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8940684 Cross-linked collagen comprising an antifungal agent  
The disclosure describes collagen constructs comprising antifungal agents, preferably, copper, and related methods.
8940293 Transplantation of bone marrow stromal cells for treatment of neurodegenerative diseases  
The present invention relates to a treatment of an autoimmune demyelinating disease/disorder. Also included in the present invention is the use of bone marrow stromal cells for the treatment of...
8940698 Cartilage material  
Cartilage materials such as cartilage fluff and a cartilage composition comprising a particulate material are disclosed. These are suitable for stimulating chondrogenesis and/or producing cartilage...
8940699 Model systems and treatment regimes for treatment of neurological disease  
The invention provides animal models and clinical trials for assessing agents for potential use in treating and effecting prophylaxis stroke and other neurological diseases, particularly those...
8940306 Method for enhancing immune response with peptide  
An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid β ...
8940289 Fusion molecules and IL-15 variants  
The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making such proteins. The instant invention additionally...
8940700 E-selectin compositions and use thereof for inducing E-selectin tolerance  
The invention relates to compositions and methods for treating or preventing vascular dementia in a mammal comprising mucosal administration of an amount of E-selectin polypeptide sufficient to...
8937218 Transformed soybean plant which accumulates vaccine, and use thereof  
A transformed soybean plant having a gene encoding a modified seed storage protein introduced therein, obtained by inserting a gene encoding an Alzheimer's disease vaccine to a variable region(s)...
8937039 Peptide-based peroxidase inhibitors and methods of using same  
The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox...
8933034 Chimeric neuregulins and method of making and use thereof  
Composition containing a chimeric neuregulin polypeptides and method of making such polypeptides are disclosed. The chimeric neuregulin comprises a first moiety of at least 10 amino acids, wherein...
8933020 Methods and compositions related to improving properties of pharmacological agents targeting nervous system  
Disclosed are compositions and methods related to improving pharmacological properties of bioactive compounds targeting nervous system.
8932592 Compositions and methods for treating inflammatory disorders  
The present invention features compositions and methods related to humanized antibodies and FKN-binding fragments thereof that bind fractalkine.
8927497 Absorption enhancers for intranasal administration  
A composition including a surfactant and at least one alkyl glycoside and/or saccharide alkyl ester and a drug. The surfactant composition(s) when admixed with a drug is non-toxic and...
8927491 Methods for forming compositions for treating joints comprising bone morphogenetic protein and hyaluronic acid  
Methods and compositions are disclosed for an intra-articular injection for the treatment of osteoarthritis. The methods and compositions comprising combinations of hyaluronic acid and a bone...
8926974 Methods of treating a tauopathy  
The present disclosure provides methods of treating a tauopathy, involving administering an anti-Tau antibody. The present disclosure also provides anti-Tau antibodies, and formulations comprising...
8927498 Compositions and methods useful in enhancement of memory  
Compounds derived from a transduction complex that enhance memory in mammals and methods of enhancing memory using said compounds are disclosed.
8927493 Promoter for regeneration of tendon-bone junction tissue or ligament-bone junction tissue  
An object of the present invention is to provide a drug for promoting the regeneration of tendon-bone junction tissue or ligament-bone junction tissue. The present invention relates to a promoter...
8920808 Cytokine-based fusion proteins for treatment of multiple sclerosis  
The present invention provides fusion proteins including an autoimmune antigen, an allergen antigen or an alloantigen, and an anti-inflammatory cytokine. Compositions and methods including the...
8920819 Delivery of hydrophilic drugs  
Compositions comprising a lipophilic derivative of a hydrophilic drug and an amphiphile compound for use in therapy of the human or animal body are provided. Methods of medical treatment, wherein a...
8921321 Therapeutic strategies for prevention and treatment of alzheimer's disease  
The invention relates to therapeutic agents for use in the prevention or treatment of Alzheimer's disease. In particular the invention relates to use of inhibitors of cell cycle reentry and...
8921306 Nociceptin mimetics  
The present invention relates to nociceptin peptide mimetics that have α-helical structures and bind to and modulate the opioid receptor-like-1 (ORL-1) receptor. The peptide mimetics are ...
8921320 Targeted osmotic lysis of cancer cells  
A targeted osmotic lysis (TOL) of tumor cells that over-express voltage-gated sodium channels (VGSCs) has been developed that uses a combined therapy of a drug that blocks sodium,...
8920778 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Targeting agent for tumor site
 
It is an object of the present invention to provide a targeting agent, which enables the delivery of a drug to tumor sites or the imaging of tumor sites by utilizing its effect of accumulating to...
8916524 Composition for improving brain function and method for improving brain function  
The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present...
8916517 Analogs of pituitary adenylate cyclase-activating polypeptide (PACAP) and methods for their use  
This invention relates to novel analogs of pituitary adenylate cyclase-activating polypeptide (PACAP), which are agonists for the PACAP/vasoactive intestinal peptide (VIP) receptors: PAC1, VPAC1...
8912145 Vaccine composition for prophylaxis and/or therapy of Alzheimer's disease  
A vaccine composition for prophylaxis and/or therapy of Alzheimer's disease, which comprises a fusion protein prepared by inserting a single or tandemly repeated multiple copies of amyloid β ...
8911731 Monoclonal antibodies specific for beta-amyloid x-37 and uses thereof  
The present invention provides monoclonal antibodies which specifically recognize the shorter Aβ peptides obtained after cleavage of the APP protein mediated by γ-secretase, i.e. the Aβ-peptide fr...
8912144 Method for treating stroke via administration of NEP1-40 and inosine  
Disclosed herein is a method for stimulating axonal outgrowth of central nervous system (CNS) neurons comprising contacting the CNS neurons with an effective amount of NEP1-40 and inosine, to...
8901079 Treatment of parkinson's disease via administration of GLI-1 protein  
Described herein are compositions and methods for the treatment of Parkinson's disease (PD) and/or to protect dopaminergic nigrostriatal neuronal cell bodies from 6-OHDA-induced neurotoxicity in a...
8900579 Siglec-15 antibodies in treating bone loss-related disease  
Novel antibodies and antigen binding fragments that specifically binds to Siglec-15 are described herein In some embodiments, the antibodies or antigen binding fragments may block the biological...
8900574 Mesenchymal stem cells for the treatment of CNS diseases  
An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least...
8901078 Crosslinked human or animal tissue products and their methods of manufacture and use  
Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present...
8895510 Pan-selectin inhibitor with enhanced pharmacokinetic activity  
Compounds, compositions and methods are provided for treatment of diseases or complications associated therewith, in which a selectin plays a role. More specifically, particular glycomimetics and...
8895541 Methods for inhibiting the development of huntington's disease  
This invention relates to Huntington's disease and more specifically to methods for inhibiting the development of or treating Huntington's disease by administering estrogen, testosterone,...
8895506 Protein stabilization formulations  
The present invention is directed to stabilizing Bone Morphogenetic Protein in various lyophilized formulations and compositions. The present invention comprises formulations primarily including...
8895511 Use of sarcoplasmic CA2+-ATPase type 2 protein for diagnosing and treating learning or mental disorders  
The present invention embraces methods for the diagnosis and treatment of learning or mental disorders, as well as the identification of agents useful in the treatment of such disorders based upon...
8895512 Composition for improving brain function and method for improving brain function  
The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present...
8889622 Methods of inhibiting seizure in a subject  
The present invention relates to methods of inhibiting seizure in a subject. In particular, the invention provides methods of increasing brain leptin levels in a subject.
8889627 Treatment of multiple sclerosis with combination of laquinimod and fingolimod  
This invention provides a method of treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome comprising administering to the subject laquinimod as an add-on...
8889626 Triple cross-linked collagen, method of manufacturing the same, and use thereof  
The present invention relates to a method for manufacturing a triple cross-linked collagen, which comprises the following steps: providing a soluble collagen sample; mixing the collagen sample with...
8883143 Treatment of traumatic-induced migraine headache  
A method for selection and treatment of externally caused migraine headache, the method includes identifying a patient group having chronic migraine headache; determining the identified patient...
8883728 Intranasal administration of active agents to the central nervous system  
Pharmaceutical compositions and methods for delivering a polypeptide to the central nervous system of a mammal via intranasal administration are provided. The polypeptide can be a catalytically...
8883964 Compositions comprising modified collagen and uses therefor  
The invention provides modified collagen and related therapeutic and diagnostic methods.
8877207 Nanoparticles of cerium oxide targeted to an amyloid-beta antigen of Alzheimer's disease and associated methods  
Disclosed is a composition immunologically targeted to Alzheimer's disease (AD), the composition containing amine functionalized nanoparticles of Cerium oxide coated with polyethylene glycol and...
8877161 GM1-like peptides and uses thereof  
Compositions and methods relating to interfering with the interaction of gangliosides, such as GM1, with their ligands are provided. For example, methods are provided for treating infections by...
8877158 Targeting agent to newly formed blood vessels  
It is an object of the present invention to provide a targeting agent that enables drug delivery to a neovascular site and the imaging of such a neovascular site, utilizing the effect of the agent...
8877221 Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same  
Osteoconductive matrices and methods are provided that have one or more statins disposed in calcium phosphate particles. The matrices may be injected into a fracture site. The osteoconductive...
8877712 Use of Del-1 in hair, bone and cartilage regeneration  
Methods and compositions are described enhancing bone density or formation, including for stabilizing bone grafts, bone repair, joint replacement, and cartilage repair that includes providing a...
8871710 Method for inducing tissue growth, differentiation and/or regeneration by delivering a GDF-5 related precursor protein  
This invention relates to the production and use of pharmaceutical growth factor compositions with novel characteristics, e.g. improved solubility and controlled release characteristics under...
8871715 Use of selenium compounds, especially selenium yeasts for altering cognitive function  
The present invention relates to compositions and methods for altering cell function. In particular, the present invention provides compositions comprising selenium (e.g., SEL-PLEX) and methods of...