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4957902 |
Peptide inhibitors of wound contraction
The present invention involves the inhibition of wound contraction by polypeptides having an amino acid sequence which is similar or identical to certain amino acid sequences of type (I) collagen....
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H000810 |
Biologically active amides
The present invention provides novel peptides of formula (I): R--(X 1 ) m --(X 2 ) n --X 3 --X 4 --X 5 --X 6 --X 7 --(X 8 ) p --(X 9 ) q --R 1 (I) together with their salts, esters,...
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4943628 |
HIV peptide-inducted T cell stimulation
The present invention provides peptides derived from HIV-1 which are capable of stimulating T cell proliferation. Such peptides are useful for immunizing human subjects against HIV infection.
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4943562 |
Tetra- and pentapeptides containing the lysyl-arginyl-aspartyl sequence and their applications as medicines, particularly anti-thrombotic medicines
The peptides according to the invention are of the following general formula I: Z-Lys-Arg-Asp-X-Y (I) wherein: X is the residue of one of the 20 common...
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4943561 |
Gastrin releasing peptide antagonist
Small cell lung carcinoma (SCLC) cells contain gastrin releasing peptide (GRP) receptors. The response of the cells to GRP is rapid growth. We have found a group of peptide derivatives that act as...
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4940713 |
Substituted glutamic acids
The present invention provides a compound of formula (I): ##STR1## wherein R 1 is hydrogen, C 1 -4 alkyl, acetyl or formyl; R 2 and R 3 are the same or different and are hydrogen or C 1 -4...
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4933324 |
Fatty acid-neuroactive drug conjugate as a prodrug
The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be...
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4933323 |
Novel peptide and salts thereof and peptide antiallergic agents containing these peptides
Novel peptide having the primary structure Asp-Ser-Asp-Gly-Lys or pharmaceutically acceptable salts thereof. The present peptide possesses activity of inhibiting histamine release and IgE antibody...
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4931429 |
α-aminoacyl β-aminoacyl aminodiols as anti-hypertensive agents
Compounds characterized generally as α-aminoacyl β-aminoactyl aminodiols are useful as renin inhibitors for the treatment of hypertension.
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4927809 |
Oligopeptidyl nitrile derivatives, agents containing them and their use
Compounds of the formula I A--R--NH--CHR 1 --(CH 2 ) a --NHC(NH)NH 2 in which R 1 is the cyanide group, R is Pro or D--Phe--Pro, A is a hydrogen atom or a protective group...
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4923964 |
Human splenin
The present invention is directed to the protein human splenin (hsP), substantially free of material associated with the protein in its natural environment in the human spleen. In particular, the...
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4921836 |
Substituted glutamic acids
The present invention provides a compound of formula (I): ##STR1## wherein Y is sulfur; R 2 and R 3 are the same or different and are hydrogen or C 1 -4 alkyl; R 4 is NR 11 R 12 ; R 11 , R 12...
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4906616 |
Hydrolyzed sodium casein compositions for dialysis procedures
A medicinal composition, particularly but not exclusively for use in fluids for medical dialysis, contains, as an agent for maintaining the osmolality of the fluid, a protein hydrolysate resulting...
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4885277 |
Anticoagulant therapy
A composition and method for treating thrombotic disorders. The composition comprises a peptide comprising an amino acid sequence corresponding to the sequence of the amino acid residues in the EGF...
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4880812 |
Pyrimidine compounds
The present invention provides a compound of formula (I): ##STR1## wherein R 1 is hydrogen , C 1 -4 alkyl, acetyl or formyl; R 2 and R 3 are the same or different and are hydrogen or C 1 -4...
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4880779 |
Method of prevention or treatment of AIDS by inhibition of human immunodeficiency virus
The present invention relates to a method of prevention or treatment of AIDS by inhibition of the human immunodeficiency virus (HIV). Inhibition of the virus is achieved by administration of an...
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4871717 |
Peptides
Heptapeptide analogs of somatastatin which inhibit secretion of growth hormone.
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4870055 |
Segmented polypeptide bioelastomers to modulate elastic modulus
A method of increasing the modulus of elasticity of a biopolymer is disclosed, which comprises incorporating a hexameric unit of the formula --X--(APGVGV) n --Y-- wherein A is a...
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4868287 |
Inhibition of mineral deposition by polyanionic/hydrophobic peptides and derivatives thereof having a clustered block copolymer structure
A poly-amino acid compound capable of inhibiting mineral deposition, which has the structure: poly (X) n poly (Y) m where each X is a residue independently selected from the group consisting...
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4866039 |
Peptides containing the 18 to 23 residues of vasoactive intestinal peptide, and analogues
Peptides comprising, in sequence, units selected from the amino acid residues 17 to 24 of VIP, and consisting at least of the amino acid residues 18 to 23, or an analogue thereof wherein one or...
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4866161 |
Inhibition of tartar deposition by polyanionic/hydrophobic peptides and derivatives thereof which have a clustered block copolymer structure
A method of treating a tooth so as to inhibit deposition of a mineral thereon, which comprises contacting the tooth with a mineral deposition inhibitory effective amount of a poly-amino acid...
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4866040 |
Aminocarnitine directed pharmaceutical agents
Carnitine, aminocarnitine and cysteic acid serve as carriers to bring pharmaceutically active compounds to desired sites in the body, e.g. skeletal muscle or the heart. The pharmaceutically active...
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4863903 |
Substituted 5-amino-4-hydroxyvaleryl derivatives
Compounds of the formula ##STR1## in which R 1 represents hydrogen or acyl, X 1 represents an optionally N-alkylated amino acid residue that is bonded N-terminally to R 1 and C-terminally to X 2...
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4855405 |
Glutamate receptor inhibitor
A novel glutamate receptor inhibitor obtained from Joro spider venom glands, and its manufacturing method.
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4851387 |
5-substituted amino-4-hydroxy-pentanoic acid derivatives and their use
A 5-substituted amino-4-hydroxy-pentanoic acid derivative having the formula: ##STR1## wherein R 1 is a hydrogen atom or an N-protecting group, R 2 , R 3 and R 5 may be any of a variety of...
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4845195 |
Inhibitor of ribonucleotide reductase
The pentapeptide Val Val Asn Asp Leu has been found to be the shortest peptide sequence that inhibits the activity of the ribonucleotide reductase enzyme of herpes simplex virus in vitro thereby...
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4837203 |
Pharmacologically active compounds and use
The peptides of the formula X--Tyr--X 2 --Gly--Phe(4NO 2 )--Pro--NH 2 wherein X is hydrogen or an amidino group and X 2 is D-S-methylmethionyl or D-arginyl, together with their...
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4837304 |
Inhibitor of ribonucleotide reductase
A series of oligopeptides each of which contains a D-amino acid has been found to inhibit the activity of the ribonucleotide reductase enzyme of herpes simplex virus in vitro thereby inhibiting...
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4818748 |
Renin inhibitors and aminoacid and aminoaldehyde derivatives
Anti-hypertensive compounds of the formula ##STR1## in which A represents hydrogen, C 1 -C 8 -alkyl, C 7 -C 14 -aralkyl, phenylsulphonyl, tolylsulphonyl or C 1 -C 8 -alkylsulfphonyl, or...
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4816449 |
Immunotherapeutic anti-inflammatory peptide agents
Anti-inflammatory peptides of the formula A-B-C-D-E, useful in treating allergies, autoimmune diseases, and other disorders, and methods for using them are described.
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4816444 |
Cell growth inhibitory substance
A potent cell growth inhibitory substance obtained from the Indian Ocean sea hare Dolabella, herein denominated "dolastatin 10"; and pharmaceutical preparations containing same; and methods useful...
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4804650 |
Analogs of atrial natriuretic peptides
Compounds and compositions comprising synthetic analogs of Atrial Natriuretic Peptides are provided, together with methods for their production and use as natriuretics, diuretics and/or...
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4801614 |
Process for using endogenous enkephalins and endorphins to inhibit growth of tumerous cells
A process for the therapeutic treatment of cancer patients involving stimulation and promotion of the natural immune system (both T cell and NK cell activity) resisting and inhibiting tumorous...
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4800085 |
Slow-release composite and process for producing the same
A slow-release composite having pyroglutamyl-histidyl-triptophyl-seryl- tyrosyl-D-leucyl-leucyl-arginyl-proline ethylamide or a salt thereof encapsulated in a polymer matrix and a process the same...
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4790988 |
Method and compositions for the treatment of thrombotic episodes
Fibrinogen degradation product pentapeptide 6A and its variants are used in the treatment of thrombi, in particular myocardial infarcts. In a preferred embodiment pentapeptide 6A and tissue...
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4784988 |
Peptides correlated to lysozyme
A peptide made up of at least 3 amino acids comprised in sequential form in the following structure: ##STR1## where Y may be absent or represent a glycine residue, where the amino acids ##STR2##...
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4782044 |
Composition containing cordiodilatin or fragments thereof and methods of obtaining cardiodilatin
This invention teaches therapeutic compositions containing the hormone cardiodilatin of active fragments thereof, as well as methods for obtaining the cardiodilatin. The compositions are useful in...
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4771036 |
Method and ophthalmic composition for the prevention and reversal of cataracts
The subject invention concerns a process for the prevention and reversal of cataracts. Specifically, the invention comprises the treatment of the eye lens with an effective cataract inhibiting...
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4766109 |
Hydrophobic peptides
Hydrophobic peptides having antihypertensive activity are disclosed. Also disclosed are pharmaceutical compositions comprising a hydrophobic peptide and a method of treatment of mammalian...
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4757049 |
Process for using endogenous enkephalins and endorphins to stimulate the immune system of patients with aids
A process for the therapeutic treatment of AIDS (acquired immune deficiency syndrome) involving stimulation and promotion of the natural immune system (both T cell and NK cell activity) resisting...
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4757050 |
Ureido renin inhibitors
Compounds of the formula ##STR1## are disclosed. These compounds intervene in the conversion of angiotensinogen to angiotensin II by inhibiting renin and thus are useful as antihypertensive agents.
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4753927 |
Method of blocking immune complex binding to immunoglobulin Fc receptors
A method of modulating immune responses in mammals by blocking immune complex binding to immunoglobulin Fc receptors is described, comprising administering a peptide comprising a portion selected...
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4749690 |
Treatment of allergy with thymopentin
A method for treating allergy by administration of the peptide thymopentin.
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4749687 |
Renin inhibitors containing statine or derivatives thereof
A series of novel peptide and polypeptide derivatives containing statine or derivatives thereof (e.g., aminostatine, cyclostatine) are disclosed that are useful for inhibiting the...
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4749688 |
Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
The method of treating hypertension with neutral metalloendopeptidase (NMEP) inhibitors, NMEP inhibitors in combination with atrial peptides, and NMEP inhibitors in combination with angiotensin...
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4746648 |
Peptide derivatives which inhibit renin and acid proteases
The invention relates to peptide derivatives modeled on the basis of pepstatin. These derivatives inhibit renin and acid proteases.
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4743585 |
Renin inhibitors
The invention concerns novel renin-inhibitory peptides which are useful for treating renin associated hypertension and for treating hyperaldosteronism. Novel intermediates, processes for preparing...
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4742048 |
Tetrapeptides and pentapeptides, their preparation and compositions containing them
Tetrapeptides and pentapeptides of the formula: ##STR1## wherein R represents hydrogen or a fatty acid residue, R 1 represents hydroxy, amino, alkoxy of 1 to 4 carbon atoms, optionally substituted...
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4728638 |
Somatostatine derivatives
Somatostatine derivatives of the general formula ##STR1## wherein either (a) A is ##STR2## W is -CO-N(A 4 ) or -N(A 5 )-CO- and Y 1 and Y 2 are H or together a bond or (b) A is H, alkyl,...
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4725580 |
Peptide derivatives, analogous to pepstatin, which inhibit renin and acid proteases
The invention relates to pepstatin analogs which inhibit renin and acid proteases. These analogs are particularly suitable for the treatment of arterial tension.
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