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8889622 Methods of inhibiting seizure in a subject  
The present invention relates to methods of inhibiting seizure in a subject. In particular, the invention provides methods of increasing brain leptin levels in a subject.
8889627 Treatment of multiple sclerosis with combination of laquinimod and fingolimod  
This invention provides a method of treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome comprising administering to the subject laquinimod as an add-on...
8889626 Triple cross-linked collagen, method of manufacturing the same, and use thereof  
The present invention relates to a method for manufacturing a triple cross-linked collagen, which comprises the following steps: providing a soluble collagen sample; mixing the collagen sample with...
8883143 Treatment of traumatic-induced migraine headache  
A method for selection and treatment of externally caused migraine headache, the method includes identifying a patient group having chronic migraine headache; determining the identified patient...
8883728 Intranasal administration of active agents to the central nervous system  
Pharmaceutical compositions and methods for delivering a polypeptide to the central nervous system of a mammal via intranasal administration are provided. The polypeptide can be a catalytically...
8883964 Compositions comprising modified collagen and uses therefor  
The invention provides modified collagen and related therapeutic and diagnostic methods.
8877207 Nanoparticles of cerium oxide targeted to an amyloid-beta antigen of Alzheimer's disease and associated methods  
Disclosed is a composition immunologically targeted to Alzheimer's disease (AD), the composition containing amine functionalized nanoparticles of Cerium oxide coated with polyethylene glycol and...
8877161 GM1-like peptides and uses thereof  
Compositions and methods relating to interfering with the interaction of gangliosides, such as GM1, with their ligands are provided. For example, methods are provided for treating infections by...
8877158 Targeting agent to newly formed blood vessels  
It is an object of the present invention to provide a targeting agent that enables drug delivery to a neovascular site and the imaging of such a neovascular site, utilizing the effect of the agent...
8877221 Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same  
Osteoconductive matrices and methods are provided that have one or more statins disposed in calcium phosphate particles. The matrices may be injected into a fracture site. The osteoconductive...
8877712 Use of Del-1 in hair, bone and cartilage regeneration  
Methods and compositions are described enhancing bone density or formation, including for stabilizing bone grafts, bone repair, joint replacement, and cartilage repair that includes providing a...
8871710 Method for inducing tissue growth, differentiation and/or regeneration by delivering a GDF-5 related precursor protein  
This invention relates to the production and use of pharmaceutical growth factor compositions with novel characteristics, e.g. improved solubility and controlled release characteristics under...
8871715 Use of selenium compounds, especially selenium yeasts for altering cognitive function  
The present invention relates to compositions and methods for altering cell function. In particular, the present invention provides compositions comprising selenium (e.g., SEL-PLEX) and methods of...
8871235 Compositions and their use in bone healing  
The present invention is directed to implantable compositions comprising substantially spherical bioactive glass particles.
8865219 Orodispersible tablets of bitter active principles  
The invention concerns coated granules including (A) at least one amine-containing pharmacological active principle, preferably as an acid addition salt, the pharmacological active principle being...
8859523 Crosslinked compounds and methods of making and using thereof  
Described herein are crosslinked compounds useful in numerous treatments. Described herein are methods of making crosslinked compounds via (1) the oxidative coupling of two or more thiol compounds...
8859500 Method for ameliorating pain by modification of NMDA receptors through inhibition of SRC  
The present invention provides a method for ameliorating inflammatory and/or neuropathic pain in a subject by modifying the activity of N-methyl-D-aspartate (NMDA) receptors in cells of the subject...
8859501 Protofibril-binding antibodies and their use in thereapeutic and diagnostic methods for parkinson's disease, dementia with lewy bodies and other alpha-synucleinopathies  
Antibodies and fragments thereof have high affinity for human α-synuclein protofibrils and low binding of α-synuclein monomers, wherein the antibodies or fragments have specified Complementarity D...
8859505 Cysteine protease inhibitors  
Compounds of the formula I wherein R2a and R2b are independently H, halo, C1-C4alkyl, C1-C4haloalkyl or C1-C4alkoxy, or R2a andR2b together with the carbon atom to which they are attached form a...
8853166 Neurotrophic factor MANF and uses thereof  
The present invention generally relates to the field of treatment of neuronal disorders and more particularly to neurotrophic factor MANF and uses thereof. The present invention provides a...
8853361 Preparation, for use, in particular, for tissue augmentation and healing  
The invention relates to a sterile preparation which can be implanted on or in organic tissues, comprising: a natural or modified globin material which is insoluble at physiological pH and/or a...
8846003 Collagen-binding synthetic peptidoglycans, preparation, and methods of use  
This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the...
8846315 Disease risk factors and methods of use  
Provided herein are genetic variants associated with development of a condition of interest (e.g., Alzheimer's disease). Methods of treatment with an active agent (e.g., with a particular active...
8841254 Method for treatment of anxiety  
Human H3 preprorelaxin, human H3 prorelaxin, human H3 relaxin, human relaxin analogues having a modified A chain and/or a modified B chain are described. Also described are nucleic acid sequences...
8841260 Methods and compositions for treating Huntington's Disease  
Disclosed herein are methods and compositions for treating or preventing Huntington's Disease.
8835391 Alpha B-crystallin as a therapy for multiple sclerosis  
The invention provides methods for treating inflammatory diseases by administering to the subject an effective amount of an agent that provides alpha B-crystallin activity, where the dose is...
8828404 Vaccine and method for treatment of neurodegenerative diseases  
Methods and compositions are provided for treatment of neurodegenerative diseases in which there is accumulation of misfolded and/or aggregated proteins, excluding prion diseases. In particular,...
8828937 Bone morphogenetic protein 2 (BMP2) variants with reduced BMP antagonist sensitivity  
The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No....
8828941 Composition and method for the treatment or prevention of spinal disorders  
The present invention provides compositions of matter suitable for the prevention of and/or treatment of a spinal disorder and/or spinal pain, e.g., caused by and/or associated with intervertebral...
8828943 Anticonvulsant combination therapy  
A method for alleviating and/or treating epileptic seizures comprising administering a pharmaceutical composition comprising (a) lacosamide and/or a pharmaceutically acceptable salt thereof; and...
8828949 Aprotinin polypeptides for transporting a compound across the blood-brain barrier  
The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptides derived from aprotinin and from aprotinin analogs as well as conjugates...
8828942 Means for treating synucleinopathies  
The present invention relates to peptides or polypeptides for producing medicaments for preventing and/or treating synucleinopathies.
8828389 Methods of diagnosing ALS  
The invention relates to an epitope protection assay for use in diagnosis, prognosis and therapeutic intervention in diseases, for example, involving polypeptide aggregation, such as prion...
8822418 Treatment of muscular dystrophies and related disorders  
The invention provides, among other aspects, compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan;...
8815808 Modulation of activity of neurotrophins  
The present invention relates to methods for modulating the activity of one or more neurotrophins, such as neural growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin-3...
8815814 Cosmetic composition containing oligopeptides  
The invention is directed to the cosmetic use of tetrapeptides according to formula (I) R1-Val-Leu-Leu-Lys-R2 (I) wherein R1 is linked to the NH2-terminal group of the peptide and is chosen from...
8815261 Composition for external application comprising aripiprazole and organic acid as active ingredients  
[Summary] An external preparation formulation superior in the transdermal absorbability has been desired as a new administration route of aripiprazole. Transdermal absorption of aripiprazole has...
8815233 Method for treating pervasive development disorders  
A method of utilizing the chymotrypsin level of an individual as a measure of the success of secretin, other neuropeptides, and peptides or digestive enzyme administration to such individuals, and...
8815810 Treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain  
The present invention relates to the use of Meteorin for the treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain. In a preferred embodiment the disorder to be treated is...
8815803 Method for increasing body height comprising systemic administration of CNP-53  
This invention provides a composition for increasing a body height of a patient with short stature or an individual other than patients with short stature. More specifically, the invention...
8815809 Cysteine protease inhibitors  
Compounds of Formula II whereinR1a is H; and R1b is C1-C6alkyl, Carbocyclyl or Het; orR1a and R1b together define a saturated cyclic amine with 3-6 ring atoms;R2a and R2b are independently H, halo,...
8815511 Determination of single nucleotide polymorphisms useful to predict response for glatiramer acetate  
This invention provides a method for treating a human subject afflicted with multiple sclerosis or a single clinical attack consistent with multiple sclerosis with a pharmaceutical composition...
8809278 Cyclic tetrapeptides  
Cyclic tetrapeptides that are kappa opioid receptor (KOR) antagonists can be used in therapeutic applications for treating, inhibiting, and/or preventing drug addiction, drug use, or drug seeking...
8809274 Adhesive hemostatic agent based on porcine atelocollagen and method for production thereof  
Disclosed is an adhesive hemostatic agent based on non-blood constituents including DOPA, able to strongly adhere to collagen fibers, and which comprises an antifibrinolytic agent in addition to an...
8809275 Peptoids and methods for treating alzheimer's disease  
Provided herein are peptoids capable of inhibiting or reversing amyloid β (Aβ) fibril or plaque production. The peptoids form a helical structure with three monomers per helical turn and have at l...
8802630 Method of treating brain injury  
A novel use of a neuropeptide for treating brain injury in a subject in need thereof is provided. The present invention also provides various amenable routes of administering urocortin, that is,...
8802626 Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects  
Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with...
8802088 Mixture of peptide-bound tryptophan and polypeptide-bound tryptophan  
The present invention relates to a composition which comprises tryptophan whereby 10 to 90%, preferably 20 to 80% of the tryptophan is present as free tryptophan or peptide-bound tryptophan and 10...
8796214 Neurotrophic peptides  
The present invention relates to a neurotrophic peptide having an amino acid sequence of VGDGGLFEKKL (SEQ ID NO:1) and alternatively comprising an adamantyl group at the C- and/or N-terminal end....
8796213 Apoaequorin-containing compositions and methods of using same  
Compositions containing apoaequorin and methods for their use in treating symptoms and disorders related to calcium imbalances associated with, for example, sleep quality, energy quality, mood...