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7618957 |
Perfluoroalkyl-containing complexes, process for their production as well as their use
The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with nitrogen-containing radicals of general formula I, process for...
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7615632 |
Crystalline forms of temozolomide
Disclosed are novel crystalline forms of Temozolomide, methods of preparation thereof, medicaments including the novel crystalline forms of Temozolomide, and uses thereof in the treatment of...
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7615548 |
Method to inhibit ischemia and reperfusion injury
Methods of treating or inhibiting ischemia and reperfusion injury are provided.
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7612082 |
Prostaglandin EP4 antagonists
Disclosed herein are methods and compositions related to compound 1 or compound 2
or pharmaceutically acceptable salts, or prodrugs thereof, which are antagonists of a prostaglandin EP 4 ...
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7612056 |
Substituted diaza-spiro-[4.5]-decane derivatives and their use as neurokinin antagonists
This invention concerns substituted diaza-spiro-[4.5]-decane derivatives having neurokinin antagonistic activity, in particular NK 1 antagonistic activity, a combined NK 1 /NK 2 antagonistic...
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7612055 |
Macrocyclic lactams and pharmaceutical use thereof
The present invention relates to novel macrocyclic compounds of the formula
wherein R 1 , R 2 , R 3 , U, V, W, X, Y, Z and n are as defined in the specification, the number of ring atoms...
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7612054 |
Dibenzo[b,f]oxepine-10-carboxamides and pharmaceutical uses thereof
The present invention pertains to novel dibenzo[b,f]oxepine-10-carboxamides compound to a process for the preparation of such compounds of formula I, their use as a pharmaceuticals, especially in...
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7608613 |
Analogs of benzoquinone-containing ansamycins and methods of use thereof
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present...
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7608612 |
Radiosensitizer formulations and methods for use
The present invention provides radiosensitizer compositions, in controlled-release formulations or other acceptable formulations, particularly nitrohistidine radiosensitizer compositions, which may...
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7608611 |
Hsp90 inhibitors, methods of making and uses therefor
The invention provides purified 18,21-didehydro-18,21-dideoxo-18,21-dihydroxy-geldanamycin derivatives, pharmaceutically acceptable salts thereof and prodrugs thereof that are potent Hsp90 binding...
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7601709 |
Macrocyclic hepatitis C serine protease inhibitors
The present invention relates to compounds of Formula I, II or Ill, or a pharmaceutically acceptable salt, ester, or prodrug, thereof:
wherein W is a substituted or unsubstituted heterocyclic...
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7598398 |
Acyl indoles, compositions containing such compounds and methods of use
The present invention relates to substituted indoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for...
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7598253 |
Reverse-turn mimetics and methods relating thereto
Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have...
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7595310 |
Glucuronate salt of a piperazine compound
The present invention provides a salt form, and compositions thereof, useful as a modulator of one or more GPCRs and which exhibits desirable characteristics for the same. The present invention...
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7592331 |
Macrocyclic factor VIIa inhibitors useful as anticoagulants
The present invention relates generally to novel macrocycles of Formula (I):
or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables...
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7592330 |
Methods and compositions for preserving the viability of photoreceptor cells
Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering a...
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7589083 |
Compounds and compositions to control abnormal cell growth
A class of compounds commonly containing a trialkylammonium group have been synthesized and characterized as anticancer compounds. A representative of this class,...
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7585839 |
Medical uses of intercellular communication facilitating compounds
Disclosed are novel peptides including antiarrhythmic peptides that have improved stability. Further disclosed are compositions that include such peptides and methods of using the compositions...
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7582664 |
Acylaminothiazole derivatives, preparation method thereof and use of same in therapeutics
The invention relates to a compound of formula (I):
Wherein R 1 , R 2 , R 2′ , R 3 , R 4 and R 5 are as defined herein. The invention also relates to the use of said compound in therapeutics.
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7579337 |
Analogs of benzoquinone-containing ansamycins and methods of use thereof
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present...
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7579336 |
Pharmaceutical composition comprising temozolomide ester
The present invention discloses general formula I of Temozolomide-8-carboxylate compounds, the process for preparation, pharmaceutical compositions comprising the compounds and the use of the...
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7579334 |
Compounds with anti-inflammatory activity
The present invention relates to new compounds represented by Formula I:
wherein M represents a macrolide subunit of the substructure II:
L represents the chain of the substructure III:
...
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7579324 |
Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
This invention features a compound of the following formula:
T-(-L-C) m ,
T...
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7576074 |
Receptor-type kinase modulators and methods of use
The present invention provides compounds for modulating receptor kinase activity, particularly ephrin and EGFR, and methods of treating diseases mediated by receptor kinase activity utilizing the...
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7576062 |
Compounds with growth hormone releasing properties
Disclosed are compounds of formula I
wherein R 1 , R 2 , R 5 , R 6 , R 7 , R 8 , G, J, L, M, a, b, c, d, e, and f are as defined in the specification, and compositions containing them. These...
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7572798 |
Combi-molecules having signal transduction inhibitory properties and DNA damaging properties
The present invention relates to a series of new chemical agents that demonstrate anti-tumor activity. More particularly, the present invention relates to molecules, referred to as...
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7566706 |
Analogs of benzoquinone-containing ansamycins and methods of use thereof
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present...
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7560449 |
Methods and therapeutic combinations for the treatment of demyelination
The present invention provides methods for treating demyelination and associated conditions by administering at least one sterol absorption inhibitor and compositions, therapeutic combinations and...
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7553832 |
Methods and compositions for specific inhibition of protein splicing by small molecules
The present invention relates to compositions (i.e., various organic small molecules as exemplified herein) and methods for the inhibition of protein splicing and especially relates to the...
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7553831 |
Compounds to treat Alzheimer's disease
The present invention is disubstituted amines of formula (I)
and disubstituted amines of formula (II)
useful in treating Alzheimer's disease and other similar diseases.
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7550597 |
Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor tyrosine kinase and/or Lck tyrosine kinase, to pharmaceutical compositions comprising...
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7547688 |
Methods for treatment of nocturia
A method for the treatment of nocturia which consists of administering to a mammal in need of such treatment a therapeutically effective amount of a nonsteroidal anti-inflammatory drug consisting...
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7544675 |
Chemical compounds with dual activity, processes for their preparation and pharmaceutical compositions
The present invention concerns chemical compounds combining affinity and antagonism against the human m3 muscarinic receptor with activity as selective phosphodiesterase IV (PDE IV) inhibitors,...
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7538114 |
Glycine transporter-1 inhibitors
The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition...
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7528124 |
1,3-dihydro-2H-indol-2-one derivative
A 1,3-dihydro-2H-indol-2-one derivative expressed by Formula 1 (wherein R 1 is a halogen atom, a C 1 to C 4 alkyl group, etc., and R 2 is a hydrogen atom, a halogen atom, etc., or R 2 is in...
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7524837 |
Benzotriazapinone salts and methods for using same
This invention relates to pharmaceutically acceptable salts of compounds of formula (I)
Such salts are useful, for example, for the treatment of gastrin related disorders.
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7514442 |
Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
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7511064 |
Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
The present invention relates to derivatives of 4-(Thio- or Selenoxanthene-9-ylidene)-piperidine or acridine and pharmaceutically acceptable salts thereof, use of these compounds as a medicament...
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7507817 |
Prostaglandin prodrugs
Novel compounds, and therapeutic methods, compositions and medicament related thereto are disclosed herein.
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7507727 |
Substituted quinobenzoxazine analogs and methods of using thereof
The present invention relates to quinobenzoxazines analogs having the general formula:
and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein V, A, X, Z, W, U and R 5 ...
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7507726 |
Peptide deformylase inhibitors
Novel PDF inhibitors and novel methods for their use are provided.
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7498460 |
Isophthalic acid derivatives
The present invention relates to isophthalic acid derivatives, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in...
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7498359 |
Composition and method for preventing recurrence of stroke
By using a composition for preventing onset and/or recurrence of stroke which contains ethyl icosapentate as its effective component, onset and/or recurrence of stroke is prevented, or in...
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7494986 |
Cycloalkylamine derivatives as NK-1/SSRI antagonists
The present disclosure relates to chemical compounds and their use in human therapy. A specific embodiment relates to compounds of Formula (I) or an isomer, a pharmaceutically acceptable salt or...
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7485631 |
Phorboxazole compounds and methods of their preparation
Novel macrolactone compounds, their methods of preparation, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments,...
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7485630 |
Neuroprotective macrocyclic compounds and methods for their use
Embodiments of this invention provide novel peptidomimetics that contain a macrocycle. Such compounds are neuroprotective and have utility as therapeutic agents for treatment of diseases, injuries...
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7482472 |
Substituted isoindoles and their use
The invention relates to coagulation of the blood. Disclosed are novel compounds of formula (I),
a method for the production of these compounds, pharmaceutical compositions containing them, and...
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7479498 |
Treatments for viral infections
The present invention relates to improved methods and compositions for treating viral infections and other diseases and conditions that induce a cytokine storm. More particularly, the present...
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7476767 |
Alpha-hydroxy sulfonate aldehydes, germicidal compositions containing the alpha-hydroxy sulfonate aldehydes, or mixtures of alpha-hydroxy sulfonate aldehydes and phthalaldehydes, and methods of using the compounds or compositions for disinfection or sterilization
Disclosed herein are α-Hydroxy sulfonate aldehydes and synthesis methods therefor. Germicidal compositions including the α-hydroxy sulfonate aldehydes, are also disclosed. In one aspect, a...
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7470715 |
Estrogen modulators
The present application is directed to a new class of isoxazoles and their use as estrogen modulators.
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