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7582623 |
Photoactive metal nitrosyls for blood pressure regulation and cancer therapy
Disclosed are nitric oxide delivery agents and methods of their use, more specifically to photoactive compounds, which are able to perform targeted delivery of nitric oxide in vitro and in vivo and...
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7579338 |
Methods and compositions for treating atheroma, tumors and other neoplastic tissues
The radiation sensitization potential of a candidate compound can be screened by determine its ability to generate one or more reactive oxygen species under appropriate conditions. Compounds...
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7572782 |
Use of targeted oxidative therapeutic formulation in bone regeneration
A pharmaceutical formulation and its use. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by an...
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7547689 |
Methods and compositions for treating atheroma, tumors and other neoplastic tissues
Compositions comprising motexafin gadolinium, as well as methods for using these compositions in the treatment of brain metastases, are described herein.
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7544367 |
Chemical method of making a suspension, emulsion or dispersion of pyrithione particles
A method for producing a suspension, emulsion or dispersion of de-agglomerated particles (advantageously submicron-sized particles) of pyrithione salts comprising contacting agglomerated pyrithione...
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7528125 |
Water-soluble zinc ionophores, zinc chelators, and/or zinc complexes and use for treating cancer
Disclosed herein are novel zinc ionophores, zinc chelators and/or zinc complexes with enhanced aqueous solubility. Methods of treating cancer using at least one zinc ionophore and/or zinc chelator...
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7524938 |
Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins
A method of producing a metalloprotein inhibitor, the method comprising generating antibodies directed at a composition including a metal ion-bound chelator, wherein the composition is selected...
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7521440 |
Targeted oxidative therapeutic formulation
Pharmaceutical formulation, its method of preparation, and its use. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as...
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7511031 |
Noninvasive vascular therapy
The present invention is drawn to apparatus for transcutaneous photodynamic therapy (“PDT”) of a target tissue or compositions in a mammalian subject, which includes a light source that is...
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7488817 |
Metal complex protein kinase inhibitors
This inventive subject matter relates to novel metal complex protein kinases inhibitors, methods for making such compounds, and methods for using such compounds for treating diseases and disorders...
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7470677 |
Oxidant scavengers
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of...
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7462369 |
Anti-viral compositions and methods of making and using the anti-viral compositions
Disclosed are anti-viral compositions containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients), and a pharmaceutical carrier. Also disclosed...
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7449454 |
Metallotexaphyrin derivatives
Novel derivatives of metallotexaphyrins are prepared by modifying the apical ligands associated with the central metal component of a metallotexaphyrin.
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7445845 |
Synthesis, spectroscopy, photophysics of multi-chromophoric ZN(II) group 8 metal complexes
Novel multichromophoric complexes comprising the formula
R 1 —R A -[MC]-([R M ] z -[MC]) m -RA—R 2
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7414044 |
Use of targeted oxidative therapeutic formulation in treatment of type 2 diabetes
A pharmaceutical formulation and its use. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by an...
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7410960 |
Metal complexes and therapeutic uses thereof
A compound of formula I or a salt thereof
[ML 1 L 2 ] 2+ (I)
where M is...
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7384927 |
Alkylated porphyrins as pesticides acting both in the presence and absence of light
An insecticidal composition comprising at least one compound of the tetrapyrrole series having at least one hydrocarbon chain at least 12 carbon atoms long as a peripheral substituent, wherein the...
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7371742 |
Porphyrin derivatives for photodynamic therapy
This invention relates to porphyrin compounds used to destroy or impair the functioning of a target biological material in photodynamic therapy, in particular against virus, tumoral cells,...
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7354953 |
Time-release compositions for delivery of [Cr3O(carboxylate)6(H2O)3]+
A time release composition is provided containing:
a chromium complex having formula 3
[Cr 3 O(carboxylate) 6 (ligand) 3 ] + ...
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7326725 |
Fungicidal composition based on at least one pyridylmethylbenzamide derivatives and at least on dithiocarbamate derivative
1) Fungicidal compositions comprising: a) at least one pyridylmethylbenzamide derivative of formula (I), in which the various radicals are as defined in the description, and b) at least one...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7323044 |
Biocidal compositions
The invention provides co-solvents for preparing clear solutions of a biocidal agent known as 10, 10′-oxybisphenoxarsine (OBPA). The clear solutions are stable over a relatively broad range of...
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7320786 |
Photodynamic therapy treatment for eye disease
This invention discloses methods, kits, and instructions to treat neovasculature diseases of the eye through the administration of a targeted photosensitizing agent and subsequent exposure to light...
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7297690 |
Fluorescent lanthadine complex
A luminescent lanthanide complex using a photo induced electron transfer as the luminescence controlling principle is presented. The complex comprises a substituted 2-quinolinol containing a sensor...
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7276494 |
Photosensitisers
A compound for use as a photosensitiser in PDT, in photochemical internalisation in the production of a cancer vaccine or in the diagnosis or detection of medical conditions, the compound having a...
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7267990 |
Chelation of charged and uncharged molecules with porphyrin-based compounds
Porphyrins containing one or more neutral or negatively-charged, closo- or nido-carborane substituents are useful as chelators. The carbon-carbon bonds linking the boron-containing groups to the...
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7265100 |
Separation of regioisomers of metal phthalocyanines
The present invention refers to a process for the separation of regioisomeric mixtures of metal phthalocyanines of formula (I), to the regioisomers obtained by this process, and their use as...
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7208180 |
Method and preparation for the preventing and/or treating vascular disorders and secondary disorders associated therewith
The present invention relates to a method for the prevention and/or treatment of vascular disorders and/or secondary disorders associated therewith, such as depression. The method according to the...
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7192650 |
Element having porphyrin polymer fixed on a substrate and method of preparing the same
A photo-functional molecule element having, on a substrate, a porphyrin polymer containing covalently-fixed porphyrin units, and the method of preparing the same. The photo-functional molecule...
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7189707 |
Substituted porphyrins
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby...
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7163703 |
Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
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7160873 |
Texaphyrin coordination compounds and uses thereof
Novel coordination polymers, their pharmaceutical formulations, useful for treating atheroma, tumors and other neoplastic tissue, as well as other conditions that are responsive to the induction of...
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7157421 |
Piracetam and piracetam analog conjugate and a pharmaceutical composition for treatment of neuronal disorders
A compound of the formula
where R 1 is H, C 1 –C 4 alkyl and OH; R 2 in is H, C 1 –C 4 alkyl and OH; R 3 is H and C 1 –C 4 alkyl; R 4 is H and C 1 –C 4 alkyl; n is an integer...
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7153841 |
Metal substituted non-centrosimmetrical phthalocyanine analogues, their preparation and use in photodynamic therapy and in vivo diagnostic
Phthalocyanine analogues having an active group able to link the phthalocyanine t carriers molecules and phthalocyanine to carriers molecules and phthalocyanine analogues as phthalocyanine-carrier...
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7147840 |
Oxo-bacteriopyropheophorbide-a carboxylic acid and esters thereof
A compound having the structural formula:
where R is H or lower alkyl of 1 through 12 carbon atoms. In general, the compounds of the invention are 13 2 -Oxo-bacteriopyropheophorbide—a...
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7144879 |
Substituted metal-phthalocyanines, their preparation and the use thereof
The present invention is directed to metal-phthalocyanines of general formula (I) to the corresponding conjugates, the processes for their preparation and use in the photodynamic therapy of...
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7141540 |
Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof
Amphiphilic biocompatible cyclodextrin grafted polymers comprising a hydrophobically modified cyclodextrin moiety, a linear linker and a biocompatible hydrophilic polymer backbone, wherein said...
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7138391 |
Hydrophilizable and hydrophilic cyanine dyes
The present invention provides an IR-absorbing dye of formula (I) or (II):
wherein
Q 1 , Q 2 , Q 3 and Q 4 are the same or different and are independently selected from a C 3-20 ...
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7135197 |
Stable pharmaceutical composition useful for treating gastrointestinal disorders
The present invention provides a pharmaceutical composition comprising at least one pharmaceutically acceptable bismuth-containing compound, at least one pharmaceutically acceptable...
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7125862 |
Porphyrin-metal complexes and oxygen infusions containing the same
A porphyrin metal complex that can form a stable oxygen complex and acts effectively as an oxygen infusion, which comprises:
a transition metal ion M of period 4 or 5 coordinating to a porphyrin...
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7122537 |
Cyclic salen-metal compounds as scavengers for oxygen radicals and useful as antioxidants in the treatment and prevention of diseases
This invention provides antioxidant cyclic salen-metal compounds, compositions of such antioxidant cyclic salen-metal compounds having superoxide activity, catalase activity and/or peroxidase...
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7112599 |
Oxazole compounds for the treatment of neurodegenerative disorders
The present invention relates to compounds of the Formula
wherein R 3 , R 5 , R 6 , R 7 , and Z, and other variables enumerated under one or more of R 3 , R 5 , R 6 , R 7 , and Z, are as...
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7109189 |
Mitochondrially targeted antioxidants
The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to a glutathione peroxidase mimetic. These compounds can be used to...
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7109188 |
Methods and compositions for treating atheroma, tumors and other neoplastic tissue
Injectible formulations comprising motexafin gadolinium are described herein.
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7101907 |
Topical administration of statins for treatment of bone disorders
The topical administration of statins for the treatment of bone disorders is disclosed.
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7094866 |
Covalently fixed porphyrin polymer having porphyrin metal complex substituted with coordinating hetero aromatic ring as constituting unit thereof,and method of producing the same
A covalently linked linear porphyrin polymer represented by formula (1):
wherein
R represents an alkyl group or
(wherein a, b and d independently represent H, an alkyl...
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7087214 |
Water-soluble porphyrin platinum compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases
The invention relates to novel, water-soluble porphyrin platinum compounds of the tetraarylporphyrin platinum derivatives type or of the hematoporphyrin platinum derivatives type with high tumor...
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7081472 |
Substituted bis-indole derivatives useful as contrast agents, pharmaceutical compositions containing them and intermediates for producing them
Metal-complexable substituted bis-indole derivatives comprising the structure shown in formula (I) hereunder: enantiomers and pharmaceutically acceptable salts thereof and metal complexes thereof,...
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7078059 |
Treatment of bone diseases
The invention provides a method for enhancing bone formation, inhibiting osteoclastic differentiation and/or activating osteoblastic differentiation whereby to manage, treat or achieve prophylaxis...
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7071158 |
Antioxidant enhancement of therapy for hyperproliferative conditions
A method to enhance the cytotoxic activity of an antineoplastic drug comprising administering an effective amount of the antineoplastic drug to a host exhibiting abnormal cell proliferation in...
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