Hsp70 peptide stimulating natural killer (NK) cell activity and uses thereof
The present invention relates to an immunostimulatory peptide derived from an Hsp70 protein and peptides comprising said immunostimulatory peptide. Furthermore the present invention pertains to...
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7514401 |
Methods of use of fibroblast growth factor, vascular endothelial growth factor and related proteins in the treatment of acute and chronic heart disease
Disclosed herein is a rational, multi-tier approach to the administration of growth factor proteins in the treatment of heart disease. Also disclosed is a method to evaluate the effectiveness of...
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7514077 |
Methods of antagonizing signal transduction in dorsal root ganglion cells with IL-31 antagonists
Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include...
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7514398 |
Growth factor complex
An isolated protein complex is provided which includes a growth factor, growth factor binding protein and vitronectin. Preferably, the isolated protein complex includes an insulin-like growth...
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7514082 |
Anti-viral VSF protein and hybridoma producing the same
Disclosed are a novel virus suppressing factor (VSF) protein having antiviral activity against a variety of viruses and a hybridoma secreting such a VSF protein. In addition, the present invention...
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7514101 |
Artificial bait based on a peptide attractant found in horseshoe crab eggs
The present invention relates to a novel attractant for fish and mollusks isolated from the eggs of the horseshoe crab, Limulus polyphemus . The invention also relates to a method for attractant...
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7514400 |
Synthetic mimics of mammalian cell surface receptors: method and compositions
The present invention relates to new synthetic receptors. More particularly, the present invention relates to the use of the synthetic receptors for delivering a protein, peptide, drug, prodrug,...
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7514072 |
Method for the treatment of cerebral ischaemia and use of erythropoietin or erythropoietin derivatives for the treatment of cerebral ischaemia
The present invention relates to a method for the treatment of cerebral ischaemia and a drug for the treatment of cerebral ischaemia in particular in humans, as occurs for example in the case of...
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7514403 |
Process for the stabilization of proteins in an aqueous solution comprising cysteine in a concentration between 150 and 220mM
The present invention relates to a process for the storage of proteins in an aqueous solution. The addition of cysteine delays the temporal decrease in the effective concentration of the protein....
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7514397 |
Methods for inhibition of membrane-fusion-associated events, including Hepatitis B virus transmission
The present invention relates to peptides which exhibit potent anti-viral activity. In particular, the invention relates to methods of using such peptides as inhibitory of hepatitis B virus...
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7514399 |
Bonding tissues and cross-linking proteins with naphthalimide compounds
Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide...
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7514076 |
Antitumor agents
An antitumor agent, which is a combination of an oxidoreductase, such as xanthine oxidase chemically conjugated to a polymer such as poly ethylene glycol, for initial administration and...
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7514092 |
Compositions and methods of their use for improving the condition and appearance of skin
The present invention relates to compositions and methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating,...
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7510840 |
Method of inhibiting growth or survival of a cell by providing an anti-108P5H8 antibody
A novel gene (designated 108P5H8) and its encoded protein, and variants thereof, are described wherein 108P5H8 exhibits tissue specific expression in normal adult tissue, and is aberrantly...
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7510720 |
Vaccine to control equine protozoal myeloencephalitis in horses
The present invention provides vaccines and methods for making the vaccines that actively or passively protect an equid or other animal against Sarcocystis neurona. In particular, the present...
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7511012 |
Myostatin binding agents
The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one...
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7511118 |
PSMA peptide analogues
Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at...
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7511124 |
Compositions comprising phosphatidylethanolamine-binding peptides linked to anti-viral agents
Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for...
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7511011 |
Synthetic lipid mixtures for the preparation of a reconstituted surfactant
The invention relates to reconstituted surfactants consisting of artificial phospholipids and peptides able to lower the air-liquid surface tension, more particularly to reconstituted surfactants,...
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7511095 |
Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith
The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs...
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7511119 |
PRAME peptide analogues
Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at...
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7511017 |
Methods of treatment with TNFR5
The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic...
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7511019 |
Method of treating coronary artery disease by administering FGF-4
The present invention has multiple aspects. In particular, in one aspect, the present invention is directed to a unit dose comprising 0.2 μg/kg to 36 μg/kg of a recombinant FGF or an...
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7511010 |
Pharmaceutical or cosmetic composition and use of a PKC inhibitor with an MMP inhibitor for inhibiting Langerhans' cell migration
The invention concerns a pharmaceutical or cosmetic composition, characterised in that it comprises at least a compound for inhibiting Langerhans' cell migration, said active compound being...
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7511009 |
Retinal pigmented epithelium derived neurotrophic factor
The present invention relates to a purified retinal pigmented epithelium derived neurotrophic factor composition and a method for purifying such a retinal pigmented epithelium neurotrophic factor....
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7507716 |
Method for treating pain with prolactin antagonists
The embodiments disclosed herein provide methods for inhibiting, reducing and/or treating pain in a subject by administering to a subject in need thereof a pharmaceutical formulation that includes...
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7507709 |
Synergistic effects of OP/BMP morphogens and GDNF/NGF neurotrophic factors
OP/BMP morphogen may be combined with GDNF/NGF neurotrophic factors to promote the survival or growth, or inhibit the death or degeneration, of mammalian cells, particularly neural cells, which...
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7507705 |
Methods for the modulation of neovascularization and/or the growth of collateral arteries and/or other arteries from preexisting arteriolar connections
Described is the modulation of the neovascularization and/or growth of collateral arteries and/or other arteries from preexisting arteriolar connections. Methods are provided for enhancing...
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7507419 |
Topically applied Clostridium botulinum toxin compositions and treatment methods
Hyperactive glandular conditions are treated using topically formulated botulinum toxin compositions. In the preferred embodiment of the invention, topical botulinum preparations are applied...
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7507794 |
Isolated soluble corticotropin releasing factor receptor type 2 (sCRFR2)
The present invention is directed to compositions and methods related to soluble G-protein coupled receptors (sGPCR). In ceratin aspects the invention includes compositions and methods related to a...
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7507707 |
Methods of inducing ovulation using a non-polypeptide camp level modulator
The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to female...
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7507710 |
Anti-amyloid immunogenic compositions, methods and uses
The present invention provides a recombinant immunogenic obtained by tandem multimerization of a B-cell epitope bearing fragment of Aβ42, within the active loop site of a carrier (display site),...
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7507745 |
Pharmaceutical compositions based on fluorenecarboxylic acid esters and soluble TNF receptor fusion proteins
The present invention relates to novel pharmaceutical compositions based on fluorene carboxylic acid ester derived anticholinergics of formula 1
and soluble TNF receptor fusion proteins,...
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7507790 |
Fiber-shaping peptides capable of interacting with self-assembling peptides
The present invention relates to a fiber-shaping peptides that are capable of interacting with self-assembling peptides to form protein structures. The present invention also relates to methods of...
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7507708 |
Antitumoral compounds
The present invention is directed to new kahalalide antitumoral compounds, in particular to analogues of kahalalide F, useful as antitumoral, antiviral, antifungal agents and in the treatment of...
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7507706 |
Cytokine receptor chain
Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods...
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7504375 |
Antimicrobial polypeptides
The present invention relates to polypeptides having antimicrobial activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to...
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7504379 |
Protection of cardiac myocardium
The invention provides compositions and methods for protecting vascular tissues from injury that occurs, for example, during occlusion of one or more arteries. In some embodiments, the injury is...
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7504374 |
Method for inducing deposition and maturation of bone comprising a co-therapeutic regimen of LMP-1 and BMP-2
The present invention relates to the methods and compositions for the treatment of subjects having compromised bone conditions. Specifically, the invention relates to combinatorial therapeutic...
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