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7579334 |
Compounds with anti-inflammatory activity
The present invention relates to new compounds represented by Formula I:
wherein M represents a macrolide subunit of the substructure II:
L represents the chain of the substructure III:
...
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7417038 |
Methods of treating cachexia
A method of treating weight loss due to underlying disease in a patient the method comprising administering to the patient an effective amount of an agent which reduces sympathetic nervous system...
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7405206 |
Anti-inflammatory androstane derivatives
There are provided compounds of formula (I)
wherein
R 1 represents O, S or NH; R 2 represents —C(═O)-aryl or —C(═O)-heteroaryl; R 3 represents hydrogen, methyl (which may be in...
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7387800 |
Sesquiterpenoid derivatives having adipocyte differentiation inhibitory effect
The objective of the present invention is to identify compounds having an inhibitory effect on adipocyte differentiation, and to provide pharmaceutical compositions and food compositions for...
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7320971 |
2″ oxo-voruscharin and derivatives thereof
2″ oxo-voruscharin compound and derivatives thereof are disclosed as well as pharmaceutical compositions which include 2″ oxo-voruscharin compound or derivatives thereof. The disclosed 2″...
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RE40000 |
Method of treatment for decreasing mortality resulting from congestive heart failure
A method of treatment using a compound of Formula I:
wherein:
R 1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl; R 2 is hydrogen,...
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7074778 |
Asthma associated factors as targets for treating atopic allergies including asthma and related disorders
This invention relates to methods for treating asthma or allergy in a mammal by administering a 3-aminosteroid compound to a mammal in need thereof. The 3-aminosteroid compound being capable of...
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7015210 |
Methods of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists
A method for treating or preventing ophthalmic disorders comprising the administration of one or more aldosterone receptor antagonists that contain a 9,11-epoxy moiety, such as eplerenone is...
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6984633 |
Method to treat cardiofibrosis with a combination therapy of an angiotensin II antagonist and epoxymexrenone
A therapeutic method is described for treating cardiofibrosis or cardiac hypertrophy using a combination therapy comprising a therapeutically-effective amount of an angiotensin II receptor...
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6979454 |
Biologically active composition
A biologically active stick composition comprising a biologically active agent dissolved in a carrier system including an unsaturated fatty acid alcohol in mutual dissolution with an alkylene...
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6878745 |
Selective preventives/remedies for progressive lesions after organ damage
Drugs for preventing and/or treating progressive lesions after organ damage without inhibiting the function of the organ or the regeneration function thereof, by selectively regulating the...
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6878699 |
Taccalonolide microtubule stabilizing agents
In accordance with the present invention, there have been identified extracts from a tropical plant that initiate paclitaxel-like microtubule bundling. Bioassay-directed purification yields the...
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6863902 |
Immediate release eplerenone compositions
The invention relates to oral pharmaceutical compositions useful as aldosterone receptor blockers comprising the active agent micronized eplerenone in an amount of about 10 mg to about 1000 mg and...
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6828313 |
Use of oxandrolone in the treatment of burns and other wounds
The subject invention provides a method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount of an oxandrolone to the patient. The...
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6759399 |
Use of antimineralocorticoid compounds against narcotic withdrawal syndrome
The method of treating narcotic withdrawal symptoms in warm-blooded animals comprising administering to warm-blooded animals in need thereof an amount of a compound having anti-mineralocorticoid...
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6747020 |
Methods of treating heart failure and hypertension using combinations of eplerenone and an angiotensin converting enzyme inhibitor
Methods of using eplerenone, an angiotensin converting enzyme inhibitor and optionally a diuretic are described for treatment of heart failure and hypertension.
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6716829 |
Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders
Combinations of aldosterone blockers and Cyclooxygenase-2 inhibitors useful in the treatment of inflammation are disclosed.
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6699846 |
Mono- and disaccharides for the treatment of nitric oxide related disorders
Methods for treating diseases or conditions modulated or ameliorated by nitric oxide, particularly ischemia and reperfusion injury, are provided, using glycolipids structurally related to...
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6670347 |
19-nor-17α-pregna-1,3,5(10)-trien-17β-ols with a 21,16α-lactone ring
This invention relates to new 19-nor-17α-pregna-1,3,5(10)-trien-17β-ols with a 21,16α-lactone ring of formula II, process for their production and pharmaceutical preparations that contain...
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6653306 |
Epoxy-steroidal aldosterone antagonist and angiotensin II antagonist combination therapy
A combination comprising therapeutically-effective amount of an epoxy-steroidal aldosterone receptor antagonist and a therapeutically-effective amount of an angiotensin II receptor antagonist is...
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6627623 |
Inducing cell apoptosis and treating cancer using 1-O-acetylbritannilactone or 1,6-O,O-diacetylbritannilactone
Compositions and methods for preventing and treating cancer are provided that comprise extracts of Inula britannica or compounds isolated therefrom. The compounds of 1-O-acetylbritannilactone or...
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6608047 |
Use of low dosage amount of spironolactone for treatment of cardiovascular disease
Use of low dosages of an aldosterone receptor antagonist, spironolactone, is described for treatment of circulatory disorders. This therapy would be particularly useful to treat or retard the...
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6592902 |
Controlled release eplerenone compositions
The invention relates to oral pharmaceutical compositions useful as aldosterone receptor blockers comprising the active agent micronized eplerenone in an amount of about 10 mg to about 1000 mg and...
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6541464 |
Steroids substituted at the 11-position, process for their preparation, their use as medicament and the pharmaceutical compositions containing them
Compounds of the formula Where the substituents are defined in the application.
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6531461 |
Medicament for the treatment of diabetes
A series of compounds of general structure I and metal salts thereof. These compounds are useful in the treatment of diabetes mellitus and associated conditions when administered in an effective...
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6495165 |
Eplerenone compositions having improved bioavailability
The invention relates to oral pharmaceutical compositions useful as aldosterone receptor blockers comprising the active agent micronized eplerenone in an amount of about 10 mg to about 1000 mg and...
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6482813 |
Steroids substituted at the 11-position, process for their preparation, their use as medicament and the pharmaceutical compositions containing them
Compounds of formula for treating osteoporosis with minimal estrogenic activity are disclosed.
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6461596 |
Composition and method for promoting hair growth
A composition suitable for topical application contains a hair growth promoter integrated into a carrier and a method for local treatment to produce increased hair growth. The composition is...
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6410524 |
Combination therapy of angiotensin converting enzyme inhibitor and aldosterone antagonist for reducing morbidity and mortality from cardiovascular disease
Combinations of an ACE inhibitor, an aldosterone antagonist, and a loop diuretic are described for use in treatment of circulatory disorders. Of particular interest are therapies using captopril,...
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6391867 |
Use of spironolactone for treatment of symptomatic heart failure
Use of an aldosterone receptor antagonist, spironolactone, is described for treatment of heart failure. This therapy would be particularly useful to treat or retard the development of symptomatic...
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6306845 |
Method for treating demyelinating disease
The present invention provides a method for treating a demyelinating disease in a subject which includes administering to the subject a therapeutically effective amount of a high affinity...
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6245755 |
Use of aldosterone antagonists to inhibit myocardial fibrosis
This invention discloses a method of inhibiting aldosterone-mediated myocardial, perivascular and interstitial fibrosis using epoxymexrenone and other aldosterone antagonists.
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6239121 |
4- Halogenated steroids, preparation method and intermediates, application as medicines and pharmaceutical compositions containing same
A subject of the invention is the compounds of formula (I): ##STR1## in which X is a halogen atom, D represents the remainder of an optionally substituted pentagonal or hexagonal ring and...
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6177416 |
Oxyiminopregnancarbolactones
3-Oxyiminopregnane-21-carbolactones of formula I, ##STR1## wherein R is as defined by the specification, their production and use as pharmaceutical agents are described.
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6011026 |
Method of treating menopause or perimenopause
A method of treating menopause or perimenopause without estrogenic activity at the uterine level in women comprising administering to women an amount of a steroid of the formula ##STR1## wherein...
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5929111 |
A-seco steroids effective at treating ophthalmic pathological neovascularization and controlling intraocular pressure
A-seco steroids are disclosed. Methods of use are disclosed for treating ophthalmic pathological neovascularization and controlling intraocular pressure.
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5767113 |
Compounds useful for concurrently activating glucocorticoid-induced response and reducing multidrug resistance
In accordance with the present invention, it has been discovered that certain synthetic steroid compounds are capable of inhibiting the efflux pump which is believed to be responsible for multidrug...
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5763430 |
Method of treating a viral infection by administering a steroid compound
A method of treating a viral infection includes administering an effective amount of a compound having the following structure: ##STR1## or a pharmaceutically acceptable salt thereof. This compound...
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5760025 |
Steroid derivatives for the treatment of prostatic hypertrophy, their preparation and uses
Compounds of formula (I): ##STR1## wherein: R 1 is hydrogen, alkyl, aryl-substituted alkyl or aromatic heterocyclic-substituted alkyl; R 2 is: aryl-substituted alkyl, aromatic...
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5721226 |
Method for inhibiting angiogenesis using squalamine and squalamine steroid derivatives
A method of inhibiting angiogenesis in a patient includes administering to the patient an effective amount of squalamine or a pharmaceutically acceptable salt of squalamine. Alternatively, a...
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5679668 |
Method of controlling fertility in males with 20-substitute of steroids
The invention is a method of controlling fertility in male warm-blooded animals by administering a compound of the formula ##STR1## wherein R 1 and R 2 are individually selected from the group...
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5618806 |
17α and 17β-substituted estra-1,3,5(10)-triene-3-carbboxlic acid
Invented are 17α and 17β-substituted acyl-3-carboxy aromatic A ring analogues of steroidal synthetic compounds. Representative of such compounds include the following ##STR1## wherein Z is α or...
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5583127 |
17-iminomethylalkenyl-5 β, 14 β-androstane and 17-iminoalkyl-5 β, 14 β-androstane derivatives active on the cardiovascular system, and pharmaceutical compositions containing same
Disclosed are 17-iminomethylalkenyl and 17-iminoalkyl-14β-hydroxy-5β-androstane derivatives of the formula (I): ##STR1## wherein the symbol means α or β configuration or a Z or E...
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5529992 |
Method for inhibiting myocardial fibrosis by administering an aldosterone antagonist which suppresses aldoster one receptors
This invention discloses a method of using an aldosterone antagonist such as spironolactone, at a dosage which does not disrupt a patient's normal electrolyte and water-retention balance, to...
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5489582 |
14-deoxy-14α-cardenolides 3β-thioderivatives and pharmaceutical composition comprising same for treating cardiovascular disorders
14-Deoxy-14α-cardenolides 3β-thioderivatives and pharmaceutical compositions comprising same for treating cardiovascular disorders, such as heart failure and hypertension, are disclosed.
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5478817 |
Digitoxigenin and dihydrodigitoxigenin 3β-derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disorders
Digitoxigenin and dihydrodigitoxigenin 3β-derivatives, a process for their preparation and pharmaceutical compositions containing same for the treatment of cardiovascular disorders such as heart...
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5446036 |
13-alkyl-11beta-phenylgonanes
There are provided 13-alkyl-11beta-phenyl-gonanes of formula I ##STR1## wherein Z is an oxygen atom or N--OH; R 2 is alpha- or beta-position methyl or ethyl; R 1 is selected from heteroaryl...
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5426102 |
14β-H-, 14-and 15-En-11β-aryl-4-oestrenes
Novel compounds of the general formula I ##STR1## and the pharmacologically tolerable addition salts thereof with acids are described, in which either Ia) R 11 represents a hydrogen atom in the...
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5420120 |
Anti-inflammatory glucocorticoid compounds for topical ophthalmic use
Topically administrable C-21 thioether glucocorticoid steroid derivatives are disclosed as effective anti-inflammatory agents for the treatment of ophthalmic inflammatory disorders. These C-21...
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5382434 |
Low steroid dose dry pharmaceutical preparation
Disclosed are dry pharmaceutical preparations containing potent steroidal medicinal agents in combination with an excipient capable of binding the agent to an extent greater than 80% and a having a...
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