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4774236 |
17α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and pharmaceutical compositions containing them
Steroids of the formula: ##STR1## which are characterized by a 17α-cyanomethyl, azidomethyl, methoxymethyl, phenylmethyl, or ethynylmethyl substituent and a 17β-hydroxy/esterified hydroxy...
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4771042 |
Inhibition of angiogenesis involving the coadministration of steroids with heparin or heparin fragments
A method of inhibiting angiogenesis in a warm blooded animal which comprises administering to said animal an anti-angiogenic effective amount of a compound of the formula: ##STR1## wherein the...
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4764513 |
Antigestagens for shifting the endometrial maturation
The endometrial maturation in the post-ovulatory phase (luteal phase) of mammals is delayed with reference to the nidation point by administration of antigestagens.
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4761407 |
Solid galenical form for oral administration, and the process for its preparation
New solid galenical form for oral administration, consisting of a mixture of one or more active products and two or more excipients which can be liquefied at a temperature compatible with the...
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4753932 |
Novel 10-substituted steroids
A novel steroid of the formula ##STR1## wherein X is methylene and R is an optionally substituted carbocyclic aryl or heterocyclic aryl or optionally substituted vinyl or ethynyl or X is a simple...
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4738956 |
Hydrocortisone composition having enhanced bioavailability and percutaneous absorption
A new and improved topically applied pharmaceutical preparation for the treatment of itching, rash, eczema, insect bites, poison ivy and the like and an improved vehicle for delivering the active...
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4732892 |
L-α-amino acids as transdermal penetration enhancers
The disclosed invention provides methods and compositions ulilizing L-α-amino acids for enhancing the rate of penetration through the skin of both topical medicaments and of drugs employed for...
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4732755 |
Skin burn treatment
A new method for treatment of skin burn is disclosed. A known material, sodium polyacrylate, has been discovered to be useful in the treatment of burns. The method of treatment includes spreading...
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4722837 |
Medicated shampoo composition
A medicated shampoo composition for treating scalp disorders comprising a safe and effective combination of pharmacologically active ingredients is disclosed. The active ingredients comprise...
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4705783 |
9α, 11β-substituted and 11β-substituted estranes
9 alpha, 11 beta and 11 beta-substituted estranes are disclosed which exhibit elevated estrogenic and postcoital contraceptive activities. A process for their manufacture and their use in...
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4701451 |
Novel 6,16-dimethylcorticoids their preparation and use
Compounds of Formula I ##STR1## wherein the bond is a single bond or a double bond, X is hydrogen, fluorine, chlorine, or bromine, R 1 is formyl, alkanoyl or alkoxyalkyl each of which...
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4701449 |
Novel 10-substituted steroids and their use in the induction of aldosterone antagonistic activity
Novel 10-substituted steroids of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl and substituted alkyl of 1 to 8 carbon atoms, alkenyl, substituted alkenyl,...
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4654209 |
Preparation for percutaneous administration
A preparation for percutaneous administration of nitroglycerine, said preparation comprising nitroglycerine incorporated in a cream base in an amount not less than about 0.05% by weight based on...
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4634695 |
Steroid derivatives
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R 1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting...
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4634696 |
Novel 11 beta-substituted-19-nor-steroids
Novel 19-nor-steroids of the formula ##STR1## wherein R 1 is an organic group of 1 to 18 carbon atoms optionally containing at least one heteroatom with the atom immediately adjacent the 11-carbon...
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4614736 |
Novel anti-inflammatory treatment
A novel method of treating inflammation of the colon and rectum of warm-blooded animals comprising administering to the colon and rectum of warm-blooded animals an anti-inflammatorily effective...
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4609651 |
11β-arylestradienes, their production, and pharmaceutical preparations containing same
11β-Arylestradienes of general Formula I are disclosed ##STR1## wherein R 2 is a hydrogen atom, a methyl group, or an ethyl group, R 3 is a hydrogen atom or an acyl group, R 1 and A-B...
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4606913 |
High internal phase emulsions
An improved high-internal-phase emulsion having increased stability under conditions of long term storage at elevated temperatures and freeze-thaw conditions, methods for preparing and stabilizing...
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4604384 |
Pharmaceutical gel composition
A composition for use for the treatment of burns, cuts, wounds, abrasions and the like, comprises a pharmaceutically acceptable glycol, preferably propylene glycol, and a cellulose derivative,...
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4602009 |
Corticoid derivatives and process for production thereof
Novel corticoid 17α-alkoxycarbonyl carboxylate derivatives are disclosed. These derivatives have strong topical anti-inflammatory activity and extremely weak systemic adverse reactions and are...
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4599331 |
Etianic acids as antiangiogenics
This invention provides a method for inhibiting angiogenesis in mammals. A pharmaceutically acceptable formulation containing a compound of the formula ##STR1## where X 1 X 2 and X 3 are H, C1,...
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RE32161 |
Pharmaceutical compositions containing urea
Pharmaceutical compositions for application topically or by suppository comprise: (a) a medicament, preferably protected from degradation by moisture by being presented in small particles of a...
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4588718 |
Carboxy containing ester prodrugs of corticosteroids
A compound of the formula ##STR1## wherein St represents a corticosteroid moiety bonded to the carbonyl via the 21-hydroxy group of said corticosteroid; wherein Z is a bond or --O--; wherein ...
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4587236 |
Novel 6α-methylprednisolone derivatives, their preparation, and their use
6α-Methylprednisolone derivatives of Formula I ##STR1## wherein R 1 is 1-oxoalkyl of 2-6 carbon atoms or benzoyl and R 2 is 1-oxoalkyl of 2-6 carbon atoms, are pharmacologically efficacious...
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4585766 |
6-oxygenated corticoid 17α-carbonates and process for production thereof
Novel 6-oxygenated corticoid 17α-carbonates are disclosed. These compounds have strong topical anti-inflammatory activity which are accompanied by extremely weak systemic adverse reaction. The...
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4581226 |
Method of treating sensitive animal tissue with a specially processed seawater solution
A method of treating various sensitive animal body tissues comprising applying to the tissue a solution prepared from specially processed seawater. The solution is prepared by filtering off-shore...
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4567172 |
6α-Methylprednisolone derivatives
A 6α-methylprednisolone derivative of the general formula: ##STR1## wherein R 1 is a hydrogen atom or stands for the grouping ##STR2## where R 3 is a straight or once-branched chain C 1 -4 alkyl...
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4554271 |
Use of high doses of derivatives of 6α-methylprednisolone for the acute treatment of stroke syndrome
Use of water soluble 21-dibasic esters of 1-dehydro-6α-methylhydrocortisone for the acute treatment of stroke syndrome in humans.
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4550100 |
Process for the preparation of 17α-bromoethynyl- and 17α-iodoethynyl-17β-hydroxy steroids and novel products thereof
A process for preparing bromine- or iodine-unlabeled or radioactively labeled 17α-bromoethynyl- and 17α-iodoethynyl-17β-hydroxy steroids of the androstane and estrane series of the partial...
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4542025 |
Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
An anti-inflammatory agent containing microparticle composition prepared by a process, comprising (a) dissolving or dispersing an anti-inflammatory agent in a solvent and dissolving a biocompatible...
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4536401 |
11β-aryl estradienes, processes for their production and pharmaceutical preparations containing them
Compounds of the formula I ##STR1## wherein R 1 is ##STR2## wherein R I and R II each independently is alkyl of 1-4 carbon atoms, or R I and R II together with the connecting N-atom form a 5-...
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4514384 |
Hemorrhoid treatment method
A method of treating hemorrhoids by applying to hemorrhoidal tissues a composition including by weight carbamide peroxide or benzoyl peroxide in an amount of between about 2% and 40%,...
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4507290 |
Esters of 17 α-ethynyl 19-nor-testosterone and 17 α-ethynyl-18-homo-19-nor-testosterone and pharmaceutical compositions containing the same
Esters of 17 α-ethynyl 19-nor-testosterone and 17 α-ethynyl-18-homo-19-nor-testosterone and the 3-oximes thereof having long-active contraceptive activity.
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4496554 |
Oleaginous emollient vehicle for steroid formulations
An ointment-like composition for the topical administration of a corticosteroid is disclosed. For the topical administration of corticosteroids an ointment-like composition comprising not less than...
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4478822 |
Drug delivery system utilizing thermosetting gels
This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a...
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4474753 |
Topical drug delivery system utilizing thermosetting gels
This invention relates to a unique drug delivery system for application to the skin which drug delivery system is a liquid at room temperature, but when administered topically to the skin becomes a...
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4474751 |
Ophthalmic drug delivery system utilizing thermosetting gels
This invention describes the application of selected polymers as novel drug delivery systems which use the body temperature and pH to induce a liquid to gel transition of the polymer which contains...
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4472394 |
Method for increasing weight in domestic animals
The present invention relates to a method for promoting weight gain in a domestic farm animal which comprises subcutaneously implanting a slow-release implant which contains norgestomet in a...
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4472392 |
Sulfonate containing ester prodrugs of corticosteroids
Novel solution stable ester prodrugs of corticosteroids of the formula ##STR1## and their salts.
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4464365 |
11β-Chloro-Δ.sup.15 -steroids, a process for their preparation and pharmaceutical preparations containing them
11β-Chloro-Δ 15 -steroids of Formula I ##STR1## wherein R 1 is hydrogen or acyl and R 2 is ethynyl, chloroethynyl, or propynyl have strong progestational activity.
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4457910 |
Anhydrous multi-purpose moisturizing composition
A method of prolonging the activity of a physiologically active agent by prolonging the agent's contact with the skin, even in the presence of water which would normally flush the agent away. The...
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4456602 |
Amine containing ester prodrugs of corticosteroids
Novel solution stable ester prodrugs of corticosteroids of the formula ##STR1##
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4452794 |
Medicine having transplant rejection and/or immunological inflammation inhibiting activities, as well as a method for inhibiting transplant rejection and/or immunological inflammation
A medicine having transplant rejection and/or immunological inflammation inhibiting activities is provided, said medicine comprising a combination of a prostaglandin derivative and an...
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4450151 |
Powder aerosol composition
A powder aerosol composition is obtained by first preparing a suspension consisting of a hydrophobic powdered substance having its pH adjusted to fall within the range 5 to 9, alcohol and water,...
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4448774 |
Steroid formulation
There is described an aqueous pharmaceutical solution comprising a steroid selected from prednisolone, prednisolone sodium phosphate, prednisone and methyl prednisolone, the steroid being present...
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4448765 |
Liposomes and their use in treating human or other mammalian patients
Microvesicles are stabilized by the incorporation of a polymer having aliphatic lipophilic groups with a chain of at least six atoms attached to the backbone thereof. Such microvesicles may...
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4447424 |
Steroid derivatives
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R 1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting...
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4435390 |
Hydrocortisone derivatives, the preparation and use thereof
Hydrocortisone derivatives of Formula I ##STR1## wherein is a single bond or a double bond, n is 1 or 2, R 1 is hydrogen or methyl, R 2 is alkyl of 1-6 carbon atoms, and R 3 is...
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4431640 |
Process for inducing anabolic and androgenic activity in animals
Novel Δ 4 ,9 -estradienes of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms and acyl of an organic carboxylic acid of 1 to 18 carbon...
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4427671 |
Steroids esterified in position 17 and thioesterified in position 21, a process for preparing them and their use as medicaments
Compounds of formula: ##STR1## wherein A and B each represent, independently of each other, a straight-chained or branched alkyl group having from 1 to 6 carbon atoms or a phenyl group optionally...
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