|
Match
|
Document |
Document Title |
|
|
7407940 |
Antimicrobial hexapeptides
The invention encompasses hexapeptides consisting of alternating hydrophobic residues (B) at positions 2, 4, and 6, hydrophilic, charged residues (X) at positions 1 and 3, and a naphthylalanine...
|
|
|
7407938 |
Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
One embodiment of the invention relates to compounds of the formula I,
in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate...
|
|
|
7404948 |
Peptidic conjugates for alopecia prevention and treatment
The invention relates to novel peptidic conjugates containing a Gly-His-Lys sequence and used for dermatology or cosmetology for stimulating hair growth or stopping hair fall.
|
|
|
7402559 |
Composition and method of treatment for urogenital conditions
The present invention is directed to a composition and method for treating uro-genital conditions. One embodiment disclosed is a pharmaceutical composition for use in the treatment of uro-genital...
|
|
|
7402556 |
Prodrugs activated by plasmin and their use in cancer chemotherapy
The product of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide having a plasmin peptide substrate of 2-4 amino acids and mono- or...
|
|
|
7396817 |
Biologically active peptides comprising Isoleucyl-valyl-threonyl-asparaginyl-threonyl-threonine (IVTNTT)
The peptide Isoleucyl-valyl-threonyl-asparaginyl-threonyl-threonine (SEQ ID NO.1) is disclosed with its use as a pharmaceutical composition in reducing symptoms of viral disease and stimulating...
|
|
|
7396814 |
Metallopeptide compositions for treatment of sexual dysfunction
Metallopeptide compositions are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. The...
|
|
|
7393835 |
Peptide inhibitors of protein kinase C
PKC V5 isozyme-specific peptides are described. The sequences and compositions comprising the sequences are useful for treating diseases states associated with the PKC isozyme from which they are...
|
|
|
7390526 |
Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon
Biocompatible composites comprising peptide amphiphiles and surface modified substrates and related methods for attachment thereon.
|
|
|
7378397 |
TRH-degrading ectoenzyme inhibitors
Peptide derivatives useful as inhibitors of activity of thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) are of formula I a :
wherein:
R 1 is an optionally substituted 4-, 5-...
|
|
|
7378396 |
Therapeutic agents and methods for cardiovascular disease
The present invention provides methods and agents for treating subjects who have or are at risk of developing or having cardiovascular disease. Such agents inhibit binding of myeloperoxidase (MPO)...
|
|
|
7375083 |
Pharmaceutical compositions for prevention of overdose or abuse
The invention relates to pharmaceutical compositions comprised of a chemical moiety attached to an active agent in a manner that substantially decreases the potential of the active agent to cause...
|
|
|
7375082 |
Abuse-resistant hydrocodone compounds
The present invention decreases the potential for abuse of opioids, particularly hydrocodone, by covalent modification. The invention provides methods of delivering hydrocodone as conjugates that...
|
|
|
7368421 |
Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
The present invention provides a new use of DP IV-inhibitors. The compounds of the present invention, and their corresponding pharmaceutically acceptable acid addition salt forms, are useful in...
|
|
|
7368119 |
Compositions and methods for WT1 specific immunotherapy
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an...
|
|
|
7365047 |
Use of pentagastrin to inhibit gastric acid secretion or as a diuretic
This invention pertains to the discovery that pentagastrin, when administered in conjunction with a proton pump inhibitor (PPI) is synergistic with the PPI and significantly increases the efficacy...
|
|
|
7361638 |
Pharmaceutical combination for the treatment of tissue damage owing to an arterial irrigation defect
This invention relates to a medicine for humans, and particularly to a pharmaceutical combination comprising Epidermal Growth Factor (EGF) and Growth Hormone secretagogue hexapeptide (GHRP) for use...
|
|
|
7361634 |
Pain-sensitive therapeutic wound dressings
The invention provides a wound dressing comprising a therapeutic agent and a matrix comprising polymers joined by cross-linkages which cross-linkages comprise oligopeptidic sequences which are...
|
|
|
7354904 |
Bacteriocin inducer peptides
Novel peptides produced by bacteriocin-producing bacteria stimulate the production of bacteriocins in vitro. The producer bacteria are cultured in the presence of a novel inducer bacteria and a...
|
|
|
7345022 |
Anti-fibril peptides
Novel peptides are disclosed that may be used as inhibitors of amyloidogenesis, as suppressors of amyloid toxicity, and as therapeutic agents for amyloid-associated diseases such as Alzheimer's...
|
|
|
7345020 |
Mimetics of CD4 that inhibit immune response
The application concerns a method of identifying compounds that can be used to inhibit undesired human CD4 + T cell immune responses by identifying compounds that block the interaction of CD4 and...
|
|
|
7338939 |
Abuse-resistant hydrocodone compounds
The present invention decreases the potential for abuse of opioids, particularly hydrocodone, by covalent modification. The invention provides methods of delivering hydrocodone as conjugates that...
|
|
|
7338938 |
Methods for treating a patient undergoing chemotherapy
The present invention provides improved methods, kits, and pharmaceutical compositions for increasing hematopoietic cell survival and/or reducing or preventing the side effects of chemotherapy, and...
|
|
|
7326686 |
Compounds and methods for regulating cell adhesion
Methods for using modulating agents to enhance or inhibit cadherin-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. In particular, the modulating agents may be...
|
|
|
7314866 |
Ku-70-derived Bax-suppressing peptides and use thereof for the protection of damaged cells
A method of protecting cells from cell death comprising the step of supplying to the cell an effective amount of a Bax-inhibiting peptide is disclosed.
|
|
|
7312193 |
Calcium phosphopeptide complexes
Phosphopeptides containing the Ser(P) cluster sequence motif Ser(P)-Ser(P)-Ser(P)-Glu-Glu- can stabilize their own weight in amorphous calcium phosphate (ACP) [Ca 3 (PO 4 ) 1.87 (HPO 4 ) 0.2 xH 2...
|
|
|
7307063 |
Melanocortin metallopeptides for treatment of sexual dysfunction
Metallopeptides are provided for use in treatment of sexual dysfunction in mammals. The metallopeptides are agonists for at least one of melanocortin-3 or melanocortin-4 receptors. The...
|
|
|
7304032 |
CD-10 activated prodrug compounds
The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and,...
|
|
|
7294615 |
Compounds that associate on the intermolecular level and aggregate bodies that contain them
Compound of the general formula (I)
X(B) m (I)
wherein
X is an m-valent...
|
|
|
7291601 |
Arginine-rich anti-vascular endothelial growth factor peptides that inhibit growth and metastasis of human tumor cells by blocking angiogenesis
Disclosed are novel peptides inhibitory of the activity of vascular endothelial growth factor (VEGF) and their use in the treatment of angiogenesis-related diseases, including cancer. A...
|
|
|
7291599 |
Use of inhibitors of enzymes having activities of amino peptidase N and/or dipeptidyl peptidase IV and of pharmaceutical preparations thereof for a therapy and prevention of chronical neurodegenerative diseases
The invention relates to a process for the treatment of neurodegenerative diseases wherein mis-folded proteins accumulate in characteristic lesions and contribute substantially to a pathogenesis...
|
|
|
7288523 |
Peptide binding the KLVFF-sequence of amyloid-β
The invention relates to compounds of formula (I) or (II), which are of interest especially for inhibition of polymerization of amyloid β peptide, as model substances for synthesis of amyloid β...
|
|
|
7288522 |
Method of promoting erythropoiesis
The present invention provides methods, compounds, pharmaceutical compositions, and kits for the augmentation of erythropoiesis by potentiating erythropoietin-induced differentiation with...
|
|
|
7285525 |
Suppression of immune response via inhibition of cathepsin S
Methods and products for suppressing a class II MI-IC-restricted immune response in a mammal, or in mammalian cells, are described. The methods depend upon inhibiting invariant chain proteolysis by...
|
|
|
7271146 |
Methods for treatment of Helicobacter pylori-associated disorders
The present invention relates to methods for treating pathological conditions associated with Helicobacter sp infections, specifically H. pylori infection. The present invention further relates...
|
|
|
7268118 |
Thymosin β4 compositions
A composition with a polypeptide including amino acid sequence LKKTET [SEQ ID NO:1] or a conservative variant thereof, the composition further including a carrier for application to a surface of a...
|
|
|
7262163 |
Short amphipathic peptides with activity against bacteria and intracellular pathogens
“Minimalist” antimicrobial peptides are disclosed based on 50 to 80% α,α-dialkylated amino acids. The peptides are short, cationic, amphipathic, and possess a high helix propensity. Polar...
|
|
|
7250400 |
Peptides and derivatives thereof showing cell attachment, spreading and detachment activity
The present invention relates to peptides and derivatives thereof showing cell attachment, spreading and detachment activity. Particularly, the present invention relates to the peptide NKDIL (SEQ...
|
|
|
7250399 |
Compounds having growth hormone releasing activity
Compounds that promote growth hormone releasing activity are disclosed. These compounds have the formula:
A 1 -A 2 -X; A 1′ -X′; or A...
|
|
|
7247609 |
Growth factor modified protein matrices for tissue engineering
Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling and/or drug delivery. The proteins can be incorporated so that they are...
|
|
|
7238671 |
Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
The present invention provides novel human glucagon-like peptide-1 (GLP-1) peptide mimics that mimic the biological activity of the native GLP-1 peptide and thus are useful for the treatment or...
|
|
|
7238670 |
Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
The present invention provides novel human glucagon-like peptide-1 (GLP-1) peptide mimics that mimic the biological activity of the native GLP-1 peptide and thus are useful for the treatment or...
|
|
|
7238668 |
Inhibition of lymphocyte adherence with CS-1-peptides and fragments thereof
The present invention relates to a method for inhibiting the adhesion of one cell to another comprising interfering with the interaction between the extracellular matrix receptor and its ligand. ...
|
|
|
7235526 |
Protein kinase C peptides for use in withdrawal
A method for managing withdrawal from an addictive substance is described. The method involves administering one or more peptides having specific activity for the ε and/or γ isozyme of protein...
|
|
|
7232803 |
Antimicrobial compounds and formulations
The invention relates to the use of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto at least two bulky and lipophilic groups and having...
|
|
|
7232802 |
Compositions and methods for promoting myocardial and peripheral angiogenesis
Methods, compositions and devices are disclosed for use in growing new blood vessels to restore or improve blood flow to ischemic tissues and organs of the body. Compositions comprising IGD...
|
|
|
7232801 |
IL-16 antagonists
In accordance with the present invention, novel IL-16 antagonists, preferably peptides derived from CD4, have been isolated and synthesized. These peptides possess IL-16 antagonistic properties...
|
|
|
7223734 |
Plasma protein-binding ligands
The invention provides an isolated or purified peptide that binds at least one plasma protein. In one embodiment, the isolated or purified peptide binds to fibrinogen, comprises no more than 10...
|
|
|
7217694 |
Inhibitors of IAPP fibril formation and uses thereof
New antifibrillogenic agents and compositions containing same, methods of using the antifibrillogenic agents and compositions for inhibiting amyloid fibril formation, and effective therapeutics for...
|
|
|
7211269 |
Cosmetic or dermatological use of peptides for promoting adhesion between skin cells
Method for preparing a cosmetic or dermatological composition, of a sufficient amount of peptides of sequence (Gly-Pro-Gln) n -NH 2 , wherein: n ranges between 1 and 3, and the amino acids can be...
|