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7524834 |
Sterile powders, formulations, and methods for producing the same
The invention provides sterile glucocorticosteroids and sterile formulations containing glucocorticosteroid and use thereof in the treatment of an allergic and/or inflammatory condition of the nose...
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7468362 |
Carbonate and carbamate modified forms of glucocorticoids in combination with β2 adrenergic agonists
Compositions containing β 2 adrenergic agonists in combination with carbonates and carbonates of the formula
and in combination with related steroid carbonates and carbonates are disclosed....
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7267813 |
Inhalation particles incorporating a combination of two or more active ingredients
Crystalline spherical inhalation particles incorporating a combination of two or more different active ingredients and a process for the preparation thereof. The particles have a narrow particle...
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7172752 |
Combination particles for the treatment of asthma
Inhalation particles incorporating, in an individual particle, a combination of a βhd 2-agonist and a glucocorticosteroid in a predetermined and constant ratio, a process for the preparation...
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7119082 |
11β-long-chain-substituted 19-nor-17α-pregna-1,3,5(10)-trien-17β-ols with a 21,16α-lactone ring
This invention relates to new 19-nor-17α-pregna-1,3,5(10)-trien-17β-ols with a 21,16α-lactone ring with a long-chain substituent in 11β-position of general formula II
in which R 11 means a...
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7112580 |
3-nitrogen-6, 7-dioxygen steroids and uses related thereto
A compound of the formula:
and pharmaceutically acceptable salts, solvates, stereoisomers and prodrugs thereof, in isolation or in mixture, wherein R groups are as defined by the present...
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7108867 |
Process for preparing particles
A process for preparing particles of a substance, such as a protein or polypeptide, comprising: (a) preparing a first liquid comprising water, the substance and a modulator, wherein the modulator...
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7087590 |
19-norbufalin derivatives, their preparation and pharmaceutical compositions containing them
A 19-norbufalin derivative compound of formula (I):
wherein the R groups are as defined by the present specification. The compounds are Na + K − -ATPase inhibitors and can be used in the...
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7015210 |
Methods of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists
A method for treating or preventing ophthalmic disorders comprising the administration of one or more aldosterone receptor antagonists that contain a 9,11-epoxy moiety, such as eplerenone is...
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6986904 |
Formulation
A new metered unit dose comprising 40 μg or less of budesonide is disclosed as well as a formulation thereof and the use thereof for the treatment of conditions in the nose.
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6956031 |
11β-Substituted 19-nor-17-α-pregna-1,3,5(10)-trien-17β-ols with a 21,16α-lactone ring
This invention relates to new 19-nor-17α-pregna-1,3,5(10)-trien-17β-ols with a 21,16α-lactone ring with a long-chain substituent in 11β-position of general formula II
in which R 11 is a...
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6787533 |
Process for R-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregna,4-dien-11β, 16α, 17α-triol-3,20-dione derivatives
R-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregna-1,4-dien-11beta,16alpha,17alpha-triol-3,20-dione derivatives is effected by fractional crystallization.
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6767901 |
Ciclesonide contained pharmaceutical composition for application to mucosa
The present invention provides a pharmaceutical composition for application to the mucosa to be used in drug therapy comprising a water-insoluble and/or water-low soluble substance, ciclesonide,...
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6743414 |
Inhalation administration of biophosphonates
The present invention relates to the treatment and prevention of bone diseases in humans, including osteoporosis in postmenopausal women, Paget's Disease and hypercalcemia, by administration of a...
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6716437 |
Topical composition and method for enhancing lipid barrier synthesis
The present invention relates to topical compositions useful in enhancing lipid synthesis in skin comprising an effective amount of cafestol or kahweol, or derivative thereof, in combination with a...
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6531461 |
Medicament for the treatment of diabetes
A series of compounds of general structure I and metal salts thereof. These compounds are useful in the treatment of diabetes mellitus and associated conditions when administered in an effective...
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6512004 |
Promoters of neural regeneration
The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent...
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6432937 |
Treatment for joint inflammation
The invention provides the use of a glucocorticoid substance which has a minimal systemic effect in the manufacture of a medicament for oral or rectal administration for non-topical use in the...
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6395746 |
Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
Methods of treating or preventing ophthalmic, otic, and nasal infections and attendant inflammation are described. The methods utilize ophthalmic, otic, and nasal compositions containing a new...
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6375984 |
Aqueous-based pharmaceutical composition
An aqueous pharmaceutical composition which is capable of being sprayed into the nasal cavity of an individual and which comprises: (A) a pharmaceutically effective amount of solid particles of...
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6291445 |
Low dose budesonide formulations and uses thereof
A metered unit dose comprising 40 μg or less of budesonide is disclosed, as well as formulations thereof, and the use thereof for the treatment of nasal conditions.
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6287540 |
Formulation for inhalation
A dry powder composition comprising one more potent pharmaceutically active substances and a carrier substance, all of which are in finely divided form, wherein the formulation has a poured bulk...
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6271219 |
Topical formulations comprising skin penetration agents and the use thereof
Disclosed are topical pharmaceutical compositions comprising a pharmaceutically active agent such as a corticosteroid, a diol, cetyl alcohol, glyceryl monostearate, laurocapram, stearyl alcohol,...
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6264923 |
Medicinal aerosol formulation of ciclesonide and related compounds
A pharmaceutical aerosol formulation suitable for oral and/or nasal inhalation including an anti-inflammatory steroid of the formula ##STR1## in which: R 1 is 1-butyl, 2-butyl, cyclohexyl or...
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6239120 |
Method and means for treating glomerulonephritis
The invention provides the use of a glucocorticoid having a first pass metabolism in the liver of at least 90% as active substance, for the manufacturing of a medicament for oral or rectal...
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6197762 |
Nitrosated and nitrosylated steroids compositions, and methods for treating respiratory disorders
Disclosed are (i) compounds of a steroid, a β-agonist, an anticholinergic, a mast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linked to a NO or NO 2 group or a...
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6197761 |
17β-2-oxo-tetrahydrofuranyl)-carbothioic acid ester, -carboxylic acid ester and -carboxylic acid amide androstane derivatives
Compounds of the androstane series are described having general formula ##STR1## and solvates thereof, in which R 1 represents O, S or NH; R 2 individually represents OC(O)C 1 -6 alkyl; R 3 ...
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6114318 |
17β-(2-oxo-tetrahydrofuranyl)-thio- substituted androstane derivatives
Compounds of the androstane series are described having the formula (I) and solvates thereof in which R 1 and R 2 are the same or different and each represents hydrogen or C 1 -6 alkyl; R 3 and...
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RE36606 |
Synergistic pharmaceutical compositions
A pharmaceutical composition comprises a synergistic combination of about 0.01-0.15% by wt. triamcinolone acetonide and about 0.04-0.3% by wt. halcinonide as active ingredients, in combination with...
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5990100 |
Composition and method for treatment of psoriasis
Pharmaceutical compositions and methods for use in the treatment of psoriasis, having isopropyl myristate as a first active ingredient and a different anti-psoriatic agent as a second active...
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5985862 |
Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
The present invention discloses novel pharmaceutical compositions having steroid nitrate ester(ONO 2 ) derivatives, and to their use treating undesired smooth muscle contractions and inflammatory...
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5972919 |
Combination of a bronchodilator and a steroidal anti-inflammatory drug for the treatment of respiratory disorders, as well as its use and the preparation thereof
Effective amounts of formoterol (and/or a physiologically acceptable salt and/or solvate thereof) and budesonide are used in combination for simultaneous, sequential or separate administration by...
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5955439 |
Pharmaceutical aerosol containing at least one sugar
This invention relates to aerosol formulations of use for the administration of medicaments by inhalation and in particular to a pharmaceutical aerosol formulation which comprises (a) particulate...
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5939409 |
Processes for the production of anti-inflammatory steroids
Disclosed are processes for preparing the 22R and 22S epimers of the compound ##STR1## The processes involve acetalization, transacetalization, hydrolysis (of an ester) or hydrogenation (of a...
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5929111 |
A-seco steroids effective at treating ophthalmic pathological neovascularization and controlling intraocular pressure
A-seco steroids are disclosed. Methods of use are disclosed for treating ophthalmic pathological neovascularization and controlling intraocular pressure.
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5908833 |
Colon or ileum-specific steroid derivatives
Novel compounds which are a glucocorticosteroid (GCS) chemically bound to a sugar, having the general formula GCS 1 --O--Sugar 1 for colon- or ileum-specific delivery of the GCS to inflamed...
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5902609 |
Composition for the control of wound scar production
This invention pertains to a composition for controlling wound scar production containing a calcium antagonist and a protein synthesis inhibitor. The method can be used to minimize wound scars,...
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5888995 |
Steroid esters
The invention concerns compounds of formula I ##STR1## in which R 1 is hydrogen or a straight or branched hydrocarbon chain; R 2 is hydrogen or a straight or branched hydrocarbon chain; R 3 is...
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5872147 |
Use of oxandrolone in the treatment of chronic obstructive pulmonary disease
The subject invention provides a method of treating a symptom associated with chronic obstructive pulmonary disease in a patient suffering from chronic obstructive pulmonary disease which comprises...
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5863910 |
Treatment of chronic inflammatory disorders of the gastrointestinal tract
The present disclosure relates to an oral formulation for treating gastrointestinal inflammation that includes an effective amount of budesonide suspended in an edible oil, typically a vegetable...
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5847009 |
Prophylaxis in the parenteral administration of particulate dispersions in fluorocarbon emulsions
Methods for preventing or ameliorating the transient adverse physiological response to particulate dispersions (TAPR response) when these dispersions are administered parenterally to a patient. The...
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5837698 |
Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
The present invention relates to a pharmaceutical composition or preparation which comprises hydroxyl containing steroidal hormones and organic nitrite/nitrate or other nitric oxide donating agents.
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5801165 |
Antiinflammatory, immunosuppressive and antialleric 16, 17-alkylidioxy-steroids
Compounds of formula I ##STR1## where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , n, and are as defined herein, their use as antiinflammatory, immunosuppressive, and antiallergic agents, pharmaceutical...
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5792758 |
Steroid nitrite ester derivatives useful as anti-inflammatory drugs
The present invention discloses novel steroid nitrite ester derivatives, and to their use treating inflammatory diseases.
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5770589 |
Treatment of macular degeneration
In the treatment of age-related macular degeneration, a method for treating an inflammatory response in the macula of the eye by use of a depot injection of a suitable anti-inflammatory agent into...
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5767113 |
Compounds useful for concurrently activating glucocorticoid-induced response and reducing multidrug resistance
In accordance with the present invention, it has been discovered that certain synthetic steroid compounds are capable of inhibiting the efflux pump which is believed to be responsible for multidrug...
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5763430 |
Method of treating a viral infection by administering a steroid compound
A method of treating a viral infection includes administering an effective amount of a compound having the following structure: ##STR1## or a pharmaceutically acceptable salt thereof. This compound...
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5760025 |
Steroid derivatives for the treatment of prostatic hypertrophy, their preparation and uses
Compounds of formula (I): ##STR1## wherein: R 1 is hydrogen, alkyl, aryl-substituted alkyl or aromatic heterocyclic-substituted alkyl; R 2 is: aryl-substituted alkyl, aromatic...
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5733901 |
Prednisolone derivatives
Epimers of the compound having the formula (I) are disclosed, both in their pure form and mixed in any desire mix ratio. ##STR1##
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5721228 |
Rectal flunisolide compositions for treating inflammatory intestinal disorders
Topical rectal therapeutic composition containing, as the active ingredient, flunisolide and/or one or more ester derivatives of same, in combination with suitable excipients and/or diluents, for...
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