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8815804 Methods and compositions related to targeting tumors and wounds  
Disclosed are compositions and methods useful for targeting tumors, sites of injury and blood clots. The compositions and methods are based on peptide sequences that selectively bind to and home to...
8815805 Formulations having an antagonist of α5β1 for anti-angiogenesis and cancer treatment  
The teachings provided herein generally relate to a combination therapy and are directed to pharmaceutical compositions and methods for administering a combination of an α5β1 antagonist with an α...
8809280 Therapeutic peptides  
The present invention provides a peptide, peptidomimetic or amino acid derivative having a net positive charge of at least +2 and incorporating a disubstituted β amino acid, each of the ...
8808698 Methods for inhibition of lymphangiogenesis and tumor metastasis  
The present invention is directed to compositions and methods for inhibiting the development of new lymphatic vessels, and for inhibiting tumor cell dissemination through the lymphatics. In...
8802627 Fusion protein composed of matrix metalloproteinase-2 inhibitor peptide derived from amyloid-B precursor protein and tissue inhibitor of metalloproteinase-2  
The present invention provides an agent capable of inhibiting MMP-2 specifically. Disclosed is a fusion molecule composed of a β-amyloid precursor protein molecule-derived domain having an ...
8802153 System for targeted delivery of therapeutic agents  
The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides...
8802635 Antioxidant, anti-inflammatory, anti-radiation, metal chelating compounds and uses thereof  
Potent compounds having combined antioxidant, anti-inflammatory, anti-radiation and metal chelating properties are described. Short peptides having these properties, and methods and uses of such...
8802632 Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof  
Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a...
8802631 Peptides and methods for the treatment of gliomas and other cancers  
The invention is based on the discovery that STM/Hop promotes proliferation of human glioblastoma-derived cells but not of normal astrocytes and that the proliferation requires the binding of...
8802634 CD40-L Inhibitory Peptides  
The present invention provides compositions comprising peptidyl inhibitors of CD40L-dependent signalling that are not derived from a natural binding partner of CD40L such as CD40, or from a native...
8802618 Controlled modulation of amino acid side chain length of peptide antigens  
The invention provides a method for the creation of peptide antigens comprising epitopes with at least a first modification comprising a shortened or lengthened amino acid side chain. By extension...
8796220 Vaccine for the prevention of the recurrence HER2/neu expressing cancer  
The invention features methods to induce and maintain a protective cytotoxic T-lymphocyte response to a peptide of the HER2/neu oncogene, E75, with the effect of inducing and maintaining protective...
8796426 Combination of an anti-EDb fibronectin antibody-IL-2 fusion protein, and a molecule binding to B cells, B cell progenitors and/or their cancerous counterpart  
The present invention relates to a combination of an anti-EDb fibronectin antibody-IL-2 fusion protein, and a molecule binding to B cells, B cell progenitors and/or their cancerous counterpart and...
8796219 Target-activated cell/tissue-penetrating peptide for delivery of impermeable compounds and use thereof  
The present invention relates to a target-activated cell/tissue-penetrating peptide for delivery of impermeable compounds (Target Activated Cell/tissue Translocation peptide for Impermeable...
8795627 Treatment of liver disorders by administration of RAP conjugates  
The present invention relates to the use of receptor-associate protein (RAP) and fragments and variants thereof to improve delivery of therapeutic compounds to the liver and provides methods to...
8796218 Complex and production process  
A method for preparing a biologically active complex, said method comprising a recombinant protein having the sequence of α-lactalbumin, such as human α-lactalbumin or a fragment thereof but w...
8791073 Peptide-modified polyurethane compositions and associated methods  
Peptide-modified polyurethanes comprising the reaction product of an isocyanate, a chain extender, and a peptide are provided. Also provided processes for making a peptide-modified polyurethane...
8791285 Activatable nanoprobes for intracellular drug delivery  
An activatable nanoprobe is provided having a core component and an active agent associated with the core component via a bond configured to be cleaved upon exposure to an endogenous compound.
8791076 Agonists of neurotrophin receptors and their use as medicaments  
The invention relates to compounds of Formula I: and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, and R3 are defined as set forth in the specification. The compounds are...
8791075 Methods and compositions for inhibition of BCL6 repression  
The invention is directed to a compound that binds to a BCL6 lateral groove and prevents binding of a corepressor to the lateral groove. The present invention is further directed to methods for...
8791074 Mutated anthrax toxin protective antigen proteins that specifically target cells containing high amounts of cell-surface metalloproteinases or plasminogen activator receptors  
The present invention provides methods of specifically targeting compounds to cells overexpressing matrix metalloproteinases, plasminogen activators, or plasminogen activator receptors, by...
8784811 Method of treating cancer using antibodies to a non-ligand binding region of NOTCH1  
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis,...
8785392 Method for inhibiting cancer metastasis by administration of the extracellular domain DLK1 or a DLK1-FC fusion protein  
A recombinant expression vector, comprising extracellular soluble domain genes of DLK1 and IgG antibody Fc domain genes, is constructed, and DLK1-Fc fusion protein is expressed and purified at 293E...
8784797 Methods, pharmaceutical compositions and kits for use in the treatment of adult T-cell leukemia/lymphoma  
The present invention relates to methods, pharmaceutical compositions and kits for use in the treatment of Adult T-cell leukemia/lymphoma. More particularly, the present invention relates to a...
8785371 Drug delivery of temozolomide for systemic based treatment of cancer  
The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a...
8785373 Agents capable of downregulating an MSF-A-dependent HIF-1alpha and use thereof in cancer treatment  
Methods and pharmaceutical compositions for the treatment of cancer or acute ischemia are provided. Also provided are methods of identifying agents capable of preventing the formation of or...
8785395 Adult stem cells/progenitor cells and stem cell proteins for treatment of eye injuries and diseases  
The present invention encompasses methods and compositions for treating an ocular disease, disorder or condition in a mammal. The invention includes a population of mesenchymal stromal cells that...
8778879 Homogeneous vaccine composition comprising a conjugate of EGF and P64K for the treatment of tumors  
The present invention concerns the biotechnology sector and more specifically human healthcare. In particular, the present invention describes a vaccine composition for therapeutic use thereof on...
8778350 Method of treating cancer with an HLA-A*3303-restricted WT1 peptide and pharmaceutical composition comprising the same  
Disclosed are: a peptide comprising an amino acid sequence composed of contiguous nine amino acid residues derived from a WT1 protein, wherein an amino acid residue at position 2 in the amino acid...
8779092 Metastasis-specific peptides and their diagnostic and therapeutic applications  
The present invention concerns peptide sequences that specifically recognize cells of human hepatic metastases. The invention comprises also the use of nucleic acids coding for such peptides, as...
8772445 Production and use of antitumoral cyclodepsipeptides  
A compound having the general structure R1, R2, R3 and R4 being selected from the group consisting of a hydrogen atom (H) and a C1-C20 alkyl, and R5 being a phenyl radical.
8772243 Methods for predicting the response to anti-cancer treatment with an agonist of TLR7 or an agonist of TLR8  
The present invention relates to methods for predicting the response to treatment with an agonist of TLR7, or an agonist of TLR8 or an anti-cancer agent for treating cancer, in particular non-small...
8771691 Methods for the treatment and the prognostic assessment of malignant pleural mesothelioma  
The present invention relates to methods for the treatment and the prognostic assessment of malignant pleural mesothelioma.
8772244 Tubulin inhibitors  
The present invention relates to novel tubulin binding molecules of formula (I) and their use for the treatment of cancer and other diseases.
8772238 Use of ixolaris, a tissue factor inhibitor, for the treatment of cancer  
The invention provides methods for treatment of tissue factor (TF) mediated or associated diseases or processes, such as cancer, by administering at least an active fragment of an Ixolaris...
8765687 WT1 HLA class II-binding peptides and compositions and methods comprising same  
This invention provides WT1 peptides and methods of treating, reducing the incidence of, and inducing immune responses against a WT1-expressing cancer, comprising same.
8765713 Method for determination of sensitivity to anti-cancer agent  
A marker for determining sensitivity of a patient to an anti-cancer agent, and novel cancer therapeutic means employing the marker, wherein the marker for determining sensitivity to an anti-cancer...
8765913 Human frizzled (FZD) receptor polypeptides and methods of use thereof for treating cancer and inhibiting growth of tumor cells  
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis,...
8765684 Solid materials of {[(2S,5R,8S,11S)-5-benzyl-11-(3-guanidino-propyl)-8-isopropyl-7-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid} and methods for obtaining them  
The instant invention relates to novel solid materials of...
8765682 Method for in vivo residue-specific DOPA incorporation into mussel adhesive proteins  
The present invention relates to recombinant mussel adhesive protein wherein a DOPA residue is in vivo incorporated instead of a tyrosine residue, and a method for producing the same. More...
8765909 Metastin derivatives and use thereof  
The present invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, a gonadotropic...
8765666 Adenovirus dodecahedron particles for delivery of pharmaceutical agents  
The embodiment of the invention is a virus-like particle vector, a process for the manufacture thereof, use of the virus-like particle vector and a pharmaceutical composition, which contains the...
8765683 T-140 peptide analogs having CXCR4 super-agonist activity for cancer therapy  
The present invention is directed to novel therapeutic uses of T-140 analog peptides and compositions comprising same. Specifically, the invention provides compositions and methods useful in cancer...
8759289 Method for sensitizing cancer stem cells to cancer therapy  
Disclosed herein are compositions and methods useful for the treatment of cancer, such as breast cancer. In some embodiments, the methods and compositions include human prolactin, or human...
8758822 Method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs  
The present invention relates to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, and more particularly, to a method for manufacturing uniform size...
8754034 Structure-based design of peptide inhibitors of amyloid fibrillation  
The invention provides methods for designing peptides that inhibit aggregation in target polypeptides. The candidate inhibitory peptidic compounds have an oligomeric sequence that forms...
8754042 Oligopeptide compounds and uses thereof  
The present invention relates to novel agents, pharmaceutical compositions containing them, and their use in therapy, particularly anti-microbial and anti-cancer therapy. In particular, the present...
8754035 Compositions and methods for visualizing and eliminating cancer stem cells  
The present invention relates generally to the field of cancer diagnosis and treatment, and more particularly to compositions and methods that may be useful for eliminating cancer cells with...
8753638 Compositions and methods comprising histidyl-TRNA synthetase splice variants having non-canonical biological activities  
Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
8754046 MHC class II restricted T cell epitopes from the cancer anitgen, NY ESO-1  
The present invention discloses the identification and isolation of novel MHC class II epitopes derived from the cancer antigen, NY ESO-1. The novel MHC class II epitopes from NY-EsO-1 are...