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7595310 |
Glucuronate salt of a piperazine compound
The present invention provides a salt form, and compositions thereof, useful as a modulator of one or more GPCRs and which exhibits desirable characteristics for the same. The present invention...
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7498312 |
Compositions containing piperacillin and tazobactam useful for injection
An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in piperacillin/tazobactam parenteral combinations. The...
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7307062 |
Method for treating a mental disorder
A method of treating an individual exhibiting at least one symptom of a mental disorder is provided which comprises administering to the individual an antimicrobial composition in an amount...
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7241741 |
Methods and compositions for the treatment of asthma and related disorders
The present invention provides methods for the treatment of respiratory tract mucositis in individuals in need of such treatment, the method comprising the systemic administration to the individual...
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7101572 |
Taste masked aqueous liquid pharmaceutical composition
A substantially taste masked liquid pharmaceutical composition containing a pharmaceutically effective amount of an unpleasant tasting drug dissolved or dispersed in an aqueous excipient base, said...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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7094397 |
Methods and reagents for the treatment of multiple sclerosis
The invention features methods and reagents for the diagnosis, monitoring, and treatment of multiple sclerosis. The invention is based in part on the discovery that Chlamydia is present in...
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7067500 |
Betaines as adjuvants to susceptibility testing and antimicrobial therapy
The present invention is directed to methods of antimicrobial therapy for a patient infected with, or suspected of being infected with a microorganism that has mycolic acid structures in its outer...
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6949519 |
Macrolide solvates
Azithromycin in the form of a monohydrate comprising from 4.0% to 6.5% of water, a process for its preparation and its use in pharmaceutical compositions.
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6900184 |
Compositions containing pipercillin and tazobactam useful for injection
The invention pertains to pharmaceutical compositions of Zosyn® piperacillin with tazobactam in the presence of a buffer, preferably citrate, a particulate formation inhibitor, preferably EDTA...
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6890526 |
Methods and reagents for the treatment of multiple sclerosis
The invention features methods and reagents for the diagnosis, monitoring, and treatment of multiple sclerosis. The invention is based in part on the discovery that Chlamydia is present in...
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6884784 |
Diagnosis and management of infection caused by chlamydia
The present invention provides a unique approach for the diagnosis and management of infections by Chlamydia species, particularly C. pneumoniae . The invention is based, in part, upon the...
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6806256 |
Taste masked liquid pharmaceutical compositions
This invention is directed to a taste masked liquid pharmaceutical composition comprising a pharmaceutically active agent and a taste masking composition. In particular, the taste masking...
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6743440 |
Polycyclic quinone and ionophore composition for the synergistic reduction of methane formation in ruminant animals
A composition, preferably used to reduce methane formation in a ruminant, wherein the composition is a combination of a polycyclic quinone compound and an ionophore compound.
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6706290 |
Methods for eradication of nanobacteria
Nanobacteria contribute to pathological calcification in the human and animal body, including diseases such as kidney stones, salivary gland stones, dental pulp stones and atherosclerosis. The...
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6689756 |
Treatment of neurological disease
Provided is, among other things, a method of treating in an animal infection or neoplasm of cerebrospinal tissue characterized by a risk of death, the method comprising: (a) injecting a...
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6630135 |
Use of sustained release antibiotic compositions in ophthalmic surgical procedures
An improved method of sterilizing the field of surgery prior to an ophthalmic surgical procedure is described. The invention eliminates the need for painful and potentially traumatic injections of...
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6627625 |
Treatment of behavioral disorders with β-lactam compounds
Administration of β-lactam compounds including β-lactam antibiotics and β-lactamase inhibitors provides significant neurotropic effects in warm-blooded vertebrates evidenced inter alia by...
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6610652 |
Microdose therapy
Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve...
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6576625 |
Targeted vesicular constructs for cytoprotection and treatment of H. pylori infections
A composition for targeted vesicular for treatment of H - Pylori infections and for protection of the cell. The composition contains lectins, phospholipids, sterols, and one or more drugs. The...
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6565882 |
Antibiotic composition with inhibitor
Antibiotic composition having four dosage forms with different release profiles providing for initial release of a beta lactam antibiotic followed by release of a beta-lactamase inhibitor, followed...
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6544991 |
Compositions and methods for treating bacterial infections
A composition having antibacterial activity is disclosed. More particularly, a mixture of an oxazolidinone compound, sulbactam, and ampicillin active agents, demonstrating activity against...
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6518252 |
Method of treating aquatic animals with an antimicrobial agent and chelating agent
The present invention relates to novel method of reducing microbial infections, especially bacterial infections, of animals, especially of aquatic animals such as fish maintained in tanks or...
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6512004 |
Promoters of neural regeneration
The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent...
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6495539 |
B-lactam-like chaperone inhibitors
Compounds of the formula and the salts, esters and amides thereof wherein Z is S, SO, SO 2 or O; each of R 1 , R 2 and R 3 is independently H or substituted or unsubstituted alkyl (1-10C),...
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6489317 |
Method for eradication of Helicobacter pylori
The invention provides methods for the treatment and/or prevention of recurrence of a gastrointestinal disorder associated with Helicobacter pylori in a patient requiring said treatment and/or...
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6475522 |
Synthetic polymer compositions containing antibiotics as antidegradants
Synthetic polymer compositions contain antibiotics as antidegradants. Antibiotics from classes of glycopeptides and β-lactams have been found to prevent or inhibit synthetic polymer degradation.
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6461607 |
Probiotic, lactic acid-producing bacteria and uses thereof
The present invention discloses compositions and methodologies for the utilization of probiotic organisms in therapeutic compositions. More specifically, the present invention relates to the...
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6436398 |
2 β-substituted-6-alkylidene penicillanic acid derivatives as β-lactamase inhibitors
Compound of formula I: wherein R 1 , R 2 , R 3 , R 4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting...
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6429191 |
Treatment of hearing impairments
Compositions and methods are provided for prophylactic or therapeutic treatment of a mammal for hearing impairments involving neuronal damage, loss, or degeneration, preferably of spinal ganglion...
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6426342 |
Use of β-lactamase inhibitors as neuroprotectants
Novel neuroprotectant methods are described. β-Lactamase inhibitors are used to prevent or reduce loss of neuronal cells and neuronal cell function in patients afflicted with or susceptible to...
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6406880 |
Betaines as adjuvants to susceptibility testing and antimicrobial therapy
The present invention is related to methods and compositions for susceptibility testing of bacteria containing mycolic acid structures using betaine-like detergents, and inducing the susceptibility...
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6380181 |
Synthetic catechol derivatives, method for production and use thereof
Catechol derivatives of general formula (I) in which R 1 denotes O-acyl and R 2 represents amino acid residues in the 3- and/or 4-position function as siderophores and/or as biological...
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6365635 |
Antibacterial composition for topical administration containing antibiotic
The present invention provides a safe antibacterial composition for topical administration which stably contains a penem antibiotic having a broad-spectrum and potent antibacterial activity while...
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6333305 |
Antibiotic TKR2999, process for the preparation thereof and microbe
The antibiotic TKR2999 having the physicochemical properties described below and its pharmacologically acceptable salt: (1) FAB-MS m/z 971 [M+H)] + , (2) the molecular formula: C 44 H 78 N 10 ...
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6326387 |
Methods and compositions for stimulating neurite growth
The present invention relates to methods and pharmaceutical compositions for stimulating the growth of neurites in nerve cells. The compositions comprise a neurotrophic amount of a compound which...
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6319904 |
Formulation comprising antibacterial substance and antiulcer substance
The present invention includes a formulation which comprises an antibacterial substance and an antiulcer substance, wherein at least either of them is formulated into a gastrointestinal...
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6294526 |
Use of flavone derivatives for induction of β-lactam-sensitivity of MRSA
A novel screening system for detecting a non-antibiotic compound having β-lactam-sensitivity-inducing activity comprising a non-antibiotic compound and a β-lactam antibiotic two times serially...
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6284744 |
Peritoneal induced medicaments
A solution of hyaluronic acid and water-soluble salts thereof in a pharmaceutically acceptable media in which the hyaluronic acid concentration is at least about 0.4% by weight based on the weight...
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6277829 |
Process for preparing of aqueous formulation for opthalmic use
The present invention describes a process for the preparation of aqueous formulations containing azithromycin for ophthalmic use, as well any formulations obtained by this process and their topical...
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6271222 |
Penem antibacterial compounds, compositions and methods of treatment
The present invention relates to penem antibacterial agents in which the releaseable liphophilic aromatic side-chain, tethered to the carbapenem nucleus via a methylene linker, necessary for...
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6248718 |
Lesion-directed dry dosage forms of antibacterial agents for the treatment of acute mucosal infections of the oral cavity
The invention provides a medicament for topically treating acute bacterial infections in the oral mucosa, and methods of use. The medicament comprises a dry dosage (such as a troche or powder) of...
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6232305 |
Substituted amino bicyclic-β-lactam penam and cepham derivatives as cysteine protease inhibitors
The present invention provides substituted amino bicyclic-β-lactam penam derivatives and substituted amino bicyclic-β-lactam cepham derivatives and their diastereoisomers of formula I, as well as...
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6207661 |
Premixed formulation of piperacillin sodium and tazobactam sodium injection
The present invention provides a premixed form of a buffered piperacillin product having a near neutral pH and capable of a shelf life of at least nine months, with freezer storage (-20° C. or...
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6156745 |
2β-substituted-6-alkylidene penicillanic acid derivatives as β-lactamase inhibitors
Compounds of formula I: ##STR1## wherein R 1 , R 2 , R 3 , R 4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting...
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6153747 |
Process for the preparation of 2-halomethyl-penems and their use for the preparation of antibacterial penems
Process for the preparation of 2-halomethyl-penems (I) comprising (a) reacting an acetoxy-(protected hydroxyethyl)-2-azetidinone (III) with a 2-halothioacetic acid to form a...
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6140306 |
Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (BPI) protein product and antibiotic
The present invention relates to methods and compositions for treating gram-negative bacterial infections, using BPI protein products. Co-treatment, or concurrent administration, of BPI protein...
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6093414 |
Silver-based antimicrobial compositions
The present invention relates generally to silver-based antimicrobial compositions and processes for making such compositions. More particularly, the present invention describes stable, purified...
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6077536 |
Pharmaceutical formulation
A pharmaceutical formulation comprising an amoxycillin hydrate and an effervescent couple, for example citric acid plus sodium bicarbonate or sodium glycine carbonate, or tartaric acid or malic...
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6054431 |
Anti-gram-positive bacterial methods and materials
The present invention relates to methods of treating gram-positive bacterial infections by administration of a BPI protein product alone, or in combination with an antibiotic. BPI protein product...
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