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8173591 |
Variants of pigment epithelium derived factor and uses thereof
The present invention provides anti-angiogenic variants of pigment epithelium derived factor (PEDF) comprising at least one altered phosphorylation site, polynucleotides encoding same and uses...
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8163702 |
Treatment of melanoma
An immunomodulatory compound is administered to treat, prevent, inhibit, or reduce melanoma in a subject.
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8110542 |
Methods of expressing proteins with disulfide bridges
This invention relates to methods of expressing eukaryotic proteins in prokaryotic hosts, particularly eukaryotic proteins that require formation of disulfide bridges for biological activity....
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8088737 |
Compositions, methods and kits relating to Her-2 cleavage
The present invention relates to compositions, methods and kits based on the ADAM-mediated cleavage of Her-2. The present invention also relates to treatments for cancer, and in particular, breast...
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8039438 |
Synthetic peptides that cause F-actin bundling and block actin depolymerization
Synthetic peptides derived from sucrose synthase, and having homology to actin and actin-related proteins, sharing a common motif, useful for causing acting bundling and preventing actin...
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8034781 |
Angiotensin-(1-7) and angiotensin-(1-7) agonists for inhibition of cancer cell growth
The present invention describes the use of angiotensin-(1-7) peptide as an anti-cancer therapeutic. Thus, in one embodiment, the present invention comprises a composition to inhibit the growth of...
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8012935 |
Synthetic peptides and methods for treating cancer invasion and metastasis
The present invention relates to synthetic oligopeptides that exhibit inhibitory activity towards cancer invasion and metastasis. The peptides of the invention comprise PRKPKWDK (SEQ ID:2) peptide...
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7998934 |
PAI-2 conjugates for the treatment and imaging of cancer
A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises...
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7960348 |
Metastin derivatives and use thereof
The present invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, a gonadotropic...
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7875586 |
Treatment of metastatic colon cancer with b-subunit of shiga toxin
The present invention relates to compositions and methods for treating invasive or metastatic cancer, particularly metastatic colon cancer using the B-submit of shiga toxin. The invention further...
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7871981 |
Inhibition of cell motility, angiogenesis, and metastasis
Disclosed are methods of inhibiting cell motility, for example, by inhibiting the binding between an intracellular transducer and a receptor protein tyrosine kinase, and more particularly by...
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7820156 |
Method of treatment using a cytokine able to bind IL-18BP to inhibit the activity of a second cytokine
The present invention relates to the use of a cytokine-1, preferably from the IL-1 family more preferably IL-1F7b, or an isoform, mutein, fused protein, functional derivative or fragment thereof...
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7795205 |
Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
The present invention relates generally to methods of inhibiting angiogenesis in a patient by administering an effective angiogenesis-inhibiting amount of a thrombin inhibitor, and to the treatment...
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7786083 |
Metastin derivatives and use thereof
The present invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, a gonadotropic...
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7767642 |
Therapeutic peptides for the treatment of metastatic cancer
Interaction between MUC1 and β-catenin can be interrupted using polypeptides or antibodies that specifically bind to the binding site on MUC1. Interruption provides the beneficial effect of ...
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7749967 |
Peptides of a melanoma antigen and their use in diagnostic, prophylactic, and therapeutic methods
Immunogenic peptides of a melanoma antigen recognized by T cells, designated gp100, bioassays using the peptides to diagnose, assess or prognose a mammal afflicted with cancer, more specifically...
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7718615 |
Contortrostatin (CN) and methods for its use in preventing metastasis and other conditions
Contortrostatin, a homodimeric disintegrin, modulates the adhesion, motility, and invasiveness of integrin expressing tumor cells. When formulated as a pharmaceutically acceptable composition, the...
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7662783 |
CLK-peptide and SLK-peptide
The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen type-IV with substantially...
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7645449 |
Sensitizing cells for apoptosis by selectively blocking cytokines
The invention refers to the use of a cytokine antagonist which modulates the expression and/or the function of a cytokine, particularly a Th2 helper cell cytokine, in a cell and causes the...
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7642238 |
Molecular determinants of myeloma bone disease and uses thereof
To identify molecular determinants of lytic bone disease in multiple myeloma, the expression profiles of ˜12,000 genes in CD138-enriched plasma cells from newly diagnosed multiple myeloma patients ...
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7629136 |
Assays and methods using biomarkers
Methods and assays examining expression of one or more biomarkers in a mammalian tissue or cell sample are provided. According to the disclosed methods and assays, detection of the expression of...
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7611699 |
Methods of using cytokine zalpha11 ligand
Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino...
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7601341 |
Vascular endothelial growth factor fusion constructs used to inhibit osteoclastogenesis
The 121-amino acid isoform of vascular endothelial growth factor (VEGF121) is linked by a flexible G4S tether to a cytotoxic molecule such as toxin gelonin or granzyme B and expressed as a soluble...
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7597904 |
Metalloproteinase inhibitory agent
The present invention relates to an active agent, in particular a metalloproteinase inhibitory agent of casein-derived peptides obtained by hydrolysis of casein by a food grade bacteria. The...
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7579314 |
Use of RGD-enriched gelatine-like proteins for inhibition of cancer metastasis
The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD...
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7569543 |
Compositions of Angiopoietin, fragments, mutants and analogs thereof and uses of the same
The present invention relates to Ang-1, Ang-2, and Ang-3, and to methods and uses of the same. The present invention also relates to ECM-binding fragments, non-ECM-binding fragments, proteolytic...
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7557085 |
Metabolic-based methods for modulating gene expression
This invention provides methods for modulating cellular gene expression for genes operably linked to an NRSE element that is recognized by an NRSF transcriptional repressor, by changing the...
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7547441 |
PAI-2 conjugates for the treatment and imaging of cancer
A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises...
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7531516 |
Peptidic compounds selectively binding to P-selectin
The present invention relates to compounds which bind selectively to the adhesion molecule human P-selectin, and particularly to such compounds comprising a peptide with an amino acid sequence...
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7517855 |
Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof
The present invention relates generally to peptides, which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, methods of making peptides, which inhibit angiogenesis, cell...
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7491696 |
Proteolysis resistant active VEGF
The invention relates to endothelial growth factor (VEGF) in which the alanine at AA position 111 is replaced by proline. The arginine at AA position 110 may moreover be replaced by another amino...
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7488717 |
Methods of inhibiting chemokine binding to chemokine receptors
Novel peptides or peptidomimetic agents or small molecules for modulating the biological effect of a chemokine. According to the present invention, the therapeutic agents preferably are endowed...
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7435718 |
CXCR4 antagonist treatment of hematopoietic cells
In accordance with various aspects of the invention, CXCR4 antagonists may be used to treat hematopoietic cells, such as progenitor or stem cells, to promote the rate of cellular multiplication,...
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7432245 |
Pharmaceutical formulation comprising a peptide angiogenesis inhibitor
Parenteral formulations of peptides which are useful for sustained release are disclosed. Also disclosed are methods of preparation for the formulations.
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7419957 |
Peptides of melanoma antigen and their use in diagnostic, prophylactic and therapeutic methods
Immunogenic peptides of a melanoma antigen recognized by T cells, designated gp100, bioassays using the peptides to diagnose, assess or prognose a mammal afflicted with cancer, more specifically...
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7419667 |
Drug for cancer therapy
A lactoferrin hydrolysate mixture or lactoferrin partial peptide that can be obtained by hydrolyzing lactoferrin with a hydrolytic enzyme and has an action of enhancing cytotoxic activity of an...
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7365054 |
Methods for treatment of tumors and metastases using a combination of anti-angiogenic and immuno therapies
The invention provides methods for treating tumors and tumor metastases in a mammal comprising administering, to a mammal in need of treatment, a therapeutic amount of an antagonist sufficient to...
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7338937 |
Calcium-activated chloride channel proteins and their use in anti-metastatic therapy
Nucleotide sequences which encode a mammalian lung endothelial cell adhesion molecule are disclosed. Also disclosed are nucleotide sequences which encode a lung endothelial cell adhesion...
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7329644 |
Preparation and use of cyclic and branched peptides and their labelled derivatives as therapeutic agents, cholecystokinin agonists or antagonists, and diagnostic agents to identify and locate tumours
This patent application describes the preparation of cyclic and branched peptides of general formula (I) and their conjugated derivatives labelled with a paramagnetic or radioactive metal. The...
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7320960 |
Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4
Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the...
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7282476 |
Proaerolysin containing protease activation sequences and methods of use for treatment of prostate cancer
Disclosed herein are modified proaerolysin (PA) peptide. In some examples, the proteins include a prostate-specific protease cleavage site and can further include a prostate-tissue-specific binding...
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7247610 |
Use of glutamate antagonists for the treatment of cancer
Disclosed are methods for treating cancer by administering an inhibitor of the interaction of glutamate with the KA receptor complex.
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7186683 |
Use of GLP for the treatment, prevention, diagnosis, and prognosis of bone-related and nutrition-related disorders
The present invention relates to methods for prevention and treatment of bone-related or nutrition-related disorders using a GLP molecule or GLP activator either alone or in combination with...
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7081354 |
Interleukin and albumin fusion protein
Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences...
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7067109 |
Cancer treatment kits comprising therapeutic conjugates that bind to aminophospholipids
Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor...
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7060679 |
Conformationally constrained backbone cyclized somatostatin analogs
Methods of use of pharmaceutical compositions and novel peptides which are conformationally constrained backbone cyclized somatostatin analogs, having somatostatin receptor subtype selectivity, are...
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7056701 |
Hormone and albumin fusion protein
Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences...
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6946439 |
Compositions and methods for inhibiting cellular proliferation comprising TFPI fragments
Compositions and methods effective in inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related to neovascularization and tumor...
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6821947 |
Endorepellin: methods and compositions for inhibiting angiogenesis
Angiogenesis is a highly regulated process, yet many diseases are driven by unregulated angiogenesis. For example, the growth and metastasis of tumors is dependent on the growth of new blood...
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6800611 |
Metastin derivatives and their use
The invention relates to metastin derivatives represented by the formula: X-AA1-AA2-AA3-AA4-Z (I), or a salt thereof, or a pro-drug thereof, which have cancer metastatis suppressing activity and...
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