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8940862 Selective anticancer chimeric peptides which bind transferrin receptor  
It is an object of the present invention to provide a substance usable as an anticancer agent or DDS, which has intracellular stability, which is capable of evading side effects from functional...
8940695 Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy  
The present invention provide purified Flt4 receptor tyrosine kinase polypeptides and fragments thereof, polynucleotides encoding such polypeptides, antibodies that specifically bind such...
8940686 Cytokine  
A novel cytokine, U83A, is described, as are variant forms of the cytokine, having a wide range of agonistic and antagonistic activity against chemokine receptors. Uses of the chemokine in...
8940863 Selective anticancer chimeric peptides which bind neuropilin receptor  
It is an object of the present invention to provide a substance usable as an anticancer agent or DDS, which has intracellular stability, which is capable of evading side effects from functional...
8940701 Compounds for, and methods of, treating cancer and inhibiting invasion and metastases  
Invasion-inhibiting peptides comprising either a modified cysteine (where the sulfur atom is modified with a alkyl group or other suitable group), and/or b) D-amino acids, for the treatment...
8940288 Method for treating cancer by administering IL-15 and IL-15Ralpha complexes  
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention...
8940700 E-selectin compositions and use thereof for inducing E-selectin tolerance  
The invention relates to compositions and methods for treating or preventing vascular dementia in a mammal comprising mucosal administration of an amount of E-selectin polypeptide sufficient to...
8937039 Peptide-based peroxidase inhibitors and methods of using same  
The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox...
8933027 Method of treating a disease or condition characterised by aberrant epithelial cell proliferation  
A method is provided for treating a disease or condition characterized by aberrant epithelial cell proliferation and/or migration. One step of the method can include administering to a mammal an...
8933037 Methods involving PDGFRBETA inhibitors  
The invention refers to PDGFRbeta inhibitor for use in the antiproliferative treatment of T-cell lymphoma, in particular NHL, ALCL and PTCL.
8933031 Polypeptide inhibiting angiogenesis and application thereof  
Provided is a low molecular polypeptide that can inhibit angiogenesis consisting of amino acid sequence YRGKKA, which is same to one portion sequence in apolipoprotein (a) Kringle V. Also provided...
8933078 Method of treating cancer with combinations of histone deacetylase inhibitors (HDAC1) substances  
A method for treating cancer is described using combination therapies comprising the use of hyperbaric oxygen with histone deacetylase inhibitors, with and without glycolytic therapies. The patient...
8932642 Treating prostate, ovarian, or breast cancer with a whole, leech saliva extract  
Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing...
8933038 Method of treating cancer with an HLA-A*3303-restricted WT1 peptide and pharmaceutical composition comprising the same  
Disclosed are: a peptide comprising an amino acid sequence composed of contiguous nine amino acid residues derived from a WT1 protein, wherein an amino acid residue at position 2 in the amino acid...
8927500 Peptidomimetic macrocycles  
Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary...
8921305 Crotoxin administration for cancer treatment and pain relief  
Disclosed is a method for treating cancer and/or pain using an intra-patient dose escalation procedure to deliver dosages of crotoxin.
8921323 Methods and compositions for modulating BCL-2 family polypeptides  
The present invention is based, at least in part, on the identification of a novel active site on BCL-2 family polypeptide such as BAX, which when bound by a compound, modifies the activity of the...
8920800 Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins  
The present invention provides methods of treating a patient having a cancer comprising administering to the patient a soluble Fibroblast Growth Factor Receptor 1 (FGFR1) fusion protein such as an...
8920790 Uses of IL-12 in hematopoiesis  
Methods for enhancing or stimulating hematopoiesis including the step of administering Interleukin-12 (IL-12) to yield hematopoietic recovery in a mammal in need. Preferred methods include the step...
8921320 Targeted osmotic lysis of cancer cells  
A targeted osmotic lysis (TOL) of tumor cells that over-express voltage-gated sodium channels (VGSCs) has been developed that uses a combined therapy of a drug that blocks sodium,...
8920807 Vault complexes for cytokine delivery  
The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault...
8920809 Chimera comprising bacterial cytotoxin and methods of using the same  
This invention provides, a recombinant polypeptide encoding a chimera. The chimera includes a DNase I fragment or a homologue thereof and a Cdt fragment or a homologue thereof. Further, the...
8916541 Synergistic combination of honokiol and modified citrus pectin in cancer therapy  
The invention comprises the administration of an amount of honokiol (HNK) and Modified Citrus Pectin (MCP) or similar pectin or alginate in amounts synergistic to inhibit cancer. The inhibition can...
8916161 Method of treating or preventing benign prostatic hyperplasia using modified pore-forming proteins  
The present invention provides a method of treating BPH using modified pore-forming proteins (MPPs). These MPPs are derived from naturally occurring cytotoxic proteins (nPPs) that kill cells by...
8916681 Compound, use and method  
The present invention relates to the use of an antagonist of kisspeptin in the manufacture of a medicament for the treatment of a condition induced and/or worsened by kisspeptin activity in an...
8916517 Analogs of pituitary adenylate cyclase-activating polypeptide (PACAP) and methods for their use  
This invention relates to novel analogs of pituitary adenylate cyclase-activating polypeptide (PACAP), which are agonists for the PACAP/vasoactive intestinal peptide (VIP) receptors: PAC1, VPAC1...
8912136 Methods and compositions related to clot-binding compounds  
Disclosed are compositions and methods related to clot-binding compounds. For example, disclosed are compositions comprising a surface molecule and at least one modified clot-binding compound. The...
8912146 Derivatives of APF and methods of use  
Derivatives of bladder epithelial antiproliferative factor and methods of using them are disclosed. In specific embodiments, the glycopeptide compositions are useful for the treatment and/or...
8911736 Combination therapy for treating breast cancer  
The invention provides compositions and methods for treating breast cancer. Specifically, the invention relates to administering a Transforming Growth Factor beta (TGFβ) antagonist in combination ...
8912214 Use of Chk2 kinase inhibitors for cancer treatment  
Described herein are Chk2-inhibitor compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.
8911775 pH-sensitive block copolymer forming polyionic complex micelles and drug or protein carrier using the same  
Disclosed is a pH-sensitive block copolymer that forms polyionic complex micelles. The block copolymer is prepared by copolymerization of (a) a polyethylene glycol compound, (b) a poly(amino acid)...
8906860 Methods and compositions inhibiting tumor cell proliferation  
The invention provides agents, compositions, pharmaceutical compositions and method for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a...
8906852 Inhibitors of protein tyrosine kinase activity  
This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth...
8906376 Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease  
Drug-Linker-Ligand Conjugates are disclosed in which a Drug is linked to a Ligand via a peptide-based Linker unit. In one embodiment, the Ligand is an Antibody. Drug-Linker compounds and Drug...
8901082 Immunity-inducing agent and method for detection of cancer  
An immunity-inducing agent comprising as an effective ingredient(s) at least one polypeptide selected from the following polypeptides, the polypeptide(s) having an immunity-inducing...
8901276 Peptide reagents and methods for detection of colon dysplasia  
The present invention is directed to peptide reagents, methods for detecting colon pre-cancer (dysplasia with non-polypoid or polypoid morphology) or cancer using the peptide reagents, and methods...
8900600 Identification, optimization and use of cryptic HLA-A24 epitopes for immunotherapy  
The present invention discloses peptides such as an isolated peptide consisting of an immunogenic HLA-A*2402-restricted epitope. For example, the isolated peptide may be selected from the group...
8900565 Indole derivatives as inhibitors of histone deacetylase  
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of histone deacetylase 8 (HDAC8). Also described herein are methods of using...
8901280 Antibody against RGD in amino acid sequence of extracellular matrix protein and production method and use of the same  
The present invention provides a monoclonal antibody which specifically recognizes RGD in the amino acid sequence of extracellular matrix proteins of a human and a mouse. By specifically inhibiting...
8901083 Administration of angiocidin for the treatment of leukemia  
Methods are presented for the therapeutic administration of angiocidin in the treatment of cancers such as glioma, breast cancer, and leukemia. Methods are also presented for inducing growth arrest...
8895514 Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers  
The present invention relates to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. The present invention discloses tumor-associated T-helper cell...
8895500 Modified human tumor necrosis factor receptor-I polypeptide or fragment thereof, and method for preparing same  
The present invention relates to a modified human tumor necrosis factor receptor-1 polypeptide which is capable of binding to a tumor necrosis factor in vivo or ex vivo, or to a fragment thereof....
8895245 Inhibitors of human EZH2 and methods of use thereof  
The invention relates to inhibition of wild-type and certain mutant forms of human histone methyltransferase EZH2, the catalytic subunit of the PRC2 complex which catalyzes the mono- through...
8889616 MUC1 based glycolipopeptide vaccine with adjuvant  
Provided herein are liposomal glycolipopeptidic vaccine formulations comprising an adjuvant and an immunogen for immunotherapy and/or treatment of cancer.
8889628 Soluble tandem selectin glycoprotein ligand molecules  
Recombinant proteins comprised of multiple selectin binding domains derived from the glycopeptide PSGL-1, in a novel tandem configuration, are disclosed, including their fusions with...
8883966 RAB6KIFL/KIF20A epitope peptide and vaccines containing the same  
The present invention provides oligopeptides comprising the amino acid sequence selected from the group consisting of SEQ ID NOs: 3, 4 and 5. The present invention also provides a pharmaceutical...
8883737 Methods of treating cancer  
Described are methods and compositions for treating epithelial tumors with a folate-vinca conjugate in combination with at least one other chemotherapeutic agent in which the tumors include...
8883735 Low density lipoprotein-related protein 6 (LRP6)-half life extender constructs  
The present invention relates to LRP6 constructs that bind to LRP6 receptor. The LRP6 constructs comprise at least one LRP6 binding moiety and a half-life extender molecule such that the LRP6...
8883738 Use of a peptide fragment of CD44v6 in the treatment of ophthalmic diseases  
The present invention relates to the use of peptide compounds for the prevention and/or treatment of ophthalmic diseases. In particular, the present invention relates to a peptide compound...
8883718 Treating cancer  
Provided is a cyclic peptide which comprises: (i) a CDK4 peptide region; and(ii) a cell-penetrating region; wherein the CDK4 peptide region comprises the amino acid sequence P1R1x1y1R2P2V (SEQ ID...