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6967195 |
2-substituted pregna-1-3,5(10) triene and chola-1,3,5(10) triene derivatives and their biological activity
Compounds of formula (I) in which: R 1 represents a hydrogen atom or an O-protecting group; R 2 represents a hydroxyl, lower alkoxy, carboxaldehyde, lower alk-1-enyl or hydroxy- or lower...
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6964954 |
Use of DHEA derivatives on keratinous substances
Methods of improving the appearance of keratinous substances using at least one DHEA derivative such as the skin, hair, eyelashes and/or nails, in particular for preventing or treating cutaneous...
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6962909 |
Treatment of neovascularization disorders with squalimine
Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing...
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6958327 |
18 Norsteroids as selectively active estrogens
The invention relates to novel 18-norsteroids (gonatrienes) of general formula (I), wherein R 1 , R 2 , R 3 , R 6 , R 7 , R 8 , R 9 , R 11 , R 11′ , R 14 , R 15 , R 15′ , R 16 , R 17 and R...
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6956030 |
Use of mometasone furoate for treating upper airway diseases
The administration of aerosolize particles of mometasone furoate in the form of dry powders, solutions, or aqueous suspension for treating corticosteroid-responsive diseases of the surfaces of...
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6953785 |
Estra-1,3,5(10)-triene derivatives
Provided is steroid sulfatase inhibitors comprising, as the active ingredient, an estra-1,3,5(10)-triene derivative which is represented by formula (I):
{wherein R 1 and R 2 are the same or...
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6953586 |
Growth promoting pharmaceutical implant
A combination growth promoting pharmaceutical pellet system which delivers doses of both a growth stimulating pharmaceutical agent and a supplemental agent that enhances the growth produced by the...
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6949531 |
14 β, 16, 17-methylene steroids as novel androgens
Disclosed are androgenic steroids of the (14β,17α)-17-(hydroxymethyl) type. The invention relates to an improvement thereof, which is based on the presence of a β-oriented, annellated...
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6949523 |
Aglycon dammarane sapogenins, their use as anti-cancer agents, and a process for producing same
This invention relates to a group of novel sapogenins, their use in anti-cancer applications, and to a process for their production. More particularly, this invention pertains to a novel group of...
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6949533 |
6,7-Oxygenated steroids and uses related thereto
Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of...
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6949532 |
Use of mometasone furoate for treating airway passage and lung diseases
The administration of aerosolize particles of mometasone furoate in the form of dry powders, solutions, or aqueous suspension for treating corticosteroid-responsive diseases of the surfaces of...
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6936599 |
Estriol therapy for multiple sclerosis and other autoimmune diseases
The present invention discloses administering steroid hormones to mammals to treat autoimmune related diseases, more particularly, Th1-mediated (cell-mediated) autoimmune diseases including:...
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6927213 |
Cationic cholesteryl derivatives containing cyclic polar groups
The present invention discloses compounds which are cationic cholesteryl derivatives having a nitrogen-containing ring structure as their polar head group. These compounds are useful for delivering...
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6924274 |
Use of Δ5-androstene-3β-ol-7,17-dione in the treatment of lupus erythematosus
Lupus erythematosus can be treated by administering therapeutic amounts of Δ5-androstene-3β-ol-7,17-dione and metabolizable precursors thereof, such as Δ5-androstene-3b-acetoxy-7,17-dione, which...
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6924275 |
Aminophenol derivatives and their use in cosmetics
Use of at least one aminophenol derivative of formula (I) below:
in which:
R represents a hydrogen atom or a radical —COR 2 , wherein R 2 represents a saturated or unsaturated, linear,...
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6911438 |
Hormone replacement formulation
The formulation comprises a combination of three estrogens and selected amount of other elements. The three estrogens include 2-hydroxyestrone, 17-beta estradiol, and estriol. The amount of 17-beta...
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6906049 |
Contraceptive medicine based on a progestational agent and an oestrogen and preparation method
The present invention relates to the field of chemistry and more particularly to that of therapeutic chemistry. The invention relates more particularly to novel contraceptive compositions formed...
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6900193 |
Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
The present invention relates, inter alia, to compounds having the general formula:
in which: R 1 is a member selected from the group consisting of —OCH 3 , —SCH 3 , —N(CH 3 ) 2 ,...
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6894038 |
Use of biogenic estriol diester prodrugs for the treatment of autoimmune diseases
The invention relates to the use of esters of estriol, for example, an estriol 3,17-dipropionate or an estriol 3,17-dihexanoate, for the treatment of autoimmune diseases, such as multiple sclerosis...
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6884793 |
Combination preparation for contraception based on natural estrogens
The combination preparation for contraception includes from 2 to 4 first stage daily dosage portions each including an effective amount of at least one natural estrogen as sole active ingredient,...
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6881730 |
Steroid compounds with a c17-alkyl side chain and an aromatic a-ring for use in therapy
Compounds of Formula (I) in which: R 1 and R 2 , which may be the same or different, each represents a lower alkyl, alkenyl or alkynyl group; R 3 represents a methyl group having α- or...
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6881728 |
14-β, 17-α-hydroxymethylandrostane derivatives as androgens
Androgenic steroids having a (14β,17α-)-17-(hydroxymetheyl) configuration, useful for the preparation of male contraceptives and pharmaceutical formulations for the treatment of androgen...
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6878699 |
Taccalonolide microtubule stabilizing agents
In accordance with the present invention, there have been identified extracts from a tropical plant that initiate paclitaxel-like microtubule bundling. Bioassay-directed purification yields the...
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6875758 |
Method of treating hyperlipidemic and hyperglycemic conditions in mammals using pregnadienols and pregnadienones
The invention provides a method of using pregnadienones and pregnadienols represented by the structural formula (I) as shown herein below
Wherein X═OH or O or combination thereof and...
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6852710 |
2-alkoxyestradiol analogs with antiproliferative and antimitotic activity
The application discloses novel 2-alkoxyestradiol analogs which exhibit anti-proliferative properties, and methods of making and using such compounds to inhibit undesired cell proliferation and...
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6849616 |
Methods to potentiate intravenous estramustine phosphate
Estramustine phosphate is an anti-mitotic chemotherapeutic drug with proven efficacy against cancer. The invention describes methods which potentiate the therapeutic benefit of intravenous...
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6844334 |
(3) and (6) substitued estrogenic compounds
Novel estrogenic compounds of Formula I are provided.
wherein the bond represented by the wavy line may be a single or double bond such that when the wavy line is a single bond, R 1 is...
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6844320 |
Treatment of preeclampsia, toxemia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor
Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both,...
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6841548 |
Pharmaceutical preparations containing estra-1,3,5(10)-triene derivatives
The invention concerns pharmaceutical preparations containing estra-1,3,5(10)-triene derivatives as active ingredients which carry a group of the general formula
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6831073 |
Hormonal composition consisting of an oestrogen compound and of a progestational compound
A method of treating estrogenic deficiencies in women while further avoiding the appearance of osteoporosis, withdrawal bleeding and cardiovascular diseases in post-menopausal women without any...
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6821961 |
Monounsaturated fatty acids of at least 20 carbon atoms and perhydrocyclopentanophenanthrene nucleus combination molecules and their use as weight-loss agents
The pharmaceutical and/or cosmetic compositions for treatment of obesity and/or overweight contain an effective amount of a fatty-acid monoester of an estrogen and a fatty acid wherein the estrogen...
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6806263 |
Antigestagenically active steroids with a fluorinated 17-alpha-alkyl chain
17α-fluoroalkyl steroids of formula I as well as their physiologically compatible salts with acids and for —CO 2 R 9 radicals with R 9 meaning hydrogen, as well their physiologically...
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6797282 |
Combination progestin oral contraceptive regimen
An oral contraception regimen which comprises sequentially administering two or more progestational agents exhibiting different effects on the human endometrium in combination with an estrogen. The...
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6794375 |
Palatable arginine compounds and uses thereof for cardiovascular health
The present invention is directed to a compound having the structure (I): and acceptable salts, polypeptides, and pro-forms thereof, wherein R is selected from the group consisting of: (a)...
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6790843 |
C-19-halogen-substituted steroids of the androst-9(11)-ene-series, methods for the production and use thereof
The invention relates to new C-19-halogen-substituted steroids of the androst-9(11)-ene series, namely 17β-hydroxy-19-halogen-androsta-4,9(11)-dien-3-ones of general formula (I) and process for...
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6790463 |
Uses of targeted oxidative therapeutic formulation in arteriosclerosis
The use of a pharmaceutical formulation in treating coronary arteriosclerosis and a two-component pharmaceutical formulation. The pharmaceutical formulation contains peroxidic species or reaction...
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6790842 |
11β LONG-CHAIN SUBSTITUTED ESTRATRIENES, METHOD FOR THEIR PRODUCTION, PHARMACEUTICAL PREPARATIONS CONTAINING SAID 11β LONG-CHAIN SUBSTITUTED ESTATRIENES, AND THEIR USE FOR PRODUCING MEDICAMENTS
This invention describes a 11β-long-chain-substituted estratriene of general formula (I), in which R 11 is a long-chain radical that has a nitrogen atom and optionally a sulfur atom, which in...
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6784170 |
Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one
Syntheses of steroids such as 3-hydroxy-7α-methyl-21-[2′-methoxy-4′-(diethylaminometh
yl)-phenoxy]-19-norpregna-1,3,5(10)triene citrate (“SR 16234”) and analogs thereof are provided,...
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6780854 |
Orally active androgens
Novel, orally active androgens are 7α-substituted Δ 14 -nandrolone derivatives. The compounds satisfy the general formula: wherein R 1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C 1-6...
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6780855 |
11β-HALOGEN-7α-SUBSTITUTED ESTRATRIENES, PROCESS FOR THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS THAT CONTAIN THESE 11β-HALOGEN-7α-SUBSTITUTED ESTRATRIENES AS WELL AS THEIR USE FOR THE PRODUCTION OF PHARMACEUTICAL AGENTS
This invention describes the new 11β-halogen-7α-substituted estratrienes of general formula I in which R 11 is a fluorine or chlorine atom, and the other substituents have the meanings that...
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6777389 |
Cosmetic or dermatological use of 7-hydroxylated steroids in combination with elastin derived peptides
The present invention is directed to a composition and method for enhancing the appearance of skin or tissue. The invention is preferably a combination of elastin-derived peptides and steroidal...
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6777200 |
Kinesin motor modulators derived from the marine sponge Adocia
This invention provides novel compounds derived from a marine sponge, Adocia sp., that specifically modulat kinesin activity by targeting the kinesin motor domain and mimicking the activity a...
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6767904 |
Steroid derived antibiotics
A series of novel steroid derivatives are described. The steroid derivatives are antibacterial agents. The steroid derivatives also act to sensitize bacteria to other antibiotics including...
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6767903 |
New7α, 17α-bis-alkylated testosterone derivatives and their use in long-term therapy of androgen-dependent diseases
The invention relates to new 7α, 17α, 17β-substituted testosterone derivatives of general formula (I) and their use as pure antiandrogens for the long-term therapy of androgen-dependent...
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6759408 |
Combination regimens using progesterone receptor modulators
This invention relates to cyclic combination therapies and regimens utilizing substituted indoline derivative compounds which are antagonists of the progesterone receptor having the general...
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6759400 |
Meiosis regulating compounds
Certain compounds, structurally related to natural compounds which can be extracted i.a. from bull testes and from human follicular fluid, can be used for regulating the meiosis in oocytes and in...
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6759399 |
Use of antimineralocorticoid compounds against narcotic withdrawal syndrome
The method of treating narcotic withdrawal symptoms in warm-blooded animals comprising administering to warm-blooded animals in need thereof an amount of a compound having anti-mineralocorticoid...
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6756366 |
Orally active androgens
Orally Active androgens are derivative of 7α-methyl-19-nortestosterone. The compounds satisfy formula (I) wherein R 1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C 1-6 )alkyl, or (C 1-6...
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6753326 |
14, 15-.α.-methylene equilenine derivatives, methods for producing the same and medicaments containing them
Described are novel equilenin derivatives of general formula I methods for producing the same and medicaments containing these compounds. The new compounds have antioxidative activity and are...
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6747018 |
Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
Novel anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependent disorders. Preferred compounds have a 1,3,5-estratriene nucleus, and...
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