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7534781 |
Crystalline amoxicillin trihydrate powder
The invention relates to crystalline amoxicillin trihydrate powder having a bulk density higher than 0.45 g/ml. The invention also relates to a process for preparing crystalline amoxicillin...
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7250176 |
Method of treating a bacterial infection
Bacterial infections may be treated using a high dosage regimen of amoxicillin and potassium clavulanate. Preferably, the dosage is provided by a bilayer tablet.
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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6627625 |
Treatment of behavioral disorders with β-lactam compounds
Administration of β-lactam compounds including β-lactam antibiotics and β-lactamase inhibitors provides significant neurotropic effects in warm-blooded vertebrates evidenced inter alia by...
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6613807 |
Therapeutic polyanhydride compounds for drug delivery
Polyanhydrides which link low molecular weight drugs containing a carboxylic acid group and an amine, thiol, alcohol or phenol group within their structure into polymeric drug delivery systems are...
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6511972 |
Pharmaceutical suspension formulation comprising amoxycillin clavulanic acid and cellulose
A liquid aqueous pharmaceutical suspension formulation containing as amoxycillin trihydrate, potassium clavulanate and microcrystalline cellulose filler is provided.
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6495539 |
B-lactam-like chaperone inhibitors
Compounds of the formula and the salts, esters and amides thereof wherein Z is S, SO, SO 2 or O; each of R 1 , R 2 and R 3 is independently H or substituted or unsubstituted alkyl (1-10C),...
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6489317 |
Method for eradication of Helicobacter pylori
The invention provides methods for the treatment and/or prevention of recurrence of a gastrointestinal disorder associated with Helicobacter pylori in a patient requiring said treatment and/or...
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6486214 |
Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
Polyanhydrides which link low molecular weight drugs containing a carboxylic acid group and an amine, thiol, alcohol or phenol group within their structure into polymeric drug delivery systems are...
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6436398 |
2 β-substituted-6-alkylidene penicillanic acid derivatives as β-lactamase inhibitors
Compound of formula I: wherein R 1 , R 2 , R 3 , R 4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting...
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6380181 |
Synthetic catechol derivatives, method for production and use thereof
Catechol derivatives of general formula (I) in which R 1 denotes O-acyl and R 2 represents amino acid residues in the 3- and/or 4-position function as siderophores and/or as biological...
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6316015 |
Hyperbactericidal surfaces
A surface is provided with antibiotic or antiseptic properties. A solid substrate is modified by covalently fixing one or more spacers having reactive extremities via a proximate reactive...
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6294526 |
Use of flavone derivatives for induction of β-lactam-sensitivity of MRSA
A novel screening system for detecting a non-antibiotic compound having β-lactam-sensitivity-inducing activity comprising a non-antibiotic compound and a β-lactam antibiotic two times serially...
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6232305 |
Substituted amino bicyclic-β-lactam penam and cepham derivatives as cysteine protease inhibitors
The present invention provides substituted amino bicyclic-β-lactam penam derivatives and substituted amino bicyclic-β-lactam cepham derivatives and their diastereoisomers of formula I, as well as...
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6177421 |
Amoxicillin and clavulanate composition
A storage-stable combination of at least one β-lactam antibiotic and at least one β-lactam inhibitor compressed into tablet form having a hardness of greater than 30 KP is disclosed.
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6156745 |
2β-substituted-6-alkylidene penicillanic acid derivatives as β-lactamase inhibitors
Compounds of formula I: ##STR1## wherein R 1 , R 2 , R 3 , R 4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting...
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6127355 |
High molecular weight polymer-based prodrugs
The present invention is directed compositions of the formula: ##STR1## wherein: D is a residue of a biologically active moiety; X is an electron withdrawing group; Y and Y' are independently...
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6066629 |
Storage stable amoxycillin and clavulanate suspension composition
A dry powder formulation of antibiotic and β-lactam inhibitor is provided which is suitable for use in a liquid suspension.
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6048852 |
β-thiopropionyl-aminoacid derivatives and their use as β-lactamase inhibitors
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6013647 |
Benzoxazinedione derivatives, method of producing them and uses thereof
This invention relates to new benzoxazinedione derivatives corresponding to the formula I: ##STR1## wherein R 1 =H or carboxyalkyl, R 2 =H, alkyl or phenyl, and R 3 represents different acid...
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5994340 |
Azetidinone derivatives as β-lactamase inhibitors
New 2-oxo-1-azetidine sulfonic acid derivatives with an aminoalkyl substituted "anti" (E-isomer) oxyimino group in the acylamino substituent at the 3 position of the monobactam ring. These...
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5900413 |
Treatment of H. pylori infections
An infection with Helicobacter may successfully be treated with a compound of the formula ##STR1## wherein R 1 is hydrogen or methyl and R 2 is hydrogen or L-alanine-L-alanyl, and the...
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5883074 |
Potentiators of antibacterial agents
Methods for screening for compounds which potentiate the activity of antibacterial agents against bacteria resistant to the antibacterial agent alone, pharmaceutical compositions including such...
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5849797 |
D-β-lysylmethanediamine derivatives and preparation thereof
Now are provided (R)-3,6-diamino-N-(ω-aminoalkyl)-hexanamides which are novel compounds having the general formula (I): ##STR1## wherein n stands for 2-5, and which may be for example,...
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5801153 |
Method of enhancing the antimicrobial properties of antibacterial antibiotics to massively control and prevent bacterial, fungal, and viral diseases in plants
A method for controlling plant diseases utilizes a mixture of antibiotics and food additives or food preservatives. The mixture is sprayed on the plants twice per week for three weeks, then once...
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5747483 |
Penem derivatives, their preparation and pharmaceutical compositions containing them
Penem derivatives of general formula (I), below, and pharmaceutically acceptable salts thereof are disclosed. ##STR1## wherein: R 1 is H, C 1 -C 6 alkoxy, C 3 -C 7 cycloalkyl, or an optionally...
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5681563 |
7-vinylidene cephalosporins and methods of using the same
Cephalosporins with an exocyclic allene in the 7-position and their pharmaceutically active salts are potent inhibitors of β-lactamases and are therefore useful in the treatment of penicillin...
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5668130 |
Medicament for treating gastrointestinal disorders
The use is described of both (i) ranitidine bismuth citrate and (ii) one or more Helicobacter pylori-inhibiting antibiotics in treating or preventing gastrointestinal disorders. Pharmaceutical...
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5474993 |
Lactam inhibitors of cholesterol esterase
The present invention is related to compounds which inhibit pancreatic cholesterol esterase. The compounds have the formula: ##STR1## wherein R 1 is H or C 1 -6 alkyl; R 2 is H or C 1 -6...
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5122377 |
Oral delivery system for veterinary drugs
A veterinary drug delivery system suitable for oral administration to animals comprising a suitable medication, a nonvolatile oil, silicone dioxide, capric/caprylic triglyceride and/or...
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5069899 |
Anti-thrombogenic, anti-microbial compositions containing heparin
Anti-thrombobenic, anti-microbial compositions containing heparin reacted with quaternary ammonium components and bound with water-insoluble polymers are disclosed. Such compositions may also...
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4997830 |
Pharmaceutical composition for the treatment of periodontitis
A pharmaceutical combination of Metronidazole and Amoxicillin for the treatment of periodontitis. Conventional therapeutic doses of both the Metronidazole and Amoxicillin given as a combination...
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4988679 |
Liquid sustained release composition
There is provided an orally ingestible liquid composition for suspending therein an orally administrable pharmaceutically active composition releasable over an extended period of time comprises...
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4966899 |
Antibacterial lyophilized preparation of aspoxicillin
An antibacterial lyophilized preparation which comprises as an active ingredient aspoxicillin and a basic salt of aspoxicillin in a molar ratio of 1 : about 0.7 to 7 and optionally an alkali metal...
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4919932 |
Pharmaceutical formulation for the treatment of bacterial infections
A pharmaceutical formulation having a synergistic anti-bacterial activity and comprising (a) a cephalosporin derivative or a physiologically acceptable salt or ester thereof and (b) a penem...
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4898731 |
Antibiotic combinations of penicillins
An antibacterial synergistic composition consisting essentially of a mixture of a penicillin or cephalosporin derivative of the formula ##STR1## and a penicillin of the formula ##STR2## preferably...
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4898728 |
Process for production of composition containing lecithin and polyvinylpyrrolidone
A process for the production of a sterile composition containing lecithin and polyvinyl pyrrolidone is disclosed in which the lecithin and polyvinyl pyrrolidone, optionally with one or more...
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4876086 |
Injectable compositions of amoxycillin trihydrate
Injectable pharmaceutical compositions are provided which comprise fine particles of amoxycillin trihydrate coated with a dispersing agent, the ratio of amoxycillin trihydrate to dispersing agent...
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4863915 |
β-lactam antibiotics
Crystalline anhydrous amoxycillin is prepared by removing bound solvent molecules from a crystalline solvate (other than the trihydrate) of amoxycillin. A preferred crystalline solvate is the...
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4861768 |
2 β-substituted thiomethylpenicillin derivatives and their preparation and use
Disclosed is a penicillin derivative of the formula: ##STR1## wherein n is an integer of 0, 1 or 2; Y is a cyano group, a lower acyl group, a mono- or di-lower alkylthiocarbamoyl group, ##STR2##...
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4803196 |
Pharmaceutical compositions containing β-lactam antibiotics
A solid pharmaceutical composition comprising one or more β-lactam antibiotics in acid or amphoteric form in association with at least one physiologically acceptable base in the presence of a...
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4742052 |
Antibacterial β-lactam compounds
Novel β-lactam compounds classified into penem compounds, a process for preparing the same and use of such β-lactam compounds are disclosed. These β-lactam compounds exhibit excellent...
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4692441 |
Chorine esters as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal cavities
Choline esters are used as drug absorption enhancing agents for drugs which are poorly absorbed from the nasal, oral, and vaginal cavities.
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4607029 |
Novel sodium amoxicillin preparations
Novel sodium amoxicillin preparations which are easily converted into stable, suitably injectable solutions which are free of allergic reactions-causing chemicals and which contain besides sodium...
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4591459 |
Intermediates for 6-(aminoacyloxymethyl) penicillanic acid 1,1-dioxides
beta-Lactamase inhibitors which are aminoacid esters of 6-alpha- and 6-beta-(hydroxymethyl)pencillanic acid 1,1-dioxides; pharmaceutically-acceptable salts thereof; conventional esters thereof...
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4560553 |
Use of eucalyptol for enhancing skin permeation of bio-affecting agents
Eucalyptol is used to enhance skin permeation of bio-affecting agents.
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4540689 |
Penicillin derivative
A penicillin derivative having an antibacterial activity similar to a penicillin antibiotic in a living body without affecting the intestinal bacterial colonies, a process for preparing the...
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4540688 |
β-Lactam antibiotics
Compounds of formula (I) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof have antibacterial activity: ##STR1## wherein R is hydrogen, C 1 -6 alkylcarbonyl or C 1 -6...
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4537887 |
Pharmaceutical formulation
A unit dose pharmaceutical composition suitable for oral administration which composition comprises a pharmaceutically acceptable carrier, a desiccant, amoxycillin trihydrate equivalent to 20 mg to...
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4521533 |
Salts of 6-alpha-(aminomethyl)penicillanic acid 1,1-dioxide esters and beta-lactam antibiotics
Salts of readily hydrolyzable esters of 6-alpha-(aminomethyl)penicillanic acid 1,1-dioxide and (a) prodrug forms of ampicillin and amoxicillin or (b) ampicillin and amoxicillin and a dibasic acid...
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