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8790699 Foam-formed collagen strand  
Foam-formed collagen strands and methods for forming strands involve depositing a dispersed solution of an isolated cleaned, de-fatted, enzymatically-treated (or non-enzyme treated) human-derived...
8791072 Modulating neuromuscular junction density changes in botulinum-toxin treated tissue  
A method may include administering botulinum toxin to a tissue of a patient and administering a neuropeptide of the CRF family to the tissue of the patient. In some examples, the botulinum toxin is...
8791076 Agonists of neurotrophin receptors and their use as medicaments  
The invention relates to compounds of Formula I: and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, and R3 are defined as set forth in the specification. The compounds are...
8790698 Use of a regenerative biofunctional collagen biomatrix for treating visceral or parietal defects  
Techniques for treating visceral or parietal membrane and tissue defects include the application of a collagen biomatrix to the defect to repair and regenerate a visceral or parietal membrane, for...
8791071 Cartilage material  
Cartilage materials such as cartilage fluff and a cartilage composition comprising a particulate material are disclosed. These are suitable for stimulating chondrogenesis and/or producing cartilage...
8785389 Polymeric collagen biomaterials  
This invention relates to the production of biomaterials from polymeric collagen (PC) and its seeding with cells and other components of biomaterials. Polymeric collagen is isolated from tissue,...
8785606 Compositions and methods for promoting neuronal outgrowth  
Neural outgrowth in the central nervous system is achieved by administering chondroitinase AC and/or chondroitinase B to degrade chondroitin sulfate proteoglycans that inhibit or contribute to the...
8785391 Compound and method for treatment of alzheimer's disease and familial dementia  
An isolated protein is provided for use in treatment of a condition selected from the group consisting of Alzheimer's disease, familial Danish dementia and familial British dementia in a mammal,...
8785390 Methods for treatment of Alzheimer's disease  
An isolated protein selected from the group consisting of (i) proteins comprising an amino acid sequence having at least 70% identity to the C-terminal domain of lung surfactant protein C precursor...
8778343 Antibodies that bind tau oligomers  
Embodiments of the invention are directed to compositions and methods related to Tau oligomers and Tau oligomer specific antibodies.
8778883 Foamy biomaterial for biological tissue repair  
A kit for producing a foamed biocompatible material includes a container configured to sustain a high pressure, and a tissue-repair composition placed in the container. The composition contains a...
8778884 Glioprotectant peptide for use in the treatment of amyotrophic lateral sclerosis (ALS) and methods related thereto  
The described invention relates to the use of the TAT-BH4 peptide for treating or preventing the progression of ALS. The methods include, postponing the appearance of symptoms and improving motor...
8772242 Therapy for enteric infections  
There is disclosed herein a composition for treating gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers diarrhea,...
8772241 Peptide and use thereof  
The present invention provides a peptide represented by formula (I) of X1-Leu-X2-Leu-X3 wherein X1 represents Glu or Asp, X2 represents His, Lys or Arg, X3 represents Asp or Glu, with Glu, Asp,...
8771689 Alpha B-crystallin as a therapy for ischemia or inflammation  
The invention provides methods for treating inflammatory diseases by administering to the subject an effective amount of an agent that provides alpha B-crystallin activity, where the dose is...
8772225 Biomarkers for multiple sclerosis  
The present invention relates to the diagnosis of neurological disorders, more specifically to the diagnosis of multiple sclerosis. A biomarker panel is provided which can be used to detect if a...
8772238 Use of ixolaris, a tissue factor inhibitor, for the treatment of cancer  
The invention provides methods for treatment of tissue factor (TF) mediated or associated diseases or processes, such as cancer, by administering at least an active fragment of an Ixolaris...
8765675 Use of calcitonin in osteoarthritis  
The present invention relates to a novel use of calcitonin in osteoarthritis, and to methods of treating and/or preventing osteoarthritis in mammals, particularly humans.
8765679 Extract and peptides derived from Oryza sativa Japonica Group and uses thereof  
The invention relates to isolated peptides derived from Oryza sativa Japonica Group, pharmaceutical compositions comprising same, and uses thereof for treating, preventing, ameliorating, and/or...
8759302 Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis  
A method for treating a subject afflicted with an autoimmune disease with a pharmaceutical composition comprising glatiramer acetate and a pharmaceutically acceptable carrier, comprising the steps...
8758770 Alpha-MSH therapies for treatment of autoimmune disease  
Methods and compositions for the enteral treatment of autoimmune disease such a multiple sclerosis with polypeptide therapeutics. Enteral therapeutics comprise monomeric alpha-MSH polypeptides such...
8759297 Genetically encoded multifunctional compositions bidirectionally transported between peripheral blood and the cns  
Provided herein are compositions for increasing transport of agents across the blood-brain barrier, in some embodiments in both directions, while allowing their activity once across the barrier to...
8758791 Highly compression resistant matrix with porous skeleton  
A highly compression resistant matrix is provided for implantation at or near a target tissue site beneath the skin. The matrix comprises a polymer and a ceramic skeleton. The compression...
8758806 Human lubrication gel  
Human lubricating gels, methods and kits for delivering a therapeutic agent to a target tissue site beneath the skin of a patient utilizing human lubricating gel are provided, the human lubricating...
8759296 Bone morphogenic protein binding peptide  
A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2. BBP increases the overall osteogenic activity of rhBMP-2, increases the rate at which...
8754034 Structure-based design of peptide inhibitors of amyloid fibrillation  
The invention provides methods for designing peptides that inhibit aggregation in target polypeptides. The candidate inhibitory peptidic compounds have an oligomeric sequence that forms...
8754036 Method for treating neuropathic pain  
An object of the present invention is to provide a substance which is able to be an active ingredient for the improvement of dysfunction caused by nerve damage. An improving agent for dysfunction...
8754044 Neuroprotection by hepatic cells and hepatocyte secretory factors  
The present invention relates to compositions and methods for neuroprotection. In particular, provided herein are compositions (e.g., hepatocyte secretory factors) for alleviating and/or protecting...
8754037 Modified human tumor necrosis factor receptor-1 polypeptide or fragment thereof, and method for preparing same  
Provided is a modified human tumor necrosis factor receptor-1 polypeptide or a fragment thereof that binds to a tumor necrosis factor in vivo or ex vivo. The modified human tumor necrosis factor...
8754049 Organic compound for the regulation of vectorial ion channels  
A cyclic organic compound which comprises 16 amino acids or 17 amino acids and has no carboxyl group C-terminally and/or no amino group N-terminally. Optionally, one of the amino acids is a...
8747841 Polypeptides and use thereof for treatment of traumatic or degenerative neuronal injury  
The present invention relates to polypeptides transiently activating Ras homolog gene family member A (RhoA) GTPase, polynucleotides encoding said polypeptides and pharmaceutical compositions...
8748578 Mutant channelrhodopsin 2  
The invention relates to mutant channelrhodopsins having improved properties, nucleic acid constructs encoding same, expression vectors carrying the nucleic acid construct, cells comprising said...
8748387 Methods for treating pain  
The invention provides agents useful for treating pain. An exemplary agent comprises or consists of the a portion of a retroviral Tat protein. One such agent is the peptide Tat-NR2B9c. This peptide...
8748384 Modulation of activity of proneurotrophins  
The present invention provides agents for inhibiting binding of a pro-neurotrophin to a Vps1 Op-domain receptor, in particular the binding of a pro-NGF or a pro-BDNF to a Sortilin receptor. The...
8747924 Methods for preventing and treating neurodegenerative diseases  
The present invention provide a method for the prevention and treatment of a neurodegenerative disease including Alzheimer's Disease, Huntington's Disease, and Parkinson's Disease, using a grape...
8748367 Use of antisecretory factor  
The present invention relates to the use of an antisecretory protein or homologues thereof having the same properties, or certain fragments thereof in the manufacture of a medicament or a medical...
8748579 Collagen-based matrix for use as restorative material, and method for preparing the same  
Disclosed herein are a collagen-based matrix for use as a restorative material and a method for the preparation thereof. An atelocollagen dispersion is spread at a predetermined thickness over a...
8748386 Immunological targeting of pathological Tau proteins  
The present invention relates to methods and compositions for treating, preventing, and diagnosing Alzheimer's Disease or other tauopathies in a subject by administering an immunogenic tau peptide...
8748385 Adult cerebellum-derived neural stem cells and compositions and methods for producing oligodendrocytes  
This disclosure describes a novel population of cerebellum-derived neural stem cells that can be isolated from the adult brain, expanded, and differentiated into neurons, astrocytes and...
8741847 Agent and methods for reducing inflammatory markers  
A method for treating an autism spectrum condition includes administering an effective dose of a TNF-α inhibiting agent to a person having an autism spectrum condition or pervasive development ...
8741260 Fusion proteins for delivery of GDNF to the CNS  
The invention provides compositions, methods, and kits for increasing transport of GDNF across the blood brain barrier while allowing its activity to remain substantially intact. The GDNF is...
8735356 Anticonvulsant combination therapy  
A pharmaceutical composition comprising a Compound (a) of a class of peptide Compounds and at least one further Compound (b) for the prevention, alleviation and/or treatment of epileptic seizures.
8729026 Method for inhibiting autophagy of motor neurons  
A method for inhibiting the autophagy of motor neurons in a subject is provided. The method comprises administrating to the subject an effective amount of an active ingredient selected from the...
8729024 Targeted delivery of pharmaceutical compounds  
Techniques are provided for targeting a pharmaceutically active compound using, as a carrier, a molecule (or molecules) having greater affinity for a particular site in a living organism's body...
8729020 Methods for the treatment of aortic fibrosis with VIP fragments  
The invention relates to compositions comprising vasoactive intestinal peptide (VIP) or fragments thereof, and the use of such compositions in the treatment of aortic fibrosis and other associated...
8728817 Compositions and methods for making and using laminin nanofibers  
The present invention provides methodologies and parameters for fabrication of the hybrid biomaterial by blending pure laminin or complex extracts of tissues containing laminin with biopolymers...
8729025 Methods for altering MRNA splicing and treating familial dysautonomia by administering kinetin, benzyladenine, and tocotrienols  
This invention relates to methods for altering the splicing of mRNA in cells. In particular, this invention also relates to methods for increasing the ratio of wild type to misspliced forms of mRNA...
8722042 Use of ventricular enlargement rate in intravenous immunoglobulin treatment of alzheimer's disease  
The present invention relates to the use of MRI monitoring of ventricular enlargement rate as an objective measure for the purpose of assessing disease progression in patients suffering from...
8722626 Method for controlling fibrosis and other pathological deposits in tissues comprising administering a GHRP-6 composition  
The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological...
8716227 Graft prosthesis, materials and methods  
A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure...