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4261986 |
4-Halo etianic acids and derivatives thereof
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17β-carboxylic acids and esters substituted at the 4-position with a fluoro or chloro and optionally substituted at the six position with...
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4261984 |
17β-thiocarboxylic acid esters of 3-oxo-4-halo-16β-methylandrost-4-enes
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17β-thiocarboxylic acid esters substituted at the 4-position with a fluoro or chloro, optionally substituted at the 6- position with fluoro...
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4260605 |
Novel alkylated pregnanes, processes for their preparation and pharmaceutical compositions containing same
The present invention relates to novel 21-alkylated steroids of the pregnane series having the formula: ##STR1## wherein R 1 =alkyl (1-4 C); R 2 =carboxyacyl (1-18 C); X=H, F or Cl; Y=O, H(OH),...
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4255415 |
Polyvinyl alcohol ophthalmic gel
An ophthalmic gel having an improved intensity and duration of the biological response is provided by utilizing a polyvinyl alcohol-sodium borate gel buffered to a pH of 6.5-8.5.
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4252797 |
Corticosteroid calcium compositions and treatment of rheumatic diseases therewith
A dosage composition of corticosteroids with calcium and optionally vitamins B12, C and/or D for treatment of arthritis and other rheumatic disease.
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4250164 |
Method of treating psoriasis of the nails and composition
An improved method of treating psoriasis of the nails comprising applying nail polish containing an anti-psoriasis effective amount of a topical steroid effective against psoriasis therein and...
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4247547 |
Tretinoin in a gel vehicle for acne treatment
An acne treatment gel composition, effective at low concentrations of tretinoin, is provided for topical application. The composition is highly effective in treating acne conditions and is capable...
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4244942 |
Creamy preparation containing steroid and process for the preparation thereof
A creamy preparation containing a steroid compound having a pH of 4 to 7 and a viscosity of 10,000 to 100,000 centipoises, which is applicable to the skin and comprises a steroid compound...
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4243664 |
Novel corticoids
Novel corticoids of formula I ##STR1## wherein X is β-hydroxymethylene, β-fluoromethylene or carbonyl; Y is fluorine, chlorine, hydroxy, or acyloxy of 1-10 carbon atoms; and R 1 is acyloxy of...
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4242334 |
Corticoid 17-(alkyl carbonates) and processes for their preparation
What is disclosed is corticoid 17-(alkyl carbonates) of the formula ##STR1## as defined in the specification, which compounds can be used in veterinary therapy and human therapy, in the form of...
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4242335 |
Novel 17α-aryl-steroids
Novel 17α-aryl-steroids of the formula ##STR1## wherein R 1 is alkyl of 1 to 3 carbon atoms, R 2 is selected from the group consisting of hydrogen, alkyl of 1 to 12 carbon atoms and acyl of an...
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4233296 |
11β-Substituted-Δ.sup.4,9 -estradienes
Novel steroids of the formula ##STR1## wherein R 1 is linear or branched alkyl of 1 to 12 carbon atoms, unsaturated alkyl of 2 to 8 carbon atoms optionally substituted, optionally substituted aryl...
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4233297 |
Novel Δ.sup.4 -androstenes
Novel Δ 4 -androstenes of the formula ##STR1## wherein R 1 is alkyl of 1 to 3 carbon atoms, Y is selected from the group consisting of hydrogen, fluorine and methyl, R 2 is selected from the...
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4233295 |
Corticosteroid formulations containing sebacate carrier
Corticosteroid formulations in the form of creams, lotions or ointments are provided which are used as anti-inflammatory agents, wherein the corticosteroid, such as halcinonide...
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4221787 |
Esteramide prodrugs of anti-inflammatory corticosteroids
Transient, C-21 and/or C-17 esteramide prodrugs of the anti-inflammatory corticosteroids, prepared by esterification of hydroxy steroids, are disclosed.
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4207315 |
Process for treating proliferative skin diseases using certain diamino compounds
A process and pharmaceutical compositions for alleviating proliferative skin diseases such as psoriasis, atopic dermatitis, etc., comprising administering to humans or domesticated animals,...
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4207316 |
Novel 17-substituted 11 β-hydroxy steroids of the pregnane series, their manufacture, preparation and use
Corticoids of the formula ##STR1## wherein represents a single bond or a double bond; X is hydrogen, fluorine, chlorine or methyl; Y is hydrogen and Z is hydrogen, fluorine or chlorine, or ...
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4203981 |
Novel 17 α-aryl-steroids
Novel steroids of the formula ##STR1## wherein R 1 is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of 1 to 18 carbon atoms, R 2 is selected from the group...
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4201778 |
6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory agents, methods for their manufacture, and 6-oxo-1,4-pregnadiene intermediates
Novel 6-acyloxy-3,20-dioxo-1,4,6-pregnatrienes and 6-acyloxy-3,20-dioxo-4,6-pregnadienes, useful anti-inflammatory agents, are prepared by reaction of the corresponding...
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4198403 |
17 Beta-thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters substituted at the 4-position with a fluoro, chloro or bromo and optionally substituted at the six position...
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4189477 |
Novel Δ.sup.4 -pregnenes
Novel Δ 4 -pregnenes of the formula ##STR1## wherein X 1 is selected from the group consisting of O and ##STR2## Y is selected from the group consisting of hydrogen and halogen, R 1 is...
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4188385 |
Thioetianic acid derivatives
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters are useful as antiinflammatory steroids. These compounds are optionally substituted at the 6 alpha-position...
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4187301 |
17 Beta-thiocarboxylic acid esters of 6 alpha, 6 beta-difluoro-3-oxoandrost-4-enes
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters substituted at the 6 alpha, 6 beta-positions with fluorine substituents are useful as anti-inflammatory...
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4185101 |
1,3,5(10),6,8-19-Nor-pregnapentaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor
1,3,5(10),6,8-19-Nor-pregnapentaene-20-ones exhibit anti-mitotic activity with minimal or no hormonal activity. They are particularly useful in the treatment and control of psoriasis when applied...
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4172132 |
1,3,5(10),6,8,14-19-Nor-pregnahexaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor
1,3,5(10),6,8,14-19 Nor-pregnahexaene-20-ones exhibit anti-mitotic activity with minimal or no hormonal activity. They are particularly useful in the treatment and control of psoriasis when applied...
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4168306 |
17α-Acetylenic-Δ.sup.4 -androstenes
17α-Acetylenic-Δ 4 -androstenes of the formula ##STR1## wherein R is saturated or unsaturated alkyl of 1 to 12 carbon atoms and the dotted line indicates the optional presence of a double bond...
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4154730 |
Novel 17-spirosultines
Novel 17-spirosultines of steroids and the corresponding γ-hydroxy acids of the formula ##STR1## wherein R 1 is alkyl of 1 to 4 carbon atoms, A is hydrogen and B is hydrogen or hydroxyl of...
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4150126 |
Novel enol esters of steroids, compositions containing such compounds, processes for their preparation and methods of treatment therewith
This invention relates to novel enol esters of steroids having an antitumor activity and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the...
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4124707 |
7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor
Novel 3,20-dioxo-7α-halogeno-1,4-pregnadienes are described and their use as anti-inflammatory agents. Preferred are 7α-bromo- and 7α-chloro- derivatives, particularly 7α-bromo- and...
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4119717 |
16-S-acyl derivatives of fusidic acid
The present invention relates to a new series of fusidic acid derivatives, to salts and easily hydrolysable esters thereof, to the preparation of these compounds, and to pharmaceutical compositions...
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4115544 |
Ocular system made of bioerodible esters having linear ether
An ophthalmological bioerodible dosage form for ophthalmic drugs is disclosed. The dosage form comprises particles of 10 to 300 microns made of drug dispersed within a drug release rate controlling...
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4105761 |
Anabolisant-androgenic compounds
Anabolisant-androgenic compositions comprising an effective amount of 17β-n-amyloxy-Δ 4 ,9,11 -estratriene-3-one and a pharmaceutical carrier and to a novel method of inducing androgenic and...
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4093721 |
Pharmaceutical compositions of 6α,9α-difluoro-androst-4-ene-17β-carboxylates and derivatives thereof
The specification describes anti-inflammatory steroids having the following formula ##STR1## wherein X represents a hydrogen or fluorine atom, R' represents a methyl, ethyl, n-propyl or iso-propyl...
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4089801 |
Process for the preparation of liposomes
Synthetic liposomes, for example containing a biologically active substance, are prepared by dispersing a first aqueous liquid with the aid of ultrasonic vibration in a water-immiscible carrier...
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4083974 |
Topical steroidal anti-inflammatory preparations containing polyoxypropylene 15 stearyl ether
The present invention discloses topical preparations containing anti-inflammatory steroids. These may be ointments or solutions which contain as a solubilizing agent for the steroid,...
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4070462 |
Steroid ointment
An improved ointment for the topical administration of steroids is comprised of a therapeutically effective amount of a 17-mono or 17,21-diester of betamethasone in a non-aqueous base comprised of...
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4060606 |
16-Ethers of fusidic acid derivatives
The present invention relates to a new series of fusidic acid derivatives, to salts and easily hydrolysable esters thereof, to the preparation of these compounds, and to pharmaceutical compositions...
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4051241 |
Method of treating diseases by daily administration of 6-chloro-11β,17α,21-trihydroxypregna-1,4,6-triene-3,20-dione
This invention relates to a method of treating allergic, dermatologic and rheumatic diseases in mammals which comprises daily orally administering to said mammal in a single dose an effective...
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4049804 |
Novel pregnanoic acid derivatives
Pregnanoic acid derivatives of general formula ##STR1## wherein is a single bond or a double bond; X is hydrogen, fluorine or methyl; Y is hydrogen, fluorine or chlorine; Z is...
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4045555 |
Method for the photostabilization of polyhydroxylated sterols and stabilized biological insecticidal product obtained thereby
Insect metamorphosis hormones of the polyhydroxylated sterol type are light sensitive and tend to lose their activity under the action of light, especially UV radiations. An insect controlling...
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4039668 |
Corticoid-containing inhalants
Inhalants comprising at least one corticoid of the general formula ##STR1## wherein --B--A-- is CH 2 --CH 2 --, CH=CH-- or CCl=CH--; X is a hydrogen atom, a fluorine atom, or methyl; Y is a...
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4029777 |
18-Methyl-19-nor-20-ketopregnanes and process for the preparation thereof
18-Methyl-19-nor-20-keto steroids of the formula ##STR1## wherein R 1 and R 2 collectively are an oxygen atom, or each is hydrogen, or one of R 1 and R 2 is hydrogen and the other is hydroxy,...
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4029778 |
Cortical steroid nitrogen mustard compositions and treatment therewith
New 21-esters of corticoid steroid hormones, the esters having an antitumor activity, are prepared by reacting a reactive derivative of the general formula ##STR1## wherein R 1 can be hydrogen,...
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4011316 |
Cyclohexa-2,5-diene-1-thiones
Compounds of the general formula ##STR1## are provided wherein the substituents R, which may be the same or are different, represent hydrogen atoms or hydrocarbyl groups and the groups R 1 ...
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4011315 |
21-Acetals and mixed acetals of steroidal 21-aldehydes, intermediates and methods of preparation
21-ACETALS AND MIXED ACETALS OF STEROIDS OF THE CORTICOID SERIES ARE PREPARED FROM THE CORRESPONDING 21-HYDROXY STEROIDS AND HAVE UTILITY AS ANTI-INFLAMMATORY AGENTS.
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4007271 |
Dermatalogical compounds and compositions
Mono-, di- or tri-(X,Y-substituted-benzoyl) esters of 1,8,9-trihydroxyanthracene, wherein the anthracene moiety can be substituted by methyl at the 3-position, X is halogen, hydroxy, nitro,...
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4003991 |
Ophthalmic formulation
An ophthalmic "ointment" comprising water, a solid water-soluble polymer of controlled molecular weight, and a medicament or therapeutic agent such as pilocarpine in its pharmacologically...
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3996358 |
21-Esters of steroidal-21-aldehyde hydrates and 21-aldehyde hemiacetals and methods of preparation
21-Esters of 21-aldehyde hydrates and 21-aldehyde hemiacetals of steroids of the corticoid series are prepared from the corresponding 21-hydroxy steroids and have utility as antiinflammatory agents.
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3984544 |
Retinoic acid esters of steroids of the pregnane series, their use in the treatment of acne and pharmaceutical formulations useful therefor
Novel retinoic acid esters of anti-inflammatory steroids of the pregnane series are described and their use in the treatment and control of acne vulgaris via the topical or intralesional route. A...
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3966713 |
11β-FLUOROANDROSTENES
11β-Fluoroandrostenes of the formula ##SPC1## Wherein R 1 and R 2 are hydrogen atoms, methylene or another C--C bond; R 3 is H or Cl, R 4 is H, F or Cl; and X is carbonyl, β-hydroxymethylene,...
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