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8466110 |
Use of an agent that restores tissue perfusion and oxygenation
The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders...
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8466111 |
Cyclopenta{G}quinazoline derivatives for the treatment of rheumatoid arthritis or acute myeloid leukaemia
A cyclopenta[g]quinazoline derivative, containing an L-Glu-γ-D-Glu dipeptide group, of formula (I): wherein R1 is amino, C1-4 hydroxyalkyl, C1-4 fluoroalkyl or methoxy-C1-4-alkyl; R2 is hydrogen, ...
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8460661 |
Methods of using antibodies that bind the glutamate ligand binding region of Notch1
Isolated antibodies that specifically binds to an extracellular conserved ligand binding region of a human Notch receptor and inhibits growth of a tumor are described. Also described are methods of...
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8461314 |
Nucleic acid sequences for biosynthesis of non-MccJ25-related lariat peptides
A nucleic acid sequence is provided, encoding at least one of a precursor of a lariat peptide, a processing factor of a lariat peptide, and an export factor of a lariat peptide, wherein the lariat...
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8461118 |
Lytic peptides having anti-proliferative activity against prostate cancer cells
Lytic peptides, including fusion peptides of lytic peptides conjugated with luteinizing hormone-releasing hormone or modified versions thereof to target luteinizing hormone-releasing hormone...
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8460660 |
Anti-mesothelin antibodies
The present invention provides monoclonal anti-mesothelin antibodies and antibody fragments and methods for their use. The antibodies can be completely human.
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8461117 |
Chemical linkers and cleavable substrates and conjugates thereof
The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand...
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8455444 |
CDH3 peptide and medicinal agent comprising the same
The present invention provides a peptide of the following (A) or (B): (A) a peptide including an amino acid sequence of SEQ ID NO: 1 or 2;(B) a peptide including an amino acid sequence of SEQ ID NO...
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8454978 |
Immunostimulating agent
An immunostimulating agent, which can stimulate immunity effectively, is described. The immunostimulating agent contains an active ingredient including a calcium receptor activator such as...
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8454968 |
Method for inducing immunity with a peptide fragment from human CAPRIN-1
The invention relates to an immunity-inducing agent comprising, as an active ingredient, at least one polypeptide having immunity-inducing activity that is selected from among polypeptides (a),...
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8455431 |
Inhibitors of the trypsin-like site of the proteasome and methods of use thereof
The present invention is an inhibitor of the trypsin-like β2/β2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an a...
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8455625 |
Fusion protein of antibody L19 against fibronectin ED-B and interleukin 12
Conjugate for targeting therapeutic or diagnostic agent or drug to cells or tissues in a body, e.g. areas of neoplastic growth or angiogenesis. Use of conjugate for in vivo diagnosis or therapy...
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8450283 |
Composition for treating cancer and use thereof
The present invention provides a cyclic peptide containing RRXR motif. The present invention also provides a composition comprising the said cyclic peptide and a pharmaceutical acceptable carrier....
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8450278 |
MUC18 targeting peptides
Provided are MUC 18 targeting peptides which may be used, e.g., to therapeutically target B-I lymphocytes to reduce the influence of these cells on the metastatic potential of melanoma cells and/or...
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8450279 |
Cell permeable Nm23 recombinant proteins, polynucleotides encoding the same, and anti-metastatic composition comprising the same
The present invention discloses cell permeable Nm23 recombinant proteins where a macromolecule transduction domain (MTD) is fused to a metastasis suppressor Nm23. Also disclosed are polynucleotides...
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8445444 |
Compositions and methods for diagnosing, treating, and preventing prostate conditions
Disclosed are compositions and methods for diagnosing, preventing, and treating prostate cancer and prostate intraepithelial neoplasia (PIN).
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8445443 |
Cell permeable p18 recombinant proteins, polynucleotides encoding the same, and anticancer composition comprising the same
The present invention discloses cell permeable p18 recombinant proteins where a macromolecule transduction domain (MTD) is fused to a tumor suppressor p18. Also disclosed are polynucleotides...
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8445442 |
CCL18 and CCL3 methods and compositions for detecting and treating cancer
The invention relates to methods of treating cancer by administering one or more chemokines that are downregulated in cancerous cells. More specifically, the invention provides methods for treating...
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8445635 |
Modified H2 relaxin for tumor suppression
Modified H2 relaxms which act as antagonists of the relaxm receptor in cells and tissues, in particular, modified H2 relaxms comprising one or more alterations of the ammo acid sequence at...
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8445638 |
Use of a truncated eIF-5A1 polynucleotide to induce apoptosis in cancer cells
The present invention relates to the combinatorial use of an siRNA targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a...
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8445491 |
Wnt protein signalling inhibitors
The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of...
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8440795 |
Kunitz-type recombinant inhibitor
The present invention presents a Kunitz-type recombinant inhibitor obtained from a gene cloned from a cDNA library of salivary glands of the Amblyomma cajennense, and the inhibitor named...
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8440626 |
Antineoplastic peptides
The present invention provides antineoplastic peptides of formula I, IR1R2N-CHX-CO-A-B-D-E-(G)S-K wherein R1, R2, X, A, B, D, E, G, K and s have the meanings stated in the description. The...
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8440630 |
Akt activity specifically inhibiting polypeptide
The present invention is to provide a polypeptide specifically inhibiting the activity of Akt (Protein Kinase B), the DNA thereof, the antibody thereof, an inhibitor of Akt activity or an antitumor...
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8440620 |
Methods, compositions and articles of manufacture for contributing to the treatment of cancers
Methods, compositions and articles of manufacture for contributing to the treatment of cancers, including solid tumors, are disclosed. The methods, compositions and articles of manufacture can...
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8440625 |
Secreted protein acidic and rich in cysteine (SPARC) as chemotherapeutic sensitizers
The present invention relates to compositions and methods of use thereof for cancer therapy sensitization. Such compositions comprise functional fragments of the nucleotide and/or polypeptide...
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8435956 |
Compositions and methods for protecting cells from toxic exposures
The present invention provides compositions and methods for protecting cells and tissues from damage associated with therapeutic treatments of cancers and other diseases and conditions where...
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8435951 |
Treating neoplasms with neurotoxin
The present invention provides a method of treating a cancer using a neurotoxin, preferably Botulinum toxin (“BTX”). The application of a neurotoxin around a cancer acts to decrease the con...
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8436137 |
Selective anticancer chimeric peptide comprising an EGF receptor-binding peptide and a cytotoxic peptide
It is an object of the present invention to provide a substance usable as an anticancer agent or DDS, which has intracellular stability, which is capable of evading side effects from functional...
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8435513 |
NOTCH1 receptor antibodies and methods of treatment
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis,...
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8431545 |
Copolymer including uncharged hydrophilic block and cationic polyamino acid block having hydrophobic group in part of side chains, and use thereof
The present invention relates to a block copolymer containing an uncharged hydrophilic polymer chain block and a cationic polyamino acid chain block, wherein the hydrophilic polymer chain block is...
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8431530 |
Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles
Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also...
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8431536 |
Target for breast cancer therapy and/or diagnosis
The present invention relates to breast cancer and methods for identifying therapeutics and diagnosis. In general, methods for identifying therapeutic agents directed to calcium flow arc disclosed....
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8425903 |
Methods of treatment by administering antibodies to notch receptors
The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides...
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8420603 |
SPARC and methods of use thereof
The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying...
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8420100 |
Tumor suppressor activating polypeptides and uses thereof
Chimeric tumor suppressor activating peptides derived from matrix attachment region binding protein (MARBP) SMARI unique in their sequence comprising a arginine rich motif flanked by serine...
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8420591 |
MUC1 and galectin-3
The invention provides methods of identifying and making compounds that inhibit the interaction between MUC1 and galectin-3. Also embraced by the invention are in vivo and in vitro methods of...
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8415304 |
Sparc and methods of use thereof
The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying...
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8415303 |
Method of treatment using a soluble human delta protein fragment
The present invention relates to nucleotide sequences of vertebrate Delta genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In...
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8409578 |
Methods for treating bone loss with antibodies to OPGL
Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are...
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8410059 |
CXCR4 antagonist and use thereof
Therapeutic drugs for cancer and chronic rheumatoid arthritis which contain a peptide having a CXCR4 antagonism, its amide, its ester or its salt are described. Also, the present invention provides...
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8410058 |
Methods of using insulin-like growth factor antibodies to treat tumors
Binding proteins, such as antibodies directed to IGF-II with cross-reactivity to IGF-I and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the...
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8409592 |
Whey and thymus function
The present invention generally relates to the field of nutrition and health. In particular, the present invention provides a composition that can be used to maintain or improve thymus health. One...
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8410061 |
Functional antagonists of hedgehog activity
Variants of hedgehog protein that contain N-terminal modifications are described that can block hedgehog function; thus allowing these variants to serve as functional antagonists. These peptides...
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8410045 |
Camptothecin-peptide conjugates and pharmaceutical compositions containing the same
The present invention relates to a novel compound of use in the improved delivery of therapeutic drug agents into target cells or tissues, composition comprising the same and uses thereof. The...
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8404242 |
Compositions and methods comprising histidyl-tRNA synthetase splice variants having non-canonical biological activities
Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
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8404640 |
Method of diagnosing and treating colon cancer
The invention provides a method of diagnosing carcinoma in a patient, the method comprising providing a sample of colorectal cells from a human patient and analyzing the sample for CXCL12...
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8404643 |
Metastin derivatives and use thereof
The present invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, a gonadotrophic...
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8404237 |
Antibodies to the NOTCH1 receptor
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis,...
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8404233 |
Neutralizing monoclonal antibody against human DLL4
The present invention provides a binding protein capable of binding to delta-like ligand 4 (DLL4) as well as methods and uses thereof in therapy, diagnosis or imaging. Also provided are fusion...
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