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9005667 Treating leukemia with a whole, leech saliva extract  
Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing...
9006183 Methods of protecting against apoptosis using lipopeptides  
The use of lipopeptides as inducers of NF-κB for the protection of mammals from the effects of apoptosis is described.
9006184 Cancer vaccine composition  
A cancer vaccine composition for human leukocyte antigen (HLA)-A*0206-positive persons, comprising a protein product of the tumor suppressor gene WT1 or a partial peptide thereof.
9000027 Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, bcl-2 and caspase-3  
The invention describes methods that are useful for treating cancer by administering a Chk1 inhibitor which can induce apoptosis in p53-defective cells when combined with a chemotherapy and/or...
8999917 Variant activin receptor polypeptides and uses thereof  
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present...
8999934 Treatment of astrocytes-tumor cells inhibitors of endothelin receptors  
The disclosure relates to an endothelin receptor antagonist for use in the prevention or treatment of brain metastases in combination with a cytotoxic chemotherapy agent, radiotherapy or both. The...
8993278 Conjugates for cancer therapy and diagnosis  
The present invention relates to conjugates of a drug and an amino acid or an amino acid derivative or analog, pharmaceutical compositions that include the conjugates and methods of use thereof. In...
8993523 Dimeric IAP inhibitors  
The present invention provides compounds of formula M-L-M′ (where M and M′ are each independently a monomeric moiety of Formula (I) and L is a linker). The dimeric compounds have been found to be ...
8993524 Compositions and methods for targeted immunomodulatory antibodies and fusion proteins  
The present invention is based on the seminal discovery that targeted immunomodulatory antibodies and fusion proteins can counter act or reverse immune tolerance of cancer cells. Cancer cells are...
8993721 Peptides for targeting apoptotic cells and uses thereof  
Described herein is an isolated polypeptide which is capable of specifically targeting apoptotic cells undergoing apoptosis and consists of the sequence (I): Cys-X1-Val-Ala-Pro-X2 (I), wherein X1...
8987414 Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles  
Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
8987412 Hydrogen bond surrogate macrocycles as modulators of Ras  
The present invention relates to peptides having one or more stable, internally-constrained HBS α-helices, where the peptide is capable of interacting with Ras and related proteins.
8987210 Chemokine-immunoglobulin fusion polypeptides, compositions, method of making and use thereof  
This application is directed to chemokine-immunoglobulin fusion polypeptides and chemokine-polymer conjugates. The fusion polypeptides and conjugates can be used for treating chemokine...
8987209 N-carboxyalkyl-auristatin and the use thereof  
The present application relates to new derivatives of monomethylauristatin F, substituted on the N terminus by a carboxyalkyl group, processes for preparing these derivatives, their use for the...
8987266 EGFR mutations  
The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are...
8980266 Serpin fusion polypeptides and methods of use thereof  
This invention relates to molecules, particularly polypeptides, more particularly fusion proteins that include a serpin polypeptide or an amino acid sequence that is derived from a serpin and...
8980269 G-protein coupled receptor-associated sorting protein 1 as a cancer biomarker  
A method for determining whether early stage cancer is present in a subject comprises detecting the expression level of GASP-1 in the subject by detecting the amount of GASP-1 peptide fragments...
8980837 Inhibitors of IAP  
The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4,...
8980300 Plasticizers for coating compositions  
A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive...
8980838 Cyclized peptidomimetic small molecule inhibitors of the WDR5 and MLL1 interaction  
Cyclic peptidomimetics that inhibit the interaction between MLL1 and WDR5 are disclosed. Methods of inhibiting MLL1 activity and methods of treating cancers also are disclosed.
8980287 Anaplastic lymphoma kinase (ALK) as oncoantigen for lymphoma vaccination  
Use of intracytoplasmatic domain of Anaplastic Lymphoma Kinase (ALK) protein and/or a nucleic acid molecule encoding for the intracytoplasmatic domain of Anaplastic Lymphoma Kinase (ALK) protein,...
8980833 Tubulysine derivatives  
The present invention relates to novel cytotoxic molecules and their use for the treatment of cancer and other diseases.
8980250 Use of des-aspartate-angiotensin I in inflammation-related pathologies and diseases  
The present disclosure generally relates to the use of des-aspartate-angiotensin I and/or its derivatives in medicine. In particular, the present invention relates to the use of...
8975232 Macrocyclic kinase inhibitors and uses thereof  
The present invention provides macrocyclic compounds of Formula (I): pharmaceutically acceptable salts thereof; and pharmaceutical compositions thereof, wherein R1, R2, R3, R4, RE, RF, RG, RH, RI,...
8975086 Method for treating or preventing bladder cancer using the DEPDC1 polypeptide  
The present invention provides therapeutic agents and methods for treating cancer using the polypeptides composed of an amino acid sequence which includes a polypeptide fragment of DEPDC1. The...
8975044 Polynucleotides encoding for frizzled-binding agents and uses thereof  
Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as...
8969300 Na-K pump modulation  
The present invention relates to a method of modulating Na+/K+ pump activity, the method comprising contacting the Na+/K+ pump with an FXYD protein or a fragment or variant thereof wherein...
8969303 Tocotrienol esters  
Esters of tocotrienols having pharmacological activities pertinent to the treatment of breast cancer and other forms of cancer are disclosed herein. Among those compounds is...
8969304 Compositions and methods for the prevention of cancer in high risk patients  
This relates to the prevention of cancer initiation. More specifically, the invention provides compositions and methods useful for altering the genetic signature in breast tissue, said alteration...
8969515 Pharmaceutical composition for treating hyperproliferative diseases  
The proposed pharmaceutical compositions and methods connected thereto relate to the field of biotechnology and medicine, in particular to pharmaceutical compositions having an antiproliferative...
8968745 Method of treating cancer with an HLA-A*3303-restricted WT1 peptide and pharmaceutical composition comprising the same  
Disclosed are: a peptide comprising an amino acid sequence composed of contiguous nine amino acid residues derived from a WT1 protein, wherein an amino acid residue at position 2 in the amino acid...
8962569 Compositions comprising spp24 peptide fragments  
Provided herein is tumor suppression composition and methods of making and using the same.
8962566 Multi-arm polymeric alkanoate conjugates  
Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the...
8962034 Antiviral therapy with a whole, leech saliva extract  
Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing...
8957026 Beta-catenin targeting peptides and uses thereof  
The invention relates to β-catenin targeting peptides comprising an α-helical segment that are optionally stapled or stitched, and pharmaceutical compositions thereof. Uses of the inventive β...
8957014 Sensitization of tumor cells to radiation therapy through administration of endothelin agonists  
Methods to sensitize tumor cells to radiation therapy through the administration of an endothelin agonist such as the ETB agonist IRL1620.
8957027 Deacetylase inhibitor therapy  
The present invention relates to deacetylase inhibitor (e.g., histone deacetylase inhibitor) therapies and demonstrates that individuals with low electrolyte levels may have increased...
8957015 Tumor suppressor gene p47ING3  
The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins,...
8951975 ECT2 peptides and vaccines including the same  
Isolated peptides derived from SEQ ID NO: 42 and fragments thereof that bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL) and thus are suitable for use in the context of cancer...
8951971 Lymphatic zip codes in tumors and pre-malignant lesions  
Disclosed herein are compositions and methods for and involving selectively targeting tumor lymphatics.
8951972 FGFR1 extracellular domain combination therapies for lung cancer  
Methods of treating cancer comprising administering a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) and/or an FGFR1 ECD fusion molecule in combination with at least one...
8946169 SPARC and methods of use thereof  
The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying...
8946168 Compositions and methods for identifying and targeting cancer cells of alimentary canal origin  
Screening and diagnostic reagents, kits and methods for primary and/or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or...
8946291 Compositions and methods for treating pigmentary conditions and melanoma  
A method of treating melanoma in a subject comprising administering an amount of SOX9 sufficient to treat melanoma is disclosed. A method of treating a hyperpigmentary condition in a subject...
8946161 Method of treatment using stable liquid formulation of G-CSF  
Provided are pharmaceutical liquid formulations of G-CSF, which are stable over a long time period and substantially free of excipients, as well as ready-to-use syringes containing such...
8946159 Administration of an antagonist of α5β1 for anti-angiogenesis and cancer treatment  
A combination therapy is provided and is directed to pharmaceutical compositions and methods for administering a combination of an α5β1 antagonist with an α2β1 antagonist to a subject. The met...
8945570 Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers  
The invention described herein relates to novel nucleic acid sequences and their encoded proteins, referred to as 158P1D7 and variants thereof, and to diagnostic and therapeutic methods and...
8945600 Methods of delivering pharmaceutical agents  
Provided are methods of delivering at least one pharmaceutical agent to the central nervous system (CNS) of a subject, methods of treating a neurological disorder or pain in a subject that include...
8946171 Immunization of an individual against carcinomas and the preliminary stages thereof  
The present invention relates to a pharmaceutical composition, comprising a cell cycle regulatory protein and/or an expressible nucleic acid coding for this in an amount suitable for immunization...
8946167 Pharmaceutical compositions containing plasma protein  
The invention is related to water-soluble products and pharmaceutical formulations in solid or liquid form mainly for parenteral use. They consist of or comprise a therapeutically active substance...