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5622944 |
Testosterone prodrugs for improved drug delivery
Compositions and methods are provided for enhanced transdermal electrotransport of 17-hydroxy sterol compounds, including testosterone. The parent sterols are modified at the 17-hydroxy position by...
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5622943 |
Minimizing progestin associated breakthrough bleeding
A method for minimizing menstrual bleeding irregularities in individuals using progestin-only pharmaceutical preparations, such as contraceptives, is disclosed.
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5620966 |
11,21-bisphenyl-19-norpregnane derivatives
The invention relates to a 11,21-bisphenyl-19-norpregnane derivative of formula I ##STR1## wherein R 1 is selected from H, halogen, (1-6C)alkoxy, and NR 5 R 6 , R 5 and R 6 being independently...
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5616573 |
Glucocorticoids
Glucocorticoids of general formula I R--Val--O--GC (II), are described, in which O-GC is the radical of a 21-hydroxycorticoid that has an antiinflammatory action, Val represents a valine radical...
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5591733 |
Methods, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, insomnia and seizure activity using certain steroid derivatives that act at a newly identified...
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5587367 |
Pharmaceutical or cosmetic composition containing a combination of a retinoid and a sterol
A pharmaceutical or cosmetic composition is disclosed comprising in combination a retinoid and a sterol capable of inhibiting the biosynthesis of cholesterol resulting in a synergistic effect in...
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5578589 |
Method for suppressing an immunoresponse with an estradiol derivative-chlorambucil conjugate
The invention is drawn to a method for suppressing an immunoresponse in animals by administering an estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R 1 is alkyl or...
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5576186 |
Diagnosis and monitoring of rheumatological diseases by detection of anti-EF1-α antibodies
A method and assay kit are provided for diagnosing systemic lupus erythematosus by detecting a concentration of anti-EF-1α antibodies that may be found within a sample of body fluid. The assay...
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5576311 |
Cyclodextrins as suspending agents for pharmaceutical suspensions
The present invention relates to stable aqueous suspension of drugs suitable for therapeutic administration without requiring solubilization or complexation of those drugs. The suspensions are...
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5576310 |
11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds
This invention relates to new 11-benzaldoxime-estra-diene derivatives of the general formula I ##STR1## wherein Z is --CO--CH 3 , --CO--O--C 2 H 5 , --CO--NH-phenyl, --CO--NH--C 2 H 5 , --CO--C 2...
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5576309 |
Estradiol derivative-chlorambucil conjugate, process for preparing the same, and pharmaceutical composition
An estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R 1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R 2 is acyl, dansyl, or alkyl; R 3 , R 4 , and R 5 ...
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5565443 |
Subcutaneous implants based on normegestrol derivatives
Subcutaneous implant for preventing conception for at least one year in women comprising an amount effect to prevent conception without suppressing intermontly bleeding of a steroid compound of...
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5556848 |
Ophthalmic suspension containing diflupredonate
An ophthalmic suspension comprising difluprednate as an active ingredient. The ophthalmic suspension of the present invention shows superior antiinflammatory action and antiallergic action by local...
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5554386 |
Delivery of therapeutic agents to receptors using polysaccharides
This invention relates to a method of directing a therapeutic agent to selected cells, wherein a complex is formed between a polysaccharide capable of interacting with a cell receptor and a...
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5552395 |
Δ9(11)-dehydro-8-isoestrone used to treat alzheimer's disease
This invention relates to treating Alzheimer's disease with 8α-3-hydroxyestra-1,3,5(10),9(11)tetraen-17-one (Δ9(11)-dehydro-8-isoestrone) (VI), ##STR1## or a pharmaceutically acceptable salt...
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5545634 |
Activation of androgen receptors with low dose non-masculinizing androgenic compounds
A method of treatment or prevention of breast and endometrial cancer, osteoporosis and endometriosis in susceptible warm-blooded animals comprising administering a low dose. Of a progestin or other...
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5525349 |
Compositions and methods for treating the cornea inconjunction with laser irradiation
Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing...
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5523316 |
Intraocular irrigating solution containing agent for controlling IOP
Improved ophthalmic irrigating solutions are described. The solutions include one or more drugs for controlling intraocular pressure, an antioxidant/free radical scavenger, electrolytes, a cellular...
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5521166 |
Antiprogestin cyclophasic hormonal regimen
The present invention is directed to cyclophasic hormonal regimens which comprise antiprogestin and progestin for human contraception whereby progestin is administered in the alternating presence...
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5516769 |
Method of inhibiting fertilization
Fertilization of an oocyte is inhibited by administering a fertilizing inhibitory amount of an antiprogestin to an ovulatory mammal in an amount which is insufficient to prevent ovulation but...
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5512558 |
Nor-bile acid derivatives, processes for their preparation and the use of these compounds as medicaments
nor-Bile acid derivatives, processes for their preparation and the use of these compounds as medicaments nor-Bile acid derivatives of the formula I G1--X--G2 ...
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5510342 |
Method of lowering cholesterol
This invention provides a method of lowering cholesterol and blood lipid levels, preventing hypercholesterolemia, hyperlipidemia, cardiovascular disease, atherosclerosis, and peripheral vascular...
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5505942 |
Use of hydrolytic enzymes for the prophylaxis of spontaneous abortion in pregnant women with habitual idiopathic abortion in their anamneses
The present invention relates to the use of hydrolytic enzymes for the prophylaxis of spontaneous abortion in pregnant women in need thereof with habitual idiophathic abortion in their anamneses.
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5504117 |
Pharmacologic preparation for the treatment of anal disorders
A medical preparation for treating anal disorders comprises an effective amount of a nitric oxide donor, preferably an organic nitrate. The preparation may be in the form of an ointment that is...
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5504074 |
Estrogenic compounds as anti-angiogenic agents
The application discloses methods of treating mammalian diseases characterized by undesirable angiogenesis by administering estradiol derivatives including those comprising colchicine or...
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5496814 |
Method of modifying bone resorption with Δ9(11)-dehydro-8-isoestrone
This invention relates to 8α-3-hydroxyestra-1,3,5(10),9(11)tetraen-17-one (Δ9(11)-dehydro-8-isoestrone) (VI), ##STR1## to the process for its preparation, to pharmaceutical compositions...
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5474989 |
Drug composition
The present invention relates to a drug composition in which the solubility and the dissolution rate of a drug having low water solubility are improved by incoroprating therein a low molecular...
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5468741 |
Use of low levels of mifepristone to treat leiomyomata
This invention provides for novel unit doses of mifepristone to treat leiomyomata. Compared to unit dosages taught by the prior art, the claimed dosages are low and surprisingly effective....
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5468736 |
Hormone replacement therapy
A method of hormone replacement therapy involves the administration of estrogen together with an amount of antiprogestin which inhibits estrogen-induced endometrial proliferation in a woman.
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5468729 |
Method for treatment of autoimmune hepatitis
A method and composition for treating autoimmune hepatitis in a patient utilizes an immunomodulatory amount of Tα 1 and an anti-inflammatory amount of a corticosteroid.
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5461041 |
Progestogen-only contraceptive
Disclosed is an oral contraceptive regimen containing daily dosage units each containing from 70 to 80 micrograms of desogestrel, 3-ketodesogestrel or mixtures thereof. It has been found that by...
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5461140 |
Bioerodible polymers for solid controlled release pharmaceutical compositions
Bioerodible ortho ester polymers useful for preparing solid form bioerodible pharmaceutical compositions such as pellets, capsules, suppositories and the like are provided. A novel synthetic method...
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5446036 |
13-alkyl-11beta-phenylgonanes
There are provided 13-alkyl-11beta-phenyl-gonanes of formula I ##STR1## wherein Z is an oxygen atom or N--OH; R 2 is alpha- or beta-position methyl or ethyl; R 1 is selected from heteroaryl...
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5443837 |
Estrus synchronization method
A method of synchronizing estrus in breeding animals comprising parenterally administering to breeding animals an estrus synchronizing amount of 17α-allyl-Δ 4 ,9,11 -estratriene-17β-ol-3-one.
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5441947 |
Methods of inhibiting vascular restenosis
Wortmannin and certain of its analogs are inhibitors of restinosis.
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5439902 |
14α, 16α-ethanoand 14α, 16α-etheno-estratrienes
The new 14α,16α-ethano- and 14α,16α-etheno-estratrienes of general formula I, ##STR1## are described, in which A-B means a C-C single bond or C-C double bond, R 1 means a hydrogen atom, a...
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5432170 |
Process for the production of semisolid preparations containing micronized active ingredients
A process for the production of semisolid preparations containing micronized active ingredients is described which is characterized in that a mixture of one or two nonionic surfactants with an HLB...
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5418228 |
Contraceptive regimen
A contraceptive method and regimen utilizing an initially greater amount of progestogen, which gradually tapers over the period in which the contraceptive is administered. The regimen includes a...
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5414014 |
Methods for efficacious removal of attached, sucking antropods from human dermis
The present invention provides methods of using compositions containing local anesthetic compounds for facilitating the removal of sucking arthropods from the skin of a mammal; for reducing...
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5407928 |
11β-aryl-gona-4,9-dien-3-ones
This invention relates to 11β-aryl-gona-4,9-dienes of the general formula I ##STR1## wherein the variables are defined in the specification. The compounds are progesterone antagonists and are...
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5407926 |
Ophthalmic composition
Pharmaceutical compositions useful in the treatment of ophthalmic inflammation and methods of treating ophthalmic inflammation with those compositions are disclosed. The compositions contain a...
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5395831 |
Treating cardiac disorders with Δ9(11)-dehydro-8-isoestrone
This invention relates to 8α-3-hydroxyestra- 1,3,5( 10),9( 11 )tetraen-17-one (Δ9( 11 )-dehydro-8-isoestrone) (VI), ##STR1## to the process for its preparation, to pharmaceutical compositions...
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5371077 |
Side chain derivatized 15-oxygenated sterols, methods of using them and a process for preparing them
Pharmaceutical compositions are provided for lowering the activity of HMG-CoA reductase and/or lowering serum cholesterol, comprising an amount effective to lower the activity of HMG-CoA reductase...
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5366968 |
Modulation of receptor-mediated ion transport
The subject application discloses methods for modulating NMDA-mediated ion transport, and inhibiting non-NMDA glutamate-induced ion transport, in neuronal cells. The methods involve contacting a...
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5362720 |
Methods of treating or preventing breast or endometrial cancer with low dose non-masculinizing androgenic compounds
A method of treatment or prevention of breast and endometrial cancer, osteoporosis and endometriosis in susceptible warm-blooded animals comprising administering a low dose of a progestin or other...
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5362721 |
Corticoid-17-alkyl-carbonates substituted in the 17-position, process for their preparation and pharmaceuticals containing them
The disclosed invention includes corticoid-17-alkylcarbonates substituted in the 17-position, a process for their preparation and pharmaceuticals containing them. These corticoid-17-alkylcarbonates...
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5348729 |
Evaluative means for detecting inflammatory reactivity
The present invention is directed to a method for testing the susceptibility of a mammal to inflammatory diseases which comprises the steps of: administering to a mammal a compound selected from...
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5344819 |
Pharmaceutical compositions for use in treating inflammation
Inflammation in mammals is treated by administering anti-inflammatory agent complexed with corticosteroid binding globulin (CBG) that is produced by recombinant DNA-based techniques.
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5342834 |
Method for androgen supplementation
A particular group of androgens is not metabolized to their 5α-reduced form in the prostate and other tissues. Thus, administration of these compounds--testosterone derivatives with a non-hydrogen...
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5336506 |
Targeting of therapeutic agents using polysaccharides
The invention relates to a method for the targeting of a therapeutic agent to a specific population of cells, wherein a complex is formed between the therapeutic agent and a polysaccharide capable...
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