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8791073 Peptide-modified polyurethane compositions and associated methods  
Peptide-modified polyurethanes comprising the reaction product of an isocyanate, a chain extender, and a peptide are provided. Also provided processes for making a peptide-modified polyurethane...
8791285 Activatable nanoprobes for intracellular drug delivery  
An activatable nanoprobe is provided having a core component and an active agent associated with the core component via a bond configured to be cleaved upon exposure to an endogenous compound.
8791076 Agonists of neurotrophin receptors and their use as medicaments  
The invention relates to compounds of Formula I: and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, and R3 are defined as set forth in the specification. The compounds are...
8791075 Methods and compositions for inhibition of BCL6 repression  
The invention is directed to a compound that binds to a BCL6 lateral groove and prevents binding of a corepressor to the lateral groove. The present invention is further directed to methods for...
8791074 Mutated anthrax toxin protective antigen proteins that specifically target cells containing high amounts of cell-surface metalloproteinases or plasminogen activator receptors  
The present invention provides methods of specifically targeting compounds to cells overexpressing matrix metalloproteinases, plasminogen activators, or plasminogen activator receptors, by...
8784811 Method of treating cancer using antibodies to a non-ligand binding region of NOTCH1  
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis,...
8785392 Method for inhibiting cancer metastasis by administration of the extracellular domain DLK1 or a DLK1-FC fusion protein  
A recombinant expression vector, comprising extracellular soluble domain genes of DLK1 and IgG antibody Fc domain genes, is constructed, and DLK1-Fc fusion protein is expressed and purified at 293E...
8784797 Methods, pharmaceutical compositions and kits for use in the treatment of adult T-cell leukemia/lymphoma  
The present invention relates to methods, pharmaceutical compositions and kits for use in the treatment of Adult T-cell leukemia/lymphoma. More particularly, the present invention relates to a...
8785371 Drug delivery of temozolomide for systemic based treatment of cancer  
The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a...
8785373 Agents capable of downregulating an MSF-A-dependent HIF-1alpha and use thereof in cancer treatment  
Methods and pharmaceutical compositions for the treatment of cancer or acute ischemia are provided. Also provided are methods of identifying agents capable of preventing the formation of or...
8785395 Adult stem cells/progenitor cells and stem cell proteins for treatment of eye injuries and diseases  
The present invention encompasses methods and compositions for treating an ocular disease, disorder or condition in a mammal. The invention includes a population of mesenchymal stromal cells that...
8778879 Homogeneous vaccine composition comprising a conjugate of EGF and P64K for the treatment of tumors  
The present invention concerns the biotechnology sector and more specifically human healthcare. In particular, the present invention describes a vaccine composition for therapeutic use thereof on...
8778350 Method of treating cancer with an HLA-A*3303-restricted WT1 peptide and pharmaceutical composition comprising the same  
Disclosed are: a peptide comprising an amino acid sequence composed of contiguous nine amino acid residues derived from a WT1 protein, wherein an amino acid residue at position 2 in the amino acid...
8779092 Metastasis-specific peptides and their diagnostic and therapeutic applications  
The present invention concerns peptide sequences that specifically recognize cells of human hepatic metastases. The invention comprises also the use of nucleic acids coding for such peptides, as...
8772445 Production and use of antitumoral cyclodepsipeptides  
A compound having the general structure R1, R2, R3 and R4 being selected from the group consisting of a hydrogen atom (H) and a C1-C20 alkyl, and R5 being a phenyl radical.
8772243 Methods for predicting the response to anti-cancer treatment with an agonist of TLR7 or an agonist of TLR8  
The present invention relates to methods for predicting the response to treatment with an agonist of TLR7, or an agonist of TLR8 or an anti-cancer agent for treating cancer, in particular non-small...
8771691 Methods for the treatment and the prognostic assessment of malignant pleural mesothelioma  
The present invention relates to methods for the treatment and the prognostic assessment of malignant pleural mesothelioma.
8772244 Tubulin inhibitors  
The present invention relates to novel tubulin binding molecules of formula (I) and their use for the treatment of cancer and other diseases.
8772238 Use of ixolaris, a tissue factor inhibitor, for the treatment of cancer  
The invention provides methods for treatment of tissue factor (TF) mediated or associated diseases or processes, such as cancer, by administering at least an active fragment of an Ixolaris...
8765687 WT1 HLA class II-binding peptides and compositions and methods comprising same  
This invention provides WT1 peptides and methods of treating, reducing the incidence of, and inducing immune responses against a WT1-expressing cancer, comprising same.
8765713 Method for determination of sensitivity to anti-cancer agent  
A marker for determining sensitivity of a patient to an anti-cancer agent, and novel cancer therapeutic means employing the marker, wherein the marker for determining sensitivity to an anti-cancer...
8765913 Human frizzled (FZD) receptor polypeptides and methods of use thereof for treating cancer and inhibiting growth of tumor cells  
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis,...
8765684 Solid materials of {[(2S,5R,8S,11S)-5-benzyl-11-(3-guanidino-propyl)-8-isopropyl-7-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid} and methods for obtaining them  
The instant invention relates to novel solid materials of...
8765682 Method for in vivo residue-specific DOPA incorporation into mussel adhesive proteins  
The present invention relates to recombinant mussel adhesive protein wherein a DOPA residue is in vivo incorporated instead of a tyrosine residue, and a method for producing the same. More...
8765909 Metastin derivatives and use thereof  
The present invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, a gonadotropic...
8765666 Adenovirus dodecahedron particles for delivery of pharmaceutical agents  
The embodiment of the invention is a virus-like particle vector, a process for the manufacture thereof, use of the virus-like particle vector and a pharmaceutical composition, which contains the...
8765683 T-140 peptide analogs having CXCR4 super-agonist activity for cancer therapy  
The present invention is directed to novel therapeutic uses of T-140 analog peptides and compositions comprising same. Specifically, the invention provides compositions and methods useful in cancer...
8759289 Method for sensitizing cancer stem cells to cancer therapy  
Disclosed herein are compositions and methods useful for the treatment of cancer, such as breast cancer. In some embodiments, the methods and compositions include human prolactin, or human...
8758822 Method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs  
The present invention relates to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, and more particularly, to a method for manufacturing uniform size...
8759481 Peptide vaccines for cancers expressing tumor-associated antigens  
The present invention provides peptides having an amino acid sequence as set forth in SEQ ID NO: 19, 22, 30, 34, 344, 358, 41, 44, 46, 48, 78, 376, 379, 80, 100, 101, 110, 111, 387, 112, 394, 114,...
8754034 Structure-based design of peptide inhibitors of amyloid fibrillation  
The invention provides methods for designing peptides that inhibit aggregation in target polypeptides. The candidate inhibitory peptidic compounds have an oligomeric sequence that forms...
8754042 Oligopeptide compounds and uses thereof  
The present invention relates to novel agents, pharmaceutical compositions containing them, and their use in therapy, particularly anti-microbial and anti-cancer therapy. In particular, the present...
8754035 Compositions and methods for visualizing and eliminating cancer stem cells  
The present invention relates generally to the field of cancer diagnosis and treatment, and more particularly to compositions and methods that may be useful for eliminating cancer cells with...
8753638 Compositions and methods comprising histidyl-TRNA synthetase splice variants having non-canonical biological activities  
Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
8754046 MHC class II restricted T cell epitopes from the cancer anitgen, NY ESO-1  
The present invention discloses the identification and isolation of novel MHC class II epitopes derived from the cancer antigen, NY ESO-1. The novel MHC class II epitopes from NY-EsO-1 are...
8754037 Modified human tumor necrosis factor receptor-1 polypeptide or fragment thereof, and method for preparing same  
Provided is a modified human tumor necrosis factor receptor-1 polypeptide or a fragment thereof that binds to a tumor necrosis factor in vivo or ex vivo. The modified human tumor necrosis factor...
8754045 Enzymatic debridement therapy for abnormal cell proliferation  
Compositions and methods are provided to destroy internal cancerous lesions selectively by the administration of a combination of a debridement protease enzyme and a denaturant of cell structural...
8753641 Combination of intercalating organometallic complexes and tumor seeking biomolecules for DNA cleavage and radiotherapy  
The invention relates to molecules for treatment and diagnosis of tumors and malignancies, comprising a tumor seeking biomolecule, which is coupled to an intercalating moiety, which is capable of...
8754047 Peptide compositions and methods of use  
The present invention provides isolated peptides with at least two cysteine residues capable of forming one or more disulfide bonds. Pharmaceutical compositions comprising the isolated peptides of...
8748578 Mutant channelrhodopsin 2  
The invention relates to mutant channelrhodopsins having improved properties, nucleic acid constructs encoding same, expression vectors carrying the nucleic acid construct, cells comprising said...
8748175 Antibodies specifically binding to the epidermal growth factor receptor  
Provided are antibodies specifically binding to the epidermal growth factor receptor (EGFR) which are effective for the treatment of EGFR-mediated cancers.
8748388 Antitumoral compounds  
Antitumoral compounds of Formula I, and pharmaceutically acceptable salts, derivatives, tautomers, prodrugs or stereoisomers thereof useful as antitumour agents.
8748470 Methods for treating ovarian cancer by inhibiting fatty acid binding proteins  
The present invention concerns methods and compositions for the inhibition or reduction of the primary tumor and metastasis by inhibition of fatty acid binding proteins.
8748390 Immunogenic epitopes of NGEP antigen  
The invention provides a peptide comprising a human cytolytic T lymphocyte (CTL) epitope from the human tumor-associated antigen (TAA) New Gene Expressed in Prostate (NGEP), which can be used in...
8748389 Treating cancer  
The present invention provides a peptide comprising an amino acid sequence that is part of the amino acid sequence of CDK4 protein, or homologous to part of the amino acid sequence of CDK4 protein,...
8741889 Method of treating non-small cell lung cancer and colon cancer with gamma-secretase inhibitor  
The present invention provides a method for treating a patient having cancer comprising administering to the patient a therapeutically effective amount of compound (1), or a pharmaceutically...
8741306 Kidney specific tumor vaccine directed against kidney tumor antigen G-250  
This invention provides an anti-cancer immunogenic agent(s) (e.g. vaccines) that elicit an immune response specifically directed against renal cell cancers expressing a G250 antigenic marker....
8741849 Kinase inhibitors and uses thereof  
The present invention relates to kinase inhibiting compositions and uses thereof. The invention further provides isolated kinase inhibiting peptides and uses thereof for inhibiting hyperplasia, for...
8735358 Methods for treating cancer by regulation of tumor necrosis factor-alpha  
The present invention relates to compositions and methods relating to an interleukin18-inducible cytokine termed tumor necrosis factor-alpha inducing factor (TAIF) or interleukin-32 (IL-32). In...
8734775 Chemokine derived peptides that bind with chemokine receptor CXCR3 and uses for chronic wound and angiogenesis inhibition treatments  
Disclosed are peptides having activity against receptor CXCR3 are disclosed that exhibit activity in preventing the formation of new vessels and activity in mediating the dissociation of...