|
Match
|
Document |
Document Title |
|
|
4427649 |
Pharmaceutical compositions
Pharmaceutical liposome compositions containing an anti-inflammatory steroid derivative bearing a lipophilic substituent, for example cortisol 21-hexadecanoate. Method of treatment of inflammation...
|
|
|
4411893 |
Topical medicament preparations
Topical therapeutic compositions are disclosed which contain from about 0.1 to 70 percent by weight of a water-soluble tertiary amine oxide and a therapeutic agent selected from the group...
|
|
|
4407792 |
Sustained release ophthalmic drug dosage
The present invention is directed to an aqueous dispersion of an ophthalmic drug and a high molecular weight polymer which forms a highly viscous gel and can be used to prolong the duration of...
|
|
|
4383992 |
Water-soluble steroid compounds
Beta-cyclodextrin forms a water-soluble complex or inclusion compound with steroid compounds having a molecular structure smaller than the interior cavity in the doughnut-shaped molecular structure...
|
|
|
4383986 |
Hemorrhoidal compositions
An antipruritic, astringent and anti-inflammatory composition is provided. The composition is useful in the treatment of hemorrhoid symptoms.
|
|
|
4377575 |
Corticoid-17-(alkyl carbonates) and process for their manufacture
What is disclosed are steroid-21-halogeno-17-(alkyl carbonates), useful as medicaments for the treatment of inflammatory dermatoses, and a method for making them.
|
|
|
4371529 |
11-Methylene-Δ.sup.15 -steroids, their preparation and use in pharmaceuticals
11-Methylene-Δ 15 -steroids of Formula I ##STR1## wherein R 1 is hydrogen or acyl and R 2 is ethynyl, chloroethynyl or propynyl, are distinguished by a strong progestational activity and...
|
|
|
4367224 |
Stable dithranol compositions in anhydrous vehicles
Stable dithranol compositions in anhydrous vehicles therapeutically effective as topical treatment for skin disorders such as psoriasis, eczema and seborrheic dermatitides are disclosed....
|
|
|
4364923 |
Chemical compounds
An antiinflammatory steroid exhibiting a tendency to crystal growth in suspension in aerosol propellants is contacted with a halogenated hydrocarbon to form a crystalline solvate, which, after...
|
|
|
4363806 |
Pharmaceutical composition
A pharmaceutical steroid composition for topical application producing a minimum of skin irritating effects. The composition comprises a corticosteroid in a multiple emulsion vehicle. A process for...
|
|
|
4361559 |
Antiinflammatory 17,17-bis (substituted thio) androstenes
3-Ketoandrostenes having in the 17-position the substituents R 1 --S-- and R 2 --S-- wherein R 1 and R 2 are the same or different and each is alkyl, cycloalkyl or aryl, have antiinflammatory...
|
|
|
4361558 |
Halogenated steroids
Novel halogenated steroids of the formula ##STR1## in which X represents a halogen atom having a maximum atomic number of 17, Y represents a hydrogen atom or hydroxyl, and R represents an...
|
|
|
4357934 |
Method of treating male infertility
Male infertility is treated by increasing the concentration of testosterone in the seminiferous tubules by intratesticular injection of an aqueous suspension of testosterone and/or chorionic...
|
|
|
4358445 |
6α-Fluoro-prednisdone 17,21 diesters
The present application relates to novel 6α-fluoro prednisolone 17, 21-diesters, to pharmaceutical compositions comprising such diesters, and to methods of treating inflammatory conditions with...
|
|
|
4347238 |
Autoclavable emulsion containing silver sulphadiazine
A mobile, drop-forming heat-sterilizable ophthalmic oil-in-water emulsion which comprises an aqueous solution of a pharmaceutically acceptable salt of polyacrylic acid lightly cross-linked with...
|
|
|
4347236 |
Process for the preparation of a mixture of an anti-inflammatory steroid and a fluoro-chloro-hydrocarbon to be used as a propellant
A process by means of which an increase in the particle size of a micro-ground anti-inflammatory steroid in the aerosol propellant is prevented. The increase in the particle size is prevented at...
|
|
|
4346086 |
Corticosteroid-containing cream
A corticosteroid-containing cream comprising (a) 0.05-0.5 parts fluocortolone (b) 2.5-20 parts fatty acid sorbitan esters and/or a mixture of fatty acid mono- and diglycerides (c) 1-5...
|
|
|
4343798 |
Topical antimicrobial anti-inflammatory compositions
Topical antimicrobial anti-inflammatory compositions, having a pH no greater than about 5, containing C 5 -C 12 fatty acids together with a corticosteroid component, are disclosed. The method of...
|
|
|
4343799 |
Use of derivatives of 6α-methylprednisolone for the prevention or reduction of adriamycin-induced cardiotoxicity
Use of water soluble 21-polybasic esters of 1-dehydro-6α-methylhydrocortisone and their salts for the prevention and treatment of cardiotoxicity induced by Adriamycin chemotherapy.
|
|
|
4340594 |
Fat emulsion containing steroid
A fat emulsion containing a steroid having an anti-inflammatory activity, comprising an effective quantity of a steroid having an anti-inflammatory activity, 5 to 50% (W/V) of soybean oil, a...
|
|
|
4335121 |
Androstane carbothioates
Compounds of the formula ##STR1## wherein R 1 represents a fluoro-, chloro- or bromo-methyl group or a 2'-fluoroethyl group, R 2 represents a group COR 6 where R 6 is a C 1 -3 alkyl group or OR...
|
|
|
4333927 |
Skin preparation
Skin preparations containing a phosphatide, a topical corticosteroid, and butylhydroxyanisole and/or butylhydroxytoluene, which may be in the form of an aqueous or oily mixture, non-aqueous,...
|
|
|
4333928 |
16 α-Alkyl steroids, their preparation, and pharmaceutical preparations thereof
16 α-Alkyl steroids of the formula ##STR1## wherein R 1 is hydrogen or methyl, R 2 is hydrogen, alkyl, acyl, or glycosyl R 3 is hydrogen or a substituted or unsubstituted, saturated or...
|
|
|
4331651 |
Depot body on the basis of silicone rubber and process for the preparation thereof
Depot body on the basis of silicone rubber for the protracting release of active ingredients which contains from 2 to 50 weight %, relative to silicone rubber, of a release-promoting substance or a...
|
|
|
4330541 |
Novel corticoid 17-thioacetals, their preparation and use
Novel corticoid 17-thioacetals of the formula: ##STR1## wherein X is hydrogen, fluorine or methyl, R 1 is hydrogen or C 1 -C 6 alkyl, and R 2 is hydrogen or the acyl group of a C 1 -16 -...
|
|
|
4328204 |
Absorbable polymer-drug compounds and method for making same
Drugs with active hydrogen containing groups are reacted with α-polyester homopolymers and copolymers to form compounds which slowly absorb and release the drug when implanted in animal tissue.
|
|
|
4323564 |
Esters of 6-chloro-11β, 17α,21-trihydroxypregna-1,4,6-triene-3,20-dione
The 17-butyrate, 17-benzoate, 17,21-methyl orthobutyrate, 17,21-methyl orthobenzoate, and 17,21-dibutyrate esters of cloprednol (6-chloro-11β, 17α, 21-trihydroxy-pregna-1,4,6-triene-3,20-dione)...
|
|
|
4322416 |
10-Alkynyl steroids
Aromatase inhibitors are provided having the formula ##STR1## wherein represents a single or double bond; R is hydrogen or C 1 -4 alkyl; R 1 is methyl or ethyl; R 2 is (H) (OR 8 ) or O; R...
|
|
|
4312865 |
Medication having penetration through cutaneous surfaces into articular and muscular areas
A medication that penetrates the surface of the skin is provided. The articular and muscular areas subject to discomfort may be relieved by the topical application of the medication. The medication...
|
|
|
4307088 |
1-Hydroxy steroids, a process for the production thereof, and pharmaceutical preparations containing them
1-Hydroxy steroids of formula I ##STR1## wherein R 1 and R 2 are independently hydrogen or alkanoyl of 1-8 carbon atoms are distinguished by strong progestational activity and only very minor...
|
|
|
4305936 |
Topical corticosteroid formulations
This present invention relates to a solution for topical or local application comprising at least one corticosteroid; from about 1% to 4% by weight of solubilization agents consisting essentially...
|
|
|
4304765 |
Ocular insert housing steroid in two different therapeutic forms
An ocular insert and an ocular composition are disclosed. The insert and the composition comprises a steroid in two different forms.
|
|
|
4303654 |
Novel 21-chloro-20-acetylenic steroids
Novel 21-chloro-20-acetylenic steroids of the formula ##STR1## wherein R 1 is alkyl of 1 to 3 carbon atoms, R is selected from the group consisting of hydrogen and acyl of an organic carboxylic...
|
|
|
4302452 |
Use of derivatives of 6α-methylprednisolone as an antiemetic
Use of water soluble 21-polybasic esters of 1-dehydro-6α-methylhydrocortisone and their salts as an antiemetic.
|
|
|
4297350 |
Male contraceptive steroids and methods of use
The steroids of the present invention have been found to be useful as male contraceptives when administered orally. Upon cessation of administration of the male contraceptive steroids of the...
|
|
|
4296206 |
Irreversible anti-glucocorticoids
The use of cortisol-21-mesylate and dexamethasone-21-mesylate as inhibitors of glucocorticoid steroid hormone action is disclosed. These compounds were found to be irreversible inhibitors of...
|
|
|
4296109 |
Corticoid 21-sulfopropionates and the salts thereof, a process for the production thereof and pharmaceutical preparations thereof
Corticoid 21-sulfopropionates of the formula ##STR1## wherein St is a steroid nucleus of a corticoid having anti-inflammatory activity, and the salts thereof with physiologically acceptable bases,...
|
|
|
4294852 |
Skin treating compositions
The invention relates to a composition for treatment and control of excessively thickened, inflexible and scaly stratum corneum which often fissures into the dermis resulting in foci of bleeding...
|
|
|
4293548 |
18-Substituted pregn-4-ene-3,20-diones
Progesterone derivatives having a vinylidene or a 1-alkynyl substituent at the 18-position and further optionally hydroxylated at the 11-position and the 21-position are described herein. Compounds...
|
|
|
4289764 |
Steroid compositions
The invention provides a pharmaceutical composition for topical application comprising an essentially saturated solution of hydrocortisone in aqueous propylene glycol solution containing at least...
|
|
|
4289762 |
10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors
Irreversible aromatase inhibitors are provided having the formulae ##STR1## wherein represents a single or a double bond; R 1 is CH 3 or C 2 H 5 ; R 2 is (H) (OR 8 ) or O; R 3 is H or C 1...
|
|
|
4285937 |
Novel androstadiene-17-carboxylic acid esters
The invention provides novel esters of androstadiene 17-carboxyclic acids of the formula ##STR1## wherein R' represents a hydroxyl group which is esterified with a carboxyclic acid having not more...
|
|
|
4284630 |
Stabilized water-in-oil emulsions
Stable water-in-oil emulsions useful as vehicles for cosmetics or for therapeutic compositions to be topically applied are disclosed. The emulsions utilize a concentration of from 0.2 to 2% by...
|
|
|
4282218 |
Amides
The disclosure relates to novel 3,4-disubstituted-branched-chain-acylanilides, processes for their manufacture and pharmaceutical compositions containing them. The compounds possess anti-androgenic...
|
|
|
4282217 |
Pharmaceutical compositions containing a corticosteroid substance
Pharmaceutical compositions containing a corticosteroid and an ester of L-arginine with an aliphatic alcohol exhibit a synergistic effect in the protection against shock. The corticosteroid may be...
|
|
|
4278669 |
3-Oxo-4-halo-16β-methylandrost-4-ene 17β-carboxylic acids and esters
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17β-carboxylic acids (and esters thereof) substituted at the 4-position with a fluoro or chloro, optionally substituted at the 6- position...
|
|
|
4277468 |
11-Methylene steroids, their preparation and pharmaceutical preparations containing them
11-Methylene steroids of Formula I ##STR1## wherein R is hydrogen or acyl, and X is oxygen or two hydrogen atoms have valuable pharmacological properties.
|
|
|
4273770 |
4-Halo steroids
Certain pregn-4-ene-3,20-diones or pregn-1,4-diene-3,20-diones 4-substituted with a fluoro or chloro are useful as topical anti-inflammatory steroids. These compounds are substituted at 9α with...
|
|
|
4267173 |
Use of 6β-fluoro-7α-halogenocorticoids as topical anti-inflammatories and pharmaceutical formulations useful therefor
Described is the use of 6β-fluoro-7α-halogeno-1,4-pregnadiene-17α,21-diol-3,20-di
ones and their esters as topical anti-inflammatory agents, and pharmaceutical formulations thereof useful...
|
|
|
4264585 |
Hydrocortisone esters, pharmaceutical formulations containing these and processes for their preparation
Hydrocortisone esters of the formula ##STR1## wherein R 1 is H, formyl or acetyl and R 2 is H or CH 3 are antiphlogistically active.
|