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8865219 Orodispersible tablets of bitter active principles  
The invention concerns coated granules including (A) at least one amine-containing pharmacological active principle, preferably as an acid addition salt, the pharmacological active principle being...
8859523 Crosslinked compounds and methods of making and using thereof  
Described herein are crosslinked compounds useful in numerous treatments. Described herein are methods of making crosslinked compounds via (1) the oxidative coupling of two or more thiol compounds...
8859500 Method for ameliorating pain by modification of NMDA receptors through inhibition of SRC  
The present invention provides a method for ameliorating inflammatory and/or neuropathic pain in a subject by modifying the activity of N-methyl-D-aspartate (NMDA) receptors in cells of the subject...
8859501 Protofibril-binding antibodies and their use in thereapeutic and diagnostic methods for parkinson's disease, dementia with lewy bodies and other alpha-synucleinopathies  
Antibodies and fragments thereof have high affinity for human α-synuclein protofibrils and low binding of α-synuclein monomers, wherein the antibodies or fragments have specified Complementarity D...
8859505 Cysteine protease inhibitors  
Compounds of the formula I wherein R2a and R2b are independently H, halo, C1-C4alkyl, C1-C4haloalkyl or C1-C4alkoxy, or R2a andR2b together with the carbon atom to which they are attached form a...
8853166 Neurotrophic factor MANF and uses thereof  
The present invention generally relates to the field of treatment of neuronal disorders and more particularly to neurotrophic factor MANF and uses thereof. The present invention provides a...
8853361 Preparation, for use, in particular, for tissue augmentation and healing  
The invention relates to a sterile preparation which can be implanted on or in organic tissues, comprising: a natural or modified globin material which is insoluble at physiological pH and/or a...
8846003 Collagen-binding synthetic peptidoglycans, preparation, and methods of use  
This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the...
8846315 Disease risk factors and methods of use  
Provided herein are genetic variants associated with development of a condition of interest (e.g., Alzheimer's disease). Methods of treatment with an active agent (e.g., with a particular active...
8841254 Method for treatment of anxiety  
Human H3 preprorelaxin, human H3 prorelaxin, human H3 relaxin, human relaxin analogues having a modified A chain and/or a modified B chain are described. Also described are nucleic acid sequences...
8841260 Methods and compositions for treating Huntington's Disease  
Disclosed herein are methods and compositions for treating or preventing Huntington's Disease.
8835391 Alpha B-crystallin as a therapy for multiple sclerosis  
The invention provides methods for treating inflammatory diseases by administering to the subject an effective amount of an agent that provides alpha B-crystallin activity, where the dose is...
8828404 Vaccine and method for treatment of neurodegenerative diseases  
Methods and compositions are provided for treatment of neurodegenerative diseases in which there is accumulation of misfolded and/or aggregated proteins, excluding prion diseases. In particular,...
8828937 Bone morphogenetic protein 2 (BMP2) variants with reduced BMP antagonist sensitivity  
The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No....
8828941 Composition and method for the treatment or prevention of spinal disorders  
The present invention provides compositions of matter suitable for the prevention of and/or treatment of a spinal disorder and/or spinal pain, e.g., caused by and/or associated with intervertebral...
8828943 Anticonvulsant combination therapy  
A method for alleviating and/or treating epileptic seizures comprising administering a pharmaceutical composition comprising (a) lacosamide and/or a pharmaceutically acceptable salt thereof; and...
8828949 Aprotinin polypeptides for transporting a compound across the blood-brain barrier  
The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptides derived from aprotinin and from aprotinin analogs as well as conjugates...
8828942 Means for treating synucleinopathies  
The present invention relates to peptides or polypeptides for producing medicaments for preventing and/or treating synucleinopathies.
8828389 Methods of diagnosing ALS  
The invention relates to an epitope protection assay for use in diagnosis, prognosis and therapeutic intervention in diseases, for example, involving polypeptide aggregation, such as prion...
8822418 Treatment of muscular dystrophies and related disorders  
The invention provides, among other aspects, compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan;...
8815808 Modulation of activity of neurotrophins  
The present invention relates to methods for modulating the activity of one or more neurotrophins, such as neural growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin-3...
8815814 Cosmetic composition containing oligopeptides  
The invention is directed to the cosmetic use of tetrapeptides according to formula (I) R1-Val-Leu-Leu-Lys-R2 (I) wherein R1 is linked to the NH2-terminal group of the peptide and is chosen from...
8815261 Composition for external application comprising aripiprazole and organic acid as active ingredients  
[Summary] An external preparation formulation superior in the transdermal absorbability has been desired as a new administration route of aripiprazole. Transdermal absorption of aripiprazole has...
8815233 Method for treating pervasive development disorders  
A method of utilizing the chymotrypsin level of an individual as a measure of the success of secretin, other neuropeptides, and peptides or digestive enzyme administration to such individuals, and...
8815810 Treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain  
The present invention relates to the use of Meteorin for the treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain. In a preferred embodiment the disorder to be treated is...
8815803 Method for increasing body height comprising systemic administration of CNP-53  
This invention provides a composition for increasing a body height of a patient with short stature or an individual other than patients with short stature. More specifically, the invention...
8815809 Cysteine protease inhibitors  
Compounds of Formula II whereinR1a is H; and R1b is C1-C6alkyl, Carbocyclyl or Het; orR1a and R1b together define a saturated cyclic amine with 3-6 ring atoms;R2a and R2b are independently H, halo,...
8815511 Determination of single nucleotide polymorphisms useful to predict response for glatiramer acetate  
This invention provides a method for treating a human subject afflicted with multiple sclerosis or a single clinical attack consistent with multiple sclerosis with a pharmaceutical composition...
8809278 Cyclic tetrapeptides  
Cyclic tetrapeptides that are kappa opioid receptor (KOR) antagonists can be used in therapeutic applications for treating, inhibiting, and/or preventing drug addiction, drug use, or drug seeking...
8809274 Adhesive hemostatic agent based on porcine atelocollagen and method for production thereof  
Disclosed is an adhesive hemostatic agent based on non-blood constituents including DOPA, able to strongly adhere to collagen fibers, and which comprises an antifibrinolytic agent in addition to an...
8809275 Peptoids and methods for treating alzheimer's disease  
Provided herein are peptoids capable of inhibiting or reversing amyloid β (Aβ) fibril or plaque production. The peptoids form a helical structure with three monomers per helical turn and have at l...
8802630 Method of treating brain injury  
A novel use of a neuropeptide for treating brain injury in a subject in need thereof is provided. The present invention also provides various amenable routes of administering urocortin, that is,...
8802626 Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects  
Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with...
8802088 Mixture of peptide-bound tryptophan and polypeptide-bound tryptophan  
The present invention relates to a composition which comprises tryptophan whereby 10 to 90%, preferably 20 to 80% of the tryptophan is present as free tryptophan or peptide-bound tryptophan and 10...
8796214 Neurotrophic peptides  
The present invention relates to a neurotrophic peptide having an amino acid sequence of VGDGGLFEKKL (SEQ ID NO:1) and alternatively comprising an adamantyl group at the C- and/or N-terminal end....
8796213 Apoaequorin-containing compositions and methods of using same  
Compositions containing apoaequorin and methods for their use in treating symptoms and disorders related to calcium imbalances associated with, for example, sleep quality, energy quality, mood...
8796225 Regulation of immune responses by modulation of the function of antigen presenting cells  
The present invention relates to the use of chaperonin 10 to modulate the function of antigen presenting cells. More particularly the invention resides in the modulation of cell surface expression...
8796216 Suppression of neuroendocrine diseases  
The present invention relates to a method for suppressing neuroendocrine disease. The therapy employs use of a non-cytotoxic protease, which is targeted to a neuroendocrine tumor cell, preferably...
8796215 Neurotrophic peptides  
The present invention relates to a neurotrophic peptide having an amino acid sequence of VGDGGLFEKKL (SEQ ID NO: 1) and alternatively comprising an adamantyl group at the C-and/or N-terminal end....
8796226 Depot systems comprising glatiramer or a pharmacologically acceptable salt thereof  
Long acting parenteral pharmaceutical compositions comprising a therapeutically effective amount of glatiramer are provided. In particular, the long acting pharmaceutical composition comprises a...
8790699 Foam-formed collagen strand  
Foam-formed collagen strands and methods for forming strands involve depositing a dispersed solution of an isolated cleaned, de-fatted, enzymatically-treated (or non-enzyme treated) human-derived...
8791072 Modulating neuromuscular junction density changes in botulinum-toxin treated tissue  
A method may include administering botulinum toxin to a tissue of a patient and administering a neuropeptide of the CRF family to the tissue of the patient. In some examples, the botulinum toxin is...
8791076 Agonists of neurotrophin receptors and their use as medicaments  
The invention relates to compounds of Formula I: and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, and R3 are defined as set forth in the specification. The compounds are...
8790698 Use of a regenerative biofunctional collagen biomatrix for treating visceral or parietal defects  
Techniques for treating visceral or parietal membrane and tissue defects include the application of a collagen biomatrix to the defect to repair and regenerate a visceral or parietal membrane, for...
8791071 Cartilage material  
Cartilage materials such as cartilage fluff and a cartilage composition comprising a particulate material are disclosed. These are suitable for stimulating chondrogenesis and/or producing cartilage...
8785389 Polymeric collagen biomaterials  
This invention relates to the production of biomaterials from polymeric collagen (PC) and its seeding with cells and other components of biomaterials. Polymeric collagen is isolated from tissue,...
8785391 Compound and method for treatment of alzheimer's disease and familial dementia  
An isolated protein is provided for use in treatment of a condition selected from the group consisting of Alzheimer's disease, familial Danish dementia and familial British dementia in a mammal,...
8785390 Methods for treatment of Alzheimer's disease  
An isolated protein selected from the group consisting of (i) proteins comprising an amino acid sequence having at least 70% identity to the C-terminal domain of lung surfactant protein C precursor...
8778343 Antibodies that bind tau oligomers  
Embodiments of the invention are directed to compositions and methods related to Tau oligomers and Tau oligomer specific antibodies.
8778883 Foamy biomaterial for biological tissue repair  
A kit for producing a foamed biocompatible material includes a container configured to sustain a high pressure, and a tissue-repair composition placed in the container. The composition contains a...