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6395723 |
Method of providing coginition enhancement with 5α-pregnan-3β-ol-20-one sulfate
This invention provides a method of providing progestational therapy to a mammal in need thereof which comprises administering a progestationally effective amount of a pharmaceutically acceptable...
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6391370 |
Micromilling plant sterols and emulsifiers
Plant sterols have been shown to be cholesterol-reducing agents in human serum. In the present invention, plant sterols, plant stanols, plant sterol esters and other non-toxic sterols are...
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6384025 |
Retinyl carbonate derivatives, preparation process and uses
The present invention relates to novel retinol derivatives having the formula (I): and to processes for preparing them. The invention also relates to the use of these compounds in or for the...
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6376482 |
Use of mesophase-stabilized compositions for delivery of cholesterol-reducing sterols and stanols in food products
Plant sterols and plant sterol esters have been shown to be cholesterol-reducing agents in human serum. In the present invention, plant sterols, plant stanols, plant sterol esters, and plant stanol...
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6372732 |
Use of delta5-androstene-3beta-ol-7, 17-dione in the treatment of lupus erythematosus
Lupus erythematosus can be treated by administering therapeutic amounts of delta-5-androstene-3-beta-ol-7,17-dione and its metabolizable precursors, which are not appreciably metabolized in vivo to...
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6369115 |
Stabilized powder formulations
A dry powder formulation for treatment of pulmonary conditions, via inhalation, includes an effective amount of formoterol or a salt or solvate thereof, in a dry powder form, an effective amount of...
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6362237 |
Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
This invention describes the use of at least one compound with a progesterone-antagonistic (PA) action and at least one compound with an antiestrogenic (AE) action, each in a...
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6358940 |
Modified 2-Alkoxyestradiol derivatives with prolonged pharmacological activity
Modified 2-alkoxyestradiol compounds wherein all hydrogens of the carbon next to the oxygen of the alkoxy moiety at position 2 are substituted with a halogen, alkyl or aromatic group, or a...
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6355630 |
Estra-1,3,5(10)-triene-7α-thioethers
This invention provides estrogens and antiestrogens of formula I having the structure wherein X, Y, Z, and R are as defined hereinbefore in the specification, or a pharmaceutically acceptable...
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6352716 |
Steroidal liposomes
Methods and compositions are described for the preparation of bioactive agents entrapped in lipid vesicles the bilayers of which comprise a salt form of an organic acid derivative of a sterol, such...
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6352970 |
Treatment of skeletal disorders
This invention relates to methods for treating bone loss in a mammal by administering to the mammal a therapeutically effective amount of leptin or a leptin mimetic. This invention also relates to...
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6352737 |
Use of nanoscale sterols and sterol esters
The invention relates to the use of nanoscale sterols and/or sterol esters with particle diameters of 10 to 300 nm as food additives and as active substances for the production of...
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6352980 |
Estrenes for inducting hypothalamic effects
The invention relates to estrene steroids, which bind to neuroepithelial receptors. The steroid is preferably administered in the form of a pharmaceutical composition containing one or more...
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6350769 |
Gaba alpha receptors mediate inhibition of T cell responses
The present invention provides new methods for modulating immune responses. The methods are based on the discovery that GABA A receptors are present on peripheral lymphocytes. Thus, GABA agonists...
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6350739 |
Methods of prevention and treatment of ischemic damage
The present invention in various embodiments provides methods of treating stroke and conferring protection on a population of cells associated with ischemia in a subject following an ischemic...
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6342489 |
Bile acid salts of metals with physiological action and the use thereof in therapy
Bile acid metal salts of therapeutic interest and pharmaceutical and veterinary composition containing same for the treatment of anemias and other conditions are described.
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6339079 |
Steroid sulfamates, method for the production and use thereof
A novel class of gonane type and D-homo-gonane type steroids having sulfatase-inhibiting and/or estrogenic activity is presented for application in the pharmaceutical industry. The number and...
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6333317 |
Regulation of amyloid precursor protein (APP) expression by administration of an estrogenic compound
It has been discovered that lipophilic hormones that interact with cytosolic or nuclear receptors regulate APP expression and synthesis, through modification of APP mRNA stability and/or regulation...
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6329354 |
Methods for the treatment of osteoporosis
Methods of treatment for osteoporosis in a human or other animal subject, comprising: administering a bone-active phosphonate to said subject, at a level of at least about 0.1 LED per day of said...
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6326050 |
Oil or fat composition containing phytosterol
An oil or fat composition comprising an oil or fat comprising 15 wt. % or more of a diacylglycerol and 1.2 to 20 wt. % of phytosterol, dissolved or dispersed in the fat and oil is provided here,...
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6326366 |
Hormone replacement therapy
The present invention relates to a hormone replacement therapy, and a composition useful therein, for women having reduced levels of endogenous estrogen. A mammalian estrogen and an isoflavone...
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6319914 |
Cytoprotective effect of polycyclic phenolic compounds
The invention comprises methods for conferring a cytoprotective effect on a population of cells, such as providing a polycyclic phenolic compound in a physiologically acceptable formulation, and...
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6316432 |
Antigestagenically active steroids with a flourinated 17 α-alkyl chain
This invention describes the new 17α-fluoroalkyl steroids of general formula I ##STR1## as well as their physiologically compatible salts with acids, and for --CO 2 R 9 radicals with R 9 ...
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6313180 |
Steroid compounds having contraceptive and anti-osteoporosis activity
The invention relates to a steroid compound having the formula (I) ##STR1## comprising a ring E, said ring sharing carbon atoms at position 16 and 17 with the five-membered ring D and being α with...
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6306838 |
Targeted vesicular constructs for cyto protection and treatment of h. pylori
A Novel Composition for targeted vesicular for treatment of H-Pylori infections and for protection of the cell is disclosed. The Composition Comprises Lectins, Phospholipids sterols an one or more...
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6303588 |
Therapeutic methods utilizing naturally derived bio-active complexes and delivery systems therefor
Methods are disclosed for correcting biological information transfer in a patient in need of such therapy which comprise administration to a patient of a composition comprising a therapeutically...
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6297229 |
Use of ursodeoxycholic acid to treat nonalcoholic steatohepatitis
A therapeutic method for the treatment of nonalcoholic steatohepatitis is provided, comprising administering to a patient in need of said treatment an effective amount of ursodeoxycholic acid or a...
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6288051 |
7 α-(5-methylaminopentyl)-estratrienes, process for their production, pharmaceutical preparations that contain these 7 α(5-methylaminopentyl)-estratrienes as well as their use for the production of pharmaceutical agents
This invention describes the new 7α-(5-methylaminopentyl)-estratrienes of general formula I ##STR1## in which R 2 stands for a hydrogen or fluorine atom, R 17 stands for a hydrogen atom, a...
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6274572 |
Pregnane derivatives with no alpha-17 substitutent, their medicinal use, manufacturing method and its intermediaries and related compounds
The subject of the invention is the products of formula (I): ##STR1## in which either R 1 represents halogen, hydroxyl, (C 1 -C 8 ) alkyloxy or (C 1 -C 12 ) acyloxy, and R 2 represents halogen...
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6271220 |
Anti-angiogenic agents
The application discloses methods of treating mammalian diseases characterized by undesirable angiogenesis by administering compounds including those having the general formulae ##STR1## wherein A...
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6267963 |
Plant sterol-emulsifier complexes
Plant sterols have been shown to be cholesterol-reducing agents in human serum. In the present invention, plant sterols, plant stanols, plant sterol esters and other non-toxic sterols are...
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6265393 |
Prevention of endometriosis signs or symptons
Methods and articles of manufacture are provided for the long-term prevention of clinical symptoms and signs produced by endometriosis. Such methods and articles of manufacture involve the...
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6258856 |
Method for preventing or controlling cataract
A method for preventing or treating pathological changes which occur in association with cataract formation in the mammalian eye by protecting lens cells against the cataractogenic effects of...
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6255299 |
Opthalmic gel composition and method of treating eye infections
An ophthalmic gel composition for human and veterinary use comprising 0.5-4% w/v of fusidic acid suspended in an aqueous vehicle containing 0.2-2% w/v of a polyanionic polymer.
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6251884 |
Sulfate conjugates of ursodeoxycholic acid, and their beneficial use in inflammatory disorders and other applications
One aspect of this invention is directed to a pharmacologically acceptable composition including a sulfate of 3 alpha, 7 beta-dihydroxy-5 beta-cholan-24-oic acid (Ursodeoxycholic acid or "UDCA")...
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6245756 |
Pharmaceutical preparations for treatment of estrogen deficiency in the central nervous system
Pharmaceutical preparations containing selected steroid compounds and methods of treating estrogen deficiency in the central nervous system (CNS) without influencing other organs or systems are...
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6239123 |
Use of estrogenic compounds as anti-fungal agents
The present invention provides compounds that are useful for inhibiting the proliferation of fungi. The compounds are estrogenic derivatives, such as 2ME2, or anti-estrogenic compounds. The...
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6239121 |
4- Halogenated steroids, preparation method and intermediates, application as medicines and pharmaceutical compositions containing same
A subject of the invention is the compounds of formula (I): ##STR1## in which X is a halogen atom, D represents the remainder of an optionally substituted pentagonal or hexagonal ring and...
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6228850 |
Antiangiogenic activity of betulinic acid and its derivatives
Use of betulinic acid and/or its derivatives for inhibiting and/or preventing angiogenesis is described. Compositions containing betulinic acid derivatives with or without betulinic acid can be...
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6225299 |
Hormonal agent for skin treatment
The pharmaceutical composition, especially for treating skin with seborrhea, Acne vulgaris and androgonically conditioned alopecia, contains a hormonal agent including the gestogen, dienogest, or a...
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6221857 |
Altering sex ratio of offspring in mammals
Methods of altering sex ratios in mammalian populations by treating pregnant female mammals (P generation) with hormones or anti-hormones are described. The sex ratio of the F1 generation born to...
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6207659 |
Effects of 17 α-dihydroequilenin on plasma lipid and lipoprotein, glucose, insulin concentrations, coronary artery vasomotor function, and reproductive organ and mammary gland proliferation in atherosclerotic mammals
The present invention relates to a method of using 17α-dihydroequilenin and metabolic conjugates thereof to prevent and reduce atherogenesis in males and females without causing endometrial...
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6207658 |
Preservation of tissue during removal storage and implantation
A method is provided for preserving tissues during removal, storage and implantation into a subject by enhancing cell viability in a population of graft cells during the transplantation procedure....
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6200966 |
Compositions for inhibiting airway wall inflammation
The invention relates to compositions which modulate airway remodelling comprisiing the sterioid 2-methyoxy-estradiol or analogues thereof, for administration by inhalation.
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6194393 |
Solution and solid-phase formation of glycosidic linkages
The invention relates to methods that permit the rapid construction of oligosaccharides and other glycoconjugates. Methods for forming multiple glycosidic linkages in solution in a single step are...
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6187750 |
Method of hormone treatment for patients with symptoms consistent with multiple sclerosis
A method for treating patients having symptoms consistent with multiple sclerosis comprising administering a regimen of doses of human growth hormone of less than 0.5 mg/day. In one aspect, the...
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6187756 |
Composition and methods for treatment of neurological disorders and neurodegenerative diseases
It has been discovered that the stimulation of β-adrenergic receptors, which activate cAMP formation, give rise to increased APP and GFAP synthesis in astrocytes. Hence, the in vitro or in vivo...
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6184215 |
Treatment of skin conditions with oxysterol activators of LXRα
Disorders of the skin and mucous membranes that have a disrupted or dysfunctional epidermal barrier are treated or prevented by topical application of compounds that are either activators of the...
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6177418 |
Tetracyclic triterpenes as cholesterol-lowering and anti-atherosclerosis agents
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6177417 |
Cholanic acid ring based 4-(trifluoroacetyl)phenyl derivatives, process for preparation and use thereof
The present invention relates to a cholanic acid ring based 4-(trifluoroacetyl)phenyl derivatives of the following formula 1, process for preparation and use thereof. The cholanic acid ring based...
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