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5382434 |
Low steroid dose dry pharmaceutical preparation
Disclosed are dry pharmaceutical preparations containing potent steroidal medicinal agents in combination with an excipient capable of binding the agent to an extent greater than 80% and a having a...
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5272140 |
11-aryl steroid derivatives
The invention relates to 11-aryl steroid derivatives, having the structure ##STR1## wherein: R 1 , R 2 , R 3 , and R 4 are as described in the specification and to processes for their...
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5244886 |
11β-phenyl-14βH steroids
New 11β-phenyl-14βH-steroids of general formula (I), where Z is an oxygen atom or the hydroxyimino-grouping N.about.OH, and M and N are either jointly a second compound or L is a hydrogen atom...
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5198427 |
Natural intense sweeteners
The present invention relates to novel sweet compounds derived from the leaves of the subtropical weed Abrus precatorius, and their use as sweeteners. In particular, the present invention...
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5173483 |
Ovulation stimulating method
A method of stimulating ovulation in warm-blooded animals comprising administering to warm-blooded animals an ovulation stimulating effective amount of at least one anti-progestomimetic compound.
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5053403 |
Methods for treatment of male-pattern baldness
Synergistic compositions for inhibiting the action of androgens comprise the combination in a single topical preparation of a 5α-reductase enzyme inhibitor and an androgen receptor blocking agent...
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4987128 |
Novel 10β-alkynyl-steroids
Novel 10β-alkynyl-steroids of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, optionally substituted alkyl and alkoxy of 1 to 8 carbon atoms, optionally...
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4978657 |
Novel 11β-substituted-19-nor-steroids
Novel 19-nor-steroids of the formula ##STR1## wherein R 1 is an organic group of 1 to 18 carbon atoms optionally containing at leat one heteroatom with the atom immediately adjacent the 11-carbon...
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4921845 |
11-arylsteroid compounds
The invention relates to new 11-arylsteroid compounds, having a strong antiprogestin and a weak or nonexistent antiglucocorticoid activity, to processes for preparing said compounds and also to...
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4904462 |
Multiply-tritiated steroidal-20,17-spirolactones and their use as tracer compounds
Novel, multiple-tritiated steroid-20,17-spirolactones of general Formula I ##STR1## wherein --A--B-- is --CH 2 --CH 2 --, --CHCH-- or ##STR2## and --C--D-- is ##STR3## R is hydrogen or tritium...
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4891365 |
17-Substituted estradienes and estratrienes
17-Substituted estradienes and estratrienes of Formula I ##STR1## wherein ##STR2## R is alkyl, alkenyl or cycloalkyl of up to 5 carbon atoms if ##STR3## R is hydrogen, alkyl, alkenyl or cycloalkyl...
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4885289 |
Alteration of character of male beard growth
The rate and character of androgen-stimulated beard hair growth in intact, sexually mature males is altered by the topical application out of a dermatologically acceptable carrier of an...
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4871724 |
Novel 11-aryloestrane and 11-arylpregnane derivatives
The present invention is concerned with 11-aryloestrane and 11-arylpregnane derivatives, characterized in that these derivatives have the following structure: ##STR1## wherein R 1 is an aryl group...
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4866049 |
Ophthalmic compositionn and method of using same
The present invention relates to ophthalmic compositions and their preparation and use. More specifically, the invention relates to ophthalmic compositions useful in the treatment of surface...
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4847246 |
Antiviral compositions derived from fireflies and their methods of use
This invention relates to antiviral organic steroid compositions and derivatives thereof; a process of producing the antiviral compositions; and a method for inhibiting viruses utilizing the...
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4837211 |
Spironolactone composition
A pharmaceutical composition, having utility as a diuretic or aldosterone antagonist, comprising spironolactone and an aqueous homogenizingly effective amount of a material selected from the group...
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4701449 |
Novel 10-substituted steroids and their use in the induction of aldosterone antagonistic activity
Novel 10-substituted steroids of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl and substituted alkyl of 1 to 8 carbon atoms, alkenyl, substituted alkenyl,...
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4684635 |
Compositions and methods for inhibiting the action of androgens
Synergistic compositions for inhibiting the action of androgens comprise the combination in a single topical preparation of a 5α-reductase enzyme inhibitor and an androgen receptor blocking agent...
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4559332 |
20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof
Steroid compounds of the 20-spiroxane series and their analogues having an open ring E of the formula, ##STR1## in which --A--A-- represents the group --CH 2 --CH 2 -- or --CHCH--, R 1 ...
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4552871 |
Steroids of the 20-spiroxane series, processes for the manufacture thereof, pharmaceutical preparations containing such compounds and the use of the latter
(5α)-20-spirox-1-en-3-ones (I) and 17-hydroxy-5α,17α-pregn-1-en-3-ones (II) of the formulae ##STR1## in which X represents O or H 2 , R 2 represents O and R 1 represents OH, OMe, OAlk, NH 2 ,...
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4543351 |
Spironolactone containing composition for combatting acne
A spironolactone containing composition for topical use in the form of a cream active in combatting acne and causing only skin absorption and therefore devoid of any undesired systemic effect.
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4291029 |
6β,7β;15,16-Dimethylene-1,4-androstadien-3-ones, their preparation and use as medicinal agents
Compounds of the formula ##STR1## wherein the 15,16-methylene group is in the α- or β-position, and E is ##STR2## are useful as diuretics.
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4219549 |
Amino-3 cardenolides, process for preparation, and pharmaceutical compositions containing same
Aminocardenolides of formula (I): ##STR1## in which R 1 , R 2 , R 4 , R 5 , and R 6 , which may be the same or different, each represents a hydrogen atom or a hydroxy, alkoxy or acyloxy group; R 3 ...
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4218447 |
Acyl derivatives of hellebrigenin
There are prepared compounds corresponding to the general formula: ##STR1## in which R represents a 2,2-dimethylethenyl; isopropyl; nonyl; a C 3 -C 6 -cycloalkyl radical; a phenyl group...
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4129564 |
Spirolactones
New spirolactones of the formula ##STR1## R is a lower alkyl of up to 5 carbon atoms, and ##STR2##
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4060607 |
Cardenolide derivatives
Cardiotonic cardenolide derivatives of the formula ##STR1## wherein n, m, R 1 to R 9 are as hereinafter defined, the mineral or organic salts thereof and a process for their preparation.
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4011316 |
Cyclohexa-2,5-diene-1-thiones
Compounds of the general formula ##STR1## are provided wherein the substituents R, which may be the same or are different, represent hydrogen atoms or hydrocarbyl groups and the groups R 1 ...
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4003996 |
Spirolactone for inhibiting the cardiotoxic effects of adriamycin
The administration of aldosterone inhibitors of the spirolactone structural type prior to and during treatment with anti-neoplastic agents such as adriamycin results in retention of the desired...
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3941880 |
Method for use of 11-lower alkyl steroids
The method of controlling estrus and ovulation in female bovines by the administration of 11-lower alkyl steroids and 11-lower alkyl steroid compositions for use therein. Drug delivery system for...
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3458632 |
METHOD OF INDUCING ANTIANDROGENIC ACTIVITY
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3070507 |
Novel corticoids from delta16-20-ketoalkenyl adducts
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3012940 |
Derivatives of pregnene (18-11) lactones and pharmaceutical compositions thereof
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3004890 |
New pregnane-18-acid derivatives
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