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4203981 |
Novel 17 α-aryl-steroids
Novel steroids of the formula ##STR1## wherein R 1 is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of 1 to 18 carbon atoms, R 2 is selected from the group...
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4201778 |
6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory agents, methods for their manufacture, and 6-oxo-1,4-pregnadiene intermediates
Novel 6-acyloxy-3,20-dioxo-1,4,6-pregnatrienes and 6-acyloxy-3,20-dioxo-4,6-pregnadienes, useful anti-inflammatory agents, are prepared by reaction of the corresponding...
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4199578 |
Composition
There is described a pharmaceutical composition comprising a mixture of particulate beclomethasone dipropionate, at least 90% by weight of the particles of becolmethasone dipropionate having an...
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4198403 |
17 Beta-thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters substituted at the 4-position with a fluoro, chloro or bromo and optionally substituted at the six position...
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4198404 |
6 Alpha, 6 beta-difluoro-etianic acid derivatives
Certain 3-ketoandrost-4-ene and 3-ketoandrosta-1,4-diene 17 beta-carboxylic acids and esters substituted at the 6 alpha and 6 beta positions with fluorine substituents are useful as...
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4189477 |
Novel Δ.sup.4 -pregnenes
Novel Δ 4 -pregnenes of the formula ##STR1## wherein X 1 is selected from the group consisting of O and ##STR2## Y is selected from the group consisting of hydrogen and halogen, R 1 is...
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4188385 |
Thioetianic acid derivatives
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters are useful as antiinflammatory steroids. These compounds are optionally substituted at the 6 alpha-position...
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4188373 |
Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
Pharmaceutical vehicles for delivery of pharmacologically active chemical materials to mucous membranes, as well as pharmaceutically active compositions containing such vehicles, are provided. The...
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4187301 |
17 Beta-thiocarboxylic acid esters of 6 alpha, 6 beta-difluoro-3-oxoandrost-4-enes
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters substituted at the 6 alpha, 6 beta-positions with fluorine substituents are useful as anti-inflammatory...
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4181720 |
Corticosteroid antiinflammatory agents
22-Optionally substituted steroids of the corticoid series are prepared from the corresponding 21-methylene steroids through the 20,21-dione steroid intermediates. These compounds have utility as...
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4177268 |
Method of alleviating inflammation by administration of dexamethasone derivatives
The present invention relates a method for the alleviation of inflammation which comprises administering to a host a therapeutically effective amount of a dexamethasone derivative of the formula...
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4124707 |
7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor
Novel 3,20-dioxo-7α-halogeno-1,4-pregnadienes are described and their use as anti-inflammatory agents. Preferred are 7α-bromo- and 7α-chloro- derivatives, particularly 7α-bromo- and...
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4115544 |
Ocular system made of bioerodible esters having linear ether
An ophthalmological bioerodible dosage form for ophthalmic drugs is disclosed. The dosage form comprises particles of 10 to 300 microns made of drug dispersed within a drug release rate controlling...
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4093721 |
Pharmaceutical compositions of 6α,9α-difluoro-androst-4-ene-17β-carboxylates and derivatives thereof
The specification describes anti-inflammatory steroids having the following formula ##STR1## wherein X represents a hydrogen or fluorine atom, R' represents a methyl, ethyl, n-propyl or iso-propyl...
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4083974 |
Topical steroidal anti-inflammatory preparations containing polyoxypropylene 15 stearyl ether
The present invention discloses topical preparations containing anti-inflammatory steroids. These may be ointments or solutions which contain as a solubilizing agent for the steroid,...
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4081541 |
Steroid derivatives
The present invention is concerned with new derivatives of the cortisone series having in particular a corticoidal, anti-phlogistic and anti-anaphylactic activity. The compounds of the present...
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4049804 |
Novel pregnanoic acid derivatives
Pregnanoic acid derivatives of general formula ##STR1## wherein is a single bond or a double bond; X is hydrogen, fluorine or methyl; Y is hydrogen, fluorine or chlorine; Z is...
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4044126 |
Steroidal aerosol compositions and process for the preparation thereof
An antiinflammatory steroid exhibiting a tendency to crystal growth in suspension in aerosol propellants is contacted with a halogenated hydrocarbon to form a crystalline solvate, which, after...
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4039668 |
Corticoid-containing inhalants
Inhalants comprising at least one corticoid of the general formula ##STR1## wherein --B--A-- is CH 2 --CH 2 --, CH=CH-- or CCl=CH--; X is a hydrogen atom, a fluorine atom, or methyl; Y is a...
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4029778 |
Cortical steroid nitrogen mustard compositions and treatment therewith
New 21-esters of corticoid steroid hormones, the esters having an antitumor activity, are prepared by reacting a reactive derivative of the general formula ##STR1## wherein R 1 can be hydrogen,...
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4016271 |
21-Adamantane-1'-carboxylate steroid compositions
The Specification describes a method of systemically treating immunological disorders or inflammatory disorders having a significant immunological component which comprises administering to a...
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4011315 |
21-Acetals and mixed acetals of steroidal 21-aldehydes, intermediates and methods of preparation
21-ACETALS AND MIXED ACETALS OF STEROIDS OF THE CORTICOID SERIES ARE PREPARED FROM THE CORRESPONDING 21-HYDROXY STEROIDS AND HAVE UTILITY AS ANTI-INFLAMMATORY AGENTS.
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4008321 |
Composition for a topical preparation and a process for producing the same
A composition for a topical preparation which comprises a steroid, crotamiton, propylene glycol and a carboxyvinyl polymer in an aqueous medium, said composition having been neutralized with an...
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3996358 |
21-Esters of steroidal-21-aldehyde hydrates and 21-aldehyde hemiacetals and methods of preparation
21-Esters of 21-aldehyde hydrates and 21-aldehyde hemiacetals of steroids of the corticoid series are prepared from the corresponding 21-hydroxy steroids and have utility as antiinflammatory agents.
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3984544 |
Retinoic acid esters of steroids of the pregnane series, their use in the treatment of acne and pharmaceutical formulations useful therefor
Novel retinoic acid esters of anti-inflammatory steroids of the pregnane series are described and their use in the treatment and control of acne vulgaris via the topical or intralesional route. A...
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3980778 |
Anti-inflammatory steroid
The disclosure covers the preparation of the compound, 6α,9α-difluoro-11β,17,21-trihydroxy-16β-methylpregna -1,4-diene-3,20-dione 17α,21-diacetate, (1) and methods and formulations for its...
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3966927 |
Methods for inducing parturition in cattle with certain intravenously-injected synthetic glucocorticoids
Methods employing compositions containing a long-acting glucocorticoid, as for example, dexamethasone trimethylacetate, for inducing parturition in cattle up to four to six weeks prior to normal...
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3962430 |
Sterilization of solid non-electrolyte medicinal agents employing sodium chloride
Sterilization of solid non-electrolyte medicinal agents by heating in an aqueous suspension which contains excess sodium chloride.
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3886268 |
Iodophor-steroid compound pharmaceutical compositions
Iodophor-steroid complex compounds and composition employing the same, exhibiting synergistic anti-inflammatory action, greater than the sum of the anti-inflammatory potency of the respective...
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3865940 |
Pharmaceutical preparation
Disclosed are antirheumatic compositions containing therapeutically effective amounts of dimethyl aminophenazone and an alkali metal salt of 1-phenyl-4-n-butyl-3,5-dioxopyrazolidine in aqueous...
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3856955 |
METHOD AND COMPOSITIONS FOR PREVENTING RETENTION OF PLACENTA FOLLOWING INDUCED PARTURITION IN CATTLE
Methods employing compositions containing a long-acting glucocorticoid, as for example, dexamethasone trimethylacetate, for preventing retention of fetal membranes following induced parturition in...
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3714353 |
THERAPEUTIC COMPOSITIONS COMPRISING A 6α; 9α-DIFLUORO-11β,1α,21-TRIHYDROXY-16α-METHYL-1,4-P REGNADIENE-3,20-DIONE AND 21-ACYLATES
This invention relates to therapeutic compositions and more particularly to therapeutic compositions comprising a 6α,9α-difluoro-11β,17α,21-trihydroxy-16α-meth yl-1,4-pregnadiene-3,20-dione...
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3529060 |
BETAMETHASONE 17-BENZOATE AND ITS USE AS AN ANTI-INFLAMMATORY
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3488421 |
TERPENIC ESTERS OF GLUCOCORTICOIDS
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3461207 |
16ALPHA - CHLORO-1,4-PREGNADIENE COMPOSITIONS AND PROCESS FOR TREATING INFLAMMATORY CONDITIONS
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3440320 |
CHELATED SUPPOSITORY AND METHOD OF USING SAME
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3426128 |
DELTA**1,4-16ALPHA-METHYL STEROIDS
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3422193 |
17-MONO ESTERS OF CORTICOIDS
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3376193 |
17-acylates of 9alpha-fluoro-11beta, 17alpha-dihydroxy-16-methyl-1, 4-pregnadiene-3, 20-dione and corresponding-11-keto steroids and pharmaceutical compositions thereof
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3342676 |
Dermatological composition containing 21-desoxy-9-alpha-fluoro-6-methyl prednisolone
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3329570 |
Therapeutic compositions comprising 21-dicyclohexylmethyl carbonate esters of pregnane derivatives
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3312590 |
Topically active anti-inflammatory 17-mono- and 17,21-diesters of betamethasone and its 9-chloro-analogs, compositions and use thereof
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3309272 |
16-alkylene pregnene derivatives
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3290214 |
Diuretic compositions containing 3'-oxo-4'-hydroxy-4'-cyclopenteno-(1', 2'-16, 17)-androstene compounds
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3234095 |
21-methyl and 21-hydroxymethyl steroid compounds
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3232835 |
2-chloro prednisones and the 9alpha-fluoro derivatives thereof
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3232839 |
delta1, 4-16alpha-methyl steroids
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3193459 |
Steroid hemisuccinate compositions and method for extemporaneous administration
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3183150 |
Novel 15-dehydro-halo-methyl-progesterones
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3152044 |
Water soluble salts of steroidal-21-acid sulfates and therapeutic compositions containing same
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