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8440622 |
Use of gelsolin to treat multiple sclerosis and to diagnose neurologic disease (stossel)
The invention relates to the use of gelsolin to treat neurologic diseases (e.g., multiple sclerosis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of neurologic diseases.
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8440615 |
Pharmaceutical and/or cosmetic composition containing active-principle activators of aconitase
A cosmetic or pharmaceutical composition, and in particular a dermatological one, including, in a physiologically adapted medium, active principles capable of activating aconitase, and methods of...
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8440618 |
Composition for the attachment of implants to collagen or other components of biological tissue
The present invention relates to a novel composition comprising an implant, scaffold or construct bound to a biological or chemical moiety. The bound moiety has the ability to bind to a component...
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8440621 |
Analogs of ShK toxin and their uses in selective inhibition of Kv1.3 potassium channels
Analogs of ShK toxin and methods for using such ShK analogs. The ShK analogs generally comprise ShK toxin attached to a chemical entity (e.g. an atom, molecule, group, residue, compound, moiety,...
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8440788 |
N-terminal VDAC variants and uses thereof
The present invention relates generally to variants and peptides of the mitochondrial protein, voltage-dependent anion channel (VDAC) and to polynucleotides encoding same. In particular, the...
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8435523 |
Antibodies against nerve growth factor (NGF) with enhanced in vivo stability
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an...
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8435949 |
Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis
The present invention provides a method of increasing neural stem cell numbers or neurogenesis by using a pheromone, a luteinizing hormone (LH) and/or a human chorionic gonadotrophin (hCG). The...
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8435943 |
Protein stabilization formulations
The present invention is directed to stabilizing Bone Morphogenetic Protein in various lyophilized formulations and compositions. The present invention comprises formulations primarily including...
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8435940 |
Methods and compositions related to improving properties of pharmacological agents targeting nervous system
Disclosed are compositions and methods related to improving pharmacological properties of bioactive compounds targeting nervous system.
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8431531 |
Methods for stimulating glucagon-like peptide-1(GLP-1) secretion and treatments comprising same
A protein hydrolysate having a degree of hydrolysis between 1 and 40% and containing between 1 and 70 wt. % of peptides having a molecular weight of less than 500 Da and less than 55 wt. % of...
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8431536 |
Target for breast cancer therapy and/or diagnosis
The present invention relates to breast cancer and methods for identifying therapeutics and diagnosis. In general, methods for identifying therapeutic agents directed to calcium flow arc disclosed....
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8431364 |
Biopolymer produced by fermenting the extract of soybean with folic acid and a composition containing thereof
Provided are a folyl extract of fermented soybean (EFS) produced by fermenting a culture including a folic acid and soybean extract by using a microorganism, and a composition including the folyl...
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8426130 |
Methods of diagnosing alzheimer's disease and markers identified by set association
The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association...
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8420775 |
Polypeptides and methods for modulating D1-D2 dopamine receptor interaction and function
The present invention provides for prevention and/or treatment of neurological or neuropsychiatric disorders involving abnormal D1-D2 dopamine receptor coupling and/or activation. Methods and...
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8420778 |
Tripeptides and derivatives thereof for cosmetic application in order to improve skin structure
The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: R1 represents H, —C(O)—R6, —SO2—R6 or —C(O)—XR6; R2 and R4, ...
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8420601 |
Biocompatible materials containing stable complexes of TSG-6 and hyaluronan and method of using same
The present invention provides a biocompatible material in the form of a water insoluble cross-linked gel, which contains a stable complex of TNF-stimulated gene 6 protein (TSG-6) and hyaluronan.
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8414888 |
Therapeutic use of IgG as a neuroprotective agent
The present invention relates to compositions containing IgG and methods for the promotion of nerve regeneration or prevention or inhibition of neuronal degeneration by IgG to ameliorate the...
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8409584 |
Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins
The present invention is directed to pharmaceutical agents and compositions useful for the treatment and prevention of amyloid disease in a subject. The invention further relates to isolated...
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8409548 |
Administration of growth factors for the treatment of CNS disorders
A method and system that is directed to the local delivery of growth factors to the mammalian CNS to treat CNS disorders associated with neuronal death and/or dysfunction is described.
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8410053 |
Methods for treating autoimmune disorders, and reagents related thereto
The invention generally relates to improved methods for treatment or prophylaxis in animal subjects (including humans) of autoimmune disorders including Type I diabetes, septic shock, multiple...
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8409575 |
Antibodies specific for amyloid beta protofibril
The invention relates to a purified antibody or fragment thereof that specifically binds an Aβ protofibril. The invention further relates to a composition that includes such antibodies. The ...
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8404642 |
Treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain
The present invention relates to the use of Meteorin for the treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain. In a preferred embodiment the disorder to be treated is...
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8399413 |
Low frequency glatiramer acetate therapy
A method of alleviating a symptom of relapsing-remitting multiple sclerosis in a human patient suffering from relapsing-remitting multiple sclerosis or a patient who has experienced a first...
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8398972 |
Methods of treating dementia using a GM-CSF antagonist
The invention is based on the discovery that GM-CSF antagonists can be used for the treatment of a patient that has Alzheimer's disease or vascular dementia, or is at risk for developing...
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8399211 |
Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
The present invention provides processes for determining the molecular weight of glatiramer acetate and other copolymers. The present invention further provides a plurality of molecular weight...
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8399010 |
Highly-mineralized osteogenic sponge compositions and uses thereof
Osteogenic sponge compositions having enhanced osteoinductive properties for use in bone repair are described. The compositions include a quickly resorbable porous carrier, a more slowly resorbed...
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8394770 |
Vm23 and Vm24, two scorpion peptides that block human T-lymphocyte potassium channels (sub-type Kv1.3) with high selectivity and decrease the in vivo DTH-responses in rats
Potassium channels Kv1.3 are known to be implicated in immunological diseases and graft rejections. Disclosed are peptides capable of blocking with high affinity and specificity potassium channels...
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8394763 |
Cyclic undecapeptides and derivatives as multiple sclerosis therapies
A method for treating a subject with multiple sclerosis is disclosed herein. In one embodiment, a method is provided for treating a subject with multiple sclerosis that includes administering to...
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8389479 |
Compositions and methods for treatment of multiple sclerosis
Disclosed are novel compositions and methods for the treatment of Multiple Sclerosis (MS), and in particular immunostimulatory compositions comprising muramyl dipeptide microparticles for use,...
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8389477 |
Amylin and amylin agonists for treating psychiatric diseases and disorders
Methods and compositions for treating psychiatric diseases and disorders are disclosed. The methods provided generally involve the administration of an amylin or an amylin agonist to a subject in...
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8389478 |
Methods and compositions for treating neurodegenerative disorders and Alzheimer's disease and improving normal memory
The disclosure relates generally to neurodegenerative disorders and more specifically to a group of presenilin/G-protein/c-src binding polypeptides and methods of use for modulating signaling and...
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8377885 |
Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
Long acting parenteral pharmaceutical compositions comprising a therapeutically effective amount of glatiramer are provided. In particular, the present invention provides a long acting...
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8377875 |
Therapeutics based on tau/microtubule dynamics
The invention is based on the discovery of a novel neuroprotective peptide. In addition, the invention rests on the discovery that the NAP peptide enhances the association of tau and the...
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RE43982 |
IGF-1 to improve neural outcome
A method of treating injuries to or diseases of the central nervous system that predominantly effects glia and/or non-cholinergic neuronal cells characterized in that it comprises the step of...
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8367619 |
Methods for promoting elastogenesis and elastin fiber formation by increasing tropoelastin expression
Compositions and methods are provided for promoting elastin fiber formation (elastogenesis) in a cell, including methods that comprise contacting a cell that is capable of elastogenesis with (i) a...
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8367610 |
Method of treating cravings by administration of nerve growth factor
A method for administering nerve growth factor to treat cravings is provided. Pharmaceutical compositions for the treatment of cravings comprising nerve growth factor are also provided.
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8366770 |
Biological artificial nerve guide and method of making
A biological nerve guide for implantation into a human body is made by providing a natural animal tissue membrane, crosslinking and fixing the membrane, minimizing the antigens from the membrane,...
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8367615 |
Stimulation of neuron regeneration by secretory leukocyte protease inhibitor
The present invention provides methods for stimulating neuronal survival, growth and regeneration by administering SLPIs to animals, such as humans. These methods can be used to treat a variety of...
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8361967 |
Beta sheet inhibiting peptides for preventing and/or treating Alzheimer's Disease
Provided are β-sheet breaker peptides binding to β amyloid peptide (Aβ1-42), which have the homologous sequence with Aβ 14-23. β-sheet breaker peptides can be used for the manufacture of a medi...
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8357658 |
Medicament for treating Parkinson'S disease
The invention relates to the manufacture of a unit dose of a medicament for relieving the symptoms and/or restoring and/or protecting the neurons of patients suffering from Parkinson's disease....
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8357402 |
Flowable wound matrix and its preparation and use
This invention relates to a flowable collagen/glycosaminoglycan (GAG) material including particles of collagen/GAG matrix that, when hydrated, can be effectively delivered to wounds having varying...
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8357659 |
Method of treating pain or itching with APETx2 peptide toxin
The invention relates to the use of the peptide toxin APETx2 that blocks the ASIC3 cationic channels and that is derived from the Anthopleura elegantissima sea anemone, and to the use of the...
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8353967 |
Self-supporting collagen tunnel for guided tissue regeneration and method of using same
A biocompatible, self-supporting, curved, collagen membrane adapted to be secured by bone tacks or bone screws over exposed bone at a desired bone graft site in the alveolar ridge of a patient such...
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8354241 |
Methods for identifying a GLP-1 secretagogue
The present invention concerns combination of an amount of a BRS-3 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a...
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8354375 |
Repair of ligament using osteogenic proteins
Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of...
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8354372 |
Cyclised alpha-conotoxin peptides
This invention relates to an oral or enteral pharmaceutical preparation comprising at least one synthetically cyclised alpha-conotoxin peptide having an amide cyclised backbone such that the...
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8349577 |
Method for evaluating blood-neural barrier permeability
A system and method for evaluating blood-neural barrier permeability. Phospholipid liposomes are labeled with a fluorescent phospholipase A2 substrate and exposed to cerebrospinal fluid. The change...
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8349796 |
Methods for treatment of distraction osteogenesis using PDGF
The present invention relates to compositions and methods for use in osteodistraction procedures. In one embodiment, a method of stimulating osteogenesis during and/or following bone distraction...
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8343924 |
Composition for improving brain function and method for improving brain function
The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present...
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8343927 |
Pharmaceutical compositions for prevention of overdose or abuse
The invention relates to pharmaceutical compositions comprised of a chemical moiety attached to an active agent in a manner that substantially decreases the potential of the active agent to cause...
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