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7608614 |
Process for preparing macrocyclic compounds
Intermediates of the formula QUIN:
and methods for their preparation are described. The intermediate compounds are useful for preparing active agents for the treatment of hepatitis C virus...
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7423049 |
Inhibitors of p38
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods...
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7410959 |
Therapeutic uses for aminosterol compounds
A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG. 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically...
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7078059 |
Treatment of bone diseases
The invention provides a method for enhancing bone formation, inhibiting osteoclastic differentiation and/or activating osteoblastic differentiation whereby to manage, treat or achieve prophylaxis...
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7060696 |
Chelated 8-hydroxyquinoline and use thereof in a method of treating epithelial lesions
A chelation complex including 8-hydroxyquinoline and zinc mixed with a carrier demonstrates therapeutic efficacy in treating lesions including cancerous lesions, precancerous lesions, cysts and warts.
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6878388 |
Vanadium compounds for treating proliferative cell disorders
Vanadium compounds useful to prevent and/or inhibit adhesion, migration, and invasion of proliferative cells into surrounding tissue.
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6867217 |
Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods...
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6809091 |
Substances capable of inducing apoptosis
A method for the manufacture of a substance having an apoptosis-inducing ability characterized in including a step of subjecting at least one compound selected from the following (a), (b), (c) and...
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6800649 |
Method for inhibiting c-jun expression using JAK-3 inhibitors
The invention provides a method for inhibiting c-jun activation in mammalian or avian cells comprising contacting the cells with a substance that inhibits the activity of Janus family kinase 3...
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6777405 |
Detection and treatment of duplex polynucleotide damage
Duplex polynucleotides containing damage or errors are detected with hindered intercalating compounds which are capable of intercalating only in the presence of such damage or error. Conditions...
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6753317 |
Dmt-Tic di- and tri-peptide derivatives and related compositions and methods of use
A compound of formula: comprising the Dmt-Tic pharmacophore and related compositions and methods of use in the inhibition of the binding of an opioid receptor-binding compound with a...
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6743786 |
Vanadium compounds for treating cancer
The invention provides methods for treating cancer and compounds that are useful for the treatment of tumors, as well as pharmaceutical compositions comprising the compounds, and synthetic methods...
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6689771 |
Amide derivatives as inhibitors of matrix metalloproteinases, TNF-α, and aggrecanase
The present application describes novel amides and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein these compounds are useful as inhibitors of matrix...
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6667339 |
Vanadium (IV) complexes containing catecholate ligand and having spermicidal activity
Vanadium (IV) complexes containing a substituted or unsubstituted catecholate ligand, and the spermicidal activity of such compounds. Preferred compounds are vanadocene (IV) complexes containing...
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6476014 |
Chelated 8-hydroxyquinoline for the treatment of epithelial lesions
Oxinates including 8-hydroxyquinoline and a heavy metal are topically applied to epidermal lesions for therapeutic effect, wherein said epithelial lesions selected from the croup consisting of...
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6410592 |
Aminomethylcarboxylic acid derivatives
The present invention relates to aminomethylcarboxylic acid derivatives general formula (I), wherein Z is (CH 2 ) n , O, S, SO, SO 2 or N—R 5 ; n is 0, 1 or 2; X represents 1-3 substituents...
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6350740 |
Transplatinum complexes as cytotoxic and anticancer agents
The invention provides a method for enhancing the water solubility of cytotoxic trans-platinum complexes. The present invention also provides a method for killing tumor cells, and a method for the...
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6329360 |
Hetero-linked phenylglycinolamides
The hetero-linked phenylglycinolamides are prepared by reaction of the corresponding hetero-linked phenylacetic acids with appropriate phenylglycinols. The hetero-linked phenylglycinolamides are...
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6306846 |
Anti-inflammatory and anti-ulcer compounds and process
Disclosed herein are anti-inflammatory and anti-ulcer copper coordination compounds and a process for using them in the treatment of arthritis and gastrointestinal ulcers in animal bodies. The...
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6232340 |
Vanadium complexes and derivatives thereof and methods related thereto
Organovanadium complexes, and more specifically hydroxyoxovanadium(V), μ-oxo dimeric oxovanadium(V) and cis-dioxovanadium(V) complexes, are provided. The complexes may be formulated into a...
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6015659 |
Inducement of thermotolerance with benzoquinonoid ansamycins
Thermotolerant phenotypes are developed in cells, tissues, organs and organisms by the administration of benzoquinonoid ansamycins such as herbimycin A and any of various analogs. The general...
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5874433 |
Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis
Inhibitor of the use of tetrahydrobiopterin as a cofactor for nitric oxide synthase, e.g., substituted 4-phenyl(hydropyridines) such as...
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5770591 |
Bis-platinum complexes as chemotherapeutic agents
A bis(platinum) complex having the structure: ##STR1## wherein X, Y, Z, X', Y', and Z' are the same or different ligands and are halide, sulphate, phosphate, nitrate, carboxylate, substituted...
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5753667 |
1-oxo-2- (phenylsulphonylamino) pentylpiperidine derivatives, their preparation and their therapeutic application
The present invention provides a compound of formula (I) ##STR1## in which R 1 represents a hydrogen atom or a (C 1 -C 4 )alkyl group, R 2 represents a hydrogen atom or a straight or branched (C...
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5686440 |
Aqueous 6- 3-(3,4-dimethoxybenzyl)-amino-2-hydroxypropoxy! carbostyril composition
This invention provides an aqueous composition wherein a hardly water-soluble active compound, 6- 3-(3,4-dimethoxybenzyl)amino-2-hydroxypropoxy!carbostyril or a salt thereof is dissolved in water...
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5624919 |
Trans platinum (IV) complexes
Novel trans-platinum IV complexes which contain heterocycle ligands such as quinoline or isoquinoline, anionic ligands such as halide or sulfate, and which optionally may contain ammonia, or a...
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5605892 |
Compositions of arginine amide with cyclodextrin of caffeine, and methods of use
An aqueous agent comprising at least one arginine amide selected from the group consisting of (2R,4R)-4-methyl-1-[N 2 -((RS)-3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-ar
ginyl]-2-piper...
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5578604 |
5-vinyl- and 5-ethinyl-quinolone- carboxylic acids
The invention relates to new 5-vinyl- and 5-ethinyl-quinolone- and -naphthyridonecarboxylic acids, to processes for their preparation, and to antibacterial compositions and feed additives...
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5550028 |
Tetrahydroxyquinone as an activator component for activated partial thromboplastin time test of blood coagulation
The compound 2,3,5,6-tetrahydroxy-1,4-quinone, its derivatives and structural analogs are used as activators for intrinsic blood coagulation and as diagnostic reagents for the activated partial...
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5525598 |
Gallium (III) complexes in pharmaceutical compositions
A method for treatment of viral infections or tumors, comprising administering a gallium complex of the formula: ##STR1## wherein R 1 represents hydrogen, a halogen or a sulfono group SO 3 M in...
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5468742 |
8-vinyl- and 9-ethinyl-quinolone-carboxylic acids
The invention relates to new 8-vinyl- and 8-ethinylquinolonecarboxylic acids, process for their preparation, and antibacterial agents and feed additives containing them.
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5453422 |
Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them
An antibacterially active quinolone or naphthyridonecarboxylic acid derivative of the formula ##STR1## in which R 1 stands for various organic radical, R 2 stands for hydrogen, alkyl having 1...
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5421867 |
Composition and process of combining a grout or mortar mix with copper-8-quinolinolate to form an antimicrobial composition
New and useful cementitious-based products, such as mortar, grout, backerboard and stucco, are all comprised of Portland cement as a common ingredient combined with optional fillers and additives...
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5409915 |
Bis-platinum (IV) complexes as chemotherapeutic agents
Novel bis(platinum) (IV) complexes coupled via diamine bridging agents are taught as well as methods for their preparation. These complexes are to be used as pharmaceutical agents, e.g., for the...
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5304559 |
Compositions containing a 4-quinolone derivative complexed with a divalent metal ion
The present invention concerns a fluid pharmaceutical composition intended to be brought into contact with a physiological fluid, characterized in that it contains, as active principle, at least...
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5284842 |
Quinolone- and naphthridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them
An antibacterially active quinolone or naphthyridonecarboxylic acid derivative of the formula ##STR1## in which R 1 stands for various organic radical, R 2 stands for hydrogen, alkyl having 1...
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5217982 |
Compounds having antihypertensive properties
This invention relates to compounds which are derivatives of cyclopentane which are useful as antihypertensive agents, to pharmaceutical compositions including such compounds, and to their use in...
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5141931 |
5-Quinolinylpyridinones, cardiotonic compositions and methods
6-Alkyl-5-(6, or 7-quinolinyl)-3-(substituted)-2(1H)-pyridinones useful as cardiotonics are synthesized by reaction of trialkylquinolinylstannanes with...
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5086048 |
Mixture of fungicidal agents
A synergistic fungicidal composition comprising ##STR1## in which R 1 represents optionally substituted phenyl, R 2 represents hydrogen, alkyl having up to 4 carbon atoms or phenyl, R 3 ...
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5066328 |
Antimicrobial coating
The present invention is directed to an antimicrobial mixture of copper-8-quinolinolate mixed with a binder composition that imparts sufficient fluidity to the copper-8-quinolinolate to permit the...
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4981854 |
A-aryl-4-quinolone-3-carboxylic acids
Antibacterially active and animal growth promoting novel 1-aryl-4-quinolone-3-carboxylic acids of the formula ##STR1## in which X is halogen or nitro, X 2 is halogen, R is optionally...
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4980353 |
1-aryl-4-quinolone-3-carboxylic acids
Antibacterially active and animal growth promoting novel 1-aryl-4-quinolone-3-carboxylic acids of the formula ##STR1## in which X is halogen or nitro, X 2 is halogen, R is optionally...
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4871728 |
Pharmaceutical composition comprising an organic zinc complex and a process for preparing the active substance
The invention refers to a novel pharmaceutical composition having especially antimycotic activity and comprising the zinc complex of 5-chloro-7-iodo-8-hydroxyquinoline of formula (I) ##STR1## and...
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4766113 |
Antimicrobial compositions and methods of using same
Our invention pertains to various new compositions, methods for using such compositions and products treated with such compositions. Our new compositions include, among other things, certain...
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4760057 |
(Acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs
This invention relates to novel (acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs having a primary or secondary amine function...
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4694000 |
Quinazoline and isoquinoline derivatives
The invention relates to novel quinazoline and isoquinoline derivatives of the general formula: ##STR1## and acid addition salts and copper complexes thereof, wherein X represents nitrogen or a CH...
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4680291 |
Propenylamines, processes for their production and pharmaceutical compositions containing them
The present invention provides propenylamines useful as anti-mycotic agents.
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4670429 |
Synergistic fungicidal compositions
The invention relates to a synergistic fungicidal composition containing more active ingredients comprising 2,3-dihydroxy-6-methyl-5-phenylcarbamoyl-1,4-oxathiine or...
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4657903 |
Transition metal complexes of the selenium analogs of 2-acetyl- and 2-propionylpyridine thiosemicarbazones useful for treating malarial infections and leukemia
This invention relates to novel transition metal complexes of 2-acetyl- and -propionylpyridine thiosemicarbazones, their selenium analogs. These compounds are useful as antimalarial and...
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4608372 |
Process for preparing β' form of copper 8-hydroxyquinoline
A process for the preparation of the β' form of the copper chelate of 8-hydroxyquinoline (copper oxinate), stabilized compositions containing said chelate, fungicidal compositions containing said...
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