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4294829 |
Powdery pharmaceutical composition and powdery preparation for application to the nasal mucosa, and method for administration thereof
A powdery pharmaceutical composition and a powdery preparation in unit dosage form for application to the mucosa of the nasal cavity, at least about 90% of which consists of particles having an...
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4294852 |
Skin treating compositions
The invention relates to a composition for treatment and control of excessively thickened, inflexible and scaly stratum corneum which often fissures into the dermis resulting in foci of bleeding...
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4279901 |
Topical ointment
Non-oxidizing, non-peroxide forming, non-aqueous vehicle for topical application of medicaments comprising ethylene carbonate and a non-aqueous petroleum wax component such a polawax or petrolatum.
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4273770 |
4-Halo steroids
Certain pregn-4-ene-3,20-diones or pregn-1,4-diene-3,20-diones 4-substituted with a fluoro or chloro are useful as topical anti-inflammatory steroids. These compounds are substituted at 9α with...
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4233295 |
Corticosteroid formulations containing sebacate carrier
Corticosteroid formulations in the form of creams, lotions or ointments are provided which are used as anti-inflammatory agents, wherein the corticosteroid, such as halcinonide...
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4221786 |
Novel halogenopregnadienes and process for the manufacture thereof
The invention relates to the preparation of polyhalogenated pregnane derivatives of the formula ##STR1## wherein X represents fluorine or chlorine and R a free or esterified hydroxyl group or...
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4198403 |
17 Beta-thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters substituted at the 4-position with a fluoro, chloro or bromo and optionally substituted at the six position...
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4188385 |
Thioetianic acid derivatives
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters are useful as antiinflammatory steroids. These compounds are optionally substituted at the 6 alpha-position...
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4187301 |
17 Beta-thiocarboxylic acid esters of 6 alpha, 6 beta-difluoro-3-oxoandrost-4-enes
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters substituted at the 6 alpha, 6 beta-positions with fluorine substituents are useful as anti-inflammatory...
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4185101 |
1,3,5(10),6,8-19-Nor-pregnapentaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor
1,3,5(10),6,8-19-Nor-pregnapentaene-20-ones exhibit anti-mitotic activity with minimal or no hormonal activity. They are particularly useful in the treatment and control of psoriasis when applied...
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4181720 |
Corticosteroid antiinflammatory agents
22-Optionally substituted steroids of the corticoid series are prepared from the corresponding 21-methylene steroids through the 20,21-dione steroid intermediates. These compounds have utility as...
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4172132 |
1,3,5(10),6,8,14-19-Nor-pregnahexaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor
1,3,5(10),6,8,14-19 Nor-pregnahexaene-20-ones exhibit anti-mitotic activity with minimal or no hormonal activity. They are particularly useful in the treatment and control of psoriasis when applied...
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4158055 |
Administration of 16α,17α-cyclopentylidenedioxy-9α-fluor O-11β,21-dihydroxy-1,4-pregnadiene-3,20-dione 21-acetate
A method of treating topical inflammation in mammals by the administration of 16α,17α-cyclopentylidenedioxy-9α-fluoro-11β,21-dihy droxy-1,4-pregnadiene-3,20-dione 21-acetate in a...
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4124707 |
7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor
Novel 3,20-dioxo-7α-halogeno-1,4-pregnadienes are described and their use as anti-inflammatory agents. Preferred are 7α-bromo- and 7α-chloro- derivatives, particularly 7α-bromo- and...
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RE29799 |
Triamcinolone acetonide derivative
Triamcinolone Bis(triamcinolone acetonide ) 4,4'-methylene-bis(3-methoxy-2-naphthoate), method of preparing the same by preparing a reactive derivative of...
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4083974 |
Topical steroidal anti-inflammatory preparations containing polyoxypropylene 15 stearyl ether
The present invention discloses topical preparations containing anti-inflammatory steroids. These may be ointments or solutions which contain as a solubilizing agent for the steroid,...
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4082881 |
Topical and other type pharmaceutical formulations containing isosorbide carrier
Topical and other type formulations are provided in the form of creams, lotions, ointments, injectables, and drops which contain a pharmaceutical, such as a steroid, dissolved in an isosorbide...
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4065452 |
21,21-Dihalo steroids
Novel, topically-active anti-inflammatory steroids are represented by the formula ##STR1## wherein X is fluoro, chloro or hydrogen; X 1 is fluoro, chloro, bromo, or hydrogen; X 2 is hydroxy or...
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4049804 |
Novel pregnanoic acid derivatives
Pregnanoic acid derivatives of general formula ##STR1## wherein is a single bond or a double bond; X is hydrogen, fluorine or methyl; Y is hydrogen, fluorine or chlorine; Z is...
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4048310 |
Topical steroid formulation in form of lotion or cream
Steroid formulations in the form of creams or lotions which are used as topical anti-inflammatory agents are provided wherein the steroid, such as 21-chloro-9α-fluoro-Δ 4 ...
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4048309 |
Topical steroid ointment formulations
Steroid ointment formulations of the solution and biphasic types which are used as topical anti-inflammatory agents are provided wherein the steroid, such as 21-chloro-9α-fluoro-Δ 4 ...
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4039668 |
Corticoid-containing inhalants
Inhalants comprising at least one corticoid of the general formula ##STR1## wherein --B--A-- is CH 2 --CH 2 --, CH=CH-- or CCl=CH--; X is a hydrogen atom, a fluorine atom, or methyl; Y is a...
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4017615 |
Propylene carbonate ointment vehicle
An ointment vehicle containing from 0.5 to 30 percent propylene carbonate, from 30 to 99.5 weight percent petrolatum and/or polysiloxane, compatible cosolvent, the concentration of which in...
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4016270 |
Method for treating dysmenorrhea with a uterine therapeutic system
A method for treating dysmenorrhea is disclosed. The method comprises administering to the uterus of a warm blooded animal having dysmenorrhea controlled and continuous low dosage amounts of a...
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4011315 |
21-Acetals and mixed acetals of steroidal 21-aldehydes, intermediates and methods of preparation
21-ACETALS AND MIXED ACETALS OF STEROIDS OF THE CORTICOID SERIES ARE PREPARED FROM THE CORRESPONDING 21-HYDROXY STEROIDS AND HAVE UTILITY AS ANTI-INFLAMMATORY AGENTS.
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4008312 |
Pregnane-21-oic acid derivatives
Pregnane-21-oic acid derivatives of the formula ##STR1## wherein THE LINKAGE REPRESENTS A SINGLE BOND OR A DOUBLE BOND; X is hydrogen, fluorine or chlorine; Y is methylene, hydroxymethylene,...
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3996359 |
Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
A process for the resolution of stereoisomeric mixtures of certain steroids obtained by synthesis into its components, comprising subjecting the stereoisomeric mixture to gel filtration, the...
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3996358 |
21-Esters of steroidal-21-aldehyde hydrates and 21-aldehyde hemiacetals and methods of preparation
21-Esters of 21-aldehyde hydrates and 21-aldehyde hemiacetals of steroids of the corticoid series are prepared from the corresponding 21-hydroxy steroids and have utility as antiinflammatory agents.
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3992534 |
Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
A process for the resolution of stereoisomeric mixtures of certain steroids obtained by synthesis into its components, comprising subjecting the stereoisomeric mixture to gel filtration, the...
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3983233 |
Compositions and method of treating with stereoisomeric mixtures of 2-unsymmetrical 16,17-methylenedioxy steroids
Novel steroids having the general formula: ##SPC1## Wherein X and Y are independently selected from hydrogen and fluorine, X being selected from hydrogen and fluorine when Y is hydrogen and X being...
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3975378 |
20-Cyano-20,21-epoxy steroids
Novel compounds useful as anti-inflammatories are represented by the formula ##SPC1## Wherein Z is a single or double bond; X and X 1 are independently H, F or Cl; and X 2 is OH or when X 1 is...
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3966925 |
Lubricant for fitting and trial mounting of prosthodontic appliances
This invention provides a lubricating compound for the fitting of crowns, bridges and other prosthodontic restorations as used in prosthodontic dentistry. This compound in a preferred embodiment...
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RE28819 |
Dialkylated glycol compositions and medicament preparations containing same
A pharmaceutical preparation having a minor amount of a medicament, a major amount of a dialkylated mono- or poly-alkylene glycol vehicle therefor, and a minor amount of one or more antioxidants...
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3919421 |
Pregnanoic acid derivatives and process for the preparation thereof
Pharmacologically active pregnanoic acid derivatives of the Formula I ##SPC1## wherein --A--B-- is --CH 2 --CH 2 --, --CH=CH--, or --CCl=CH--; X is a hydrogen atom, a halogen atom, or methyl;...
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3899581 |
Triamcinolone acetonide derivative
Triamcinolone acetonide 4,4'-methylene-bis(3-methoxy-2-naphthoate), method of preparing the same by preparing a reactive derivative of 4,4'-methylene-bis(3-methoxy-2-naphthoic) acid and reacting...
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3892855 |
Method for fertile breeding control in female bovine
This invention concerns a method for fertile breeding control in female bovine by sequentially administering a progestin followed by a luteolytic agent. The progestin blocks estrus and ovulation...
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3892857 |
Steroid formulation
A steroid formulation having enhanced properties for topical application comprises 21-chloro-9α-fluoro-Δ 4 -pregnene-11β,16α,17α-triol-3,20-dione 16,17-acetonide in a vehicle containing as...
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3892856 |
Topical steroid formulation
A steroid formulation having enhanced properties for topical application comprises 21-chloro-9α-fluoro-Δ 4 -pregnene-11β,16α,17α-triol-3,20-dione 16,17-acetonide dissolved in polyethylene...
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3867528 |
Steroidal topical cream base
A topical cream base is described which is particularly useful with steroids. This cream base when used with steroid acetonides produces greater penetration of the skin and therefore enhances the...
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3856955 |
METHOD AND COMPOSITIONS FOR PREVENTING RETENTION OF PLACENTA FOLLOWING INDUCED PARTURITION IN CATTLE
Methods employing compositions containing a long-acting glucocorticoid, as for example, dexamethasone trimethylacetate, for preventing retention of fetal membranes following induced parturition in...
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3856954 |
TOPICAL STEROID COMPOSITIONS
A stable composition for topical steroids comprises a gel formed from propylene glycol, isopropyl alcohol or ethyl alcohol and a carboxymethylene hydrocolloid polymer, and optionally containing...
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3829570 |
THERAPEUTIC COMPOSITIONS AND METHOD
Novel anti-inflammatory compositions comprised of an effective amount of an ester of fluocinolone-acetonide or 6α,9α-difluoro-16α,17α-isopropylidenedioxy-Δ 1 ,4...
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3758686 |
METHOD OF USING STEROID ACETONIDES
A method of treating topical inflammation in mammals by the administration of triamcinolone acetonide-21-valerate in a pharmaceutically acceptable carrier.
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3711606 |
ENHANCING TISSUE PENETRATION OF PHYSIOLOGICALLY ACTIVE STEROIDAL AGENTS WITH DMSO
A method of enhancing tissue penetration of physiologically active steroidal agents by conjointly applying them to the tissue with dimethyl sulfoxide. Penetration of the skin and the mucous...
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3608076 |
USE OF STEROID DERIVATIVES AS ANTIFERTILITY AGENTS
Derivatives of certain 16α, 17α-dihydroxysteroids of the pregnane series are described. These steroids are useful for controlling fertility in warmblooded female animals.
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3496273 |
1,2,ALPHA-METHYLENESTEROIDS
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3480711 |
4-HALOGENO - 1ALPHA,2ALPHA; 6BETA,7BETA - BIMETHYLENE - DELTA**4-3-KETO-STEROIDS AND PROCESS FOR MAKING THE SAME
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3457348 |
STABLE SYRINGEABLE SUSPENSIONS OF PARENTERAL DRUGS IN COMPLEX FLOC FORM
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3415929 |
Ophthalmic solution containing poly-1,3-beta-glucoside
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3352753 |
Pharmaceutical compositions of corticosteroids in gelled alcohol
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