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5888978 |
Method for reducing the severity of gastro-intestinal damage
The present invention provides methods for reducing the severity of GI damage in an individual by administering a cytokine regulatory agent to an individual that is susceptible to developing such...
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5888969 |
Use of cytokine restraining agents to treat inflammatory bowel disease
The present invention relates to the use of cytokine restraining agents to treat inflammatory bowel disease.
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5876748 |
Fibrous microtube of oligoglycine compound
A lipid represented by the following formula: MO--(CO--CH 2 --NH) p --CO--(CH 2 ) n --CO--(NH--CH 2 --CO) q --OM wherein M represents a hydrogen atom or an alkali metal, n is an integer of...
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5877147 |
Compounds for medicinal use
Muramyl peptide compounds are useful in the prophylaxis of cancers and particularly in the treatment of precancerous lesions associated with cancers of the mucosa or epithelium.
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5874410 |
Arg-Gly-Asp-Asp-Ser and pharmaceutical compositions and uses thereof
Pentapeptide having the following formula: ##STR1## (Arg-Gly-Asp-Asp-Ser).
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5872097 |
Oligopeptides with affinity to opioid receptors
Straight or cyclic pentapeptides with receptor affinity to μ or δ opioid receptors having a primary sequence backbone of Tyr-X-Phe-Leu-Z, Seq. ID Nos. 1, 2, and 3. X and Z can be covalently...
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5866558 |
6-alkynyl steroids
Compounds of formula I: ##STR1## wherein R, R 1 , R 2 , R 3 , and R 4 have any of the values defined in the specification, and their pharmaceutically acceptable salts, are inhibitors of aromatase,...
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5856309 |
Amidinopyrroline derivatives, processes for their production and pharmaceutical agents containing these compounds
Compound of formula (I) are disclosed ##STR1## as well as optically active isomers or pharmacologically acceptable salts thereof. The compounds are useful active ingredients in pharmaceutical...
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5855884 |
Treatment of stress-induced migraine headache with a corticotropin releasing hormone blocker
Non-traumatic immobilization (restrain) stress causes rapid degranulation of rat dura mast cells, as shown both by light and electron microscopy. These morphologic findings were accompanied by...
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5854211 |
Compounds with growth hormone releasing properties
Novel peptide derivatives, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are disclosed. These peptide derivatives have the...
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5854212 |
Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
A compound of the formula ##STR1## is disclosed which is useful for the treatment of fungal infections and for the treatment of infections caused by Pneumocystis carinii.
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5854388 |
Angiotensin IV peptides and receptor
A unique and novel angiotensin AT4 receptor and AIV ligand system for binding a small N-terminal hexapeptide fragment of Angiotensin II (referred to as AIV, with amino acid sequence Val 1 -Tyr 2 ...
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5849709 |
Saccharopeptides and derivatives thereof
Saccharopeptides and methods of using the novel saccharopeptides are described having the following structural formula I: W-- --Y--W--! m (I) wherein W is...
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5849701 |
Peptide inhibitors of fibronectin and related collagen-binding proteins
Peptides derived from the second type 1 repeat of human endothelial cell thrombospondin which bind to the gelatin-binding domain of fibronectin have been isolated and synthetically produced. The...
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5849702 |
Cloning and production of human von Willebrand factor GPIB binding domain polypeptides and methods of using same
The subject invention provides non-glycosylated, biologically active polypeptides which comprise the vWF (von Willebrand Factor) GP1b binding domain. These polypeptides, may be used to inhibit...
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5846548 |
Combined administration of mitogenic immumo stimulator and a thymomimetic
A method of tumor therapy involves controlling the immune system by co-administration of a mitogenic immuno-stimulating substance and a thymomimetic substance.
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5846940 |
Corneal therapeutic agent
A corneal therapeutic agent comprises at least one of a hexapeptide and a pharmacologically acceptable salt thereof, represented by formula (I) shown below, and a pharmacologically acceptable...
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5846941 |
Isosteric antiherpes peptide derivatives II
Disclosed herein are peptidomimetic compounds of the formula A--B--D--CH 2 CH{CH 2 C(O)R 1 }C(O)--NHCH{CR 2 (R 3 )COOH}C(O)--E wherein A is a terminal group, for example an optionally...
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5840682 |
Peptide antagonists of neurotensin
The invention is directed to a compound of formula ##STR1## in which R represents a hydroxyl, alkyloxy, phenylalkyloxy or --NH--CH 2 --COOH radical, R 1 represents a hydrogen atom, an...
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5840688 |
Eating suppressant peptides
Peptides corresponding to specific portions of the apolipoprotein A-IV (apo A-IV) are provided. Most of the peptides correspond to the amino terminal region of apo A-IV. In addition, those peptides...
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5840697 |
Peptide inhibitors of calmodulin
The present invention relates to novel family of peptides which inhibit calmodulin and which have the general structure Ac-A1-B2-C3-D4-E5-F6-NH 2 , (SEQ ID No. 1), wherein A1 is (D)Leu or Leu, B2...
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5837686 |
Peptides and antibodies for treatment of rheumatoid arthritis
A synthetic peptide of not more than 20 amino acid residues or analogue thereof comprising a thiol-active cysteine residue and at least two positively charged amino acid residues situated on (but...
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5837677 |
Method for the treatment of cancer with Exochelins of Mycobacterium tuberculosis
The invention is directed toward the use of desferri-Exochelins to destroy cancer cells or retard or eliminate the growth of those cancer cells.
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5834433 |
Compounds and pharmaceutical uses of peptides of bombesin and GRP
A method for controlling the growth of tumor tissues, especially small cell lung. Treatment comprises administering to a patient in need thereof, an effective amount of a bombesin/GRP type...
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5834430 |
Potentiation of antibiotics
The present invention is concerned with methods of potentiating an antibiotic. The invention also includes compositions of an antibiotic and a peptide having units of the formula: (a) (A) n ...
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5834429 |
Small peptides which inhibit binding to T-4 receptors and act as immunogens
Short peptide of the formula: R a -Ser-Thr-Thr-Thr-Asn-Tyr-R b (I) where R a represents an amino terminal residue Ala- or D-Ala and R b represents a carboxy terminal residue...
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5830864 |
Antiherpes peptide derivatives having a ureido n-terminus
Disclosed herein are peptide derivatives of the formula A--B--NHCH{CH 2 C(O)R 1 }C(O)--NHCH{CR 2 (R 3 )COOH}C(O)--D wherein A is a terminal group, for example, an alkylaminocarbonyl or a...
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5830434 |
Methods of treating non-insulin dependent diabetes mellitus with pancreatic polypeptide
The present invention provides a method of treating NIDDM in a patient diagnosed with NIDDM by administering to the patient a compound in a pharmaceutically acceptable carrier that reduces hepatic...
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5827827 |
HIV-1 protease inhibitors
A series of novel oxirane derivatives, which are useful for inhibiting HIV are disclosed. Particularly of value are peptidomimetic compounds, containing a terminal epoxide group on a peptide or...
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5824647 |
Chemotactic wound healing peptides
Peptides corresponding to amino acid sequences in the C-terminal region of TGF-β are provided. The peptides all contain at least a seven amino acid sequence substantially corresponding to the...
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5821225 |
Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which...
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5821226 |
BAL C-tail drug delivery molecules
Drug delivery conjugates of including a BAL C-tail peptide including all or a portion of the carboxy terminal region of human bile salt-activated lipase (BAL) conjugated to a biologically active...
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5814610 |
Osteogenic growth oligopeptides and pharmaceutical compositions containing them
The invention relates to biochemically pure oligopeptides having stimulatory activity on osteoblastic and/or fibroblastic cells having a molecular weight between 200 and 2,000. Preferred...
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5811401 |
Advanced glycosylation endproducts and methods of use therefor
The present invention relates to advaced glycosylation endproducts formed by the reaction of arginine-lysine or lysine-arginine dipeptides, optionally as part of a larger protein or...
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5811394 |
Technetium-99m labeled polypeptides for imaging
The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides...
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5811074 |
Method of diagnosing pituitary dependent growth hormone deficiency
A diagnostic protocol and kit for evaluating pituitary growth hormone (GH) secretory capability as a means to identify the etiology of GH deficiency in children and adults is disclosed. The...
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5807819 |
Peptides useful for altering bone resorption
The present invention provides Arg--Gly--Asp peptides that can alter the binding of osteoclasts to a matrix such as bone or can selectively alter integrin receptor binding. The invention also...
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5807830 |
Method for treatment of purulent inflammatory diseases
This invention provides methods of treating purulent inflammatory diseases by administering L-Glu-L-Trp or a salt thereof.
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5804559 |
Prodrug derivatives of enzyme inhibitors having hydroxyl groups, a process for preparing them, and their use
The invention concerns prodrugs of enzyme inhibitors in which at least one OH-- group in the enzyme inhibitor has been converted into a derivative grouping of the formula III, IV or V: ##STR1## in...
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5801149 |
Inhibition of signal transduction molecules
A peptide capable of inhibiting the interaction of an SH2 domain containing protein with a second protein.
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5798335 |
Method for the treatment or prevention of eczema/dermatitis
The present invention provides a method for the treatment or prevention of eczema/dermatitis. This method involves the administration of Peptide T or its derivatives or analogues. Preferred...
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5795866 |
ETS1 gene: a human tumor suppressor gene
The present invention relates, in general, to methods for reducing cell tumorigenicity. More particularly, the present invention provides a method for reducing cell tumorigenicity comprising...
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5795857 |
Mimetic insect pyrokinin analogs for insect control
Novel pseudopeptide analogs of the insect pyrokinin neuropeptide family which possess biological activity mimicking that of the naturally occurring neuropeptides are disclosed. By addition of a...
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5795574 |
Use of an extract from a non-photosynthetic filamentous bacterium and composition containing it
The present invention relates to the use of at least one extract from at least one non-photosynthetic filamentous bacterium as substance P antagonist in a cosmetic composition or for the...
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5795858 |
Treatment or prevention of Crohn's disease and/or ulcerative colitis
The present invention provides a method for the treatment or prevention of Crohn's disease and/or ulcerative colitis. The method involves the administration of Peptide T or its derivatives or...
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5792444 |
Labeled chemotactic peptides to image focal sites of infection or inflammation
The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a...
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5792750 |
Materials and method for control of pests
The subject invention concerns novel peptides which have the property of interfering with the biosynthesis of the enzyme trypsin. This property enables the use of these peptides to, for example,...
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5792466 |
Mimetic insect kinin analogs for insect control
Novel pseudopeptide analogs of the insect kinin neuropeptide family which possess biological activity mimicking that of the naturally occurring neuropeptides are disclosed. By substituting a...
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5786334 |
Hexapeptide having immunostimulatory activity
The hexapeptide Phe--Leu--Gly--Phe--Pro--Thr, which is derived from a myelopeptide, exhibits immunostimulatory activity when administered to a mammal.
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5786332 |
Cytokine restraining agents and methods of use in pathologies and conditions associated with altered cytokine levels
The present invention relates to novel peptides that are potent cytokine restraining agents. In addition, the present invention relates to pharmaceutical compositions comprising a pharmaceutically...
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