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6046168 |
Peptide inhibits blood triglyceride level
The present invention relates to a peptide having the amino acid sequence shown in the sequence listing; an agent for inhibiting elevations of triglyceride levels in blood comprising the above...
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6037140 |
Selective media for the culture and isolation of gram bacteria, antibiotic composition
This invention relates to a selective medium for the culture and isolation of Gram - bacteria comprising at least one antibiotic specifically active against Gram + bacteria and at least one...
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6037325 |
Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases including human neutrophil elastase,...
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6034067 |
Serine protease inhibitors
The invention relates to a compound having formula (I), wherein A, B, X, N, Z and Q are defined as described in the description. The compounds of the invention have anticoagulant activity and can...
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6034066 |
Cysteine protease inhibitors for use in treatment of IGE mediated allergic diseases
The invention provides compounds for use in the treatment of allergic diseases including juvenile asthma and eczema. The compounds can inhibit IgE mediated reaction to major environmental and...
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6034065 |
Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10
Dolastatin 10, a linear pentapeptide, has shown potent antineoplastic activity profiles against various experimental cancer systems. The design and synthesis of structural modifications of...
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6030946 |
Reversible cysteine protease inhibitors
Cysteine protease inhibitors are provided.
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6030640 |
Oligoglycine compound, fibrous microtube of oligoglycine compound and process of producing fibrous microtube
A lipid represented by the following formula: MO--(CO--CH 2 --NH) p --CO--(CH 2 ) n --CO--(NH--CH 2 --CO) q --OM wherein M represents a hydrogen atom or an alkali metal, n is an integer of...
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6030950 |
Pharmaceutical therapeutic use of glutathione derivative
Methods of adjusting or maintaining the intracellular levels of glutathione of a subject are provided. The subject is treated by administering an effective amount of an acetyl derivative of...
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6030619 |
Molecular mimetics of meningococcal B epitopes
Molecular mimetics of unique epitopes of Neisseria meningitidis serogroup B ("MenB") are disclosed. Compositions containing such molecular mimetics can be used to prevent MenB or E. coli K1 disease...
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6022857 |
Radiolabeled compounds for thrombus imaging
This invention relates to radiolabeled scintigraphic imaging agents, and methods and reagents for producing such agents. Specifically, the invention relates to specific binding compounds, including...
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6020309 |
Pharmaceuticals based on papillomaviruses
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6020312 |
Synthetic antibiotics
Compositions of the current invention are directed toward inhibiting the growth of microorganisms, particularly fungi. The compositions consist of chemically-synthesized antibiotics comprising...
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6015791 |
Serine protease inhibitors-cycloheptane derivatives
The present invention relates to certain substituted oxadiazole, thiadiazole, and triazoles, in particular those including a cycloheptane structure, that are useful as serine protease inhibitors,...
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6015790 |
Methods and compositions for treating rheumatoid arthritis
The present invention provides compositions and methods for the treatment of rheumatoid arthritis in a subject wherein one or more compounds of Formula I as defined herein alone or in combination...
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6008196 |
Perfluoroalkyl ketone inhibitors of elastase and processes for making the same
This invention relates to compounds which are inhibitors of elastase, particularly human neutrophil elastase, and to novel processes for making the same. As inhibitors of human neutrophil elastase,...
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6007819 |
Methods of inducing immunity using low molecular weight immune stimulants
The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other...
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6004933 |
Cysteine protease inhibitors
The present invention relates to cysteine protease inhibitors of the general formula (I): ##STR1## wherein Z is a cysteine protease binding moiety; X and Y are S, O or optionally substituted N; and...
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6004934 |
Tetrapeptide derivative
A tetrapeptide derivative represented by the following formula or a salt thereof has a higher cytostatic activity than dolastatin 10, and is useful as an antitumor agent: ##STR1## wherein, R 1 , R...
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6004757 |
Substrate specificity of a protein kinases
The invention provides a method for determining an amino acid sequence motif for a phosphorylation site of a protein kinase. In the method of the invention, a protein kinase is contacted with an...
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6001809 |
Inhibitors of leukocyte adhesion
This invention provides peptides which block cellular adhesion mediated by VLA-4. The peptides can be used to treat a number of inflammatory diseases, in particular, inflammatory brain disorders.
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6001813 |
Val-pro containing α-keto oxadiazoles as serine protease inhibitors
The present invention relates to certain substituted oxadiazole tripeptides, which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated...
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6001811 |
Serine protease inhibitors--N-substituted derivatives
The present invention relates to oxadiazole, thiadiazole, and triazole peptoids that are inhibitors of serine protease, specifically human neutrophil elastase; which proteases are useful in...
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6001812 |
Modulating body/cranial hair growth with derivatives of the α-type melanocyte-stimulating hormone
Methods and compositions for inducing or stimulating the growth of body or cranial hair using a peptide which comprises the Lysine-Proline-Valine sequence are described.
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6001360 |
Method and compositions for early detection and treatment of insulin dependent diabetes mellitus
Compositions and methods for the treatment or prevention of insulin dependent diabetes (IDD) are provided. Specifically, glutamic acid decarboxylase (GAD) proteins, and fragments. thereof, can be...
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5998379 |
Serine protease inhibitors-proline analogs
The present invention relates to certain substituted oxadiazole, thiadiazole, and triazole peptoids that are useful as inhibitors of serine proteases, in particular human neutrophil elastase....
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5998378 |
Compositions for the inhibition of TNF hormone formation and uses thereof
Compounds having proteolytic inhibitory activity useful for treating diseases, particularly as applied to the treatment of sepsis, AIDS or autoimmune diseases, resulting from a decrease in the...
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5994346 |
Use of exochelins in the preservation of organs for transplant
Exochelins can be used to prevent damage to organs for transplant from the formation or presence of the .circle-solid.OH radical. In particular, the invention is directed to the administration of...
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5994311 |
Cell adhesion peptides for modifying the adhesion capacity of eukaryotic cells between each other
The invention relates to adhesion peptides for modifying the adhesion capacity of eukaryotic cells between each other and their use to promote or inhibit the cell/cell adhesion of eukaryotic cells....
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5985837 |
Dolastatin 15 derivatives
Compounds of the present invention include cell growth inhibitors which are peptides of Formula I A--B--D--E--F--G (I) and acid salts thereof, wherein A,...
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5985261 |
Use of thioredoxin-like molecules for induction of MnSOD to treat oxidative damage
A method to increase cellular MnSOD production in an animal to treat oxidative damage by administering a protein having a thioredoxin active-site in reduced state. A composition and a method to...
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5981492 |
Substituted 5-membered ring heterocycles, their preparation and their use
The present invention pertains to 5-ring heterocycles of general formula (I), wherein W, Y, Z, B, D, E and R as well as b, c, d, e, f, g, and h are as indicated in the description; to methods for...
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5981470 |
Uterine fibroid treatment
The use of a) an angiotensin-converting enzyme (ACE) inhibitor such as Captopril or Enalapril, b) an angiotensin II-receptor antagonist such as Saralasin or Losartan, or c) a renin inhibitor, such...
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5977070 |
Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
A pharmaceutical composition for the nasal delivery of compounds useful for treating osteoporosis, comprising an effective amount of a physiologically active truncated analog of PTH or PTHrp, or...
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5972656 |
Mercury binding polypeptides and nucleotides coding therefore
Metal binding polypeptides which include an amino acid sequence coding for a variable region of a monoclonal antibody which immunoreacts with a mercury cation and nucleotides which include a...
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5972908 |
Collagen-based composition and process for preparing it
This process for preparing a collagen-based composition, comprises grinding collagen fibers to a particle size of between 10 and 100 microns and mixing them with water in a sufficient quantity to...
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5968513 |
Method of promoting hematopoiesis using derivatives of human chorionic gonadotropin
The present invention relates to methods of treating or preventing diseases or disorders associated with hematopoietic deficiency by administration of human chorionic gonadotropin, β-human...
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5965538 |
Azapeptide derivative
Disclosed is an azapeptide derivative represented by the formula (I): ##STR1## wherein A represents a direct bond, an α-amino acid or a residue of a dipeptide; R 1 represents a hydrogen atom or a...
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5965537 |
Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
The present invention relates to novel peptides useful as anti-cancer agents. The compounds of the invention are of Formula I, A-B-D-E-F-G (I) A, B,...
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5958886 |
Carnitine-containing peptides and a method for using the same
A carnitine-containing peptide sequence, which is a substrate for a mammalian peptide transport system, which contains at least one carnitine residue with at least one amino acid residue bonded...
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5958882 |
Compounds that inhibit T cell proliferation and methods using the same
Compounds which display a surface similar to the surface presented by one of five distinct lateral domains of CD4 are disclosed. Methods of treating individuals suspected of suffering from or...
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5958885 |
Peptide and formulations thereof inhibiting elevations of triglyceride levels in blood
The present invention relates to a peptide having an amino acid sequence of Val-Val-Tyr-Pro as well as an agent for inhibiting elevation of triglyceride levels in blood, a food for specified health...
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5955433 |
Method of thrombin inhibition
A method of inhibiting thrombin is disclosed, as well as a method of treating or preventing thrombosis and hypercoaguability. The methods employ compounds of the formula ##STR1## stereoisomers...
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5955432 |
Metabolic effects of certain glutathione analogs
Compounds of the formula ##STR1## and the esters, amides, amide/esters and salts thereof, wherein YCO is γ-glu or β-asp; G* is phenylglycine or glycine; Z is CH 2 , O or S; and X is a...
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5955431 |
Mast cell protease peptide inhibitors
Compositions and methods for inhibiting a complex containing a mast cell protease are provided. The compositions are useful for treating inflammatory disorders, such as asthma, that are mediated by...
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5952294 |
Peptidyl prodrugs and methods of making and using the same
Peptidyl prodrugs of therapeutic agents having an activating function are sclosed. These therapeutic agents having activating functions include those having an amino, thiol, or hydroxyl function....
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5952307 |
Basic α-aminoalkylphosphonate derivatives
Peptidyl derivatives of diesters of α-aminoalkylphosphonic acids with basic substituents, their use in inhibiting serine proteases with trypsin-like specificity and their roles as...
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5952306 |
Integrin receptor antagonists
Fibrinogen receptor antagonists having the formula ##STR1## for example ##STR2## which are useful for inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of...
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5948886 |
Acylated enol derivatives of α-ketoesters and α-ketoamides
This invention relates to acylated enol derivatives of α-ketoesters and α-ketoamides. The compounds of this invention are either prodrugs of known elastase inhibitors or are elastase inhibitors...
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5948750 |
Conjugates useful in the treatment of prostate cancer
Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are...
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