Matches 151 - 200 out of 619 < 1 2 3 4 5 6 7 8 9 10 11 12 13 >
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6028106 Treatment of urinary incontinence with nitric oxide synthase substrates and/or nitric oxide donors alone or in combination with estrogen or progesterone and/or other agents  
The invention provides a method for the treatment and prevention of urinary incontinence in mammals, e.g., human males and females, especially nonpregnant female mammals, by administering a nitric...
5994333 Pregnane and cholane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods  
The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a pregnane or cholane steroid, or a...
5990099 Angiostatic agents and methods and compositions for controlling ocular hypertension  
Compositions of angiostatic agents for treating GLC1A glaucoma and methods for their use are disclosed.
5972922 Steroids which inhibit angiogenesis  
Novel angiostatic Δ 4 ,9(11) -steroids (I), ##STR1## C 21 -oxygenated steroids (II) and other known steroidal compounds have been found to be useful in treating angiogenesis in mammals who have a...
5965550 Process for the preparation of 4-amino-Δ.sup.4 -3-ketosteroids via 4-nitro-Δ.sup.4 -3-ketosteroids  
The invention discloses 3-ketosteroids of the following formula used to inhibit steroid C 17 -20 lyase: ##STR1## wherein R is OH, C 1 -C 6 alkanoyl, C 1 -C 6 alkanoyloxy, C 1 -C 4 alkanol,...
5958379 Pharmaceutical composition  
A pharmaceutical composition containing at least one systemically and/or locally effective, topically applicable active substance, preferably selected from the group consisting of local...
5925629 Transurethral administration of androgenic agents for the treatment of erectile dysfunction  
A method is provided for treating erectile dysfunction in an individual. The method involves the administration of an androgenic steroid within the context of an effective dosing regimen. The...
5888996 Inhibition of NMDA receptor activity and modulation of glutamate-mediated synaptic activity  
The present invention relates to a method of inhibiting N-methyl-D-aspartate (NMDA) glutamate receptor-mediated ion channel activity (NMDA receptor activity), comprising contacting a neuronal cell...
5885978 External therapeutic composition for dermatitis  
The present invention provides an external therapeutic composition for dermatitis comprising an aqueous solution including a therapeutically effective amount of an adrenal cortical steroid, a...
5877169 Methods of treatment of ischemic damage  
The present invention is directed to a method of conferring protection on a population of cells associated with an ischemic focus, in subject, comprising: (a) providing an estrogen compound...
5861387 Controlled release systems and low dose androgens  
Methods of treatment and prevention of estrogen-related diseases, and of fertility control, include low dose (e.g. less than 50 nanomolar serum concentration) administration of certain anabolic...
5846960 Methods for preventing and treating osteoporosis with low dose non-masculinizing androgenic compounds  
A method of treatment or prevention of breast and endometrial cancer, osteoporosis and endometriosis in susceptible warm-blooded animals comprising administering a low dose of a progestin or other...
5843933 11β-aryl-4-estrenes, process for their production as well as their use as pharmaceutical agents  
Compounds of formula I ##STR1## wherein X, R 1 , R 2 , R 3 and R 4 have the meanings indicated in the description, are described, as well as processes for their production, pharmaceutical...
5837698 Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs  
The present invention relates to a pharmaceutical composition or preparation which comprises hydroxyl containing steroidal hormones and organic nitrite/nitrate or other nitric oxide donating agents.
5834451 Remedy for myotonic dystrophy  
A remedy for myotonic dystrophy, containing dehydroepiandrosterone sulfate or a pharmacologically acceptable salt thereof, being efficacious for myotonia, adynamia and amyotrophy, and having a high...
5824670 17-deoxycorticosteroid-21- O!carboxylic esters, processes for their preparation and pharmaceuticals containing these compounds  
17-Deoxycorticoid-21-carboxylic esters of the formula I ##STR1## are described, in which A is CHOH and CHCl, CH 2 , CO or 9(11) double bond; Y is H, F or Cl; Z is H, F or CH 3 ; R(1) is aryl or...
5824343 Bioerodible polymers, compositions and therapeutic method  
Bioerodible ortho ester polymers useful for preparing bioerodible pharmaceutical compositions such as implants, ointments, creams, gels and the like are provided. The pharmaceutical compositions of...
5811388 Delivery of drugs to the lower GI tract  
Pharmaceutical compositions for orally delivering a therapeutically effective amount of a drug to the colon without significant release of the drug in the upper GI tract after oral administration...
5801165 Antiinflammatory, immunosuppressive and antialleric 16, 17-alkylidioxy-steroids  
Compounds of formula I ##STR1## where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , n, and are as defined herein, their use as antiinflammatory, immunosuppressive, and antiallergic agents, pharmaceutical...
5795881 Combined use of an antigestagen and a progesterone synthesis inhibitor of the trilostane and epostane type  
A pharmaceutical agent contains a progesterone synthesis inhibitor (ProI) of the trilostane or epostane type and an antigestagen (AG). It can be used for inducing delivery at term in humans and...
5780220 Methods and compositions for inhibiting HIV replication  
A method for treating an individual exposed to or infected with HIV is disclosed which comprises administering to said individual a therapeutically effective amount of one or more compounds which...
5776923 Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone  
Sex steroid precursors such as dehydroepiandrosterone and dehydroepiandrosterone sulphate, and compounds converted in vivo to ether of the foregoing, are utilized for the treatment and/or...
5770592 Prevention and treatment of ocular neovascularization using angiostatic steroids  
Methods and formulations for treating ocular neovascularization using angiostatic steroids are disclosed.
5767113 Compounds useful for concurrently activating glucocorticoid-induced response and reducing multidrug resistance  
In accordance with the present invention, it has been discovered that certain synthetic steroid compounds are capable of inhibiting the efflux pump which is believed to be responsible for multidrug...
5763492 Methods for effecting memory enhancement mediated by non-steroidal sulfatase inhibitors  
This invention discloses a method for enhancing memory in a patient comprising administering a compound of formula ##STR1## wherein R 1 and R 2 are independently selected from the group...
5763430 Method of treating a viral infection by administering a steroid compound  
A method of treating a viral infection includes administering an effective amount of a compound having the following structure: ##STR1## or a pharmaceutically acceptable salt thereof. This compound...
5753639 Low dose androgenic compounds for prevention and treatment of endometriosis  
A method of treatment or prevention of breast and endometrial cancer, osteoporosis and endometriosis in susceptible warm-blooded animals comprising administering a low dose of a progestin or other...
5753641 Method of treatment for benign prostatic hyperplasia  
Disclosed is an improved treatment for men with benign prostatic hyperplasia (BPH), involving combination therapy of a 5α-reductase inhibitor, e.g. a 17β-substituted 4-azasteroid, a...
5744464 Antigestagens for the inhibition of uterine synthesis of prostaglandin  
Antigestagens inhibit prostaglandin synthesis by the uterus and thus can be used to treat symptoms of dysmennhorea.
5739125 11 Beta-aryl-gona-4, 9-dien-3-ones  
The invention relates to 11β-aryl-gona-4,9-dienes of formula I ##STR1## wherein the variables are defined in the specification. The compounds are progesterone synthesis inhibitors and are suitable...
5728690 Clear non-alcoholic hydrocortisone solutions  
This invention relates to clear aqueous solutions of hydrocortisone which are free of lower alcohols. When applied to the skin, either directly or by wipe, the solution is practically invisible and...
5721226 Method for inhibiting angiogenesis using squalamine and squalamine steroid derivatives  
A method of inhibiting angiogenesis in a patient includes administering to the patient an effective amount of squalamine or a pharmaceutically acceptable salt of squalamine. Alternatively, a...
5719136 Combination of progesterone antagonists and antiestrogens with partial agonistic action for hormone substitution therapy for perimenopausal and postmenopausal women  
This invention describes the use of at least one compound having a progesterone-antagonistic (PA) action and at least one compound having an antiestrogenic (AO) action with a simultaneous partial...
5719137 Method of preventing neurodegeneration and cognitive dysfunction using 17α-dihydroequilenin  
A method of using a steroidal compound, 17α-dihydroequilenin, to prevent and treat neurodegeneration and cognitive dysfunction in estrogen deficient females and to reduce the risk of Alzheimer's...
5705494 Anti-estrogenic activity of IIβ-substituted-19-NOR Steroids  
Disclosed is a method of inducing anti-estrogenic activity in warm-blooded animals by the administration of a compound of the formula ##STR1## wherein the substituents are as defined in the...
5703066 Progestationally active 19,11-bridged 4-estrenes  
In this invention, the new etheno- and ethano-19,11-bridged 4-estrenes of general formula I ##STR1## are described, in which W, R 1 , R 2 , R 6a , R 6b , R 7 , R 14 , R 15 , R 16 , R 11 , R 11 '...
5703067 Inhibitors of farnesyl-protein transferase  
The present invention is directed to steroidal or terpenoidal compounds which inhibit farnesyl-protein transferase (FPTase). The invention is further directed to chemotherapeutic compositions...
5698545 Angiostatic steroids and methods and compositions for controlling ocular hypertension  
Angiostatic steroids for use in controlling ocular hypertension are disclosed. Pharmaceutical compositions of the angiostatic steroids and methods for their use in treating ocular hypertension,...
5693628 11-benzaldoxime-estra-diene derivatives, methods for their production and pharmaceuticals containing these compounds  
This invention relates to new 11-benzaldoxime-estra-diene derivatives of the general formula I ##STR1## and their pharmaceutically acceptable salts, a method for their production, and...
5679666 Prevention and treatment of ocular neovascularization by treatment with angiostatic steroids  
Methods and formulations for treating ocular neovascularization using angiostatic steroids are disclosed.
5656301 Topical compositions containing LYCD for treatment of ocular infections and wounds  
A topical composition comprising LYCD together with known topically active useful medicinal agents such as anti-wrinkling, antibiotic, anticancer, antifungal, antiinflammatory such as anti-acne,...
5656294 Colonic delivery of drugs  
Pharmaceutical compositions for orally delivering a therapeutically effective amount of a drug to the colon without significant release of the drug in the upper GI tract after oral administration...
5652231 Carcinostatic for hormonotherapy containing dienogest as effective component  
A carcinostatic for a hormonotherapy containing dienogest or its solvate, which is expected to exert therapeutic effects for a broad range of cancer cases at a far lower dose than that of...
5646136 Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids  
Methods for treating angiogenesis, tumors, and ocular hypertension with steroids are disclosed herein. The steroids have angiostatic activity with reduced glucocorticoid activity.
5641768 5-androstene 3β, 17β diol for treatment  
The present invention provides a composition comprising a dosage from containing 0.2 to 30 mg of 5-androstene 3 β,17β diol in a pharmaceutical carrier, and a method of preventing cells from...
5637310 Method of treating prostatic adenocarcinoma  
Invented is a Method of Treating Prostatic Adenocarcinoma by employing asteroid 5-α-reductase inhibiting compound or a combination of steroid 5-α-reductase inhibiting compounds.
5635197 Treatment and prevention of prostatic cancer metastasis  
A series of benzoquinolin-3-ones are pharmaceuticals effective in preventing the development of prostatic cancer, or preventing or treating the metastasis to bone of prostatic cancer.
RE35517 Method, compositions, and compounds for modulating brain excitability  
Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, and seizure activity using certain steroid derivatives that act at a newly identified site on the...
5631248 Supersaturated topical compositions  
Two-component pharmaceutical compositions for topical application to the human or animal body comprising two miscible liquid phases having different lipophilicities and a drug dissolved in at least...
5629007 Method of preventing prostatic cancer development  
A series of benzoquinolin-3-ones are pharmaceuticals effective in preventing the development of prostatic cancer, or preventing or treating the metastasis to bone of prostatic cancer.
Matches 151 - 200 out of 619 < 1 2 3 4 5 6 7 8 9 10 11 12 13 >