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8173626 |
Methods, dosing regimens and medications using anti-progestational agents for the treatment of disorders
The present invention relates to the treatment of disorders using anti-progestational agents. More specifically, the present invention relates to the treatment of disorders using low doses of...
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8158613 |
Topical pharmaceutical formulations and methods of treatment
In certain embodiments, the present invention is directed to a pharmaceutical formulation for topical administration on a mammal, comprising a unit dose of a therapeutically effective amount of a...
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8153171 |
Solution for dissolving pre-melanoma lesions and melanoma lesions including psoriasis, herpes simplex lesions and eczema lesions
Alcohol constitutes a majority of the solution. Water, melaleuca alternifolia, amebicidal, acetate, aloe barbadensis, larrea tridentat and benzoic acid constitute a minority of the solution. The...
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8143240 |
17α, 21-dihydroxypregnene esters as antiandrogenic agents
17α,21-Dihydroxypregna-4,9-diene-3,20-dione and 17α,21-dihydroxypregna-4-ene-3,20-dione 17 and/or 21 esters of having remarkable antiandrogenic activity, and the processes for the preparation thereof.
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8124129 |
Crystalline form of the compound A-348441
There is provided a hemihydrate of (3β,5β,7α,12α)-7,12-dihydroxy-3-{2-[{4-[17β-hydroxy-3-o
xo-17α-prop-1-ynylestra-4,9-dien-11β-yl]phenyl}(methyl)ami
no]ethoxy}cholan-24-oic acid in a crysta...
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8119619 |
Pregnane steroids and their use in the treatment of CNS disorders
Steroid compounds possessing a hydrogen donor in 3beta position, either in the form of a hydroxy- or a sulfate group, function as efficient blockers of the 3alpha-hydroxy-pregnan-steroid action and...
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8097606 |
Antiglucocorticoids for the treatment of catatonia
The invention provides a method of ameliorating the symptoms of catatonia in a patient who is in need of treatment for catatonia. The method comprises administration of a therapeutically effective...
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8067433 |
Methods, compositions, and kits for the treatment of ophthalmic disorders
The invention features methods, kits, and compositions for the treatment of ophthalmic disorders. The compositions include a corticosteroid in combination with a non-steroidal...
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8058266 |
Methods and compositions for treatment of macular and retinal disease
The present invention describes linking a therapeutic agent to a compound which is known to be naturally concentrated in a tissue affected by, or that is causing, a disease, to create a prodrug for...
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8053426 |
Progesterone receptor antagonists
The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group.
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8034366 |
Ocular implant made by a double extrusion process
The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of...
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8003629 |
21-substituted progesterone derivatives as new antiprogestational agents
A compound having the general formula: in which: R1 is a member selected from the group consisting of —OCH3, —SCH3, —N(CH3)2, —NHCH3, —CHO, —COCH3 and —CHOHCH3; R2 is a member selected from...
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7998947 |
Materials and methods for treatment of cancer and identification of anti-cancer compounds
The subject invention pertains to the treatment of tumors and cancerous tissues and the prevention of tumorigenesis and malignant transformation through the modulation of JAK/STAT3 intracellular...
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7994188 |
Compounds for treating inflammatory diseases
The invention relates to the use of (1α.2β,4β.5α.7β)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9
-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane salts for preparing a pharmaceutical composition for ...
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7960367 |
Pregnane steroids and their use in the treatment of CNS disorders
Steroid compounds processing a hydrogen donor in 3beta position, either in the form of a hydroxy- or a sulfate group, function as efficient blockers of the 3alpha-hydroxy-pregnan-steroid action and...
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7951790 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Progesterone receptor antagonists
The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group.
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7947669 |
Agent for improving insulin resistance
To inhibit production of adipocytokines, in particular, adipocytokines that elicit insulin resistance and to prevent onset of pathosis caused by the insulin resistance, or improve the pathosis, the...
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7915265 |
Combinations for the treatment of immunoinflammatory disorders
The invention features pharmaceutical compositions that include dipyridamole and a corticosteroid.
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7902178 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Progesterone receptor antagonists
The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group.
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7897587 |
Topical dermatological formulations and use thereof
A topical formulation of an androstane steroid compound of improved solubility in combinations of the solvents propylene glycol and propylene carbonate.
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7888340 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Pregnane steroids and their use in the treatment of CNS disorders
Steroid compounds processing a hydrogen donor in 3beta position, either in the form of a hydroxy- or a sulfate group, function as efficient blockers of the 3alpha-hydroxy-pregnan-steroid action and...
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7888385 |
Airway alkalinization as therapy for airway diseases
The present invention relates to a method of treating asthma by raising the pH of the airways of an individual. The effect can be mediated directly by administering a pharmaceutically acceptable...
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7884091 |
Methods for treating delirium using glucocorticoid receptor-specific antagonists
This invention generally pertains to the field of psychiatry. In particular, this invention pertains to the discovery that agents which inhibit the binding of cortisol to its receptors can be used...
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7858606 |
Triterpenoid derivatives
The present invention relates to the use of a compound of formula (I), or a pharmaceutically acceptable salt, crystal form, complex, hydrate, or hydrolysable ester thereof, in the preparation of a...
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7858607 |
System for use by compounding pharmacists to produce hormone replacement medicine customized for each consumer
The invention concerns a concentrated hormone pharmaceutical composition having from about 0.6 to about 80% of at least one hormone; from about 20 to about 90.4% of at least one solvent, and...
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7842680 |
Diene and triene compounds and formulations
The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in t...
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7829555 |
Drug targeting
The invention provides a method of targeting a drug to areas of hypoxic and/or ischemic tissue within the body in which the desired drug species is linked to a non-cytotoxic bioreductive carrier....
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7820642 |
Nandrolone 17β-carbonates
Disclosed are compounds of the formula (I) wherein R is C1-C30 alkyl, which may be optionally further substituted with one or more of C5-C8 cycloalkyl groups, or a C5-C12 cycloalkyl, which may be...
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7799770 |
Solid body forms of mesoprogestin 11β-{4E-(hydroxyiminomethyl)-phenyl}-17α methoxymethyl-17β-methoxy-estra-4,9-dien-3-one
The invention relates to novel solid body forms of mesoprogestin 11β-[4E-(hydroxyiminomethyl)-phenyl]-17α-methoxymethyl-17Î
²-methoxy-estra-4,9-dien-3-one (oxime J 867), particularly a highly pu...
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7794738 |
Compositions and methods for enhancing corticosteroid delivery
The present invention comprises a composition, method of enhancing potency and method of delivering corticosteroids in a vehicle comprising at least two penetration enhancers, and solvents and...
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7790461 |
Nano-emulsion technology for drug elution
Embodiments of the invention provide to apparatuses and media used in drug elution studies and methods for making and using them. One embodiment of the invention is a drug elution method that can...
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7790145 |
Respiratory dispersion for metered dose inhalers
A respiratory dispersion is provided for the pulmonary delivery of at least two bioactive agents. The dispersion comprises a propellant suspension medium having dispersed therein a plurality of...
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7781421 |
Neuroactive 13, 24-cyclo-18, 21-dinorcholanes and structurally related pentacyclic steriods
Novel pentacyclic steroids and pentacyclic D-homosteroids comprising: (i) the tetracyclic steroid ring system or tetracyclic D-homosteroid ring system, respectively; (ii) a C(3) substituent...
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7776846 |
Enhancement of activity and/or duration of action of selected anti-inflammatory steroids for topical or other local application
Methods and compositions for enhancing the activity and/or duration of action of soft anti-inflammatory steroids of the haloalkyl 17α-alkoxy-11β-hydroxyandrost-4-en-3-one-17β-carboxylate type an...
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7759330 |
21-substituted progesterone derivatives as new antiprogestational agents
A compound having the general formula: in which: R1 is a member selected from the group consisting of —OCH3, —SCH3, —N(CH3)2, —NHCH3, —CHO, —COCH3 and —CHOHCH3; R2 is a member selected from...
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7749488 |
Pharmaceutical foam
The present invention provides various pharmaceutically active topical delivery compositions. In particular, compositions of the present invention are present in a pressurized container comprising...
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7732493 |
2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
The invention relates to new 2-substituted D-homo-estra-1,3,5(10)-trienes of general formula I in which R2 means a C1-C8-alkyl group, a C1-C8-alkyloxy group or a halogen atom,R13 means a hydrogen...
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7732432 |
17-carbamoyloxy cortisol derivatives as selective glucocorticoid receptor modulators
The present invention encompasses compounds of Formula (I) or pharmaceutically acceptable salts or hydrates thereof, which are useful as selective glucocorticoid receptor ligands for treating a...
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7709495 |
Methods and reagents for the treatment of inflammatory disorders
The invention features a method for treating an immunoinflammatory administering a compound of formula (I), e.g., ibudilast or KC-764, alone or in combination with a corticosteroid,...
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7704985 |
Treatment of irritable bowel syndrome and related bowel diseases
The present invention discloses a method of treating an individual having irritable bowel syndrome or a related disorder, comprising the step of administering to said individual a pharmacologically...
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7691811 |
Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye
Methods and compositions for enhancing the activity and/or duration of action of loteprednol etabonate and other soft anti-inflammatory steroids of the haloalkyl...
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7678781 |
11-phosphorous steroid derivatives useful as progesterone receptor modulators
The present invention is directed to novel 11-phosphorous steroid derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by a...
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7666859 |
Skin compositions containing hydrocortisone
Skin compositions comprising, hydrocortisone; allantoin; and a water-based vehicle that is essentially free of petroleum jelly, mineral oil and wax; and related method for protecting, healing...
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7638508 |
Glucocorticosteroid compound having anti-inflammatory activity
A compound of formula (I): wherein X represents O or S;R1 represents C1-6 alkyl, C3-8 cycloalkyl, C3-8 cycloalkylmethyl or C3-8 cycloalkenyl any of which optionally may be substituted by one or...
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7632826 |
Use of agonists of the glucocorticosteroid and/or mineralo-corticosteroid receptors, in particular corticosteroids for the treatment of addiction
Corticosteroid receptors and/or mineralo-corticoid receptors are administered in combination with an addictive drug or the pharmacodynamic equivalent thereof for the therapy of an addictive disease...
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7628978 |
Stabilized preparations for use in metered dose inhalers
Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a plurality of perforated microstructures...
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7629334 |
Mesoprogrestins (progesterone receptor modulations) as a component of compositions for hormone replacement therapy (HRT)
The use of mesoprogestins as pharmaceutical components for the manufacture of a medicament for hormone replacement therapy (HRT) and as components for the combined use together with an estrogen for...
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7597914 |
Ala-septic pre-cancerous liquid dissolving solution and method
Alcohol constitutes a majority of the solution. Water, melaleuca alternifolia, amebicidal, acetate, aloe barbadensis, larrea tridentat and benzoic acid constitute a minority of the solution. The...
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7579335 |
Androstane 17α-carbonate derivatives for use in the treatment of allergic and inflammatory conditions
The present invention is directed to compounds of formula (I): wherein R1 represents C4-C7 branched alkyl group, a bicycloalkyl group, or a C5-C6 cycloalkyl which optionally may be substituted with...
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7566743 |
System and method for medical treatment
This invention relates to a system for and method for medical treatment of respiratory diseases. The system and method are particularly effective for the treatment of and protection from diseases...
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