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5122520 |
Acid addition salts of amidated taurine or glycine, their preparation and use
Acid addition salt of taurine or glycine, their amino group being amidated with a carboxylic acid residue which contains the structure of a 3α, 7α, 12α-trihydroxysteroid, their acid group being...
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5118671 |
Complexes of aescin, β-sitosterol or cholesterol, and phospholipids and pharmaceutical compositions containing them
Complexes formed between aescin, cholesterol or β-sitosterol and phospholipids are described. The molar ratio of phospholipids to aescin/β-sitosterol or cholesterol is from 0.5 to 2. The...
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5116830 |
Stereoisomerically pure 17α-ethynyl-estra-2-en-17β-ol and the 17β esters thereof, methods of preparation and uses
This invention relates to a stereoisomerically pure Δ 2 compound of the formula (I): ##STR1## wherein: R 1 is hydrogen or --(CO)--R 2 , wherein: R 2 is an organic substituent selected...
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5096898 |
Bile acid unsaturated derivatives and pharmaceutical compositions containing them
Bile acid derivatives of formula I ##STR1## wherein: R is hydrogen or hydroxy; X is a carboxy or a SO 3 H group, have valuable pharmacologic properties.
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5089482 |
Pharmaceutical compositions for nasal administration containing steroid hormones and dimethyl-β-cyclodextrin
Pharmaceutical compositions having a formulation and form suitable for nasal administration, and containing 17β-estradiol and/or progesterone. According to the invention, the composition also...
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5084450 |
Novel steroids
Compounds of the formula ##STR1## wherein X is O or ##STR2## R is hydrogen or acyl of an organic carboxylic acid of 1 to 12 carbon atoms, the wavy lines indicate the α- or β-position, the...
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5082663 |
External adhesive preparation containing steroids
An external adhesive preparation comprising a steroid for treatment of skin diseases in admixture with an adhesive gel base comprising as essential components a water-soluble high molecular weight...
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5079239 |
Sterol disulfates and methods of use
Novel sterol disulfates have been isolated from the marine sponge Petrosia weinbergii. These compounds, and derivatives thereof, are useful antiviral compounds. One of these compounds is active...
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5079265 |
Composition and methods for providing optimum bioavailability of the active ingredient 2-hydroxy-5-methyllaurophenoxime (HMLO)
Improved bioavailability, particularly when the drug is administered orally, of the active ingredient 2-hydroxy-5-methyllaurophenoxime (HMLO) of a pharmaceutical preparation is achieved by...
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5079240 |
Synthetic conjugated bile acid and method of use thereof
A method is described for the replacement of bile acid in the biliary tract during conditions of bile acid deficiency which comprises administering an effective amount of a synthetic bile acid...
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5064822 |
Novel 3-keto-19-nor-Δ.sup.4,9 -steroids
Novel 3-keto-19-nor-Δ 4 ,9 -steroids of the formula ##STR1## wherein R 1 is selected from the group consisting of naphthyl, phenylphenyl, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon...
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5061700 |
Glyceryl acetate ointment vehicles
Compositions of matter serving as topical ointment vehicles and comprising a glyceryl acetate, preferably triacetin, and an oleaginous material that can be combined with a medicament, preferably a...
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5053406 |
Compositions and methods for preventing and treating rotaviral infections
Compositions useful in the prevention and treatment of rotaviral infections are disclosed. The subject compositions contain cholesterol 3-sulfate or functional derivatives thereof. Cholesterol...
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5053229 |
Cosmetic compositions
Novel cosmetic compositions comprising a lipid derived from horny cells can enhance a moisture retention ability of the horny layer and are useful for remedy of dry skin. When the lipid is used in...
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5051261 |
Method for preparing a solid sustained release form of a functionally active composition
The invention is a sustained release dosage or delivery form, such as a tablet, pill, granule or the like capable of providing sustained release of a functionally active ingredient and the method...
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5047244 |
Mucoadhesive carrier for delivery of therapeutical agent
A mucoadhesive carried suitable for a therapeutic agent is disclosed. This carrier allows controlled release of the therapeutic agent via mucosal tissue. The mucoadhesive carrier comprises a...
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5043329 |
Methods and compositions employing unique mixtures of polar and neutral lipids for protecting the gastrointestinal tract
Disclosed are compositions composed of unique mixtures of phospholipids and neutral lipids and methods of employing such compositions to treat the luminal lining of the gastrointestinal tract in...
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5041433 |
11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5-α-reductase
Invented are carboxyl and carboxyl alkyl ester substituted 11-keto and hydroxy analogues of synthetic steroidal compounds, pharmaceutical compositions containing these compounds, and methods of...
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5041432 |
Steroid derivatives useful as hypocholesterolemics
Lanosterols substituted in the 14 and/or 15 position(s) which are active in inhibiting lanosta-8,24-dien-3β-ol 14α-methyl-demethylase activity, suppressing 3-hydroxy-3-methylglutaryl coenzyme A...
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5036062 |
Novel esters
The present invention concerns novel compounds having the general formula ##STR1## wherein R 1 , R 2 and R 3 are selected form the group consisting of hydrogen or lower alkyl having 1-4 carbon...
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5032586 |
7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase
Invented are carboxyl and carboxyl alkyl ester substituted 7-keto and hydroxy analogues of synthetic steroidal compounds, pharmaceutical compositions containing these compounds, and methods of...
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5030627 |
Δ.sup.4 -19-sulfur substituted-androstene derivatives having aromatase-inhibiting activity
The invention relates to Δ 4 -androstene derivatives with aromatase-inhibiting activity having the formula: ##STR1## wherein R 1 =O, (αR 5 ,βH) or N--O--R 6 ; R 2 =H, (1-12C)hydrocarbon...
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5028600 |
Novel pharmaceutical composition
A composition for intravenous administration of 3-alpha-hydroxy-5-beta-pregnan-20-one (pregnanolone), comprising a stable oil-in-water emulsion, capable of being sterilized by autoclaving, of from...
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5026692 |
Use of sex hormone
Method of treatment of immunodeficiency disease which comprises administering therapeutically effective amount of sex hormone to a subject in need of such treatment.
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5023249 |
Fertility drug and method of producing the same
A fertility drug is made from an effective component comprising ferulyl stanol derivative represented by the following formula (I) and/or phytosterol fatty acid ester represented by the following...
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5017568 |
Steriod 5-alpha-reductase inhibitors
Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid...
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5006340 |
Curable compositions for dental drugs having sustained release property
A crude drug ingredient having bactericidal activity incorporated into a curable composition comprising a (meth)acrylate type monomer, a polymerization initiator and if necessary a filler to...
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5004737 |
Quaternary ammonium-substituted sterol derivatives
The present invention relates to a novel quaternary ammonium-substituted sterol derivative of the following formula: ##STR1## wherein Q represents an anion of a strong inorganic acid, A represents...
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5002936 |
Lipophilic complexes of pharmacologically active inorganic mineral acid esters of organic compounds
The present invention provides a composition with the structure (L) m (E) n wherein (L) m and (E) n are bound as a complex, wherein L is a lipophilic compound; wherein E is a nonlipophilic,...
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5001116 |
Inhibition of angiogenesis
Angiogenesis in mammals is inhibited by administration of the active agents (1) heparin or a heparin fragment which is a hexasaccharide or larger or analogous compounds and (2) a steroid having...
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4999348 |
Liquid crystal containing cosmetic and pharmaceutical compositions and methods for utilizing such compositions
Cosmetic and pharmaceutical compositions and methods comprising delivery systems for the controlled release and enhanced penetration of biologically active materials (e.g., Vitamin A) to the skin....
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4997826 |
Tetrahydrocortisol in glaucoma therapy
Pharmaceutical compositions comprising tetrahydrocortisol and method of using same in the control of intraocular pressure are disclosed.
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4994267 |
Transdermal acrylic multipolymer drug delivery system
A dermal composition comprising a drug, a multipolymer of ethylene-vinyl acetate, an acrylic polymer, and optionally one or more monomers, a natural or synthetic rubber and a tackifying agent. The...
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4977147 |
17-methylene- and 17-ethylidene-estratrienes
A pharmaceutical preparation for treating menopausal symptoms, estrogen deficiency and hormone-dependent tumors, and for use as a contraceptive, comprises a compound of formula I ##STR1## wherein R...
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4970205 |
Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase
Invented are sulfonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid...
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4966897 |
4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
This invention is directed to 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ols and related compounds and also to a method for using such compounds in the treatment of androgen-dependent...
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4966898 |
4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C.sub.17-20 lyase inhibitors
This invention is directed to 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds and also to a method for using such compounds in the treatment of androgen-dependent...
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4961922 |
Complexes based on anthralin and a sterol, a process for obtaining them and their use in therapeutics and cosmetics
A complex based on anthralin and a sterol, characterized in that its melting point is 10 to 25 degrees Celsius lower than that of the constituent of the complex melting at the lowest temperature...
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4957910 |
Method and composition for the treatment and prevention of viral infections
A method is provided for treating a viral infection in a subject by administering a surfactant and/or a steroid so as to produce a high concentration thereof in the systemic circulation. The method...
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4954488 |
Method of treating hyperaldosteronism using 17β-cyclopropylaminoandrostene derivatives
The present invention is directed to a method for the treatment of hyperaldosteronism and related disorders which comprises administering to an appropriate patient an appropriate...
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4942158 |
Transdermal steroid penetrant compositions and methods utilizing isopropanol and isobutanol
A unique combination of isopropyl and isobutyl alcohols synergistically increases the permeability of the skin to steroid drugs.
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4940586 |
Skin permeation enhancer compositions using sucrose esters
A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture...
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4939134 |
26-aminocholesterol and derivatives and analogs thereof in the regulation of cholesterol accumulation in body tissue
This invention relates to cholesterol synthesis and to the accumulation and regulation of cholesterol levels in body tissue. More specifically, the invention provides that the compound...
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4937238 |
Prevention of mammary carcinoma
To reduce the risk of breast cancer, a drug is periodically administered to young mammals before pregnancy in doses of about 1 microgram to 50 micrograms per kilogram of body weight. The drug: (1)...
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4937262 |
Platinum derivatives and cancer treatments
Derivatives of platinum group metals, particularly platinum itself, wherein the metal is linked to one or more pharmaceutically acceptable steroid, fatty acid or other lipophilic residues aiding...
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4923640 |
Process for the production of 17α-ethinyl-17β-hydroxy-18-methyl-4,15-estradien-3-one and new intermediate products for this process
A process for the production of 17α-ethinyl-17β-hydroxy-18-methyl-4,15-estradien-3-one is described comprising reacting a 17-enolester of formula II ##STR1## wherein R 1 represents an alkyl...
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4921848 |
Biliary acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
Compounds of formula I ##STR1## wherein: R 1 is hydrogen or hydroxy, and the methyl and hydroxy groups at 6- and 7-positions respectively can be either in α or β configuration, are useful in...
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4921849 |
Injection containing 3-benzoyloxy-1,3,5(10)-estratriene-17-[4-{p-(bis(2-chloroethyl)amino)phe nyl}butanoyloxy)acetate as an active ingredient
Disclosed herein is an injection containing 3-benzoyloxy-1,3,5(10)-estratriene-17-[4-{p-bis(2-chloroethy
l)amino)phenyl }butanoyloxy]acetate, which has been known as an orally administrable...
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4917898 |
Pharmaceutical compositions for the prophylaxis and therapy of calculosis of biliary tract and of biliary dyspepsia
Pharmaceutical compositions for the prophylaxis and therapy of biliary tract calculosis and of biliary dyspepsia, containing as the active principle taurohyodeoxycholic acid, are herein described.
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4912097 |
Novel 11 β-alkynylphenyl-10-nor-steroids
Novel 11β-alkynylphenyl-19-nor-steroids of the formula ##STR1## wherein R 1 is alkynyl of 2 to 8 carbon atoms optionally substituted with at least one member of the group consisting of --OH...
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