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7579335 |
Androstane 17α-carbonate derivatives for use in the treatment of allergic and inflammatory conditions
The present invention is directed to compounds of formula (I):
wherein
R 1 represents C 4 -C 7 branched alkyl group, a bicycloalkyl group, or a C 5 -C 6 cycloalkyl which optionally may be...
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7498321 |
17β-carbothioate 17α-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents
There are provided according to the invention compounds of formula (I) wherein R 1 represents C 1-6 alkyl or C 1-6 haloalkyl; R 2 represents —C(═O)-aryl or —C(═O)-heteroaryl; R 3 ...
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7479486 |
Sulphur analogues of 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) for treating excess of glucocorticoids
The present invention is related to novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues, their use as antiglucocorticoids for the treatment and/or prophylaxis of disease associated to an...
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7468362 |
Carbonate and carbamate modified forms of glucocorticoids in combination with β2 adrenergic agonists
Compositions containing β 2 adrenergic agonists in combination with carbonates and carbonates of the formula
and in combination with related steroid carbonates and carbonates are disclosed....
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7456161 |
Use of DHEA and DHEA-sulfate for the treatment of chronic obstructive pulmonary disease
A method for treating or preventing chronic obstructive pulmonary disease (COPD) by using as active agent a non-glucorticoid steroid, analogue thereof, such as dehydroepiandrosterone (DHEA) and...
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7390796 |
Fatty acid modified forms of glucocorticoids
Compounds are disclosed of the formula
in which R 3 is C 8 to C 24 hydrocarbon or the residue of misoprostol. The compounds are useful for treating rhinitis and asthma, particularly by...
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7378405 |
Stabilized steroid composition and method for its preparation
Stabilized 17-substituted hydrocortisone containing compositions and methods of manufacture. Isomerization of the hydrocortisone component of topical steroid compositions is markedly reduced by...
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7335650 |
Composition
There is provided a pharmaceutical composition comprising (i) a compound of the formula
wherein: X is a hydrocarbyl ring having at least 4 atoms in the ring; K is a hydrocarbyl group; Rs is a...
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7291609 |
Specific glucocorticosteroid compound having anti-inflammatory activity
A compound of formula (I):
or a physiologically acceptable solvate thereof.
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7291608 |
Anti-inflammatory 17.β.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.α
There are provided compounds of formula (I)
wherein the variables are as defined by the present specification; and solvates thereof, processes for preparing them and their use in therapy.
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7253155 |
Combinations for the treatment of immunoinflammatory disorders
The invention features a method for treating a patient having an immunoinflammatory disorder, by administering to the patient (i) a tetra-substituted pyrimidopyrimidine, and (ii) a corticosteroid...
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7217422 |
Compositions and methods for enhancing corticosteroid delivery
The present invention comprises a composition, method of enhancing potency and method of delivering corticosteroids in a vehicle comprising at least two penetration enhancers, and solvents and...
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7208485 |
Crystalline forms of halobetasol propionate
The present invention provides a crystalline halobetasol propionate selected from the group consisting of halobetasol propionate having crystalline Form I characterized by power X-ray diffraction...
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7186708 |
Steroidal compounds
Steroidal compounds or their salts having general formula:
A—B—C—NO 2
...
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7163934 |
Methods for treating delirium glucocorticoid receptor-specific antagonists
This invention generally pertains to the field of psychiatry. In particular, this invention pertains to the discovery that agents which inhibit the binding of cortisol to its receptors can be used...
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7101693 |
Plasticized hydrophilic glasses for improved stabilization of biological agents
The stabilization of biomaterials such as proteins in a nominally dry, hydrophilic glassy matrix is vastly improved by the addition of an appropriate amount of a small-molecule pasticizer such as a...
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7074388 |
Water stabilized medicinal aerosol formulation
This invention relates to a medicinal aerosol suspension formulation and more particularly, to a medicinal aerosol formulation containing a particulate drug or a combination of at least two...
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7045513 |
DHEA composition and method
Disclosed are improved pharmaceutical formulations comprising dehydroepiandrosterone (DHEA), enriched in selected polymorphic forms, for therapeutic applications. In one embodiment, the formulation...
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6979454 |
Biologically active composition
A biologically active stick composition comprising a biologically active agent dissolved in a carrier system including an unsaturated fatty acid alcohol in mutual dissolution with an alkylene...
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6921757 |
Organic compounds
Compounds of formula (I), where R is a monovalent cyclic organic group having from 3 to 15 atoms in the ring system, useful as pharmaceuticals
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6852710 |
2-alkoxyestradiol analogs with antiproliferative and antimitotic activity
The application discloses novel 2-alkoxyestradiol analogs which exhibit anti-proliferative properties, and methods of making and using such compounds to inhibit undesired cell proliferation and...
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6844320 |
Treatment of preeclampsia, toxemia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor
Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both,...
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6835724 |
Corticoid 17,21-dicarboxylic esters and corticosteroid 17-carboxylic ester 21-carbonic esters, processes for their preparation and pharmaceuticals containing these compounds
Corticoid 17,21-dicarboxylic esters and corticosteroid 17-carboxylic ester 21-carbonic esters, processes for their preparation and pharmaceuticals containing these compounds Corticoid...
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6762175 |
Fatty acid derivatives
The properties of biologically active compounds, for example drugs and agrochemicals, which contain in their molecular structure one or more functional groups selected from alcohol, ether, phenyl,...
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6759399 |
Use of antimineralocorticoid compounds against narcotic withdrawal syndrome
The method of treating narcotic withdrawal symptoms in warm-blooded animals comprising administering to warm-blooded animals in need thereof an amount of a compound having anti-mineralocorticoid...
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6680310 |
Methods for preventing antipsychotic-induced weight gain
This invention generally pertains to the field of psychiatry. In particular, this invention pertains to the discovery that agents capable of inhibiting the binding of cortisol to its receptors can...
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6677326 |
Corticosteroid formulation comprising less than 2.5 mg prednisolone for once daily administration
The subject invention concerns a unit dose formulation comprising less than 2.5 mg of prednisolone or an equivalent, equipotent amount of another corticosteroid. One embodiment of a method of the...
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6656970 |
Method and compositions for solubilization of pentacyclic triterpenes
The present invention provides compositions and methods for the solubilization of poorly soluble drugs such as triterpenes like betulinic acid and/its derivatives in pharmaceutically acceptable...
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6641800 |
Pressurized aerosol compositions comprising powdered medicament dispersed in hydrofluoroalkane
Pressurized aerosol composition for administration by inhalation comprising a liquefied hydrofluoroalkane, a powdered medicament dispersed therein, and a suspending agent comprising a polymer...
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6488960 |
Corticosteroid formulation
The present invention pertains to a unit dose formulation comprising 0.25 to 2 mg of a corticosteroid. This small dose can be used to treat rheumatoid arthritis, especially if adapted to release at...
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6451287 |
Fluorinated copolymer surfactants and use thereof in aerosol compositions
Amphiphilic fluorinated block copolymers are disclosed which are useful for increasing the dispersability of particles, preferably drug particles, in a fluorine-containing propellant.
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6444660 |
Lipid soluble steroid prodrugs
The present invention is directed to novel lipid soluble steroid prodrugs, compositions comprising steroid prodrugs, and uses of the same.
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6436368 |
Process for preparing beclomethasone dipropionate freon® clathrate
Described is a process for preparing beclomethsaone dipropionate Freon® clathrate comprising the use of an agent which selectively binds methanol to selectively remove methanol from a mixture of...
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6426339 |
Formulations and methods for providing prolonged local anesthesia
The use of glucocorticosteroids in methods and formulations for prolonging and/or reactivating local anesthesia or local anesthesia previously induced by a local anesthetic agent, is disclosed.
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6395746 |
Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
Methods of treating or preventing ophthalmic, otic, and nasal infections and attendant inflammation are described. The methods utilize ophthalmic, otic, and nasal compositions containing a new...
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6369115 |
Stabilized powder formulations
A dry powder formulation for treatment of pulmonary conditions, via inhalation, includes an effective amount of formoterol or a salt or solvate thereof, in a dry powder form, an effective amount of...
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6350739 |
Methods of prevention and treatment of ischemic damage
The present invention in various embodiments provides methods of treating stroke and conferring protection on a population of cells associated with ischemia in a subject following an ischemic...
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6344448 |
Composition for the treatment of hair loss
A method and compound having betamethasone dipropionate and all-trans-retinoic is disclosed for the treatment of hair loss. The method also includes identifying any underlying conditions causing...
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6319914 |
Cytoprotective effect of polycyclic phenolic compounds
The invention comprises methods for conferring a cytoprotective effect on a population of cells, such as providing a polycyclic phenolic compound in a physiologically acceptable formulation, and...
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6319901 |
Methods for prolonging cell membrane permeability
Methods for improving the efficiency of electroporation protocols as well as methods to enhance the permeabilized state, in order to improve the intracellular delivery of therapeutic substances,...
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6241969 |
Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
The present invention provides compositions containing corticosteroid compounds as active agents for the treatment of ailments and diseases of the respiratory tract, particularly the lungs, by way...
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6228850 |
Antiangiogenic activity of betulinic acid and its derivatives
Use of betulinic acid and/or its derivatives for inhibiting and/or preventing angiogenesis is described. Compositions containing betulinic acid derivatives with or without betulinic acid can be...
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6225297 |
Combination contraceptive
This invention relates to a combination product that consists of individual dosage units of a competitive progesterone antagonist and, in addition, sequentially provided individual dosage units of...
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6218435 |
Reduction of hair growth
A method of reducing hair growth in a mammal includes applying, to an area of skin from which reduced hair growth is desired, a dermatologically acceptable composition containing a suppressor of...
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6204245 |
Treatment of narcolepsy with immunosuppressants
The invention provides compositions and methods for treatment of narcolepsy or isolated cataplexy. Such methods entail administering a therapeutically effective regime of at least one...
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6172054 |
Combination therapy for lowering and controlling intraocular pressure
Angiostatic agents and another IOP lowering compound are combined in ophthalmic compositions to treat glaucoma and ocular hypertension. Methods for treating glaucoma and ocular hypertension are...
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6143736 |
Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
Methods, compositions, and compounds for modulating the GABA A receptor-chloride ionophore complex to alleviate stress, anxiety, seizures, mood disorders, PMS and PND and to induce anesthesia.
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6096731 |
Method for preventing tissue damage associated with graft-versus-host or host-versus-graft disease following transplantation
A method for preventing tissue damage associated with graft-versus-host disease in a patient having undergone hematopoietic cell transplantation, and host-versus-graft disease in a patient having...
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6093389 |
Methods and compositions for attracting and controlling termites
The present invention provides a composition for attracting termites containing a steroid derivative of formula I ##STR1## The present invention also provides a method for attracting or controlling...
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6028106 |
Treatment of urinary incontinence with nitric oxide synthase substrates and/or nitric oxide donors alone or in combination with estrogen or progesterone and/or other agents
The invention provides a method for the treatment and prevention of urinary incontinence in mammals, e.g., human males and females, especially nonpregnant female mammals, by administering a nitric...
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