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7544367 |
Chemical method of making a suspension, emulsion or dispersion of pyrithione particles
A method for producing a suspension, emulsion or dispersion of de-agglomerated particles (advantageously submicron-sized particles) of pyrithione salts comprising contacting agglomerated pyrithione...
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7481873 |
Small particle copper pyrithione
Disclosed herein is a composition comprising a non-dusting copper pyrithione dispersion comprising small solid particles of copper pyrithione dispersed in a liquid dispersant, said solid particles...
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7455851 |
Pyrithione biocides enhanced by silver, copper, or zinc ions
The present invention is directed to an antimicrobial composition, comprising pyrithione or a pyrithione complex; and a zinc or copper or silver source selected from the group consisting of zinc or...
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7345046 |
Heteroaryl-fused pyrimidinyl compounds as anticancer agents
Heteroaryl-fused pyrimidinyl compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the...
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7338946 |
Compositions containing a ruthenium(III) complex and a heterocycle
Compositions, containing a ruthenium(III) complex and a heterocycle, methods for their manufacture, medicament containing these compositions and a kit. The invention relates to a composition (A),...
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7316996 |
Bisacyloxypropylcysteine conjugates and the use thereof
The invention provides lipopeptide conjugates in which a cysteine that is double-substituted by a fatty acid is bonded by means of the carboxyl group to a highly soluble, physiologically compatible...
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7135197 |
Stable pharmaceutical composition useful for treating gastrointestinal disorders
The present invention provides a pharmaceutical composition comprising at least one pharmaceutically acceptable bismuth-containing compound, at least one pharmaceutically acceptable...
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7078059 |
Treatment of bone diseases
The invention provides a method for enhancing bone formation, inhibiting osteoclastic differentiation and/or activating osteoblastic differentiation whereby to manage, treat or achieve prophylaxis...
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7030147 |
Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative
Epothilone derivatives are co-administered with an antidiarrheal agent, e.g., a DPP-IV inhibitor, in the treatment of a proliferative disease.
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7012072 |
Pharmaceutical oxaliplatinum preparation for parenteral administration and method for obtaining same
The present invention relates to a stable pharmaceutical preparation of oxaliplatin for parenteral administration, in which the oxaliplatin is in solution in a solvent at a concentration of at...
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7011854 |
Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof
Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases...
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7011839 |
Otic microbial combination for treatment of animals with ruptured tympanic membrane
Disclosed herein is an improved composition that is useful in treating otic infections comprising an antimicrobial and silver sulfadiazine in a therapeutically effective combination to treat otic...
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6958359 |
Vanadium compounds as anti-angiogenic agents
Vanadium compounds for inhibiting angiogenesis useful for treating or preventing diabetic retinopathy, hemangiomas, cancers with abnormal blood vessel supply, restenosis following vascular injury,...
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6903100 |
USE OF REGULARLY SCHEDULED HIGH DOSE INTRAVENOUS METHOTREXATE THERAPY, WITH INTERIM ADMINISTRATION OF IMMUNOMODULATORY AGENTS, TO TREAT MULTIPLE SCLEROSIS AND OTHER DISEASES OF THE CENTRAL NERVOUS SYSTEM
The present invention is directed to the treatment of multiple sclerosis by periodically administering a high dose of methotrexate at a level sufficiently high to cross the blood brain barrier. The...
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6900198 |
Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity,...
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6878388 |
Vanadium compounds for treating proliferative cell disorders
Vanadium compounds useful to prevent and/or inhibit adhesion, migration, and invasion of proliferative cells into surrounding tissue.
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6867217 |
Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods...
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6809091 |
Substances capable of inducing apoptosis
A method for the manufacture of a substance having an apoptosis-inducing ability characterized in including a step of subjecting at least one compound selected from the following (a), (b), (c) and...
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6777404 |
Use of corticotropin releasing factor antagonists and related compositions
The present invention relates to compositions and methods of achieving a therapeutic effect including, the treatment or prevention of Syndrome X in an animal, preferably a mammal including a human...
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6753016 |
Preservation of wood products
A method for the protection of wood and other wood materials without affecting dimensional stability or surface integrity of the treated material is described. The method involves treating wood...
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6743786 |
Vanadium compounds for treating cancer
The invention provides methods for treating cancer and compounds that are useful for the treatment of tumors, as well as pharmaceutical compositions comprising the compounds, and synthetic methods...
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6686344 |
Organic-arsonic compounds
Novel organic arsonic compounds are described as tumor inhibiting, and cancer treating compounds. Methods and compositions for inhibiting tumor cells and treating cancer are also provided.
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6667339 |
Vanadium (IV) complexes containing catecholate ligand and having spermicidal activity
Vanadium (IV) complexes containing a substituted or unsubstituted catecholate ligand, and the spermicidal activity of such compounds. Preferred compounds are vanadocene (IV) complexes containing...
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6608049 |
Indazoles
The invention relates to new indazole derivatives, processes for their preparation, and their use in medicaments.
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6544504 |
Combined use of interleukin 10 and methotrexate for immuno-modulatory therapy
A combination of interleukin 10 and methotrexate is used to suppress autoimmune diseases including arthritis and psoriasis. It has been discovered that administration of a combination of...
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6514960 |
Use of bismuth subgallate in inhibition of production of nitric oxide synthase
The present invention discloses the use of bismuth subgallate in the inhibition of the production of nitric acid synthase. Also disclosed is the synergistic efficacy of bismuth subgallate in...
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6482817 |
Hybrid pigments
The invention provides hybrid pigments containing: (a) at least one benzimidazolone triphenodioxazine compound of the formula (I) and (b) at least one pyrrolo-[3,4-c]-pyrrole compound, or (c) at...
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6482814 |
Biocidal composition and its use
A composition comprising a C 3-5 -alkyl-1,2-benzisothiazolin-3-one and the metal complex of a cyclic thiohydroxamic acid such as the 2:1 zinc salt of either 3-hydroxy-4-methylthiazol-2(3H)-thione...
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6482816 |
Organic arsenic compounds
Novel organic arsenic compounds are described as cytotoxic agents with potent anti-tumor activity against cancer cells and particularly, with regard to human leukemic cells and breast cancer cells.
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6440956 |
Bicyclic polyaminoacid metal complexes, their process of preparation and their application in medical imaging
Metal chelates of the amides of formula in which R has the formula Use in medical imaging.
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6395725 |
Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals
Synthetic low molecular weight catalysts for the dismutation of superoxide are potent analgesics that are effective in elevating the pain threshold in hyperalgesic conditions such as arthritis, and...
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6350740 |
Transplatinum complexes as cytotoxic and anticancer agents
The invention provides a method for enhancing the water solubility of cytotoxic trans-platinum complexes. The present invention also provides a method for killing tumor cells, and a method for the...
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6306846 |
Anti-inflammatory and anti-ulcer compounds and process
Disclosed herein are anti-inflammatory and anti-ulcer copper coordination compounds and a process for using them in the treatment of arthritis and gastrointestinal ulcers in animal bodies. The...
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6232340 |
Vanadium complexes and derivatives thereof and methods related thereto
Organovanadium complexes, and more specifically hydroxyoxovanadium(V), μ-oxo dimeric oxovanadium(V) and cis-dioxovanadium(V) complexes, are provided. The complexes may be formulated into a...
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6221901 |
Magnesium (-)hydroxycitrate, method of preparation, applications, and compositions in particular pharmaceutical containing same
Magnesium (-)hydroxycitrate, preparation process, dietary and therapeutic uses particularly in the cardiovascular field, and compositions in particular pharmaceutical containing it.
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6214817 |
Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity
The present invention relates to compounds which are effective as catalysts for dismutating superoxide and, more particularly, the manganese or iron complexes of substituted, unsaturated...
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6204259 |
Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: ##STR1## wherein R, R', R 1 , R' 1 , R 2 , R' 2 , R 3 , R' 3 , R 4 , R' 4...
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6180083 |
Tropane derivatives useable in particular for in vivo detection of dopamine transporters
The present invention relates to tropane derivatives having particular use for the in vivo detection of dopamine transporters. These derivatives meet the formula ##STR1## in which R 1 is I or Sn...
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6114321 |
Porphyrin derivatives, pharmaceutical agents that contain the latter, and their use in photodynamic therapy and MRI diagnosis
The invention relates to new porphyrin complex compounds, pharmaceutical agents that contain the latter, and the use of porphyrin complexes for the production of agents for photodynamic therapy and...
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6013242 |
Tropane derivatives with selective binding to the serotonin reuptake transporters for treatment of mental illness and as intermediates in the formation of imaging diagnostic agents for depression
Biologically active derivatives of the tropane ring system are provided which selectively bind either to the 5-HT or DA reuptake site, leading to compounds which have use for the treatment of...
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5994322 |
Compositions for preventing dementia
Compositions for preventing or treating memory loss in the brain, comprising an effective amount of a mixture of lecithin and vitamin B 12 .
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5976498 |
Methods of diagnostic image analysis using metal complexes of nitrogen-containing macrocyclic ligands
The present invention is directed to complexes represented by the formula: ##STR1## wherein R, R', R 1 , R' 1 , R 2 , R' 2 , R 3 , R' 3 , R 4 , R' 4 , R 5 , R' 5 , R 6 , R' 6 , R 7 , R' 7 , R 8 ,...
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5922693 |
Cleaning compositions containing biostatic agent
The present invention relates to an aqueous cleaning composition containing (a) 1 to 10 weight % of at least one surfactant selected from the group consisting of anionic surfactants and...
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5888993 |
Vanadium compounds in the treatment of elevated blood sugar levels
There are provided vanadium compositions for use in the treatment of hypertension, obesity and diabetes, in particular improved oral compositions comprising oxovanadium (IV) chelates of monoprotic,...
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5885980 |
Composition and method for treating diabetes
A method of treating diabetes in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of a pharmaceutically acceptable VO +2 generating compound...
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5874433 |
Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis
Inhibitor of the use of tetrahydrobiopterin as a cofactor for nitric oxide synthase, e.g., substituted 4-phenyl(hydropyridines) such as...
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5866563 |
Vanadium compositions
There are provided vanadium compositions for use in the treatment of hypertension, obesity and diabetes, in particular improved oral compositions comprising oxovanadium (IV) chelates of monoprotic,...
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5834456 |
Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
Polyazamacrocyclofluoromonoalkylphosphonic acid compounds are disclosed which form inert complexes with Gd, Mn, Fe or La ions. The complexes are useful as contrast agents for diagnostic purposes.
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5773435 |
Prodrugs for β-lactamase and uses thereof
The instant invention relates to a novel method for the delivery of antitumor drugs to tumor cells by the administration of a tumor-selective antibody-β-lactamase conjugate that binds to tumor...
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5770591 |
Bis-platinum complexes as chemotherapeutic agents
A bis(platinum) complex having the structure: ##STR1## wherein X, Y, Z, X', Y', and Z' are the same or different ligands and are halide, sulphate, phosphate, nitrate, carboxylate, substituted...
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