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6177415 |
Bacteriohopanetetrol and related compounds useful for modulation of lipoxygenase activity and anti-inflammatory applications
The arachidonic acid-metabolizing hopanoid tetrahydroxybacteriohopane (THBH) was isolated from Zymomonas mobilis and was found to inhibit soybean 15-lipoxygenase, and thus lipoxin biosynthesis,...
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6172056 |
Pharmaceutical compositions and method for prophylaxis and therapy of radical-mediated cell damage
The method of prophylaxis and therapy of radical-mediated cell damage includes administering an effective amount of at least one steroid and at least one pharmaceutical adjuvant to a human being....
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6172054 |
Combination therapy for lowering and controlling intraocular pressure
Angiostatic agents and another IOP lowering compound are combined in ophthalmic compositions to treat glaucoma and ocular hypertension. Methods for treating glaucoma and ocular hypertension are...
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6172088 |
Testosterone compounds and use for the protection of neurons
Androgens and their derivates and analogs, such as anabolic agents, are characterized by at least one substituent or substituent grouping with radical trapping properties. These compounds are used...
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6166002 |
Substituted phenylalkenoylguanidines, process for their preparation, and their use in medicaments and in diagnostics
Substituted phenylalkenoylguanidines, processes for their preparation, uses as medicaments or diagnostics, and medicaments containing them are described. The invention relates to substituted...
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6147069 |
Effects of 17α-dihydroequilenin on plasma lipid and lipoprotein, glucose, insulin concentrations, coronary artery vasomotor function, and reproductive organ and mammary gland proliferation in atherosclerotic mammals
The present invention relates to a method of using 17α-dihydroequilenin and metabolic conjugates thereof to prevent and reduce atherogenesis in males and females without causing endometrial...
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6147068 |
Lipophilic polyamine esters for the site specific delivery of nitric oxide in pharmaceutical use
A pharmaceutical composition of matter for delivering nitric oxide. The composition is an amine that was reacted with nitric oxide. The composition of matter is lipophilic and insoluble and...
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6146615 |
Contrast agents for image enhancement in magnetic resonance imaging
A compound of formula (I): ##STR1## wherein, R 1 , R 2 , R 3 and R 4 are selected independently from hydrogen, alkyl, and alkyl substituted with one or more --O-- atoms, or where R 1 , R 2 and R...
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6143736 |
Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
Methods, compositions, and compounds for modulating the GABA A receptor-chloride ionophore complex to alleviate stress, anxiety, seizures, mood disorders, PMS and PND and to induce anesthesia.
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6143738 |
Therapeutic uses for an aminosterol compound
A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG. 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically...
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6140316 |
Estrene steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions
The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human semiochemical, e.g. an Estrene steroid, or a pharmaceutical...
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6136800 |
17-Difluoromethylene-estratrienes
This invention describes the new 17-difluoromethylene-estratrienes of general formula I ##STR1## in which R 1 is a hydrogen atom or a C 1 -C 10 alkyl group, R 5 is a methyl or ethyl group,...
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6133251 |
Combination compound for contraception based on natural estrogen
The combination preparation for contraception includes a first stage of 2 to 4 first stage daily dosage portions, a second stage of two groups of second stage daily dosage portions, a third stage...
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6130213 |
Aqueous dispersion composition of lipid vesicles based on carbamates with a cholesteryl chain
The invention relates to a composition, in particular a cosmetic or dermatological composition, having an aqueous dispersion of vesicles with a lipid membrane, characterized in that the lipid...
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6117860 |
Steroids as neurochemical stimulators of the VNO to treat paroxistic tachycardia
The invention relates to a method of alleviating the symptoms of PMS and anxiety. The method comprises nasally administering a steroid which is a human vomeropherin, such that the vomeropherin...
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6110906 |
Androgen derivatives for use in the inhibition of sex steroid activity
Methods for treating sex steroid-dependent diseases by inhibiting sex steroid activity include administration of novel compounds which include an androgenic nucleus substituted at a ring carbon...
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6096731 |
Method for preventing tissue damage associated with graft-versus-host or host-versus-graft disease following transplantation
A method for preventing tissue damage associated with graft-versus-host disease in a patient having undergone hematopoietic cell transplantation, and host-versus-graft disease in a patient having...
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6093389 |
Methods and compositions for attracting and controlling termites
The present invention provides a composition for attracting termites containing a steroid derivative of formula I ##STR1## The present invention also provides a method for attracting or controlling...
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6087353 |
Phytosterol compositions and use thereof in foods, beverages, pharmaceuticals, nutraceuticals and the like
The present invention provides a esterified and subsequently hydrogenated phytosterol composition for use alone or for incorporation into foods, beverages, pharmaceuticals, nutraceuticals, and the...
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6083941 |
Inhibition of NMDA receptor activity by pregnenolone sulfate derivatives
The present invention relates to a method of inhibiting N-methyl-D-aspartate (NMDA) glutamate receptor-mediated ion channel activity (NMDA receptor activity), comprising contacting a neuronal cell...
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6083940 |
Method and composition for effecting contraception in a mammalian male
Novel antiandrogenic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R 1 through R 10 , a and b are as defined herein. Pharmaceutical...
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6080735 |
Estra-1,3,5(10)-trien derivatives, processes for their preparation and pharmaceutical compositions containing these compounds
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6077531 |
Estradiol and progesterone-based medicament
A medicament consisting of a biological medium-soluble capsule containing a micronised progesterone suspended in oil is disclosed, characterised in that the capsule also contains estradiol enclosed...
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6066627 |
Steroids as neurochemical initiators of change in human blood levels of LH
The invention relates to a method of altering the blood levels of LH or FSH in an individual. The method comprises nasally administering a steroid which is a human vomeropherin, such that the...
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6063776 |
Sitostanol formulation with emulsifier to reduce cholesterol absorption and method for preparing and use of same
Compositions useful to reduce cholesterol absorption. The compositions may be dosed in capsule or tablet form, or by adding either in liquid or dry powder form to foods and beverages. The...
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RE36701 |
Coronary heart disease treated with oestradiol
Use of 17β-oestradiol in the treatment of coronary heart disease.
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6060465 |
Bile acids and their derivatives as glycoregulatory agents
Compounds and methods are provided for regulating serum glucose levels in patients by non-parenteral administration of a pharmaceutical in which a primary active ingredient is a cholerically active...
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6046182 |
Steroid carbamates as potentiating agents
Novel potentiating steroid carbamates having the general formula (I) ST-OCONR 1 R 2 (I) wherein ST is a steroid or steroid derivative, of the structure (II)...
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6046186 |
Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
Novel compounds useful as inhibitors of estrone sulfatase are provided. The compounds have the structural formula (I) wherein r1 is an optional double bond, R 1 and R 2 are selected from the...
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6043236 |
Estrogens
Compounds of the formula I ##STR1## a process for their preparation, their use in the treatment of autoimmune disorders as well as new intermediates for their preparation.
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6028106 |
Treatment of urinary incontinence with nitric oxide synthase substrates and/or nitric oxide donors alone or in combination with estrogen or progesterone and/or other agents
The invention provides a method for the treatment and prevention of urinary incontinence in mammals, e.g., human males and females, especially nonpregnant female mammals, by administering a nitric...
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6025349 |
Phenyl.-substituted alkenylcarboguanidides carrying perfluoroalkyl groups, a process for their preparation, their use as a medicament or diagnostic agent, and also a medicament containing them
Phenyl-substituted alkenylcarboguanidides carrying perfluoroalkyl groups, a process for their preparation, their use as a medicament or diagnostic agent, and also a medicament containing them....
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6017906 |
Polyamine conjugates for treatment of infection
The present invention relates to methods of preventing or treating an infection or disease caused by an infectious agent. The present invention also relates to the augmentation of the efficacy of...
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6013642 |
Use of estrone derivatives as steroid sulphatase inhibitors
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6011025 |
11-(substituted phenyl)-estra-4,9-diene derivatives
The invention relates to a 11-(substituted phenyl)-estra-4,9-diene derivative of formula I ##STR1## wherein A, X, R 1 and R 2 are as defined by the specification. The compounds of the invention...
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6011027 |
Use of 19-nor-4-androstenediol to increase 19-nortestosterone levels in humans
This invention involves the administration of the 19-nortestosterone precursor 19-nor-4-androstenediol as a means of increasing 19-nortestosterone levels in humans.
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6011026 |
Method of treating menopause or perimenopause
A method of treating menopause or perimenopause without estrogenic activity at the uterine level in women comprising administering to women an amount of a steroid of the formula ##STR1## wherein...
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5998396 |
Oil solubilized solutions and foods containing phytosterols and process for their production
The present invention discloses oil solubilized solutions and foods containing phystosterols containing sitosterols with improved stability, for better absorption of those phytosterols into the...
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5994336 |
Method of inhibiting proliferation of cells by administering an aminosterol compound
A method of inhibiting the proliferation of a wide variety of cells is described. This method includes administering an effective amount of a compound having the following structure: ##STR1## or a...
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5994333 |
Pregnane and cholane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a pregnane or cholane steroid, or a...
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5990099 |
Angiostatic agents and methods and compositions for controlling ocular hypertension
Compositions of angiostatic agents for treating GLC1A glaucoma and methods for their use are disclosed.
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5990078 |
Means of increasing estrogen receptor levels in neural tissue
This invention provides a method of increasing the level of estrogen receptors in the neural tissue of a subject which comprises administering to the subject estrogen in an amount effective to...
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5980945 |
Sustained release drug formulations
A sustained release drug formulation including: a drug; a biodegradable polymer which is insoluble in water; and an oil vehicle in which both the drug and the polymer are dissolved. The oil vehicle...
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5980940 |
Pharmaceutical combination preparation for hormonal contraception
The invention provides a pharmaceutical combination preparation with two hormone components in a packaging unit and intended for time-sequential oral administration, comprising a number of daily...
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5977096 |
Steroids with radical-attracting aromatic substituents, process for the production thereof and pharmaceutical compounds containing the said substances
Novel substituted steroid compounds are disclosed which are more effective than known radical-trapping agents in methods of prophylaxis and therapy of radical-mediated cell damage and of treatment...
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5972923 |
Methods and compositions to enhance the cytoprotective effects of polycyclic phenolic compounds through the synergistic interaction with anti-oxidants
The present invention concerns methods and compositions for enhancing the cytoprotective effects of polycyclic phenolic compounds through the synergistic interaction with anti-oxidants.
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5968919 |
Hormone replacement therapy drug formulations for topical application to the skin
Topical alcoholic or aqueous alcoholic gels containing testosterone, progesterone, estradiol or other hormones have enhanced penetration through skin by including in the formulation...
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5965552 |
Androstane steroids as neurochemical initators of change in human hypothalamic compositions and methods
The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human semiochemical, e.g. an Androstane steroid, or a...
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5962466 |
Reduction of hair growth using inhibitors of matrix metalloproteinases
Mammalian hair growth is reduced by inhibiting the activity of a matrix metalloproteinase in the skin.
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5962443 |
19-nur-pregnane steroids as neurochemical initiators of change in human hypothalamic function
The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a 19-nor pregnane steroid, or a...
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