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8697629 Modulation of intracellular signaling  
A method of treating a disease characterized by aberrant cell migration and/or invasion includes administering to a subject an effective amount of the peptide of SEQ ID NO:3, an Å6 polypeptide, o...
8697061 Tumor specific oligosaccharide epitopes and use thereof  
The present invention describes oligosaccharide sequences, which are specifically expressed by human tumors. The present invention is related to a method of determining an oligosaccharide sequence,...
8697064 Nitrogenated derivatives of pancratistatin  
The present invention concerns nitrogenated derivatives of narciclasine and pancratistatin of the following general formula (I) as well as their pharmaceutically acceptable salts. The present...
8697743 Antioxidant camptothecin derivatives and antioxidant antineoplastic nanospheres thereof  
The present invention is directed to antioxidant derivatives of camptothecin and antioxidant derivatives of camptothecin analogs and the preparation of nanometer-sized camptothecin prodrugs....
8691764 Inhibitors of NF-κB activity  
The present invention provides a method for inhibiting NF-κB activity in a subject, the method comprising providing an agent capable of inducing expression of annexin 1, whereby said agent induces ...
8691507 Inhibitors of human EZH2 and methods of use thereof  
The invention relates to determining the presence of an EZH2 gene mutation in a sample from a subject and inhibition of wild-type and certain mutant forms of human histone methyltransferase EZH2,...
8691749 Peptide and use thereof  
The present invention provides a peptide comprising an amino acid sequence of SEQ ID NO: 1 and a pharmaceutically acceptable salt thereof effective for treating degenerative disc diseases, treating...
8691231 Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies  
Disclosed are pharmaceutical preparations for, and methods for determining, appropriate and effective treatment with therapeutic agents comprising a single species of anti-EGFR monoclonal antibody...
8685929 Detecting CYP24 expression level as a marker for predisposition to cancer  
This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer...
8685925 Method and compositions for treating stroke with fever  
The invention provides methods of treating stroke and related conditions exacerbated by fever and/or hyperglycemia by administering peptides or peptidomimetics that inhibit binding of NMDAR 2B to...
8685928 Antagonists of MUC1  
The present invention is directed to improved compositions for cellular delivery of peptides. Using segments of only 3-5 positively-charged residues, one can effectively transfer peptides,...
8685403 Insulin-like growth factor signaling and integrin  
Interaction between insulin-like growth factor 1 (IGFI) and integrin is involved in integrin-mediated cellular signaling, such as enhanced proliferation of cells expressing integrins, especially...
8679471 Modulation of regulatory T cells by human IL-18  
The present invention relates to compositions and methods for modulating the presence and/or activity of regulatory T cells in a subject.
8679503 Methods, compositions and kits relating to chitnases and chitnase-like molecules and inflammation disease  
The present invention includes compositions and methods for the treatment of inflammatory disease (e.g., asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic...
8680056 Antiproliferative factor and methods of use  
A novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits...
8680057 Tribonectins  
The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.
8680041 Genetic variations associated with tumors  
Nucleotide and amino acid variations associated with tumors are provided. Methods for detecting variations and for diagnosing and treating tumors are provided.
8679479 Methods for purifying pegylated arginase  
Methods and composition for generation of arginase variants with high serum persistence are provided. For example, in certain aspects methods for purifying pegylated arginase are described....
8680055 Methods for decreasing steroidogenesis in prostate cancer cells  
The present invention discloses compositions and methods for treating diseases such as cancer by targeting luteinizing hormone (LH) or its receptor (LHR) involved in androgen synthesis or...
8674070 Cancer-targeting peptides and uses thereof in cancer therapy  
Cancer-targeting peptides and uses thereof in cancer therapy.
8673855 Phosphatidylinositol 3-kinases activity regulator including the fifth zinc finger domain of FOG2  
The present invention relates to a phosphatidylinositol 3-kinases activity regulator which include the fifth zinc finger domain of FOG2 and which, more specifically, can induce cancer cells to die...
8673338 Methods of delivering pharmaceutical agents  
Provided are methods of delivering at least one pharmaceutical agent to the central nervous system (CNS) of a subject, methods of treating a neurological disorder or pain in a subject that include...
8669230 Immunogenic epitopes for immunotherapy  
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present...
8669231 Activation of peptide prodrugs by hK2  
The invention provides novel peptide prodrugs that contain cleavage sites specifically cleaved by human kallikrein 2 (hK2). These prodrugs are useful for substantially inhibiting the non-specific...
8663636 Method of treating a malignant tumor by administering antibodies directed to DLL4  
The invention relates to targeted binding agents against DLL4 and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to DLL4. The described...
8664183 SPANX-B polypeptides and their use  
It is disclosed herein that SPANX-B is uniquely expressed in a number of human tumors and that SPANX-B is an immunogenic antigen that is recognized by human T cells inducing helper CD4+ and...
8663711 Use of armillaridin for treating cancer  
Novel Uses of an aromatic ester isolated from Armillaria mellea, particularly, armillaridin, are disclosed herein. The armillaridin is useful for manufacturing a medicament or a pharmaceutical...
8664180 Ophthalmic compositions containing diglycine  
Ophthalmic composition that includes 0.05% w/v to 2% w/v diglycine or a salt thereof; 0.01 ppm to 3 ppm poly(hexamethylene biguanide); 1 ppm to 10 ppm α-[4-tris(2-hydroxyethyl)ammonium ...
8664182 Methods of inhibiting cancer cell growth with HDAC inhibitors and methods of screening for HDAC10 inhibitors  
Methods of inhibiting cancer cell growth using HDAC10 inhibitors are provided. Methods of treating cancer in a subject using HDAC10 inhibitors are also provided. In certain embodiments, at least...
8663651 T-140 peptide analogs having CXCR4 super-agonist activity for immunomodulation  
The present invention is directed to novel therapeutic uses of T-140 analog peptides and compositions comprising same. Specifically, the invention provides compositions and methods useful for...
8663679 Compositions for improving breast health in women  
Disclosed are compositions and corresponding methods for treating fibrocystic breast disease or other breast-related disease or condition. The compositions comprise, per serving or dose, from zero...
8664181 Dual acting prodrugs  
A prodrug comprising at least two different pharmaceutically and/or diagnostically active compounds independently bound by cleavable linkers and a protein-binding moiety which is capable of binding...
8664184 Therapy with Clostridium perfringens enterotoxin to treat ovarian and uterine cancer  
The invention discloses high levels of receptors for Clostridium perfringens enterotoxin (CPE) have been found in ovarian cancer and uterine cancer tissue samples. In addition, successful in vivo...
8658601 Peptides and nanoparticles for therapeutic and diagnostic applications  
Provided herein are peptides and nanoparticles conjugates thereof useful for the treatment of diseases and disorders mediated by GIPC/synectin, such as cancer.
8658591 Multi-LEU peptides and analogues thereof as selective PACE4 inhibitors and effective antiproliferative agents  
Disclosed herein are PACE4 inhibitors, compositions comprising PACE4 inhibitors and their uses thereof for lowering PACE4 activity, reducing cell proliferation, reducing tumor growth, reducing...
8658600 Antineoplastic hydrogels, and enzyme-instructed preparations thereof  
Disclosed is a general methodology to create nano fibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself. It is shown that with proper molecular...
8658599 Peptide for the prophylactic or therapeutic treatment of skin tumors in initial stages  
A method to inhibit the formation of skin tumors at early stages and their subsequent progression to carcinoma in a mammal is described, the method including the topical application to the mammal's...
8658175 Anti-EGFR antibodies and their uses  
The present invention relates to antibodies directed to EGFR and uses of such antibodies, for example, to treat diseases associated with the activity and/or overproduction of EGFR.
8653038 HLA-A* 1101-restricted WT1 peptide and pharmaceutical composition comprising the same  
An HLA-A*1101-restricted WT1 peptide, specifically, a peptide comprising an amino acid sequence consisting of 9 contiguous amino acids from a WT1 protein, wherein the peptide has an ability to bind...
8653039 Peptide based inhibition of caPCNA interaction in cancer  
Peptides derived from cancer specific isoform of proliferating cell nuclear antigen (caPCNA, also known as csPCNA) or from nmPCNA-interacting proteins interfere with intracellular protein-protein...
8653031 Process for the preparation of compositions of AT1 receptor antagonist and Angiotensin—(1-7)  
We describe preparation of compounds of an AT1 receptor antagonist(s) and Angiotensin (1-7), for example, Angiotensin-(1-7) losartanate and analogues thereof, and/or mixtures of these systems,...
8653034 Compositions and methods comprising phosphatidylethanolamine-binding peptide derivatives  
Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for...
8653035 Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers  
The present invention relates to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. The present invention discloses tumor-associated T-helper cell...
8648046 Compositions and methods for visualizing and eliminating cancer stem cells  
The present invention relates generally to the field of cancer diagnosis and treatment, and more particularly to compositions and methods that may be useful for eliminating cancer cells with...
8647627 Composition for a cancer vaccine  
Pharmaceutical compositions useful as vaccines are described containing a purified surface or excreted protein qualitatively or quantitatively associated with a type of cancer, at least one...
8648045 VDAC1 compositions and methods of use thereof for regulating apoptosis  
The present invention relates generally to the mitochondrial protein, voltage-dependent anion channel (VDAC), polynucleotides encoding same and variants thereof, as well as peptide fragments,...
8648047 Methods and compositions for inhibition of multi-drug resistance by hyaluronan oligomers  
Pharmaceutical compositions and methods for sensitizing multi-drug resistant cancer or radiation resistant cancer cells to chemotherapeutic agents are provided. Compositions include ligands of...
8642555 Prodrugs  
The present invention relates to a prodrug comprising at least one cytostatic agent, wherein said prodrug is cleavable by prostate-specific antigen (PSA), a process for preparing said prodrug and a...
8642580 Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and platinum derivatives  
Compounds which are α-halogenoacryloyl distamycin derivatives of formula (I) wherein R1 is a bromine or chlorine atom; R2 is a distamycin or distamycin-like framework as set forth in the ...
8642026 Methods and compositions for contributing to the treatment of cancers  
Methods and compositions for contributing to the treatment of cancers, especially ovarian tumors, are disclosed. The methods and compositions utilize an endothelin B agonist (ETB) to enhance the...