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6013642 |
Use of estrone derivatives as steroid sulphatase inhibitors
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6011025 |
11-(substituted phenyl)-estra-4,9-diene derivatives
The invention relates to a 11-(substituted phenyl)-estra-4,9-diene derivative of formula I ##STR1## wherein A, X, R 1 and R 2 are as defined by the specification. The compounds of the invention...
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6011026 |
Method of treating menopause or perimenopause
A method of treating menopause or perimenopause without estrogenic activity at the uterine level in women comprising administering to women an amount of a steroid of the formula ##STR1## wherein...
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5994333 |
Pregnane and cholane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a pregnane or cholane steroid, or a...
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5981517 |
Androstene derivatives
The invention provides new androstene derivatives having anti-inflammatory activity, pharmaceutical compositions containing them, and methods of administering them to warm-blooded animals in the...
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5980940 |
Pharmaceutical combination preparation for hormonal contraception
The invention provides a pharmaceutical combination preparation with two hormone components in a packaging unit and intended for time-sequential oral administration, comprising a number of daily...
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5977096 |
Steroids with radical-attracting aromatic substituents, process for the production thereof and pharmaceutical compounds containing the said substances
Novel substituted steroid compounds are disclosed which are more effective than known radical-trapping agents in methods of prophylaxis and therapy of radical-mediated cell damage and of treatment...
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5972920 |
Formulation containing a carrier, active ingredient, and surfactant for treating skin disorders
One or more formulations for treating psoriasis and other skin disorders characterized by redness, itching, flaking, scaling, and plaque-type growth. The formulation includes a carrier component,...
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5972922 |
Steroids which inhibit angiogenesis
Novel angiostatic Δ 4 ,9(11) -steroids (I), ##STR1## C 21 -oxygenated steroids (II) and other known steroidal compounds have been found to be useful in treating angiogenesis in mammals who have a...
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5968917 |
Composition containing diosgenin
Method of treating osteoporosis according to the present invention comprises the administration to a subject in need thereof a therapeutically effective amount of diosgenin, a therapeutically...
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5968918 |
Method for the prevention of coronary artery spasm
The present invention relates to the prevention of coronary artery spasm in mammals by the administration of an effective amount of an antiestrogen compound to block estrogen receptors for the...
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5965550 |
Process for the preparation of 4-amino-Δ.sup.4 -3-ketosteroids via 4-nitro-Δ.sup.4 -3-ketosteroids
The invention discloses 3-ketosteroids of the following formula used to inhibit steroid C 17 -20 lyase: ##STR1## wherein R is OH, C 1 -C 6 alkanoyl, C 1 -C 6 alkanoyloxy, C 1 -C 4 alkanol,...
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5962443 |
19-nur-pregnane steroids as neurochemical initiators of change in human hypothalamic function
The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a 19-nor pregnane steroid, or a...
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5955454 |
Nasal pharmaceutical composition containing a progestogen
The invention relates to a nasal pharmaceutical preparation suitable for nasal administration containing a progestogen and a methylated β-cyclodextrin having a degree of substitution of between...
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5955455 |
Therapeutic methods and delivery systems utilizing sex steroid precursors
Sex steroid precursors such as dehydroepiandrosterone and dehydroepiandrosterone sulphate, and compounds converted in vivo to either of the foregoing, are utilized for the treatment of vaginal...
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5955439 |
Pharmaceutical aerosol containing at least one sugar
This invention relates to aerosol formulations of use for the administration of medicaments by inhalation and in particular to a pharmaceutical aerosol formulation which comprises (a) particulate...
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5935949 |
Use of androgen therapy in fibromyalgia and chronic fatigue syndrome
A method of using androgen therapy to alleviate symptoms associated with chronic fatigue syndrome and fibromyalgia syndrome is provided.
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5929061 |
Method for treating vascular headaches
The present invention provides methods for treating migraine headache comprising administering an effective amount of a neurosteroid that directly or indirectly activates GABA A receptors.
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5929060 |
Method for enhancing or accelerating re-epithelialization or re-endothelialization of a tissue
The present invention is related to a method for enhancing or accelerating re-epithelialization or re-endothelialization of a tissue. Examples of re-epithelialization in which the invention is...
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5919465 |
Methods for augmenting immunological responses through the administration of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEA-S)
Methods for augmenting immune responses in immunodeficient individuals are disclosed. The methods utilize steroid hormones, particularly DHEA, its prohormones (particularly DHEA-S), and...
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5914324 |
6-Hydroxy and 6-oxo-androstane derivatives active on the cardiovascular system and pharmaceutical compositions containing same
6-hydroxy and 6-oxo-androstane derivatives of formula (I), active on the cardiovascular system. ##STR1## wherein: the symbol A represents CH--OR, CN--OR, CH--CHN--OR and CCH--N--OR; and R...
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5906987 |
Treatment of male climacteric disorders with nitric oxide synthase substrates and/or donors, in combination with androgens and/or aromatase inhibitors
The symptoms of climacterium in male mammals, e.g., hypertension, cardiovascular disease and osteoporosis, are ameliorated by the administration to an afflicted individual one or both of a nitric...
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5898032 |
Ultra low dose oral contraceptives with less menstrual bleeding and sustained efficacy
A method of female contraception involves administering a combination of estrogen and progestin for 60-110 consecutive days in which the daily amounts of estrogen and progestin are equivalent to...
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5888996 |
Inhibition of NMDA receptor activity and modulation of glutamate-mediated synaptic activity
The present invention relates to a method of inhibiting N-methyl-D-aspartate (NMDA) glutamate receptor-mediated ion channel activity (NMDA receptor activity), comprising contacting a neuronal cell...
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5885977 |
Use of Δ5 androstenes in the treatment of HIV wasting syndrome
HIV-related weight loss, HIV-related cachexia and HIV-related wasting syndrome can be treated by administering therapeutic amounts of the steroid Δ5-androstene-3β-ol-7,17 dione and metabolizable...
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5885978 |
External therapeutic composition for dermatitis
The present invention provides an external therapeutic composition for dermatitis comprising an aqueous solution including a therapeutically effective amount of an adrenal cortical steroid, a...
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5879711 |
Stable antiandrogenic gel composition
Pharmaceutical compositions for the topical treatment of androgen-related conditions, e.g., acne in humans containing an amount of the compound represented by formula II effective for the topical...
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5880117 |
Use of 4-androstenediol to increase testosterone levels in humans
This invention relates to a method of administering the testosterone precursor 4-androstenediol as a means of increasing testosterone levels in humans.
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5880116 |
Use of celastrol to treat alzheimer's disease
The present invention provides a method for treating patients with Alzheimer's Disease which comprises administering a an effective amount of a celastrol formulation to the patients. One source of...
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5877212 |
Molecular complex and control-release of alpha hydroxyacids
Compositions comprising an alpha hydroxyacid or related acid and organic complexing agent having a molecular weight ranging preferably between about 100 and about 600 can form a control-release...
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5869475 |
Certain 3-ketosteroids used to inhibit steroid 5α-reductase
The invention discloses 3-ketosteroids of the following formula used to inhibit steroid 5α-reductase: ##STR1## wherein R is OH, C 1 -C 6 alkanoyl, C 1 -C 6 alkanoyloxy, C 1 -C 4 alkanol,...
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5861389 |
Methods of treating androgen deficiency in men using selective aromatase inhibitors
Male menopause is characterized by significant decreases in serum levels of bioavailable androgens. The administration of aromatase inhibitors to men experiencing male menopause can remedy the...
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5861391 |
Use of dehydroepiandrosterone to treat primary adrenal insufficiency and Addison's disease
The present invention provides a method of treating an individual with primary adrenal insufficiency, comprising the step of administering an effective amount of dehydroepiandrosterone to said...
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5859000 |
Method for reducing mast cell mediated allergic reactions
The present invention is directed to a method for reducing mast cell mediated allergic reactions, including mast cell mediated allergy and asthma. Mast cell mediated allergic reactions, including...
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5856299 |
Highly reactive esters of carboxy polysaccharides and carboxy polysaccharides derived therefrom
Provided are active esters of carboxy polysaccharides and semisynthetic derivatives of carboxy polysaccharides, wherein all or part of the carboxy groups thereof are esterified with an aromatic...
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5855920 |
Total hormone replacement therapy
A hormone replenishment method particularly useful in maintaining the body's neuroendocrine clock at optimal levels and combating conditions associated with advancing age is disclosed. The method...
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5854230 |
Antiandrogenic agents and related pharmaceutical compositions and methods of use
Novel antiandrogenic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R 1 through R 10 , a and b are as defined herein. Pharmaceutical...
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5849729 |
Use of hydrolyzed cocoa butter for percutaneous absorption
The present invention relates to a pharmaceutical formulation prepared from medicaments selected from the group consisting of retinoids, corticosteroids, vitamin D or α or β-hydroxy acids admixed...
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5849740 |
Methods for using ketoconazole and related substances in medicaments for treatment of type II diabetes
The present invention is a method of using ketoconazole or molecules resembling ketoconazole with comparable biological activity for the manufacture of drugs and for medical treatment of diabetes...
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5846962 |
Anti-obesity agents
Anti-obesity agents which comprise 3-ketosteroid compounds as an active ingredient are provided. The anti-obesity agents of the present invention have a high anti-obesity effect with little or no...
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5837269 |
Vaccine compositions and method for enhancing an immune response
The invention relates to a vaccine which comprises an antigen and an immune response augmenting agent. The immune response augmenting agent is capable of enhancing T cell lymphokine production....
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5837698 |
Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
The present invention relates to a pharmaceutical composition or preparation which comprises hydroxyl containing steroidal hormones and organic nitrite/nitrate or other nitric oxide donating agents.
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5834452 |
1- or 6-hydroxylated steroids
A compound of the formula ##STR1## having progestomimetic activity, wherein the substituents are as defined in the specification and compositions of a compound of formula I and an estrogen compound.
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5834451 |
Remedy for myotonic dystrophy
A remedy for myotonic dystrophy, containing dehydroepiandrosterone sulfate or a pharmacologically acceptable salt thereof, being efficacious for myotonia, adynamia and amyotrophy, and having a high...
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5827841 |
Method for enhancement of production of lymphokines and applications thereof
Disclosed is a method for enhancing the production of T cell lymphokines, which comprises exposing T cell lymphocytes which have a potential to make selected T cell lymphokines to an appropriate...
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5824670 |
17-deoxycorticosteroid-21- O!carboxylic esters, processes for their preparation and pharmaceuticals containing these compounds
17-Deoxycorticoid-21-carboxylic esters of the formula I ##STR1## are described, in which A is CHOH and CHCl, CH 2 , CO or 9(11) double bond; Y is H, F or Cl; Z is H, F or CH 3 ; R(1) is aryl or...
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5824668 |
Formulation for administration of steroid compounds
Disclosed are compositions including at least one 5β steroid and an amorphous cyclodextrin. Also disclosed are methods for treating a condition such as obesity, diabetes syndrome,...
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5811417 |
Process for producing a sterile prednisolone gel
The invention concerns a method for producing a sterile prednisolone gel. The method is characterized in that prednisolone or its pharmaceutically acceptable ester is sterilized and incorporated...
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5811388 |
Delivery of drugs to the lower GI tract
Pharmaceutical compositions for orally delivering a therapeutically effective amount of a drug to the colon without significant release of the drug in the upper GI tract after oral administration...
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5811418 |
Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
The present invention is directed to a method for preventing or reducing ischemia following injury, such as reperfusion injury following ischemia, cellular damage associated with ischemic episodes,...
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