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7615546 |
Topical delivery system for phytosterols
This invention relates to certain sugar esters of phytosterols of formula (I). These esters are useful for topical application, and for the treatment of skin condition, including age spots, acne,...
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7514420 |
Steroids having 1,8-unsaturation and formulations comprising same
The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in...
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7462610 |
Prostate cancer treatment
The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in...
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7417038 |
Methods of treating cachexia
A method of treating weight loss due to underlying disease in a patient the method comprising administering to the patient an effective amount of an agent which reduces sympathetic nervous system...
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7405207 |
Nebulizer formulations of dehydroepiandrosterone and methods of treating asthma or chronic obstructive pulmonary disease using compositions thereof
This invention relates to a sealed container containing a powder formulation comprising a dehydroepiandrosterone, its analogue(s) or salt(s) by itself or with a pharmaceutically or veterinarily...
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7348320 |
Platinum complexes containing chemically modified bile acids, having antitumor activity
The present invention relates to platinum complexes containing bile acid derivatives having antitumor activity
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7015210 |
Methods of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists
A method for treating or preventing ophthalmic disorders comprising the administration of one or more aldosterone receptor antagonists that contain a 9,11-epoxy moiety, such as eplerenone is...
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6984633 |
Method to treat cardiofibrosis with a combination therapy of an angiotensin II antagonist and epoxymexrenone
A therapeutic method is described for treating cardiofibrosis or cardiac hypertrophy using a combination therapy comprising a therapeutically-effective amount of an angiotensin II receptor...
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6759399 |
Use of antimineralocorticoid compounds against narcotic withdrawal syndrome
The method of treating narcotic withdrawal symptoms in warm-blooded animals comprising administering to warm-blooded animals in need thereof an amount of a compound having anti-mineralocorticoid...
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6716829 |
Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders
Combinations of aldosterone blockers and Cyclooxygenase-2 inhibitors useful in the treatment of inflammation are disclosed.
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6653306 |
Epoxy-steroidal aldosterone antagonist and angiotensin II antagonist combination therapy
A combination comprising therapeutically-effective amount of an epoxy-steroidal aldosterone receptor antagonist and a therapeutically-effective amount of an angiotensin II receptor antagonist is...
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6620801 |
17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
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6605604 |
Carboxylic and hydroxamic acid compounds inhibiting metalloproteases, method for preparing same and pharmaceutical compositions containing them
The invention concerns a compound of formula (I) wherein: n is equal to 0 or 1; R 1 , R 2 , R 3 , R 4 represent a hydrogen or an alkyl group, or R 1 and R 3 together form a cycloalkyl group; R 5...
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6569843 |
Steroidal sapogenins for the control of coccidiosis in animals
Steroidal sapogenins and pharmaceutically acceptable salts thereof, useful in the prevention of coccidiosis in animals and methods of administering an effective amount of steroidal sapogenin or...
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6541463 |
Inhibitors of type 5 and type 3 17β-hydroxysteroid dehydrogenase and methods for their use
Novel methods of medical treatment and/or inhibition of development of diseases are disclosed for diseases that are sensitive to androgenic or estrogenic activity. The treatments utilize inhibitors...
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6365582 |
S-substitute 11β-benzaldoxime-estra-4, 9-diene-carbonic acid thiolesters, method for the production thereof and pharmaceutical preparations containing these compounds
Thiol esters of S-substituted 11β-benzaldoxime-estra-4,9-dien-carboxylic acids of the formula I their pharmaceutically acceptable salts, a method for their synthesis and pharmaceutical...
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6245755 |
Use of aldosterone antagonists to inhibit myocardial fibrosis
This invention discloses a method of inhibiting aldosterone-mediated myocardial, perivascular and interstitial fibrosis using epoxymexrenone and other aldosterone antagonists.
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6177418 |
Tetracyclic triterpenes as cholesterol-lowering and anti-atherosclerosis agents
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6172056 |
Pharmaceutical compositions and method for prophylaxis and therapy of radical-mediated cell damage
The method of prophylaxis and therapy of radical-mediated cell damage includes administering an effective amount of at least one steroid and at least one pharmaceutical adjuvant to a human being....
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6172054 |
Combination therapy for lowering and controlling intraocular pressure
Angiostatic agents and another IOP lowering compound are combined in ophthalmic compositions to treat glaucoma and ocular hypertension. Methods for treating glaucoma and ocular hypertension are...
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6083940 |
Method and composition for effecting contraception in a mammalian male
Novel antiandrogenic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R 1 through R 10 , a and b are as defined herein. Pharmaceutical...
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6043235 |
11β-aryl-17, 17-spirothiolane-substituted steroids
The invention is directed to 11β-aryl-17,17-spirothiolane substituted steroid compounds of formula (I) exhibiting binding to the progestin receptor. ##STR1## Also disclosed are methods of using...
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5990099 |
Angiostatic agents and methods and compositions for controlling ocular hypertension
Compositions of angiostatic agents for treating GLC1A glaucoma and methods for their use are disclosed.
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5980940 |
Pharmaceutical combination preparation for hormonal contraception
The invention provides a pharmaceutical combination preparation with two hormone components in a packaging unit and intended for time-sequential oral administration, comprising a number of daily...
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5854235 |
17-spiromethylene steroids
The invention relates to a steroid derivative which steroidal skeleton is bound at carbon atom 17 to a spiromethylene ring of the formula: ##STR1## wherein R a and R b are independently selected...
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5854230 |
Antiandrogenic agents and related pharmaceutical compositions and methods of use
Novel antiandrogenic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R 1 through R 10 , a and b are as defined herein. Pharmaceutical...
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5843933 |
11β-aryl-4-estrenes, process for their production as well as their use as pharmaceutical agents
Compounds of formula I ##STR1## wherein X, R 1 , R 2 , R 3 and R 4 have the meanings indicated in the description, are described, as well as processes for their production, pharmaceutical...
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5843931 |
6,7-modified 11β-aryl-4-oestrenes
Compounds of the general formula I ##STR1## are described, in which x represents an oxygen atom or the hydroxyimino grouping >N.about.OH, R 1 represents a hydrogen atom or a methyl group, ...
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5807834 |
Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor
Pharmaceutical combination compositions including certain cholesterol absorption inhibitors and cholesterol synthesis inhibitors. The compositions are useful for the treatment of...
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5792758 |
Steroid nitrite ester derivatives useful as anti-inflammatory drugs
The present invention discloses novel steroid nitrite ester derivatives, and to their use treating inflammatory diseases.
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5776923 |
Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone
Sex steroid precursors such as dehydroepiandrosterone and dehydroepiandrosterone sulphate, and compounds converted in vivo to ether of the foregoing, are utilized for the treatment and/or...
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5763430 |
Method of treating a viral infection by administering a steroid compound
A method of treating a viral infection includes administering an effective amount of a compound having the following structure: ##STR1## or a pharmaceutically acceptable salt thereof. This compound...
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5741786 |
Steroids with a 17-spiromethylene lactone or lactol group
A steroid with a 17-spiromethylene lactone group having formula I ##STR1## wherein R 1 is O, (H,H), (H,OR), or NOR, R being selected from H, (1-6C) alkyl and (1-6C) acyl; R 2 is H, (1-6C) alkyl...
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5721226 |
Method for inhibiting angiogenesis using squalamine and squalamine steroid derivatives
A method of inhibiting angiogenesis in a patient includes administering to the patient an effective amount of squalamine or a pharmaceutically acceptable salt of squalamine. Alternatively, a...
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5703066 |
Progestationally active 19,11-bridged 4-estrenes
In this invention, the new etheno- and ethano-19,11-bridged 4-estrenes of general formula I ##STR1## are described, in which W, R 1 , R 2 , R 6a , R 6b , R 7 , R 14 , R 15 , R 16 , R 11 , R 11 '...
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5637310 |
Method of treating prostatic adenocarcinoma
Invented is a Method of Treating Prostatic Adenocarcinoma by employing asteroid 5-α-reductase inhibiting compound or a combination of steroid 5-α-reductase inhibiting compounds.
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5569652 |
Dihydrospirorenone as an antiandrogen
Dihydrospirorenone, ##STR1## preferably together with an estrogen, can be used for the production of a pharmaceutical agent suitable for treatment of hormonal irregularities during premenopause...
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5529992 |
Method for inhibiting myocardial fibrosis by administering an aldosterone antagonist which suppresses aldoster one receptors
This invention discloses a method of using an aldosterone antagonist such as spironolactone, at a dosage which does not disrupt a patient's normal electrolyte and water-retention balance, to...
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5506222 |
Method and composition for treating increased androgenic activity
The present invention relates to spironolactone contain compositions for application to an area of human skin afflicted with acne, seborrheic condition or hirsutism. N,N-dialkyl lauramides are used...
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5443837 |
Estrus synchronization method
A method of synchronizing estrus in breeding animals comprising parenterally administering to breeding animals an estrus synchronizing amount of 17α-allyl-Δ 4 ,9,11 -estratriene-17β-ol-3-one.
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5426102 |
14β-H-, 14-and 15-En-11β-aryl-4-oestrenes
Novel compounds of the general formula I ##STR1## and the pharmacologically tolerable addition salts thereof with acids are described, in which either Ia) R 11 represents a hydrogen atom in the...
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5407926 |
Ophthalmic composition
Pharmaceutical compositions useful in the treatment of ophthalmic inflammation and methods of treating ophthalmic inflammation with those compositions are disclosed. The compositions contain a...
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5336686 |
17 Methylene lactones of steroids
A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as in the application having antiglucocorticoid and antiprogestomimetic...
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5318961 |
4-amino-Δ4-steroids and their use as 5α-reductase inhibitors
The present invention relates to 4-amino-Δ 4 -steroids which are inhibitors of 5α-reductase. The compounds are useful for treating DHT-mediated diseases.
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5273971 |
13-alkyl-11β-phenylgonanes
There are provided 13-alkyl-11beta-phenyl-gonanes of formula I ##STR1## wherein Z is an oxygen atom or N--OH; R 2 is alpha- or beta-position methyl or ethyl; R 1 is selected from heteroaryl...
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5272140 |
11-aryl steroid derivatives
The invention relates to 11-aryl steroid derivatives, having the structure ##STR1## wherein: R 1 , R 2 , R 3 , and R 4 are as described in the specification and to processes for their...
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5232915 |
9α-hydroxy-19,11β-bridged steroids, their production and pharmaceutical preparations containing these steroids
9α-Hydroxy-19,11β-bridged steroids of general formula I ##STR1## are described. The more detailed meaning of A, B, R 1 , R 2 , G, Z, R 4 --Y and R 4 ' --Y' follows from the description. The...
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5189032 |
4-amino-Δ.sup.4,6 -steroids and their use as 5α-reductase inhibitors
The present invention relates to 4-amino-Δ 4 ,6 -steroids which are useful as inhibitors of 5α-reductase. The compounds are prepared by the reaction of an appropriate 4,5-epoxy steroid with...
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5043332 |
Novel 11β-substituted -19-nor-steriods
Novel 19-nor-steroids of the formula ##STR1## wherein R 1 is an organic group of 1 to 18 carbon atoms optionally containing at least one heteroatom with the atom immediately adjacent the 11-carbon...
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5017568 |
Steriod 5-alpha-reductase inhibitors
Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid...
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