|
Match
|
Document |
Document Title |
|
|
7557182 |
Molecules for transporting a compound across the blood-brain barrier
The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptide derived from aprotinin and from aprotinin analogs as well as conjugates...
|
|
|
7557078 |
Morphogen-induced nerve regeneration and repair
Disclosed are therapeutic treatment methods, compositions and devices for maintaining neural pathways in a mammal, including enhancing survival of neurons at risk of dying, inducing cellular repair...
|
|
|
7553494 |
WT1 fusion proteins
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an...
|
|
|
7553929 |
Cell permeable peptides for inhibition of inflammatory reactions and methods of use
The present invention relates to the delivery of biologically active molecules, such as peptides, into the interior of cells by administering to the cells a complex comprising the molecule linked...
|
|
|
7553811 |
Methods and compositions for modulating immunity
Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of a CD200 protein or a nucleic acid encoding a CD200 protein. The...
|
|
|
7553810 |
Lung volume reduction using glue composition
The present invention relates to methods and compositions for sealing localized regions of damaged lung tissue to reduce overall lung volume. The glue compositions provide a glue featuring an...
|
|
|
7553940 |
Long-acting EPO polypeptides and derivatives thereof and methods thereof
A polypeptide and polynucleotides encoding same comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to an EPO peptide are disclosed. Pharmaceutical...
|
|
|
RE40812 |
Nasal calcitonin formulation
A liquid pharmaceutical composition is disclosed comprising calcitonin or an acid addition salt thereof and citric acid or salt thereof in a concentration from about to about 50 mM, said...
|
|
|
7553819 |
Multivalent inhibitors of serum amyloid P component
Novel glycerol cyclic pyruvate derivates were prepared and demonstrated to inhibit the binding of an immobilized D-proline derivative to serum amyloid P component (SAP) have been prepared. As such,...
|
|
|
7553809 |
Fc receptor modulators and uses thereof
This invention relates to a method of inhibiting Fc receptor binding of immunoglobulin including the use of a Fc receptor modulating compound which binds to defined surfaces on a Fc receptor. The...
|
|
|
7553872 |
Compounds and compositions for delivering active agents
Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
|
|
|
7553941 |
Long-acting polypeptides and methods of producing same
A polypeptide and polynucleotides encoding same comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a peptide-of-interest are disclosed. Pharmaceutical...
|
|
|
7553812 |
Acyclovir-peptide analogs
Dipeptide and tripeptide ester derivatives of acyclovir and its analogs are disclosed which are useful to treat herpes virus infections. Also disclosed is a method for preparing a therapeutic agent...
|
|
|
7550427 |
Poly-pegylated protease inhibitors
Disclosed are compounds that comprise: (i) a Kunitz domain polypeptide that comprises a Kunitz domain that binds to and inhibits a protease; and (ii) a plurality of polyethylene glycol moieties...
|
|
|
7550558 |
Antimicrobial peptides and methods for identifying and using such peptides
This invention relates to a method for identifying peptides having antimicrobial activity and to the antimicrobial peptides identified thereby and methods for their use.
|
|
|
7550441 |
Controlled release polymer nanoparticle containing bound nucleic acid ligand for targeting
The present invention relates to a conjugate that includes a nucleic acid ligand bound to a controlled release polymer system, a pharmaceutical composition that contains the conjugate, and methods...
|
|
|
7550425 |
Diuretic peptide conjugates
Disclosed are a variety of peptide conjugates represented by the following general formula:
R 1 -Z-X-Z′-R 2
|
|
|
7550424 |
CA IX-specific inhibitors
Therapeutic methods for inhibiting the growth of preneoplastic/neoplastic vertebrate cells that abnormally express MN protein are disclosed. Screening assays are provided for identifying compounds,...
|
|
|
7550154 |
Methods of treatment with drug loaded polymeric materials
Polymeric microparticles have been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and can have targeting ligands directly bound to...
|
|
|
7550568 |
Monoclonal antibodies to human high molecular weight-melanoma associated antigen
The present invention provides monoclonal antibodies that react against high molecular weight melanoma-associated antigen. These antibodies may be used for diagnostic and/or therapeutic purposes.
|
|
|
7550426 |
Acetylated therapeutic procytotoxins
A class of procytotoxic agents is characterized by a capability to kill with target cell-specificity. Such an aspect can be a pore-forming protein which has at least one lysine residue, modified by...
|
|
|
7550566 |
G-CSF conjugates
Polypeptide conjugates with G-CSF activity comprising a polypeptide having at least one introduced lysine residue and at least one removed lysine residue compared to the sequence of human G-CSF,...
|
|
|
7547761 |
Low molecular weight extraction process
A process for isolating low molecular weight (“LMW”) peptides from tissue in situ comprising the steps: a) homogenizing the tissue; b) mixing the homogenized tissue with an organic solvent to...
|
|
|
7547675 |
Chemically modified polypeptides
The present invention relates to a chemically modified polypeptide in which at least one of hydroxyl groups in the polypeptide molecule is modified with a polyalkylene glycol derivative; a method...
|
|
|
7547436 |
Receptor specific transepithelial transport of therapeutics
The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke...
|
|
|
7547674 |
Methods and compositions for the repair and/or regeneration of damaged myocardium
Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration cytokines are disclosed and claimed.
|
|
|
7547441 |
PAI-2 conjugates for the treatment and imaging of cancer
A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises...
|
|
|
7544774 |
Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/IX
The present invention is directed to an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human platelet...
|
|
|
7544773 |
Antimicrobials against pathogenic bacteria and method for screening them
The present invention provides antimicrobials for efficient therapy of infections caused by bacterial pathogens. The antimicrobials include peptides corresponding to the active site of N-terminal...
|
|
|
7544666 |
NAP derivatives
An oligopeptide comprises formulae (I) or (II)
the oligopeptide derivative thereof, and a pharmaceutical composition comprising the same are provided.
|
|
|
7544768 |
Peptides for inducing apoptosis in tumor cells
The present invention relates to peptides which interact with IAPs. IAPs are highly expressed in tumor cells which fail to undergo apoptosis. By binding to IAPs, the peptides of the present...
|
|
|
7544664 |
Sequences facilitating penetration of a substance of interest
The present invention relates to an amino acid sequence being able to facilitate penetration of a substance of interest inside cells and/or cell nuclei and having the following formula (I) [(X 1 )...
|
|
|
7544655 |
Haptotactic peptides
Novel cell attachment peptides having sequences homologous to specific portions of the carboxy terminal sequence of fibrinogen chains are disclosed. The novel peptides, derived from proteins...
|
|
|
7544654 |
ψεRACK peptide composition and method for protection against tissue damage due to ischemia
A method of reducing damage to cells and tissue caused by an ischemic or hypoxic event is disclosed. The method includes administering to the cell or tissue, either in vivo or ex vivo, ψεRACK...
|
|
|
7544657 |
Stabilized Exendin-4 compounds
The present invention disclosed compositions comprising a stabilized Exendin-4 (1-39) and related compounds. The invention describes stabilized Exendin-4 agonists that include at least one modified...
|
|
|
7544375 |
Composition
A topically applied composition or cream for treatment of the skin. A preferred composition includes a) a skin plumper; b) a tetrapeptide; c) a soya plant extract; d) Centella Asiatica extract; e)...
|
|
|
7544653 |
Additive cytoprotective effects of two bioactive regions of pro-opiomelanocortin hormone
Repetitive and bioreactive regions of pro-opiliomelanocortin were identified using computational analysis. These regions KOMET, KOMET-1, KOMET-2, and KOMET-3 exhibit cytoprotective effects and may...
|
|
|
7541328 |
Coupling proteins to a modified polysaccharide
The invention relates to a method for coupling proteins to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the protein is based on a...
|
|
|
7541333 |
Angiogenically effective unit dose of FGF-2 and method of use
The present invention has multiple aspects. In particular, in one aspect, the present invention is directed to a unit dose composition comprising 0.2 μg/kg to 48 μg/kg of an FGF-2 of SEQ ID NO:...
|
|
|
7541028 |
Nanoparticles for monoclonal antibody delivery
The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent of monoclonal antibody. The nanoparticles are characterized with a positive...
|
|
|
7541330 |
Conjugates with reduced adverse systemic effects
A conjugate of an active agent and a targeting moiety having affinity for a target cell, in which the active agent has been modified by attachment of a cell membrane-impermeabilizing group so that,...
|
|
|
7541336 |
Substance fki-1033 and process for producing the same
The present invention is comprised of culturing microorganism having ability to produce FKI-1033 substance represented by the formula:
in a medium, accumulating FKI-1033 substance in the...
|
|
|
7541157 |
Method of screening groups of radioactive molecules and applications thereof
The invention relates to an amplification-free method of screening groups of radioactive molecules, comprising at least the following steps: (1) the group of molecules is administered to at least...
|
|
|
7541334 |
Hybrid peptides modulate the immune response
The present invention provides an MHC class II antigen presentation enhancing hybrid polypeptide. The hybrid has an N-terminus comprising the mammalian Ii key peptide LRMKLPKPPKPVSKMR (SEQ ID NO:...
|
|
|
7541340 |
Methods for reducing CD36 expression
The invention provides a method of reducing CD36 expression in a cell. The method comprises contacting the cell with an effective amount of an aromatic-cationic peptide having at least one net...
|
|
|
7541044 |
Administration of 5T4 antigen and immune response of cells expressing 5T4 and CEA antigens
The invention provides the use of an enzyme and a prodrug in the manufacture of a medicament for use in inducing an anti-tumor immune response in a human patient.
|
|
|
7541331 |
Surfactant treatment regimen
Regimens for the therapeutic or prophylactic administration of pulmonary surfactant to infants exhibiting or at risk of developing bronchopulmonary dysplasia are disclosed.
|
|
|
7541338 |
Glial mitogenic factors, their preparation and use
Disclosed is the characterization and purification of DNA encoding a numerous polypeptides useful for the stimulation of glial cell (particularly, Schwann cell) mitogenesis and treating glial cell...
|
|
|
7541329 |
Oil body associated protein compositions and methods of use thereof for reducing the risk of cardiovascular disease
Compositions and methods for reducing hypercholesterolemia and, accordingly, the risk of cardiovascular disease, are provided. Such compositions may comprise isolated oil body associated proteins....
|
|
|
7538187 |
Coloring compositions with peptide-based dispersants and binders
Coloring compositions comprising peptide-based dispersants and/or binders are provided. The compositions are particularly useful for the coloring or dyeing of substrates such as paper and textile...
|