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5158936 |
Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
Thiol protease inhibitors are disclosed having the formula: ##STR1## or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, wherein: n is 0 or 1; m is 0, 1 or 2; X is...
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5140010 |
Stabilized aqueous formulations of thymopentin
The present invention provides a method for preparing aqueous formulations of thymopentin, which method permits the peptide to retain its biological activity during storage at room temperature.
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5137874 |
Partially coated C.sub.10 -C.sub.20 fatty acid salts of peptides having molecular weights up to about 5,000
The invention relates to compositions for the parenteral administration of an essentially uniform and continuous amount of a peptide, which has a molecular weight of up to about 5,000, over an...
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5134122 |
Method for preparing a pharmaceutical composition in the form of microparticles
A method for preparing a pharmaceutical composition in the form of microparticles, the composition thus obtained and its use for preparing injectable suspensions.
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5134121 |
Nerve growth factor peptides
The present invention provides both agonist and antagonist nerve growth factor peptides. The NGF blocking peptides can be used to inhibit the expression of mRNA and their encoded proteins whose...
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5130130 |
Phospholipase A2 conjugated to a tarqeting moiety and their therapeutic compositions
The present invention relates to a basic protein called phospholipase A2 (PLA2), isolated from the venom of a snake of the family Elapidae, especially of a Naja snake and more particularly Naja...
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5126327 |
Melanocyte-stimulating hormone inhibitor and external preparation containing the same
A melanocyte-stimulating hormone inhibitor has an amino acid sequence represented by the following formula [I], [II] or [III] in the molecule: --His--Ser--Arg--Trp-- ...
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5126326 |
Enzyme inhibiting peptide derivatives
Disclosed herein are peptide derivatives which inhibit the activities of human immunodeficiency virus (HIV) protease and renin. The peptide derivatives can be represented by general formula R 1 ...
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5124314 |
Pharmaceutical compositions containing amylin
The present invention relates to pharmaceutical compositions for use in treating diabetes Mellitus or hypoglycemia containing Amylin as the effective additive.
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5120713 |
Treatment of obesity with an alpha-2-adrenergic agonist and a growth hormone releasing peptide
Obese patients may be effectively treated by cojointly administering an alpha-2-adrenergic agonist, such as clonidine, and a growth hormone releasing peptide, such as GHRH, to restore or...
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5118669 |
Peptides and intermediates therefor useful as antiallergic agents, vasodilators and immunoregulators
The following oligopeptides containing -Asp-Gly- or -Asp-Ser- are synthesized: H-Asp-Gly-Lys-OH H-Ser-Asp-Gly-Lys-OH H-Asp-Ser-Asp-Gly-Lys-OH H-Ala-Asp-Ser-Asp-Gly-Lys-OH The oligopeptides...
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5118665 |
Anti-oxidative and anti-inflammatory metal:peptide complexes and uses thereof
Compositions and methods for enhancing or restoring the resistance of a warm blooded animal to oxidative or inflammatory damage caused be release of reactive oxygen species by certain immune cells...
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5112596 |
Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability
The permeability of the blood-brain barrier to endogenous or exogenous neuropharmaceutical or diagnostic agents in an individual's blood stream is increased by administering a bradykinin agonist of...
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5112811 |
SDK peptides and therapeutic compositions containing them
The invention relates to peptides having the general formula H 2 N - W - Ser - Asp - Lys - X - OH wherein X represents a Pro or Lys residue or a valence bond and W represents a Thr or Pro...
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5112837 |
Quinoline derivatives having anti-tumor activity
The invention relates to a quinoline of the formula: ##STR1## wherein each of R 1 and R 2 , which may be the same or different, is hydrogen, halogeno, hydroxy, cyano, carbamoyl, nitro or amino,...
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5110795 |
Methods and compositions for the treatment of inflammatory bowel diseases and conditions
Methods and compositions for the treatment of inflammatory bowel diseases, chemically-induced irritation and inflammation, and other irritative or inflammatory conditions utilizing the peptide...
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5108990 |
Glutamic acid derivatives
All isomeric forms and mixtures of isomers of glutamic acid compounds of the formula ##STR1## wherein the glutamic acid of D- or L- configuration, R 1 is selected from the group consisting of...
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5100873 |
Irreversible peptide ligands for bombesin receptors, their use, and process for making the same
A peptide of formula (I): A-B-C-D-Gln-Trp-Ala-Val-X-Y-T-W (I) wherein either: (i) A represents a hydrogen atom, a Boc group or an acetyl group, one of B and C...
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5100663 |
Tyr-Gly compositions useful in increasing immune response
Compositions for delaying the progression from AIDS to ARC, and for alleviating symptoms of AIDS and ARC are disclosed together with clinical results of use of such compositions in clinical trials...
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5089471 |
Peptidyl beta-aminoacyl aminodiol carbamates as anti-hypertensive agents
Non-peptidyl compounds characterized generally as β-aminoacyl aminodiol carbamates are useful as renin inhibitors for the treatment of hypertension.
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5087614 |
Enzyme inhibitor and method of producing the same
Novel peptide analogues which exhibit inhibitory activity against aspartic proteinases, a novel species of actinomycetous microorganism which produces said novel peptide analogues, a process for...
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5081124 |
Method of producing antitumor effect using quinazolin-4-one derivatives
A quinazoline of the formula: ##STR1## wherein R 1 is alkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, alkylthio, aryl, aryloxy, arylalkyl, halogeno, hydroxy, mercapto, pyridylthio, pyrimidinylthio,...
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5081107 |
Polypeptide compounds
The invention releates to a polypeptide of formula I R 1 --CO--A 1 --A 2 --A 3 A 3 --A 4 --A 5 --A 6 --Q wherein each of the generic terms is disclosed in full in the specification and...
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5073541 |
Treatment of small cell lung cancer with somatostatin analogs
A method of treating a mammal suffering from cancer by administering to the mammal somatostatin or an analog thereof, the analog being a hexapeptide analog or higher, in a dosage of at least 25...
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5071835 |
Ribonucleotide reductase inhibitors
Disclosed herein are peptides of the formula Y--R 1 --R 2 --R 3 --R 4 --R 5 --R 6 --Z wherein R 1 to R 5 are designated amino acid residues; R 6 is Phe, homoPhe or an amino acid residue...
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5071848 |
Tricyclic quinoline antineoplastic agents
Isothiazolo-quinoline derivatives are described which are cytotoxic for various tumor cell lines and are useful in the treatment of neoplastic diseases.
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5066643 |
Fluorine and chlorine statine or statone containing peptides and method of use
A peptide optionally in isosteric form wherein a methylene group in the backbone chain is disubstituted, one or both substituents being fluorine and/or chlorine, in free form or in pharmaceutically...
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5063206 |
Compositions having use as treatment of neuropsychiatric deficits
The present invention relates to methods of treating mental disorders and memory deficits not caused by HIV infection. The methods involve administration of a thymoleptic effective amount of...
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5061692 |
Methods and compositions for the treatment of non-IgE-mediated diseases
Methods and compositions for the treatment of non-IgE-mediated inflammatory disease conditions utilizing the peptide Asp-Ser-Asp-Pro-Arg, or derivative thereof are disclosed.
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5061691 |
Enkephalin analogs
The invention relates to enkephalin analogs of the formula ##STR1## wherein in case of X is D-Val, D-Phe, Pro, D-Met, D-Met(O), D-Leu, D-Glu, D-Glu(Obzl), D-Lys, D-Lys(Z), or D-Arg, Y is Gly or...
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5055449 |
Vincristine-containing product
The present invention provides a pharmaceutical product for combating cancer with vincristine as active constituent, the neuropathic complications being prevented by a peptide. The product...
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5051401 |
Inhibition of mineral deposition by phosphorylated and related polyanionic peptides
A poly-amino acid compound capable of inhibiting mineral deposition, which has the structure: poly (X) m (Y) n where each X independently is aspartate, glutamate, glutamine, asparagine, or...
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5047397 |
Linear analogs of atrial natriuretic peptides
Compounds and compositions comprising synthetic analogs of Atrial Natriuretic Peptides are provided, together with methods for their production and use as natriuretics, diuretics and/or...
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5047399 |
Hydrophobic pseudo-peptides
Novel hydrophobic psuedo-peptides of formula I ##STR1## wherein R 1 is lower alkyl or -CH 2 CONR 6 R 7 ; R 2 , R 3 , R 4 and R 5 are independently lower alkyl, cycloalkyl lower alkyl, aryl...
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5039662 |
Peptide with anti-metastasis activity
The invention discloses an acylated pentapeptide that inhibits metastasis activity of malignant cells.
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5039663 |
Antibiotics called "mureidomycins A, B, C, and D" and their therapeutic use
Novel compounds, called mureidomycins A, B, C and D, may be prepared by cultivation of a suitable microorganism of the genus Streptomyces, especially Streptomyces flavidovirens SANK 60486 (FERM...
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5039660 |
Partially fused peptide pellet
A bioerodible pellet capable of administering an even and continuous dose of a peptide over a period of up to a year, when subcutaneously implanted, is provided. The bioerodible implant is a...
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5036050 |
Compositions containing thymopentin for topical treatment of skin disorders
A composition for use in the topical treatment of skin disorders such as dermatitis or poison ivy, which comprises an effective amount of thymopentin and a suitable carrier is provided. A method...
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5028592 |
Antipyretic and anti-inflammatory peptides
An antipyretic tripeptide, having the amino acid sequence lysine-proline-valine, and a method for utilizing the tripeptide to reduce fever and inflammation in mammals are disclosed. The tripeptide...
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5015628 |
Anticariogenic phosphopeptides
A phosphopeptide or a salt thereof the phosphopeptide having from 5 to 30 amino acids including the sequence A-B-C-D-E where A, B, C, D and E are independently phosphoserine, phosphothreonine,...
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5013722 |
Cholecystokinin analogs for controlling appetite
Cholecystokinin analogs useful for suppressing food intake in mammals and humans.
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5011825 |
Peptides influencing diuresis and natriuresis, a process for their preparation, agents containing them, and their use
The invention relates to peptides of the formula R N --L--N--B 2 --R C (I) in which R N denotes an acyl radical, L denotes a radical of a lipophilic, neutral α-amino...
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5008288 |
Carnitine directed pharmaceutical agents
Carnitine, aminocarnitine and cysteic acid serve as carriers to bring pharmaceutically active compounds to desired sites in the body, e.g. skeletal muscle or the heart. The pharmaceutically active...
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5004743 |
Pyridyl styrene dialkanoic acids as anti-leukotriene agents
Compounds having the formula: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and...
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5002933 |
Hexapeptide and medicinal preparation produced from it to treat erosive and ulcerative lesions of gastrointestinal tract
A novel hexapeptide is provided having the following structure: Tyr-D-Ala-Gly-Phe-Leu-Glu also provided is a proposed medicinal preparation for treatment of erosive and ulcerative lesions of the...
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4987122 |
Peptide compounds and medical method of use thereof
Novel peptides consisting of dimeric peptide chains linked by a disulphide bridge. The dimers have a stimulatory effect on haemopoiesis, by contrast with the inhibitory effect of the monomer...
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4977141 |
Peptidyl α-aminoacyl aminodiol carbamates as anti-hypertensive agents
Non-peptidyl compounds characterized generally as aminoacyl aminodiol carbamates are useful as renin inhibitors for the treatment of hypertension.
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4971973 |
Glutamic acid derivatives
The present invention provides a compound of formula (I): ##STR1## wherein Y is oxygen; R 2 and R 3 are the same or different and are hydrogen or C 1 -4 alkyl; R 4 is NR 11 R 12 ; R 11 , R 12...
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4968672 |
Adenosine receptor prodrugs
A functionalized congener approach to drugs acting at A 1 and A 2 adenosine receptor types is applicable to prodrug design. The prodrugs affect a more efficient delivery of the drug at the...
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4963485 |
Brain derivable polypeptide factors and antibodies thereto
Novel polypeptides, polynucleotide sequences, DNA constructs and compositions are provided for the preparation and use of polypeptides associated with naturally occurring polypeptides found in...
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