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5637310 |
Method of treating prostatic adenocarcinoma
Invented is a Method of Treating Prostatic Adenocarcinoma by employing asteroid 5-α-reductase inhibiting compound or a combination of steroid 5-α-reductase inhibiting compounds.
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5635197 |
Treatment and prevention of prostatic cancer metastasis
A series of benzoquinolin-3-ones are pharmaceuticals effective in preventing the development of prostatic cancer, or preventing or treating the metastasis to bone of prostatic cancer.
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RE35517 |
Method, compositions, and compounds for modulating brain excitability
Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, and seizure activity using certain steroid derivatives that act at a newly identified site on the...
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5629295 |
Steroidal glycosides for treating hypercholesterolemia
The application discloses steroidal glycoside compounds, especially spirostanyl glycosides, which have a glycosyl group O-linked to the C-3 hydroxy radical of the steroid and where the moieties at...
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5629007 |
Method of preventing prostatic cancer development
A series of benzoquinolin-3-ones are pharmaceuticals effective in preventing the development of prostatic cancer, or preventing or treating the metastasis to bone of prostatic cancer.
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5622944 |
Testosterone prodrugs for improved drug delivery
Compositions and methods are provided for enhanced transdermal electrotransport of 17-hydroxy sterol compounds, including testosterone. The parent sterols are modified at the 17-hydroxy position by...
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5622942 |
Percutaneous absorptive anesthetic
A percutaneous absorptive anesthetic is provided, wherein said anesthetic is formed by mixing a base agent of said anesthetic with one or two type of mixtures which has/have been selected from the...
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5620705 |
Progestin tablet
A hormone replacement composition, a hormone replacement dosage form, and a method of hormone replacement are disclosed and indicated for the management of hormone replacement therapy.
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5616573 |
Glucocorticoids
Glucocorticoids of general formula I R--Val--O--GC (II), are described, in which O-GC is the radical of a 21-hydroxycorticoid that has an antiinflammatory action, Val represents a valine radical...
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5610150 |
Method of treatment of androgen-related diseases
A method of treatment of androgen-related diseases such as prostate cancer in susceptible male animals, including humans, novel antiandrogens and/or novel sex steroid biosynthesis inhibitors as...
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5610152 |
Anti-obesity agent 4-cholesten-3-one
The present invention provides an anti-obesity agent comprising 4-cholesten-3-one represented by the following formula: ##STR1## as an effective component. The anti-obesity agent of the present...
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5610151 |
Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments
Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments Monomeric bile acid derivatives of the formula I Z--X--GS ...
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5604214 |
Reduction of boar odor in meat
This invention relates to a method for eliminating or lessening the incidence of boar odor in meat reared from male pigs which comprises administering to such male pigs an effective amount of a...
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5591733 |
Methods, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, insomnia and seizure activity using certain steroid derivatives that act at a newly identified...
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5587368 |
Administration of a 27-hydroxycholesterol or related compound or sterol-27-hydroxylase stimulant to prevent restenosis following vascular endothelial injury
A method for preventing or reducing restenosis wherein a 27-hydroxycholesterol or a 25,26 and/or 27-aminocholesterol, or a sterol 27-hydroxylase stimulant, is administered in a restenosis...
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5583128 |
Contraception in female primates without affecting the menstrual cycle
The invention relates to the use of aromatase inhibitors for contraception in female primates and to a method for contraception in female primates using such substances and to the use of those...
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5578588 |
Medicament for increasing the testosterone level
The invention concerns a drug for increasing the level of testosterone in the human body, the drug containing at least one testosterone precursor.
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5574022 |
Method of attenuating physical damage to the spinal cord
A method is disclosed for attenuation of nervous system damage after injury which comprises administering therapeutic amounts of PREG, PREG-S, or esters of PREG or PREG-S together with an enhancer...
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5565443 |
Subcutaneous implants based on normegestrol derivatives
Subcutaneous implant for preventing conception for at least one year in women comprising an amount effect to prevent conception without suppressing intermontly bleeding of a steroid compound of...
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5563131 |
Pregnane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a pregnane steroid, or a pharmaceutical...
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5561124 |
17-α-acyl steroids which inhibit 5-α-reductase
The invention relates to substituted 17α-acyl steroidal 5α-reductase inhibiting compounds. The invention also relates to pharmaceutical compositions containing these compounds and their use for...
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5554595 |
Selective regulation of B lymphocyte precursors by hormones
Based on the discovery that normal pregnant mice have a striking reduction in committed precursors of B lymphocytes, which could be documented in mice as early as day 6 of gestation, when IL-7...
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5550120 |
Regulating neuropeptide hormone secretion
Methods are described for regulating neuropeptide secretion to alleviate premature labor, hypertension, fluid imbalance, and risk of heart disease: using neuroactive steroids targeted for a...
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5545635 |
Inhibiting bone loss with equilenin
The present invention provides methods of inhibiting bone loss in humans comprising administering to a patient in need of treatment an effective amount of d-equilenin, 17β-dihydroequilenin, and...
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5545634 |
Activation of androgen receptors with low dose non-masculinizing androgenic compounds
A method of treatment or prevention of breast and endometrial cancer, osteoporosis and endometriosis in susceptible warm-blooded animals comprising administering a low dose. Of a progestin or other...
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5525349 |
Compositions and methods for treating the cornea inconjunction with laser irradiation
Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing...
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5514673 |
Pharmaceutical composition containing lipophilic drugs
A pharmaceutical composition having a form suitable for transmucosal administration containing progesterone and/or 17-β-estradiol as an active ingredient.
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5514667 |
Method for topical treatment of herpes infections
A method for the topical treatment of herpes virus infections of the skin and mucous membranes is disclosed- This method uses a topical preparation comprising an anti-vital drug in combination with...
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5512556 |
Use of a pregnane derivative
The invention relates to a use of pregnane derivatives of the following general formula: ##STR1## in which R=H 2 , (H,OH), (H,OAcyl), or O, and especially the pregnane...
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5505942 |
Use of hydrolytic enzymes for the prophylaxis of spontaneous abortion in pregnant women with habitual idiopathic abortion in their anamneses
The present invention relates to the use of hydrolytic enzymes for the prophylaxis of spontaneous abortion in pregnant women in need thereof with habitual idiophathic abortion in their anamneses.
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5504074 |
Estrogenic compounds as anti-angiogenic agents
The application discloses methods of treating mammalian diseases characterized by undesirable angiogenesis by administering estradiol derivatives including those comprising colchicine or...
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5502044 |
Fluorinated 4-aminoandrostadienone derivatives and process for their preparation
The present invention relates to a compound of formula (I) ##STR1## wherein (x) and (y) are single or double bonds; A is a ##STR2## R and R 3 are hydrogen or acyl; R 1 is hydrogen or fluorine;...
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5486511 |
4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C.sub.17-20 lyase and 5α-reductase
This invention is directed to 4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylylamino)androst-4-en-3-one and related compounds, a process for their synthesis, a...
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5480913 |
Anti-androgen compounds
Disclosed are novel classes of anti-androgens including dihydrophenanthrene derivatives, their method of synthesis and their use in treating disorders associated with excessive androgenic activities.
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5446036 |
13-alkyl-11beta-phenylgonanes
There are provided 13-alkyl-11beta-phenyl-gonanes of formula I ##STR1## wherein Z is an oxygen atom or N--OH; R 2 is alpha- or beta-position methyl or ethyl; R 1 is selected from heteroaryl...
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5436237 |
Method of using 4-amino-Δ.sup.4 -steroids in the treatment of benign prostatic hyperplasia
The present invention relates to 4-amino-Δ 4 -steroids which are useful as inhibitors of 5α-reductase. The compounds are prepared by the reaction of an appropriate 4-azido steroid with...
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5420121 |
Use of 4-cholesten-3-one as an anti-obesity agent
The present invention provides a method for using the anti-obesity agent comprising 4-cholesten-3-one represented by the following formula: ##STR1## as an effective component. The anti-obesity...
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5407927 |
Treatment of mild depression and restoration of IGF-I levels in aging by dehydroepiandrosterone
This invention relates to the treatment of mild depression in an aging patient population. The invention specifically relates to daily treatment with dehydroepiandrosterone to increase insulin-like...
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5376641 |
Method for making a steroid water soluble
A complex of branched beta cyclodextrin and steroid is formed by mixing a steroid and a branched beta cyclodextrin together in water for a period of about 4 to 24 hours under ambient conditions....
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5371077 |
Side chain derivatized 15-oxygenated sterols, methods of using them and a process for preparing them
Pharmaceutical compositions are provided for lowering the activity of HMG-CoA reductase and/or lowering serum cholesterol, comprising an amount effective to lower the activity of HMG-CoA reductase...
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5362720 |
Methods of treating or preventing breast or endometrial cancer with low dose non-masculinizing androgenic compounds
A method of treatment or prevention of breast and endometrial cancer, osteoporosis and endometriosis in susceptible warm-blooded animals comprising administering a low dose of a progestin or other...
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5340805 |
Danazol for treatment of urinary incontinence
The method of use of danazol for reducing or eliminating urinary incontinence and any associated frequent urination in a person suffering therefrom and pharmaceutical compositions therefor are...
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5318961 |
4-amino-Δ4-steroids and their use as 5α-reductase inhibitors
The present invention relates to 4-amino-Δ 4 -steroids which are inhibitors of 5α-reductase. The compounds are useful for treating DHT-mediated diseases.
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5314882 |
Method for promoting growth and improved meat quality in meat producing animals with female steroidal hormones
The growth rate of meat-producing animals as well as the yield and quality of the meat obtained therefrom is improved by administering to the animal prior to its sexual maturation an effective...
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RE34578 |
Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
A topical drug application for the alleviation of kerato-conjunctivitis sicca (dry eye syndrome) is comprised of a solution of sex steroids or their derivatives suspended or dissolved in a vehicle,...
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5280023 |
Ovulation-inhibiting preparation for hormonal contraception
An ovulation inhibiting preparation for hormonal contraception, comprising two hormone constituents packed spatially separate in a packing unit intended for chronological, sequential oral...
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5272139 |
Amelioration or elimination of postoperative pain
Following completion of an operative procedure, the topical application of a cortisone preparation into the area of a postoperative wound is useful in ameliorating or eliminating postoperative...
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5272140 |
11-aryl steroid derivatives
The invention relates to 11-aryl steroid derivatives, having the structure ##STR1## wherein: R 1 , R 2 , R 3 , and R 4 are as described in the specification and to processes for their...
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5264428 |
Use of stigmasta-4-en-3-one in the treatment of androgen dependent diseases
A pharmaceutical preparation which comprises stigmasta-4-en-3-one as the active ingredient. This active ingredient can be used for the treatment of androgen-dependent diseases, especially for the...
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5264427 |
20-substituted pregnene derivatives and their use as androgen synthesis inhibitors
Novel 20-substituted-pregnene derivatives, compositions containing such derivatives and methods for their use and manufacture are disclosed. The 20-substituted-pregnene derivatives inhibit the...
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